Interferon-γ has been shown to interact with Interferon gamma receptor 1 and Interferon gamma receptor 2. Interferon-γ has been ... "The heparan sulfate binding sequence of interferon-gamma increased the on rate of the interferon-gamma-interferon-gamma ... Interferon gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The ... March 2010). "Beta interferon plus gamma interferon efficiently reduces acyclovir-resistant herpes simplex virus infection in ...
It binds interferon-γ, the sole member of interferon type II. The human interferon-gamma receptor complex consists the ... Interferon-γ Receptor-1 and 2 Mutations Interferon gamma receptor (IFNGR1) family (Articles with short description, Short ... Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G (1997). "The interferon gamma (IFN-gamma) receptor: a ... Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. N Engl J Med. 1996;335:1956- ...
Halevy, S.; Cohen, A.; Grossman, N. (2005). "Clinical implications of in vitro drug-induced interferon gamma release from ... Interferon-γ (IFN-γ) release assays rely on the fact that T-lymphocytes will release IFN-γ when exposed to specific antigens. ... Interferon-γ release assays (IGRA) are medical tests used in the diagnosis of some infectious diseases, especially tuberculosis ... 2007). "Utility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in ...
... has been shown to interact with Interferon-gamma. Mutations in the IFNGR1 gene can lead to extreme ... IFNGR1 interferon gamma receptor 1". Novick D, Orchansky P, Revel M, Rubinstein M (Jun 1987). "The human interferon-gamma ... "Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine ... "High-affinity receptor for interferon-gamma (IFN-gamma), a ubiquitous protein occurring in different molecular forms on human ...
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor ... Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the IFNGR2 gene. ... "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J. Biol. Chem. 263 (24): 12036-43. ...
... the interferon gamma receptor (IFNGR1) family is a family of proteins which includes several eukaryotic and viral interferon ... The vaccinia virus interferon (IFN)-gamma receptor (IFN-gammaR), which is a 43 kDa soluble glycoprotein that is secreted from ... Alcami A, Smith GL (March 2002). "The vaccinia virus soluble interferon-gamma receptor is a homodimer". J. Gen. Virol. 83 (Pt 3 ... Members of this family include: The human interferon gamma receptor 1, which is a member of the hematopoietic cytokine receptor ...
"Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein ... Page for Interferon gamma 5' UTR regulatory element at Rfam v t e (Cis-regulatory RNA elements, All stub articles, Molecular ... Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing ... Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma ...
Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by ... "Entrez Gene: IFNA1 interferon, alpha 1". Lengyel P (1982). "Biochemistry of interferons and their actions". Annual Review of ... Uzé, G; Schreiber, G; Piehler, J; Pellegrini, S (2007). "The Receptor of the Type I Interferon Family". Interferon: The 50th ... Pestka S, Krause CD, Walter MR (Dec 2004). "Interferons, interferon-like cytokines, and their receptors". Immunological Reviews ...
... interferon gamma); or cause cell death (viz., tumor necrosis factor alpha). AGEP: Key elements promoting tissue injury in AGEP ...
In response to IL-12, MAIT cells produce and secrete interferon-gamma (IFN-γ), a cytokine that activate macrophages, assists in ... Boehm U, Klamp T, Groot M, Howard JC (1997-01-01). "Cellular responses to interferon-gamma". Annual Review of Immunology. 15: ...
Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene. The protein ... "Entrez Gene: IFI30 interferon, gamma-inducible protein 30". Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, ... The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This ... Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity ...
The cytokine interferon gamma and the Gram negative bacterial cell wall component lipopolysaccharide induce CD38 expression on ... Interferon gamma strongly induces CD38 expression on monocytes. The cytokine tumor necrosis factor strongly induces CD38 on ... in vivo during human influenza infection and blocking CD38 prevents the ability of pDCs to produce type I interferon in vitro. ...
"E38N interferon gamma polypeptide variants - US Patent 7232562 Full Text". Patentstorm.us. Archived from the original on 11 ... "Interferon gamma conjugates - US Patent 7230081 Full Text". Patentstorm.us. Archived from the original on 11 October 2012. ... "Polynucleotides encoding interferon gamma polypeptides - US Patent 7504237 Full Text". Patentstorm.us. Archived from the ...
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene ... IL-18 is up regulated by interferon-gamma. IL-18 has also been found to increase the Alzheimer's disease-associated amyloid- ... June 1998). "Overview of interleukin-18: more than an interferon-gamma inducing factor". Journal of Leukocyte Biology. 63 (6): ... "Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)". Yasuda K, Nakanishi K, Tsutsui H (February 2019). " ...
Singh, V. K. (1996). "Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism". Journal of ...
Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional ... "Entrez Gene: IFI16 interferon, gamma-inducible protein 16". Ouchi, Mutsuko; Ouchi, Toru (2008-01-01). "Role of IFI16 in DNA ... "A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells". ... 2004). "The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7- ...
"High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor Deficiency". Pediatrics. 107 ... a complete deficiency in the interferon-gamma receptor have significant elevations in plasma concentrations of interferon-gamma ... "IFNGR1 interferon gamma receptor 1 [ Homo sapiens (human) ]". Bryant, Stephen H.; Kans, Jonathan A.; Chappey, Colombe; Geer, ... "Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection". The New England Journal of ...
Fontana V, Choren V, Vauthay L, Calvo JC, Calvo L, Cameo M (December 2004). "Exogenous interferon-gamma alters murine inner ... Sharma B, Iozzo RV (February 1998). "Transcriptional silencing of perlecan gene expression by interferon-gamma". J. Biol. Chem ... Interferon- γ treatment of blastocyst-stage murine embryos leads to a loss of perlecan expression on the trophectoderm, and ... Interferon-γ signaling mediates transcriptional repression of the perlecan gene. This was first shown in colon cancer cell ...
Tumor necrosis factor alpha and Interferon gamma). Induction of the high-output iNOS usually occurs in an oxidative environment ...
Schroder K, Hertzog PJ, Ravasi T, Hume DA (February 2004). "Interferon-gamma: an overview of signals, mechanisms and functions ... IL-2 receptors have γ (gamma) chains, which are associated with JAK3, which then phosphorylates key tyrosines on the tail of ... Studies indicate that STAT2 requires a protein called interferon regulatory factor 9 (IRF9) to enter the nucleus. Not as much ... Au-Yeung, Nancy; Mandhana, Roli; Horvath, Curt M (2014). "Transcriptional regulation by STAT1 and STAT2 in the interferon JAK- ...
Haque MF, Meghji S, Nazir R, Harris M (January 2001). "Interferon gamma (IFN-gamma) may reverse oral submucous fibrosis". ... IFN-gamma is an antifibrotic cytokine which alters collagen synthesis and helps in OSF. Colchicine tablets 0.5 mg twice a day ...
... like interferon gamma, that activate macrophages and cytotoxic T lymphocytes (CTLs). Interferon gamma represents an example of ... Once activated by T lymphocytes or Natural Killer cells, interferon gamma upregulates expression of macrophages and both types ... In B lymphocytes (B cells), interferon gamma stimulates antibody class switching. All of these cells have different, ...
Huang KJ, Su IJ, Theron M, Wu YC, Lai SK, Liu CC, Lei HY (February 2005). "An interferon-gamma-related cytokine storm in SARS ... An animal study found that mice producing an early strong interferon response to SARS-CoV-2 were likely to live, but in other ... The high mortality rate of COVID-19 in older populations has been attributed to the impact of age on interferon responses. ... One such cause is the delayed Type I interferon response that leads to accumulation of pathogenic monocytes. High viremia is ...
The source of interferon-gamma can be CD4+ T cells, CD8+ T cells, natural killer cells, B cells, natural killer T cells, ... Interferon-gamma-which was once called macrophage activating factor-stimulates macrophages to produce nitric oxide. ... 6-10 Schroder K, Hertzog PJ, Ravasi T, Hume DA (February 2004). "Interferon-gamma: an overview of signals, mechanisms and ... But, during an infection, they receive chemical signals-usually interferon gamma-which increases their production of MHC II ...
IL-10 or Interferon gamma) in the tumor environment. The products of these two genes, programmed death-ligand 1 and programmed ...
Expression of this catalytic subunit (beta 2, according to systematic nomenclature) is downregulated by gamma interferon due to ... Rivett AJ, Bose S, Brooks P, Broadfoot KI (2001). "Regulation of proteasome complexes by gamma-interferon and phosphorylation ... "Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma". The Journal of Experimental Medicine ...
Dorman SE, Holland SM (2000). "Interferon-gamma and interleukin-12 pathway defects and human disease". Cytokine & Growth Factor ... Rosenzweig SD, Holland SM (February 2005). "Defects in the interferon-gamma and interleukin-12 pathways". Immunological Reviews ... due to decreased production of interferons in the central nervous system. Interferon-γ (IFN-γ)/interleukin-12 (IL-12) pathway ... UNC93B1 is very important signaling molecule involved in the production of interferon which plays a key role in the killing of ...
The vaccine resulted in specific interferon gamma cell production. Also specific T-cells for middle envelop proteins antigens ... and interferon gamma". Proceedings of the National Academy of Sciences of the United States of America. 93 (7): 2879-2883. ... Yi AK, Chace JH, Cowdery JS, Krieg AM (January 1996). "IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in ... Both helper and cytotoxic T-cells can control viral infections by secreting interferons. Cytotoxic T cells usually kill virally ...
Ashkar AA, Di Santo JP, Croy BA (July 2000). "Interferon gamma contributes to initiation of uterine vascular modification, ... Depletion of the inflammatory cytokine interferon gamma reversed the effect.[citation needed] Tumor-infiltrating NK cells have ... NKT cell activity promotes NK cell activity by secreting interferon gamma. In contrast to NKT cells, NK cells do not express T- ... It has been shown that this kind of NK cell has enhanced interferon-γ production and cytotoxicity against leukemia cell lines ...
Induction by interferon-gamma and contribution to ATP-dependent proteolysis". The Journal of Biological Chemistry. 275 (19): ...