Antimetabolites interfere with the synthesis of nucleic acids. These include: folic acid analogues, such as methotrexate purine ...
Pyrimidine analogues are antimetabolites that interfere with nucleic acid synthesis. Some of them have been shown to fit the ...
... is an antimetabolite and methionine antagonist. It prevents amino acid incorporation into proteins and interferes ...
Antimetabolites can be used in cancer treatment, as they interfere with DNA production and therefore cell division and tumor ... An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal ... Anti-metabolites also affect RNA synthesis. However, because thymidine is used in DNA but not in RNA (where uracil is used ... Antimetabolite drugs are commonly used to treat leukemia, cancers of the breast, ovary, and the gastrointestinal tract, as well ...
Purine Mercaptopurine Thioguanine Fludarabine Purine antimetabolites are commonly used to treat cancer by interfering with DNA ... Purine analogues are antimetabolites that mimic the structure of metabolic purines. Nucleobase analogues Thiopurines such as ... Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 ... v t e (Articles with short description, Short description matches Wikidata, Antimetabolites, Purines, All stub articles, ...
They are purine anti-metabolites, meaning that they interfere with the synthesis of purines required for inflammatory cells. ... Yunnan Baiyao Methotrexate is a folate anti-metabolite drug that is also used for chemotherapy. It is useful in maintenance of ...
It is classified as a purine analog, which is a type of antimetabolite. It mimics the nucleoside adenosine and thus inhibits ... the enzyme adenosine deaminase, interfering with the cell's ability to process DNA. Cancer cells generally divide more often ...
Early in the course of the disease, the lesions cause acute and marked vision loss (if it interferes with the optic nerve) that ... but in recurrent disease an antimetabolite agent may be indicated. Vision improves in almost all cases. In rare cases, a ... In cases where lesions appear to be interfering with the optic nerve, methyl prednisone is prescribed, ... providing scarring doesn't interfere with the optic nerve). It occurs equally between men and women with a male to female ratio ...
Pyrimidine Fluorouracil Floxuridine Gemcitabine Pyrimidine antimetabolites are commonly used to treat cancer by interfering ... Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines. Nucleobase analogues Fluorouracil ... Parker, William B. (2009). "Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer". Chem Rev. 109 ... v t e (Articles needing additional references from July 2013, All articles needing additional references, Antimetabolites, ...
Proton pump inhibitors - these drugs inhibit the production of stomach acid; this is thought to interfere with calcium ... methotrexate and other antimetabolite drugs, depot progesterone and gonadotropin-releasing hormone agonists. Anticoagulants - ...
Antimetabolite - an enzyme inhibitor that is used to interfere with cell growth and division Transition state analogue - a type ... Competitive inhibition increases Km (i.e., the inhibitor interferes with substrate binding), but does not affect Vmax (the ...
... is in the thiopurine and antimetabolite family of medications. Mercaptopurine was approved for medical use in ... as such it interferes with normal metabolic processes within cells, typically by combining with enzymes, to disrupt DNA and RNA ... Specifically, Mercaptopurine is a purine antimetabolite or purine antagonist as such inhibits DNA synthesis by inhibiting the ... Official information from the package insert for purinethol: Mercaptopurine is an antimetabolite antineoplastic, ...
2015). Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Similar to other antimetabolite anti- ... Sickle-cell disease (increases production of fetal hemoglobin that then interferes with the hemoglobin polymerisation as well ... This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering ... Antineoplastic antimetabolites, Bristol Myers Squibb, IARC Group 3 carcinogens, Wikipedia medicine articles ready to translate ...
Chlorophetanol Diiodohydroxyquinoline (Iodoquinol) Flucytosine (5-fluorocytosine) - an antimetabolite pyrimidine analog ... a hydroxypyridone antifungal that interferes with active membrane transport, cell membrane integrity, and fungal respiratory ...
Antimetabolites masquerade as pyrimidine-like molecules which prevents normal pyrimidines from being incorporated into DNA ... This leads to the inhibition of methylation of deoxyuridylic acid to thymidylic acid, thus interfering with DNA synthesis. The ... Floxuridine (also 5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites. Specifically, ... interferes with ability to eat and unrelieved with prescribed medication) Vomiting (vomiting more than 4-5 times in a 24-hour ...
Cytosine arabinoside interferes with the synthesis of DNA. Its mode of action is due to its rapid conversion into cytosine ... Cytarabine is in the antimetabolite and nucleoside analog families of medication. It works by blocking the function of DNA ...
These purine antimetabolites are activated in the form of thioguanine nucleotides that affect DNA replication when incorporated ... Trastuzumab, the first HER2-targeted drug developed in 1990, interferes with HER2 signalling. In 2001, a study showed that ... and the resulting antimetabolites are inactivated by TPMT. It has been established that the TPMT genotype of a patient can ...
Some trypsin inhibitors and lectins are found in legumes and interfere with digestion. Lipase inhibitors interfere with enzymes ... Antimetabolite Biopesticide Plant defense against herbivory Cammack, Richard; Atwood, Teresa; Campbell, Peter; Parish, Howard; ... Antinutrients are natural or synthetic compounds that interfere with the absorption of nutrients. Nutrition studies focus on ...
Nicotine and other harmful chemicals in cigarettes interfere with the body's ability to create estrogen, a hormone that ... antibiotics such as bleomycin and dactinomycin and antimetabolites such as methotrexate, mercaptopurine and 5-fluorouracil. ... ASA production are directed against surface antigens on sperm, which can interfere with sperm motility and transport through ... Also, cigarette smoking interferes with folliculogenesis, embryo transport, endometrial receptivity, endometrial angiogenesis, ...
Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotides to be incorporated into ... mutations in viral thymidine kinase interfere with the first of these phosphorylations; in such cases the drug remains ...
Anti-metabolites are a group of molecules that impede DNA and RNA synthesis. Many of them have a similar structure to the ... Inhibition of topoisomerase I or II interferes with both of these processes. Two topoisomerase I inhibitors, irinotecan and ... Unlike alkylating agents, anti-metabolites are cell cycle dependent. This means that they only work during a specific part of ... Subtypes of the anti-metabolites are the anti-folates, fluoropyrimidines, deoxynucleoside analogues and thiopurines. The anti- ...
The exosome has been shown to be inhibited by the antimetabolite fluorouracil, a drug used in the chemotherapy of cancer. It is ... It is presumed that this system prevents aberrant complexes from interfering with important cellular processes such as protein ...
This excessive accumulation of wastes will result in a continued build-up of wastes including urea which interferes with ... Immunosuppression medication may include calcineurin inhibitor, antimetabolite and methylprednisolone and assist in suppressing ...
Medium risk individuals would also include those taking medications that can interfere with folate absorption such as ... Other potential causes can include folate antimetabolites (such as methotrexate), mycotoxins in contaminated corn meal, arsenic ...
It can also interfere with niacin (vitamin B3), resulting in at least one case to pellagra and fatal medullary aplasia. ... Azathioprine is in the purine analogue and antimetabolite family of medications. It works via 6-thioguanine to disrupt the ...
... and antimetabolites such as 5-FU and capecitabine. JD Hainsworth developed a protocol that includes Taxol and Carboplatinum ... but researchers speculate that smoking interferes with a process called apoptosis, or programmed cell death, which helps rid ...
The excessive number of cells can also interfere with the level of other cells, causing further harmful imbalance in the blood ... People with low- to average-risk ALL receive therapy with antimetabolite drugs such as methotrexate and 6-mercaptopurine (6-MP ...
Antimetabolites, also categorized as steroid-sparing agents, such as azathioprine, methotrexate, mycophenolic acid, and ... that may interfere with the diagnosis of sarcoidosis where they are prevalent. There may also be differences in the severity of ... Baughman RP, Grutters JC (October 2015). "New treatment strategies for pulmonary sarcoidosis: antimetabolites, biological drugs ... Major categories of drug interventions include glucocorticoids, antimetabolites, biologic agents especially monoclonal anti- ...
Some treatments can interfere with the mother's ability to give birth vaginally or to breastfeed. Cervical cancer may require ... which are divided into broad categories such as alkylating agents and antimetabolites. Traditional chemotherapeutic agents act ...
A number of drugs interfere with the biosynthesis of THF from folic acid. Among them are the antifolate dihydrofolate reductase ... Carmen AJ, Carlos M (2008). "Chapter 2 - Antimetabolites". Medicinal Chemistry of Anticancer Drugs. pp. 9-52. doi:10.1016/B978- ... Cancer cells divide rapidly, and drugs that interfere with folate metabolism are used to treat cancer. The antifolate drug ...