It is an antineoplastic antibiotic and an intercalating agent. Becatecarin (BMS-181176) is a synthetic analog of rebeccamycin. ... a novel antitumor agent: J.A. Bush, et al.; J. Antibiot. (Tokyo) 40, 668 (1987) Syntheses and biological activities ( ...
"Activation of cGAS-dependent antiviral responses by DNA intercalating agents". Nucleic Acids Research. 45 (1): 198-205. doi: ...
Intercalating agents. interfere with DNA replication and transcription by wedging themselves into the spaces in between DNA's ... Alkylating agents. interfere with DNA replication and transcription by modifying DNA bases.. Busulfan, Carmustine, ... It can also detect genotoxic agents missed in in vitro tests. The positive result of induced chromosomal damage is an increase ... In genetics, genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing ...
Another option is to use SYBR Green I, a DNA intercalating coloring agent. This method is specifically advantageous because it ...
Propidium iodide is a fluorescent intercalating agent that can be used to stain cells. Propidium iodide is used as a DNA stain ... Ethidium bromide intercalates and stains DNA, providing a fluorescent red-orange stain. Although it will not stain healthy ... It is a strong oxidizing agent as the osmium has an oxidation number of +8. It aggressively oxidizes many materials, leaving ... These are chemical agents which have power of making dyes to stain materials which otherwise are unstainable Mordants are ...
Gatasheh, Mansour K; Kannan, S; Hemalatha, K; Imrana, N (2017). "Proflavine an acridine DNA intercalating agent and strong ... Proflavine is also known to have a mutagenic effect on DNA by intercalating between nucleic acid base pairs. It differs from ... Denny (2002). "Acridine Derivatives as Chemotherapeutic Agents". Current Medicinal Chemistry. 9 (18): 1655-65. doi:10.2174/ ...
DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision ...
Intercalating agents- Chemical compounds that place themselves between stacked nitrogenous bases in DNA, causing a frameshift ... Some intercalating agents, like daunorubicin, are capable of blocking replication and transcription, making them incredibly ... Alkylating agents- Compounds that attach an alkyl group to the four bases. When an alkyl group is added to guanine, it can lead ... Induced mutations are any lesions in DNA caused by an agent or mutagen. Mutagens often demonstrate mutational specificity, ...
... is a fluorescent intercalating agent that can be used to stain cells and nucleic acids. PI binds to DNA by intercalating ...
... that is able to intercalate DNA and thus prevent cell division (mitosis); Etoposide - a topoisomerase inhibitor. A phase II ... an alkylating antineoplastic agent from oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue (anthraquinone ...
... as they can act as intercalating agents. Broomhead J. A.; Young C. G. (1990). Tris(2,2'-bipyridine)Ruthenium(II) Dichloride ... In this conversion, Ru(III) is reduced to Ru(II), and hypophosphorous acid is typically added as a reducing agent. [Ru(bpy)3]2+ ...
Agbandje-McKenna performed biophysical characterization of DNA-intercalating anthroquinone anti-tumor agents. During her PhD, ... 10-diones as potential anticancer agents. 1992. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted ... 10-diones as Potential Anticancer Agents. Synthesis, DNA-binding, and Biological Studies on a Series of 2,6-disubstituted ...
... that can intercalate DNA, thereby preventing cell division. The FCM or R-FCM regimen is also sometimes used in some autoimmune ... an alkylating antineoplastic agent from the oxazafosforine group; (M)itoxantrone - a synthetic anthracycline analogue ( ...
One famous intercalation host is graphite, which intercalates potassium as a guest. Intercalation expands the van der Waals gap ... Treating graphite with strong acids in the presence of oxidizing agents causes the graphite to oxidise. Graphite bisulfate, [ ... The bond between the carbon and fluorine atoms is covalent, thus fluorine is not intercalated.[clarification needed] Such ...
These materials are prepared by treating graphite with a strong oxidant or a strong reducing agent: C + m X → CXm The reaction ... Reaction of graphite with [O2]+[AsF6]− affords the salt [C8]+[AsF6]−. A number of metal halides intercalate into graphite. The ... The bronze-colored material KC8 is one of the strongest reducing agents known. It has also been used as a catalyst in ... Millman, S E; Zimmerman, G O (1983). "Observation of spin glass state in FeCl3: intercalated graphite". Journal of Physics C: ...
... s can be induced using a variety of mutagens, including DNA intercalating agents, as well as chemicals that can ... They also found that treatment of wild-type S. cerevisiae with DNA-intercalating agents would more rapidly produce this ... and other intercalating agents. Their mechanisms work to break down and cause the eventual loss of mitochondrial DNA: if the ... mutation by chemical and physical agents in Saccharomyces cerevisiae". Mutation Research. 265 (1): 103-148. doi:10.1016/0027- ...
Investigation of possible mechanisms revealed that the compounds bind to DNA and act as intercalating agents, besides ... Anti-Cancer Agents. 5 (2): 173-182. doi:10.2174/1568011053174864. hdl:2078.1/10136. PMID 15777224. Oliver-Bever, B. (1983). " ...
This agent also intercalates into DNA and inhibits RNA synthesis in vitro and shows potential antineoplastic activity. ... Hycanthone is shown to intercalates into DNA and inhibit RNA synthesis in vitro. A growing body of evidence has shown that ...
The accumulated damage may arise from reactive oxygen species (ROS), chemical reactions (e.g. with intercalating agents), ... of prelamin A show increased DNA damage and chromosome aberrations and have increased sensitivity to DNA damaging agents. In ...
... an alkylating antineoplastic agent; Hydroxydaunorubicin, also known as doxorubicin: an anthracycline antibiotic that is able to ... intercalate DNA, damaging it and preventing the cell division. This regimen requires the use of prophylactic antibiotics to ...
Alkylating agents such as cyclophosphamide and cisplatin, as well as intercalating agent such as daunorubicin and doxorubicin ... Intercalating agents, such as ethidium bromide and proflavine, are molecules that may insert between bases in DNA, causing ... Infectious agents have been suggested to cause cancer as early as 1908 by Vilhelm Ellermann and Oluf Bang, and 1911 by Peyton ... Alkylating agents such as ethylnitrosourea. The compounds transfer methyl or ethyl group to bases or the backbone phosphate ...
Graphite was first intercalated in 1841 using a strong oxidizing or reducing agent that damaged the material's desirable ... but without oxidizing agents. The new method has yet to achieve output sufficient for commercialization. Applying a layer of ... which then intercalate into the graphite structure, peeling graphite to produce graphene. The graphene nanosheets produced ...
These agents most preferentially form a 1,3 5'-d(GNC) interstrand crosslink. The introduction of this agent slightly bends the ... These compounds intercalate into DNA at 5'-AT sequence sites and form thymidine adducts when activated in the presence of Ultra ... These cross-linking agents have the ability to act as single-agent therapies by targeting and destroying specific nucleotides ... are further exogenous agents that may induce DNA crosslinks. Unlike other crosslinking agents, aldehyde-induced crosslinking is ...
This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. v t e. ... Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA ...
Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove ... Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent. It has been used in acute lymphoblastic leukemia ... compares with the better known agent etoposide). In contrast, the structurally similar o-AMSA differing in the position of the ...
... (or homidium bromide, chloride salt homidium chloride) is an intercalating agent commonly used as a ... It is added to running buffer and binds by intercalating between DNA base pairs. When the agarose gel is illuminated using UV ... Ethidium bromide is thought to act as a mutagen because it intercalates double-stranded DNA (i.e. inserts itself between the ... In the laboratory the intercalating properties have long been used to minimize chromosomal condensation when a culture is ...
Siddik ZH (2005). "Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ... Actinomycin is a complex molecule that intercalates DNA and prevents RNA synthesis. Bleomycin, a glycopeptide isolated from ... Alkylating agents will work at any point in the cell cycle and thus are known as cell cycle-independent drugs. For this reason ... Unlike alkylating agents, anti-metabolites are cell cycle dependent. This means that they only work during a specific part of ...
... s can act as immunopotentiating agents and as agents of targeted drug delivery. Virosomes as immunopotentiating agents ... intercalated in the phospholipid bilayer membrane. They have a typical mean diameter of 150 nm. Essentially, virosomes ... Viruses are infectious agents that can replicate in their host organism, however virosomes do not replicate. The properties ... Virosomes deliver antigens and therapeutic agents to their targeted cells. ...
G-CSF is still included, even though the "G" is taken out of the acronym.) Amsacrine is an alkylating antineoplastic agent that ... Mitoxantrone is a synthetic anthracycline analogue (an anthracenedione) that, like idarubicin, can intercalate DNA and prevent ... There are several intensified versions of the FLAG regimen in which a third chemotherapeutic agent is added. In the FLAG-IDA ... In this setting, it is often combined with other agents, such as: Cyclophosphamide (FLAMSA-CYC), and/or Busulfan or treosulfan ...
These polymers can selectively bind specific sequences of double-stranded DNA by intercalating in a sequence dependent manner. ... Depending on the alkylating agent and the counteranion, various ionic liquids result, e.g. 1-butyl-3-methylimidazolium ...
KC8 is a very strong reducing agent and is pyrophoric and explodes on contact with water.[114][115] While the larger alkali ... Potassium, rubidium, and caesium react with graphite; their atoms are intercalated between the hexagonal graphite layers, ... Their great power as reducing agents makes them very useful in liberating other metals from their oxides or halides.[10]:76 ... Pure alkali metals are dangerously reactive with air and water and must be kept away from heat, fire, oxidising agents, acids, ...
It intercalates in DNA, covalently bonding to the nucleophilic guanine bases. X-ray crystallographic and nuclear magnetic ... Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [13] ... A review of human carcinogens-part F: chemical agents and related occupations ...
... intercalates into the DNA double helix where it is ideally positioned to form one or more adducts with adjacent ... The aromatic ring in 6 is activated at positions ortho to the hydroxyl group, and is alkylated by 5, an alkylating agent. The ... Psoralen intercalates into DNA and on exposure to ultraviolet (UVA) radiation can form monoadducts and covalent interstrand ... When appropriately intercalated adjacent to a pyrimidine base, a four-center photocycloaddition reaction can lead to the ...
... since doxorubicin acts by intercalating between DNA strands, and also acts on topoisomerase II enzyme thus relaxing the ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Bleomycin, a glycopeptide isolated from Streptomyces verticillus, also intercalates DNA, but produces free radicals that damage ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ... Siddik ZH (2005). Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour ...
It intercalates in DNA, and the electrophilic epoxide is attacked by nucleophilic guanine bases, forming a bulky guanine adduct ... Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [15] ... A review of human carcinogens-part F: chemical agents and related occupations ...
Cragg, Gordon M.; Newman, David J. (2005). "Plants as a source of anti-cancer agents". Journal of Ethnopharmacology. 100 (1-2 ... since it does not intercalate into DNA or bind strongly to DNA. The cytotoxic effects of teniposide are related to the relative ... Teniposide, when used with other chemotherapeutic agents for the treatment of ALL, results in severe bone marrow suppression. ...
H)ydroxydaunorubicin (also called doxorubicin or adriamycin), an intercalating agent which damages DNA by inserting itself ... C)yclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links ...
The accumulated damage may arise from reactive oxygen species (ROS), chemical reactions (e.g. with intercalating agents), ... of prelamin A show increased DNA damage and chromosome aberrations and have increased sensitivity to DNA damaging agents.[78] ...
Hydrogen: Boiling point at atmospheric pressure (common cooling agent; for reference) 18 −255 Nb3Sn[23] metallic low- ... Fulleride superconductors[49] where alkali-metal atoms are intercalated into C60 molecules show superconductivity at ... Nitrogen: Boiling point at atmospheric pressure (common cooling agent; for reference) 45 −228 SmFeAsO0.85F0.15 low-temperature ... Neon: Boiling point at atmospheric pressure (common cooling agent; for reference) 21.15 −252 ...
Richards, A. D.; Rodgers, A. (2007). "Synthetic metallomolecules as agents for the control of DNA structure". Chemical Society ... Ligands may interact with DNA by covalently binding, electrostatically binding, or intercalating.[1] Intercalation occurs when ... Development and Action of Anticancer Agents. 18. Berlin: de Gruyter GmbH. pp. 387-435. doi:10.1515/9783110470734-020.. ...
"Antimicrobial Agents and Chemotherapy. 55 (2): 526-531. doi:10.1128/AAC.00680-10. ISSN 0066-4804. PMC 3028772. PMID 21115796.. ... Alpha intercalated cell. The apical membrane of a polarized cell is the surface of the plasma membrane that faces inward to the ...
The bond between the carbon and fluorine atoms is covalent, thus fluorine is not intercalated.[clarification needed] Such ... Treating graphite with strong acids in the presence of oxidizing agents causes the graphite to oxidise. Graphite bisulfate, [C ... One famous intercalation host is graphite, which intercalates potassium as a guest.[3] Intercalation expands the van der Waals ...
Ethidium bromide intercalates and stains DNA, providing a fluorescent red-orange stain. Although it will not stain healthy ... It is a strong oxidizing agent as the osmium has an oxidation number of +8. It aggressively oxidizes many materials, leaving ...
Chronic exposure increases the risk of developing liver and gallbladder cancer,[24] as aflatoxin metabolites may intercalate ... As with other DNA-alkylating agents, Aflatoxin B1 can cause immune suppression, and exposure to it is associated with an ...
These agents increase the osmolarity of the extracellular solution, causing the cells to shrink. When these agents are ...
The key issue of Li-S battery is low electrical conductivity of sulfur cathode needing an extra mass for a conducting agent and ... where the lithium ions are intercalated in the anode and cathodes. Each sulfur atom can host two lithium ions. Typically, ...
Intercalated ethidium is in a hydrophobic environment when it is between the base pairs of the DNA, protected from quenching by ... Molecular agents has been also used to detect specific features, such as stent fibrin accumulation and enzymatic activity ... water which is excluded from the local environment of the intercalated ethidium. Ethidium bromide may be carcinogenic - an ...
Agents that form DNA adducts (e.g., ochratoxin A)[53]. *DNA intercalating agents (e.g., ethidium bromide) ... Alkylating agents (e.g., N-ethyl-N-nitrosourea (ENU)). These agents can mutate both replicating and non-replicating DNA. In ...
Intercalated disc. *Ion channel. *Junctional complex. *Tight junction. References[edit]. .mw-parser-output .reflist{font-size: ... Agents. Receptor ligands. *Hormones. *Neurotransmitters/Neuropeptides/Neurohormones. *Cytokines. *Growth factors. *Signaling ...
Li-ion batteries use an intercalated lithium compound as one electrode material, compared to the metallic lithium used in a non ... A carbon conductive agent is required to overcome its low electrical conductivity.[125] ... While charging, the lithium ions must travel to the outer edges of the graphene sheet before coming to rest (intercalating) ... Yazami used a solid electrolyte to demonstrate that lithium could be reversibly intercalated in graphite through an ...
"Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice". British Journal of Pharmacology 154 (2): 471-9 ... "Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala" ...
Metal bipyridine as well as related phenanthroline complexes are generally bioactive, as they can act as intercalating agents. ... In this conversion, Ru(III) is reduced to Ru(II), and hypophosphorous acid is typically added as a reducing agent.[1] ...
Pure tin has no structural uses.[137] It is used in lead-free solders, and as a hardening agent in alloys of other metals, such ... Subba Rao GV & Shafer MW 1986, 'Intercalation in layered transition metal dichalcogenides', in F Lévy (ed), Intercalated ... 4 (which is a strong oxidising agent, fuming in moist air and reacting with glass). Because of the shell closure at flerovium ...
This can be influenced positively or negatively by agents termed inotropes.[40] These agents can be a result of changes within ... The intercalated discs allow the cells to act as a syncytium and enable the contractions that pump blood through the heart and ... These contractile cells are connected by intercalated discs which allow a rapid response to impulses of action potential from ... Inotropes that increase the force of contraction are "positive" inotropes, and include sympathetic agents such as adrenaline, ...
... he found himself in the rare position of being a sought-after free agent at the major league level during the era of the ... had been introduced at the 1906 Intercalated Games.[30] The 1912 version consisted of the long jump, javelin throw, 200-meter ...