Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers ... Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This ... "Entrez Gene: ITGB4 integrin, beta 4". Aho S, Uitto J (Feb 1998). "Direct interaction between the intracellular domains of ... Suzuki S, Naitoh Y (Mar 1990). "Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in ...
Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene. Integrin, beta 5 has been shown to interact with PTK2 ... 1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat ... ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It ... Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 ...
This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function- ... ITGAL gene encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ... Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ...
Høye AM, Couchman JR, Wewer UM, Fukami K, Yoneda A (May 2012). "The newcomer in the integrin family: integrin α9 in biology and ... The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell ... Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins ... "Entrez Gene: ITGA9 integrin, alpha 9". Sulimova G, Kutsenko A, Rakhmanaliev E, Udina I, Kompaniytsev A, Protopopov A, Moisjak E ...
... is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin- ... "Entrez Gene: Integrin subunit beta like 1". Retrieved 2018-07-18. Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner ... The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants ...
Estevez, Brian; Shen, Bo; Du, Xiaoping (January 23, 2015). "Targeting Integrin and Integrin Signaling in Treating Thrombosis". ... His studies have focused on identifying mechanisms whereby β3 integrins mediate responses to thrombin and other SMC agonists. ... Sajid, M.; Zhao, R.; Pathak, A.; Smyth, S. S.; Stouffer, G. A. (November 23, 2003). "Alphavbeta3-integrin antagonists inhibit ... Stouffer, G. A.; Smyth, S. S. (November 1, 2003). "Effects of thrombin on interactions between beta3-integrins and ...
Integrins link extracellular matrix to keratin intermediate filaments, which interacts with intracellular domain of integrins ... Cell-matrix junctions are mainly mediated by integrins, which also clusters like cadherins to form firm adhesions. Integrins ... can induce conformational changes in integrins and initiate signalling cascades. Extracellular domains of integrins can bind to ... At these sites, integrins on the rolling white blood cells are activated and bind firmly to the local endothelial cells, ...
Schwartz, MA; Ingber, DE (1994). "Integrating with integrins". Molecular Biology of the Cell. 5 (4): 389-93. doi:10.1091/mbc. ... "The integrin-actin connection, an eternal love affair". The EMBO Journal. 22 (10): 2324-33. doi:10.1093/emboj/cdg245. PMC ... bound to the cytoplasmic domains of integrins. He then discovered other focal adhesion components including paxillin and ...
Schnapp, L (2006). Integrin, Adhesion/cell-matrix. Seattle: Elsevier. García AJ (December 2005). "Get a grip: integrins in cell ... The integrins contain multiple divalent cation binding sites in the extracellular domain ). The integrin cation binding sites ... The Ig-superfamily CAMs do not depend on Ca2+ while integrins, cadherins and selectins depend on Ca2+. In addition, integrins ... Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta ...
When an integrin receptor binds to its ECM ligand and is activated, additional integrins cluster around the activated site. In ... and integrin receptors (of which there exist several types on chondrocytes). Using the integrin-linked mechanotransduction ... Integrins have been identified on the upper shaft of the cilium, acting as anchors to the collagen matrix around it. Recent ... Integrin signaling is just one example of multiple pathways that are activated when cartilage is loaded. Some intracellular ...
It may be mediated by interaction through CXCR4 (CD184) the receptor for CXC Chemokines (e.g., SDF1) and α4β1 integrins. ... and alpha4beta1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath ...
... an 18F-Labeled αVβ3-Integrin and αVβ5-Integrin Imaging Agent". Journal of Nuclear Medicine. 52 (3): 424-430. doi:10.2967/jnumed ... CEND-1, also known as iRGD, is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. It also binds ... The discovery of RGD and elucidation of how RGD binds to integrins has led to the development of a number of drugs and ... These drugs inhibit integrin binding. PET radiotracers such as fluciclatide utilize RGD-containing peptides to home to tumors, ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA- ...
Integrins lack kinase activity; hence, integrin-mediated signal transduction is achieved through a variety of intracellular ... In plants, there are no bona fide integrin receptors identified to date; nevertheless, several integrin-like proteins were ... integrins of circulating cells are normally inactive. For example, cell membrane integrins on circulating leukocytes are ... Integrins are produced by a wide variety of cells; they play a role in cell attachment to other cells and the extracellular ...
Leahy DJ, Qu A (1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. ... Lee JO, Rieu P, Arnaout MA, Liddington R (1995). "Crystal structure of the A domain from the alpha subunit of integrin CR3 ( ... Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... 3D structures have been determined for the I-domains of integrins CD11b (with bound magnesium) and CD11a (with bound manganese ...
It forms complexes with proteins called integrins. Integrins link cells together. The complex formation may inhibit detachment ...
These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The RPSA gene encodes ... Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins". Microsc. Res. Tech. 51 (3): 280-301. doi:10.1002/1097-0029( ... together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin". J. Immunol. 163 (6): ... critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein". Biological Reviews. 91 (2): 288-310. ...
Streuli, Charles H. (2009-01-15). "Integrins and cell-fate determination". Journal of Cell Science. 122 (2): 171-177. doi: ...
Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins". Microsc. Res. Tech. 51 (3): 280-301. doi:10.1002/1097-0029( ...
Integrins act as adhesion receptors, transporting signals across the plasma membrane in multiple directions. These molecules ... There are four main types: selectins, cadherins, integrins, and the immunoglobulin superfamily. Selectins are cell adhesion ... Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". Cell. 110 (6): 673-87. doi:10.1016/S0092- ... their transmembrane anchors are composed of cadherins in those that anchor to other cells and integrins (focal adhesion) in ...
"The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton ... "The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation". The Journal of ... In addition to F-actin, the N-terminal region of talin-1 binds layilin, β1- and β3-integrin, and focal adhesion kinase. Talin-1 ... Wu JC, Sung HC, Chung TH, DePhilip RM (2002). "Role of N-cadherin- and integrin-based costameres in the development of rat ...
Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that ... 251-316, retrieved 27 February 2022 Giancotti, FG; Ruoslahti, E (13 August 1999). "Integrin signaling". Science. 285 (5430): ...
It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Yonekawa K, Harlan JM (Feb 2005). "Targeting leukocyte integrins in human diseases". Journal of Leukocyte Biology. 77 (2): 129- ... "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell. ...
November 2015). "Tumour exosome integrins determine organotropic metastasis". Nature. 527 (7578): 329-35. Bibcode:2015Natur.527 ...
Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of ... Yonekawa K, Harlan JM (2005). "Targeting leukocyte integrins in human diseases". J. Leukoc. Biol. 77 (2): 129-40. doi:10.1189/ ... integrins. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to ...
Loeser RF (2002). "Integrins and cell signaling in chondrocytes". Biorheology. 39 (1-2): 119-24. PMID 12082274. Overview of all ... integrin-mediated signaling, cell adhesion, and osteoclast motility". J. Cell Biol. 152 (1): 181-95. doi:10.1083/jcb.152.1.181 ... in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". J. Biol ... "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to ...
This provides a mechanism by which Rap1 can act directly on integrins and modulate integrin affinity and/or clustering. PKD, ... particularly the interaction of talin with integrin cytoplasmic tails. Given the known role of talin in regulating integrin ... This finding suggests that LFA-1 clustering is critical for TCR signaling to integrins that is mediated by Rap1. It also ... RAPL is also an integrin-associated protein as RAPL polarizes to the immunological synapse following antigen stimulation of T ...
It is presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is ... Lewis JM, Schwartz MA (June 1998). "Integrins regulate the association and phosphorylation of paxillin by c-Abl". The Journal ... Rose DM, Han J, Ginsberg MH (August 2002). "Alpha4 integrins and the immune response". Immunological Reviews. 186: 118-24. doi: ... Nikolopoulos SN, Turner CE (June 2001). "Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization ...
Bernstein CN, Sargent M, Gallatin WM (February 1998). "Beta2 integrin/ICAM expression in Crohn's disease". Clinical Immunology ... Yonekawa K, Harlan JM (February 2005). "Targeting leukocyte integrins in human diseases". Journal of Leukocyte Biology. 77 (2 ... Bernstein CN, Sargent M, Gallatin WM, Wilkins J (October 1996). "Beta 2-integrin/intercellular adhesion molecule (ICAM) ... "Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface". Nature. 387 (6630): 312-5. Bibcode:1997Natur. ...
Integrin signalling Integrin αvβ3 (a cell-surface adhesion molecule) is important for tumor attachment, cell-to-cell ... Several different integrins bind to fibronectin. Fibronectin-integrin interactions are important in tumor cell migration, ... invasion, metastasis and cell proliferation by signaling through integrins. Integrin-mediated tumor cell adhesion to ECM ... Endoglin is a cell-surface disulfide-linked homodimeric glycoprotein which binds to integrins and other RGD ligands and is a co ...