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*  Integrin
Integrins are found in all animals while integrin-like receptors are found in plant cells. Integrins work alongside other ... Media related to Integrins at Wikimedia Commons MBInfo - Integrin-Mediated Signalling MBInfo - Integrin Activation Eukaryotic ... The following are 16 of the ~24 integrins found in vertebrates: Beta-1 integrins interact with many alpha integrin chains. Gene ... integrins of the β2 family). This α-I domain is the binding site for ligands of such integrins. Those integrins that don't ...
*  Integrin alphaXbeta2
... (p150,95, CR4) is a complement receptor composed of CD11c and CD18. Integrin alphaXbeta2 at the US ...
*  Integrin alpha M
... (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also ... and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins. αMβ2 is expressed on the surface of many ... Integrin alphaM at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Todd RF, Petty HR (May 1997). "Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors". The ...
*  Integrin, beta 6
"Entrez Gene: ITGB6 integrin, beta 6". Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W ... Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. Mutations in ITGB6 cause amelogenesis imperfecta . ... 1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human ... Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v ...
*  Integrin-like receptors
True homologs of integrins exist in mammals, invertebrates, and some fungi but not in plant cells. Mammalian integrins are ... Integrin-like receptors (ILRs) are found in plants and carry unique functional properties similar to true integrin proteins. ... Integrin-like receptors and integrin-linked kinases together have been implicated in surface adhesion, immune response, and ion ... Most commonly, ILRs resembles the β1 subunit found in integrin proteins. This structural similarity between ILRs and integrins ...
*  Integrin, beta 5
Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene. Integrin, beta 5 has been shown to interact with PTK2 ... 1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat ... Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 ... "Entrez Gene: ITGB5 integrin, beta 5". Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; ...
*  Integrin-linked kinase
... is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal ... Integrins lack enzymatic activity and depend on adapters to signal proteins. ILK is linked to beta-1 and beta-3 integrin ... Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. Multiple alternatively spliced ... Dedhar S, Williams B, Hannigan G (1999). "Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling". ...
*  CD11c
... is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain ... CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . ... This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b ... 1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes". Leukemia. 4 (10): 682-7. PMID ...
*  Keith Burridge
CS1 maint: Multiple names: authors list (link) Brakebusch, C; Fässler, R (2003). "The integrin-actin connection, an eternal ... Schwartz, MA; Ingber, DE (1994). "Integrating with integrins". Molecular Biology of the Cell. 5 (4): 389-93. doi:10.1091/mbc. ... bound to the cytoplasmic domains of integrins. He then discovered other focal adhesion components including paxillin and ...
*  Cell adhesion molecule
Schnapp, L (2006). Integrin, Adhesion/cell-matrix. Seattle: Elsevier. García AJ (December 2005). "Get a grip: integrins in cell ... Integrins and the Ig-superfamily CAMs do not depend on Ca2+ while cadherins and selectins depend on Ca2+. In addition, ... integrins participate in cell-matrix interactions, while other CAM families participate in cell-cell interactions. Integrins, ... Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta ...
*  Mechanotransduction
When an integrin receptor binds to its ECM ligand and is activated, additional integrins cluster around the activated site. In ... and integrin receptors (of which there exist several types on chondrocytes). Using the integrin-linked mechanotransduction ... Integrins have been identified on the upper shaft of the cilium, acting as anchors to the collagen matrix around it. Recent ... Integrin signaling is just one example of multiple pathways that are activated when cartilage is loaded. Some intracellular ...
*  Hematopoietic stem cell
It may be mediated by interaction through CXCR4 (CD184) the receptor for CXC Chemokines (e.g., SDF1) and α4β1 integrins. HSCs ... Burger JA, Spoo A, Dwenger A, Burger M, Behringer D. CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate ...
*  Arginylglycylaspartic acid
Fluciclatide, an (18)F-labeled small peptide that binds to integrin αVβ3 and integrin αVβ5, is being tested as a tool to ... an 18F-Labeled αVβ3-Integrin and αVβ5-Integrin Imaging Agent". Journal of Nuclear Medicine. 52 (3): 424-430. doi:10.2967/jnumed ... Hynes, R. "Integrins: A family of cell surface receptors". Cell. 48 (4): 549-554. doi:10.1016/0092-8674(87)90233-9. Ruoslahti, ... "Integrin-based therapeutics: biological basis, clinical use and new drugs". Nature Reviews Drug Discovery. 15 (3): 173-183. doi ...
*  Von Willebrand factor type C domain
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA- ...
*  Signal transduction
Integrins lack kinase activity; hence, integrin-mediated signal transduction is achieved through a variety of intracellular ... In plants, there are no bona fide integrin receptors identified to date; nevertheless, several integrin-like proteins were ... integrins of circulating cells are normally inactive. For example, cell membrane integrins on circulating leukocytes are ... Integrins are produced by a wide variety of cells; they play a role in cell attachment to other cells and the extracellular ...
*  Von Willebrand factor type A domain
Leahy DJ, Qu A (1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. ... Lee JO, Rieu P, Arnaout MA, Liddington R (1995). "Crystal structure of the A domain from the alpha subunit of integrin CR3 ( ... The vWF domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen ... Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ...
*  Metastasis suppressor
It forms complexes with proteins called integrins. Integrins link cells together. The complex formation may inhibit detachment ...
*  Ribosomal protein SA
These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The RPSA gene encodes ... Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins". Microsc. Res. Tech. 51 (3): 280-301. doi:10.1002/1097-0029( ... together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin". J. Immunol. 163 (6): ... critical discussion regarding the non-integrin 37/67-kDa laminin receptor/RPSA protein". Biological Reviews. 91 (2): 288-310. ...
*  Cell junction
Integrins act as adhesion receptors, transporting signals across the plasma membrane in multiple directions. These molecules ... There are four main types: selectins, cadherins, integrins, and the immunoglobulin superfamily. Selectins are cell adhesion ... Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". Cell. 110 (6): 673-87. doi:10.1016/S0092- ... their transmembrane anchors are composed of cadherins in those that anchor to other cells and integrins in those that anchor to ...
*  CD18
Integrin alphaDbeta2 (paired with CD11d) The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral ... The beta 2 integrins have also been found in a soluble form. The soluble beta 2 integrins are ligand binding and plasma levels ... and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as ... "ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]". "Entrez Gene: ITGB2 integrin, beta 2 (complement component 3 receptor ...
*  Laminin, alpha 2
Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins". Microsc. Res. Tech. 51 (3): 280-301. doi:10.1002/1097-0029( ...
*  TLN1
"The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton ... "The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation". The Journal of ... In addition to F-actin, the N-terminal region of talin-1 binds layilin, β1- and β3-integrin, and focal adhesion kinase. Talin-1 ... Wu JC, Sung HC, Chung TH, DePhilip RM (2002). "Role of N-cadherin- and integrin-based costameres in the development of rat ...
*  Juxtacrine signalling
Cells use mainly the receptor integrin to interact with ECM proteins. This signaling can influence the cell cycle and cellular ... Giancotti, FG; Ruoslahti, E (Aug 13, 1999). "Integrin signaling". Science. 285 (5430): 1028-32. doi:10.1126/science.285.5430. ...
*  ICAM-1
It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor. ICAM-1 is a ... ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells ... Yonekawa K, Harlan JM (Feb 2005). "Targeting leukocyte integrins in human diseases". Journal of Leukocyte Biology. 77 (2): 129- ... "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation". Cell. ...
*  Exosome (vesicle)
"Tumour exosome integrins determine organotropic metastasis". Nature. 527 (7578): 329-335. doi:10.1038/nature15756. ISSN 1476- ...