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*  CD61
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha ... chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is ... Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation ... "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)". May, K. E.; Villar, J.; Kirtley, S.; Kennedy, ...
*  Calnexin
"The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly". The Journal of ... Calnexin also functions as a chaperone for the folding of MHC class I α-chain in the membrane of the ER. As newly synthesized ... The improperly-folded glycoprotein chain thus loiters in the ER, risking the encounter with MNS1 (alpha-mannosidase), which ... MHC class I α-chains enter the endoplasmic reticulum, calnexin binds on to them retaining them in a partly folded state. After ...
*  ADAM15
Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also ... Takagi J (2002). "[First atomic view of alpha V beta 3 integrin extracellular domain]". Tanpakushitsu Kakusan Koso. 47 (2): 153 ... 2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for ... 1999). "Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells". J. ...
*  EIF6
"The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene. ... An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two ...
*  CD18
Integrin alphaDbeta2 (paired with CD11d) The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral ... beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac ... The beta 2 integrins have also been found in a soluble form. The soluble beta 2 integrins are ligand binding and plasma levels ... "ITGB2 integrin subunit beta 2 [ Homo sapiens (human) ]". "Entrez Gene: ITGB2 integrin, beta 2 (complement component 3 receptor ...
*  FHL2
"The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... and beta-subunits of the muscle alpha7beta1 integrin receptor". J. Biol. Chem. 279 (27): 28641-52. doi:10.1074/jbc.M312894200. ... and beta-subunits of the muscle alpha7beta1 integrin receptor". The Journal of Biological Chemistry. 279 (27): 28641-52. doi: ...
*  CD49c
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes ... ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a ... "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2 ...
*  REV1
2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is ... 1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic ...
*  ITGAV
... that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta ... Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are ... Horton MA (May 1997). "The alpha v beta 3 integrin "vitronectin receptor"". The International Journal of Biochemistry & Cell ... heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational ...
*  Integrin, beta 6
2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is ... 1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human ... 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation ... Huang XZ, Chen A, Agrez M, Sheppard D (1995). "A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 ...
*  ITGB8
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain ... "Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain". J. Biol. ... Moyle M, Napier MA, McLean JW (1991). "Cloning and expression of a divergent integrin subunit beta 8". J. Biol. Chem. 266 (29 ... 2003). "Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of ...
*  ITGA10
Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell ... The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding ... and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes ... Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. ...
*  ITGA11
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I ... integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". J. Biol ... Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. ... dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in ...
*  EMID2
... integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". J. Biol ... Collagen alpha-1(XXVI) chain is a protein that in humans is encoded by the EMID2 gene. GRCh38: Ensembl release 89: ... Homma N, Gejyo F, Isemura M, Arakawa M (1989). "Collagen-binding affinity of beta-2-microglobulin, a preprotein of hemodialysis ...
*  ITGB7
"The role of alpha and beta chains in ligand recognition by beta 7 integrins". The Journal of Biological Chemistry. 275 (33): ... Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the ... Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ (Apr 1992). "Role of integrin alpha 4 beta 7/alpha 4 beta P in ... "Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization". Mammalian Genome. 2 ...
*  CD29
"The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to ... Three novel isoforms of integrin beta-1 have been identified, termed beta-1B, beta-1C and beta-1D. Integrin beta-1B is ... The cytoplasmic domain of integrin beta-1 binds to the actin cytoskeleton. Integrin beta-1 is the most abundant beta-integrin ... The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion. A second integrin beta-1 ...
*  ITGA9
Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell ... The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for tenascin-C, VCAM1 ... Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. This gene encodes an alpha integrin. ... Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays ...
*  MYH9
"Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in ... Myosin, heavy chain 9, non-muscle is a protein which in humans is encoded by the MYH9 gene. MYH9 polymorphisms have been shown ... Saez CG, Myers JC, Shows TB, Leinwand LA (February 1990). "Human nonmuscle myosin heavy chain mRNA: generation of diversity ... "Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal ...
*  Integrin
The following are 16 of the ~24 integrins found in vertebrates: Beta-1 integrins interact with many alpha integrin chains. Gene ... Integrins are obligate heterodimers, meaning that they have two subunits: α (alpha) and β (beta). Integrins in mammals have ... Integrins are found in all animals while integrin-like receptors are found in plant cells. Integrins work alongside other ... Media related to Integrins at Wikimedia Commons MBInfo - Integrin-Mediated Signalling MBInfo - Integrin Activation Eukaryotic ...
*  ITGA2B
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes ... Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin ... Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms". J. Thromb. Haemost. 5 (7): 1345-52 ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ...
*  CD11a
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing ... alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), ... Qu A, Leahy DJ (1995). "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ...
*  ITGA6
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with ... alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are ... Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha ... Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I ...
*  CD11c
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with ... The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and ... the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). ... CD11c is an integrin alpha X chain protein. ... CD11c, also known as Integrin, alpha X (complement component 3 ...
*  CD49d
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha ... Alpha 4 chain associates with either beta 1 chain or beta 7 chain. CD49d has been shown to interact with LGALS8 and Paxillin. ... "Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug ... Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. ...
*  ITGA5
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the ... Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin ... Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays ... integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide- ...
*  NME1
Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C (June 2002). "Integrin cytoplasmic domain- ... Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem ... beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect". Hum. Mol. ... and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895- ...