Overview of all the structural information available in the PDB for UniProt: P13612 (Human Integrin alpha-4) at the PDBe-KB. v ... Rose DM, Han J, Ginsberg MH (2003). "Alpha4 integrins and the immune response". Immunol. Rev. 186 (1): 118-24. doi:10.1034/j. ... The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ...
Rose DM, Han J, Ginsberg MH (August 2002). "Alpha4 integrins and the immune response". Immunological Reviews. 186: 118-24. doi: ... It is presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is ... Lewis JM, Schwartz MA (June 1998). "Integrins regulate the association and phosphorylation of paxillin by c-Abl". The Journal ... Nikolopoulos SN, Turner CE (June 2001). "Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization ...
... is a humanized monoclonal antibody against alpha-4 (α4) integrin, the first drug developed in the class of ... Rice GP, Hartung HP, Calabresi PA (2005). "Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale". ... α4-integrin is required for white blood cells to move into organs, and natalizumab's mechanism of action is believed to be the ... By attaching to integrin, natalizumab is thought to stop white blood cells from entering the brain and spinal cord tissue, ...
Davenport RJ, Munday JR (July 2007). "Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory ... binding to α4-integrins. It was originally developed by the British biopharmaceutical company Celltech plc. (now UCB S.A.) and ...
"Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676-681. Bibcode ...
2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676-81. ...
Miles A, Liaskou E, Eksteen B, Lalor PF, Adams DH (May 2008). "CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion ... alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues ... preventing it from interacting with the integrins on the surface of the lymphocytes. CD34 GLYCAM1 Integrin β7 - a constituent ... Ruiz-Velasco N, Guerrero-Esteo M, Briskin MJ, Teixidó J (March 2000). "The alpha(4) integrin subunit Tyr(187) has a key role in ...
Sheremata WA, Minagar A, Alexander JS, Vollmer T (November 2005). "The role of alpha-4 integrin in the aetiology of multiple ... Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 ... The integrin VLA-4 is expressed on the cell surfaces of stem cells, progenitor cells, T and B cells, monocytes, natural killer ... Integrin+alpha4beta1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ITGA4 ITGB1 Info with links in ...
"Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and ... Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal ... Integrins lack enzymatic activity and depend on adapters to signal proteins. ILK is linked to beta-1 and beta-3 integrin ... Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. Multiple alternatively spliced ...
Till KJ, Lin K, Zuzel M, Cawley JC (April 2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration ... and endothelial cells and it induces the chemotactic migration of T cells and the cell adhesion caused by integrin activation. ...
Till KJ, Lin K, Zuzel M, Cawley JC (April 2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration ...
Till KJ, Lin K, Zuzel M, Cawley JC (2002). "The chemokine receptor CCR7 and alpha4 integrin are important for migration of ...
Integrin α4β7 (Lymphocyte Peyer's patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and ... LPAM-1 integrin is involved in the development of graft-versus-host disease (GVHD). Donor-derived CTL cells use α4β7 integrin ... C Rüegg, A A Postigo, E E Sikorski, E C Butcher, R Pytela, D J Erle (1992). "Role of integrin alpha 4 beta 7/alpha 4 beta P in ... It has been found that gp120, which is the major HIV-1 envelope glycoprotein, can bind to α4β7 integrin. However α4β7 is not ...
It binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta- ... It was later determined that the Act-1 monoclonal antibody reacted with an α4β7 integrin that was subsequently shown to ... December 2008). "Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin". Clinical ... March 2019). "Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral ...
... which binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin ...
Bretscher, MS (1992). "Circulating integrins: alpha5-beta1, alpha6-beta4 and Mac-1, but not alpha3-beta1, alpha4-beta1 or LFA-1 ... For a cell to move, it is necessary to bring a fresh supply of "feet" (proteins called integrins, which attach a cell to the ...
... integrin alpha2 MeSH D23.050.301.264.035.289 - integrin alpha3 MeSH D23.050.301.264.035.291 - integrin alpha4 MeSH D23.050. ... integrin alpha2 MeSH D23.101.100.110.290 - integrin alpha3 MeSH D23.101.100.110.292 - integrin alpha4 MeSH D23.101.100.110.294 ... integrin alphav MeSH D23.101.100.110.299 - integrin beta3 MeSH D23.101.100.110.302 - integrin beta4 MeSH D23.101.100.110.400 - ... integrin alpha6 MeSH D23.050.301.264.035.298 - integrin alphav MeSH D23.050.301.264.035.302 - integrin beta3 MeSH D23.050. ...
Laminin subunit alpha-4 is a protein that in humans is encoded by the LAMA4 gene. Laminins, a family of extracellular matrix ... "Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and ... DeHahn KC, Gonzales M, Gonzalez AM, Hopkinson SB, Chandel NS, Brunelle JK, Jones JC (Mar 2004). "The alpha4 laminin subunit ... Richards A, Luccarini C, Pope FM (Aug 1997). "The structural organisation of LAMA4, the gene encoding laminin alpha4". European ...
... integrin alpha2 MeSH D12.776.543.750.705.408.100.400 - integrin alpha3 MeSH D12.776.543.750.705.408.100.450 - integrin alpha4 ... integrin alpha2beta1 MeSH D12.776.543.550.625.379 - integrin alpha5beta1 MeSH D12.776.543.550.625.419 - integrin alpha6beta1 ... integrin alpha1beta1 MeSH D12.776.543.750.072.200 - integrin alpha2beta1 MeSH D12.776.543.750.072.300 - integrin alpha3beta1 ... integrin alpha2beta1 MeSH D12.776.543.750.705.675.460 - integrin alpha5beta1 MeSH D12.776.543.750.705.675.514 - integrin ...
Kühn, Klaus (1997). "Extracellular matrix constituents as integrin ligands". In Elbe, Johannes A. (ed.). Integrin-ligand ... Laminin alpha4 is distributed in a variety of tissues including peripheral nerves, dorsal root ganglion, skeletal muscle and ... In muscle, it binds to alpha-dystroglycan and integrin alpha7-beta1 via the G domain, and via the other end, it binds to the ... Laminin IV domain is not found in short laminin chains (alpha4 or beta3). Beside different types of globular domains each ...
They pioneered parametric approaches to the design of water-soluble 4-helix (alpha4) and 3-helix bundles (alpha3D), and ion ... DeGrado's group also has contributed to the development of small molecule antagonists of integrins that reached clinical trials ... "The α v β 1 integrin plays a critical in vivo role in tissue fibrosis". Science Translational Medicine. 7 (288): 288ra79. doi: ... to Type I β-Turn Swap Changes Specificity for Integrins". Journal of the American Chemical Society. 118 (1): 293-294. doi: ...
1998). "The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin- ... 2001). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic ... "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in ...
1998). "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the ... "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in ...