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*  Insulin-like growth factor 2
"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in ... Insulin-like growth factor 2 has been shown to interact with IGFBP3 and transferrin. Insulin-like growth factor 2 receptor ... "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3". The Journal of ...
*  Insulin-like growth factor
"Association of Insulin-like Growth Factor I and Insulin-like Growth Factor-Binding Protein-3 with Intelligence Quotient Among 8 ... Insulin-like growth factor 1 Insulin-like growth factor 2 Growth hormone treatment HGH controversies Insulin/IGF/Relaxin family ... Insulin-like growth factor 1 (IGF-1) and Insulin-like growth factor 2 (IGF-2)), a family of six high-affinity IGF-binding ... Cohen P, Peehl DM, Lamson G, Rosenfeld RG (1991). "Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins ...
*  Pregnancy-associated plasma protein A
"Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 ... 1999). "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is ... PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in ... This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). PAPPA's ...
*  Insulin-like growth factor-binding protein
The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1 ... "Role of insulin-like growth factor binding proteins in the control of IGF actions". Prog. Growth Factor Res. 6 (2-4): 357-66. ... November 1998). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): ... Hwa V, Oh Y, Rosenfeld RG (December 1999). "The insulin-like growth factor-binding protein (IGFBP) superfamily". Endocr. Rev. ...
*  IGFBP5
1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF ... Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene. An IGFBP5 gene was ... Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". ... 1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology. ...
*  IGFALS
"Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect ... IGFALS insulin-like growth factor binding protein, acid labile subunit". Twigg SM, Baxter RC (Mar 1998). "Insulin-like growth ... Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded ... The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and ...
*  PAPPA2
... a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849-53. doi:10.1074/jbc.M102191200. ... "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824-54. doi:10.1210/er.2001-0033. ... "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5 ... Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 ( ...
*  ADAM9
2003). "ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts". ... The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, ... and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two ... ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor ...
*  IGFBP3
"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... "Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth ... "Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1". Mol ... of insulin-like growth factor binding proteins and of the acid-labile subunit of the insulin-like growth factor ternary binding ...
*  FHL2
Amaar YG, Thompson GR, Linkhart TA, Chen ST, Baylink DJ, Mohan S (April 2002). "Insulin-like growth factor-binding protein 5 ( ... Amaar YG, Thompson GR, Linkhart TA, Chen ST, Baylink DJ, Mohan S (2002). "Insulin-like growth factor-binding protein 5 (IGFBP-5 ... serum response factor (SRF), specificity protein 1 (Sp1). the pleiotropic factor IL-1β, MEF-2, and activator protein-1 (AP-1). ... Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins ...
*  MYBL2
It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. ... The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in ... CREB-binding protein, Cyclin A1, Cyclin-dependent kinase inhibitor 1C EP300, PARP1, and Retinoblastoma-like protein 1. GRCh38: ... Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene. ...
*  IGFBP4
"Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. ... Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene. This gene is a member ... "Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein". ... The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non- ...
*  ABL (gene)
Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659 ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ... an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233-41. doi:10.1038/sj.onc.1200822. PMID 9010225. ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ...
*  GRB10
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is ... This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor ... Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659 ... Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659 ...
*  IGFBP2
Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene. GRCh38: Ensembl release ... Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: ... 1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of ... Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: ...
*  IGFBP1
... insulin-like growth factor binding protein 1". Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor- ... Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is ... The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein ... 1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by ...
*  Premature rupture of membranes
Placental alpha microglobulin-1 (PAMG-1) Insulin-like growth factor binding protein-1 "Practice Bulletins No. 139". Obstetrics ... In cases of PPROM, proteins that bind and cross-link collagen to increase its tensile strength are altered. Breakdown of ... Premature rupture of membranes is also a risk factor in the development of neonatal infection. Many genes play a role in ... The cause of premature rupture of membranes (PROM) is not clearly understood, but the following are risk factors that have been ...
*  IGFBP6
1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol ... 1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, ... "Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6". Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor ... 2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". J. Clin. Endocrinol. Metab. 86 (4): ...
*  Anorexia nervosa
"Bioactive insulin-like growth factor (IGF) I and IGF-binding protein-1 in anorexia nervosa". J. Clin. Endocrinol. Metab. 92 (6 ... A main factor differentiating binge-purge anorexia from bulimia is the gap in physical weight. Someone with bulimia nervosa is ... Typically, growth hormone (GH) levels are high, but levels of IGF-1, the downstream hormone that should be released in response ... Cultural factors also appear to play a role with societies that value thinness having higher rates of disease. Additionally, it ...
*  Pappalysin-1
... (EC 3.4.24.79, insulin-like growth factor binding protein-4 protease, pregnancy-associated plasma protein-A) is an ... "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy- ... enzyme catalyses the following chemical reaction Cleavage of the Met135-Lys bond in insulin-like growth factor binding protein ... "Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible ...
*  GALNT14
2007). "N-Acetylgalactosaminyltransferase 14, a novel insulin-like growth factor binding protein-3 binding partner". Biochem. ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine ( ... 357 (2): 360-5. doi:10.1016/j.bbrc.2007.03.153. PMID 17434446. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, ...
*  Tissue transglutaminase
... identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase". The Journal of Biological ... In the extracellular space, tTG binds to proteins of the extracellular matrix (ECM), binding particularly tightly to ... Multiple Ca2+ can bind to a single tTG molecule. In contrast, the binding of one molecule of GTP or GDP inhibits the ... "Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+-dependent action of a multifunctional protein". The FEBS ...
*  Transferrin
"Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3". ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ... Transferrin has been shown to interact with insulin-like growth factor 2 and IGFBP3. Transcriptional regulation of transferrin ... When not bound to iron, transferrin is known as "apotransferrin" (see also apoprotein). When a transferrin protein loaded with ...
*  Fibronectin
Gui Y, Murphy LJ (May 2001). "Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): ... "Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage". Osteoarthritis ... collagen-binding (I6-9), fibulin-1-binding (III13-14), heparin-binding and syndecan-binding (III12-14). Fibronectin has ... The modules are arranged into several functional and protein-binding domains along the length of a fibronectin monomer. There ...
*  ADAM12
ADAM 12, a metalloprotease that binds insulin growth factor binding protein-3 (IGFBP-3), appears to be an effective early Down ... interacts with insulin-like growth factor-binding protein-3". J. Biol. Chem. 275 (24): 18574-80. doi:10.1074/jbc.M002172200. ... interacts with insulin-like growth factor-binding protein-3". J. Biol. Chem. 275 (24): 18574-80. doi:10.1074/jbc.M002172200. ... binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor ...
*  Metabolism
Binding of the hormone to insulin receptors on cells then activates a cascade of protein kinases that cause the cells to take ... These signals are usually in the form of soluble messengers such as hormones and growth factors and are detected by specific ... Metal cofactors are bound tightly to specific sites in proteins; although enzyme cofactors can be modified during catalysis, ... Insulin causes glycogen synthesis by activating protein phosphatases and producing a decrease in the phosphorylation of these ...
*  Proteins produced and secreted by the liver
Vitamin D-binding protein, carries vitamin D Insulin-like growth factor 1, a polypeptide protein hormone which plays an ... carries insulin-like growth factor 1 Major urinary proteins, carries pheromones in rodents Retinol binding protein, carries ... The liver plays the major role in producing proteins that are secreted into the blood, including major plasma proteins, factors ... All factors in the coagulation cascade. While the endothelium does produce some factor VIII, the majority of factor VIII is ...