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*  Lopinavir
... inhibitory concentration for HIV". AIDS (London, England). 19 (9). HIV drug used to reverse effects of virus that causes ... 2005). "Lopinavir concentrations in cerebrospinal fluid exceed the 50% ...
*  Borage
... inhibitory concentration (LD50) of the extract against Entamoeba histolytica was 33 µg/mL. Pliny the Elder and Dioscorides say ...
*  AETX
... inhibitory concentration (IC50) was determined as 91 nM. Shiomi, Kazuo; Qian, Wen-Hong; Lin, Xin-Yu; Shimakura, Kuniyoshi; ... AETX I is part of the sea anemone sodium channel inhibitory subfamily 1 and binds to the neurotoxin receptor site 3 of voltage- ... The LD50 of AETX K is not known so far, but its 50% ...
*  Celecoxib
SO2NHCH3 substituent diminishes COX-2 inhibitory activity as noted with a very high inhibitory concentration-50 (see structures ... Some of these analogs retained COX-2 inhibitory activity, whereas many others did not. However, when the ability of all these ... Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA (February 2008). "Celecoxib analogs that lack COX-2 inhibitory function ... which celecoxib does not inhibit at therapeutic concentrations) inhibits the production of prostaglandins and the production of ...
*  Limb perfusion
Concentration-dependent antibiotics, such as gentamicin and amikacin, are best suited for RLP because they have higher efficacy ... Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β ... Horses must be sedated, because movement can force blood past the tourniquet and reduce the concentration of drug below the ... Regional limb perfusion allows drug dose to be reduced while maintaining therapeutic concentrations at the site of interest, ...
*  Echigoshirayukidake (Basidiomycetes-X)
... inhibitory concentration (IC50) of BDM-X and α-lipoic acid for the inhibition of LPS-induced lipid peroxidation (TBARS) in vivo ... The inhibitory effect of BDM-X on lipid peroxidation is more potent than that of ABM in vitro and in exo-vivo (rat liver ... The in vivo inhibitory effects of BDM-X on lipopolysaccharide (LPS)-induced thiobarbituric acid reactive substance (TBARS) and ... The safety dose of BDM-X in human is estimated to be 150g/day (50 kg body weight). BDM-X does not induce no mutagenicity in ...
*  Reed-Muench method
... half maximal effective or inhibitory concentration, respectively, of a drug), and TCID50 (50% tissue culture infectious dose of ... the concentration of a test substance that produces an effect of interest in half of the test units. Examples include LD50 (the ... so it is easier to measure the concentration of the test substance that produces a 50% response. Reed, L.J.; Muench, H. (1938 ... See article above for overview of 50% endpoints and comparison with other methods of calculating 50% endpoints. The Reed-Muench ...
*  Surfactin
This is also known as the minimum inhibitory concentration (MIC). The antiviral effects of surfactin distinguish this ... Fortunately, these results were seen at high concentrations of about 40 µM to 60 µM. These concentrations also exhibited the ... the bacterium needs to be treated with a high concentration. In fact, surfactin needs to be in concentrations between 12-50 µg/ ... It can lower the water's surface tension from 72 mN/m to 27 mN/m at a concentration as low as 20 µM. Surfactin accomplishes ...
*  Phloxine
At a minimum inhibitory concentration of 25 µM, growth is reduced by 10-fold within 2.5 hours. At concentrations of 50 µM and ...
*  7,8-Dihydroxyflavone
7,8-DHF has also been observed to possess in vitro antiestrogenic effects at very high concentrations (Ki = 50 μM). A variety ... Unlike many other flavonoids, 7,8-DHF does not show any inhibitory activity on 17β-hydroxysteroid dehydrogenase. ... 39 (3): 638-50. doi:10.1038/npp.2013.243. PMC 3895241 . PMID 24022672. Yang YJ, Li YK, Wang W, Wan JG, Yu B, Wang MZ, Hu B ( ...
*  Synephrine
... did not produce significant and irregular contractions until a concentration of 1:2500had been reached, implying an inhibitory ... mM/L of synephrine on rat white fat cells was antagonized by various β-antagonists with the following inhibitory concentrations ... However, the potency of synephrine at these receptors is relatively low (i.e. relatively large concentrations of the drug are ... This substance is present at very low concentrations in common foodstuffs such as orange juice and other orange (Citrus species ...
*  Ampicillin/sulbactam
Its bacterial killing is largely related to the time that drug concentrations in the body remain above the minimum inhibitory ... Various studies have shown that, for maximum bacterial killing, drug concentrations must be above the MIC for 50-60% of the ... This means that longer durations of adequate concentrations are more likely to produce therapeutic success. However, when ... regrowth of bacteria has been seen when sulbactam levels fall below certain concentrations. As with many other antibiotics, ...
*  Hordenine
... at a concentration of 1 μM, had almost identical potency to that of the same concentration of β-phenethylamine in stimulating ... admixture with an equal amount of gramine markedly enhanced this inhibitory effect, in a synergistic manner. Tyramine N- ... This researcher found a mean concentration of hordenine in raw barley around 0.7 μg/g; in green malts (i.e. barley that had ... In contrast to tyramine, hordenine did not produce contraction of isolated rat vas deferens, but a 25 μM concentration of the ...
*  Eteplirsen
... nor did it have any major inhibitory potential for any of the key human drug transporters at the concentration range given in ... Following single or multiple IV infusion, the peak plasma concentrations (Cmax) of eteplirsen occurred near the end of infusion ... Plasma protein binding of eteplirsen in human is relatively low, ranging 6.1~16.5% and is independent of concentration studied ... and plasma concentration-time profiles of eteplirsen were generally similar and showed multi-phasic decline; the majority of ...
*  Margatoxin
... half maximal inhibitory concentration) of 85 pM. In this study, a negative effect was also found. There have been ... Margatoxin irreversibly inhibits the proliferation of human T-cells in a concentration of 20 μM. At lower concentrations, this ... In contrast to when the plasma concentration of margatoxin is higher than 10nM, the transient hyperactivity occurs in pigs. It ... 33 (50): 15061-15070. doi:10.1021/bi00254a015. PMID 7999764. Garcia-Calvo, M.; Leonard, R. J.; Novick, J.; Stevens, S. P.; ...
*  Fed-batch culture
At such high concentrations, the nutrients become inhibitory, even though they have no such effect at the normal concentrations ... 2. High cell density (High cell concentration)[1] In a batch culture, to achieve very high cell concentrations, e.g. 50-100 g ... To cultivate the mutant on a low concentration of the required nutrient, it is fed to the batch culture at a controlled rate. ... Keeping the concentration of this compound as low as possible (while still allowing for sufficient cell growth) permits ...
*  Strychnine
When the inhibitory signals are prevented, the motor neurons are more easily activated and the victim will have spastic muscle ... In persons killed by strychnine, the highest concentrations are found in the blood, liver, kidney and stomach wall. The usual ... Strychnine is an antagonist of glycine; it binds noncovalently to the same receptor, preventing the inhibitory effects of ... In the presence of an inhibitory neurotransmitter, such as glycine, a greater quantity of excitatory neurotransmitters must ...
*  Mucor plumbeus
The growth of M. plumbeus varied with different gas concentrations. Growth in N2 was 80% of that in air. Growth also occurred ... This study also revealed that thymol has effective inhibitory action against M. plumbeus. In nature, M. plumbeus can be found ... Growth on cheddar cheese in an atmosphere of: 20% CO2 and 5% O2 was 50% of that in air; 20% CO2 and 1% O2 was 40% of that in ... Growth on Czapek Yeast Extract Agar (CYA) and Malt Extract Agar (MEA) produces colonies at least 50 mm in diameter, often ...
*  AMPT
This increasing inhibitory effect is seen in dosages up to 1500 mg per day; at higher doses, the inhibitory effect of AMPT ... AMPT's effect on dopamine concentration and transport is reversible and short-lived. If methamphetamine is administered while ... Although it is not well understood, this relationship allows for AMPT's inhibitory property, which blocks tyrosine hydroxylase ... A relationship between cytoplasmic dopamine concentration and VMAT activity was established using cocaine, methamphetamines, ...
*  IC50
The half maximal inhibitory concentration (IC50) is a measure of the effectiveness of a substance in inhibiting a specific ... is fixed substrate concentration and Km is the concentration of substrate at which enzyme activity is at half maximal (but is ... is the fixed concentration of agonist and EC50 is the concentration of agonist that results in half maximal activation of the ... substrate and enzyme concentrations) the Ki is an absolute value. Ki is the inhibition constant for a drug; the concentration ...
*  Baricitinib
... reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC50) of 5.9 nM and Janus kinase 2 ... had no relevant influence on baricitinib concentrations in the bloodstream. While it blocks a number of transporter proteins in ... 50% of the circulating baricitinib are bound to blood plasma proteins. Less than 10% of the substance is metabolised to four ...
*  Attention deficit hyperactivity disorder
Lower urinary phenethylamine concentrations are also associated with symptoms of inattentiveness in ADHD individuals. Electro ... The 7 repeat variant of dopamine receptor D4 (DRD4-7R) causes increased inhibitory effects induced by dopamine and is ... The symptoms of ADHD arise from a deficiency in certain executive functions (e.g., attentional control, inhibitory control, and ... Urinary and blood plasma phenethylamine concentrations are lower in ADHD individuals relative to controls and the two most ...
*  Blackout (drug-related amnesia)
Activation during correct inhibitory responses relative to go responses in the left and middle frontal gyri at baseline ... A rapid increase in blood alcohol concentration (BAC) is most consistently associated with the likelihood of a blackout. ... Results showed that prior to beginning substance use, blackout and youth showed greater activation during inhibitory processing ... Wetherill, Reagan R; Castro, Norma; Squeglia, Lindsay M; Tapert, Susan F (2013). "Atypical neural activity during inhibitory ...
*  Difloxacin
The minimum inhibitory concentrations (MICs) of pathogens isolated in clinical field trials conducted in the United States ... It has broad-spectrum, concentration dependent, bactericidal activity; however, its efficacy is not as good as enrofloxacin or ... Difloxacin is rapidly and almost completely absorbed after oral administration, and approximately 50% is bound to circulating ...
*  Phytophthora palmivora
Light is inhibitory to zoospore formation but stimulatory to zoospore germination. Mature zoospores can be induced to germinate ... However, chlamydospores produced in papaya juice at lower concentrations or in other kinds of fruit juice are mostly thin- ... The average size of the sporangia is 50 X 33 µm with a length of about 1.6 times longer than it is wide. Sporangia germinate ...
*  Pre-Bötzinger complex
Glycinergic and GABAergic inhibitory neurons make up half of all inspiratory neurons. Exposure of the pre-Bötzinger complex to ... Calcium-sensitive dyes have shown that internal concentrations of calcium increase during bursts. The activation of different ... The inhibitory connections discovered indicate their ability to connect different classes of neurons, their importance in ... In addition to the inhibitory synaptic regulation of respiratory rhythm within the pre-Bötzinger complex, there is also an ...