"Blood-based protein biomarkers for stroke differentiation: A systematic review". Proteomics Clin Appl. 11 (9-10). doi:10.1002/ ... Activated protein C-protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). It ... Another complex related to APC-PCI is the activated protein C-α1-antitrypsin (APCAT) complex. Merlini PA, Ardissino D (1995). " ... v t e v t e (Coagulation system, Protein complexes, All stub articles, Biochemistry stubs, Hematology stubs). ...

Inhibitor of differentiation 4, helix protein 271, Inhibitor of DNA binding 4 HLH Protein, Inhibitor of Differentiation 4, ... ID4 is a protein coding gene. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4. This protein ... The ID4 gene is also known as DNA-binding protein inhibitor ID-4, Id-4, IDb4, IDB4, Inhibitor of DNA binding 4, ... This family is also known as inhibitors of DNA binding protein family and are composed of transcription inhibitory proteins ...

December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". ... The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein ... May 1998). "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation". The ... E2F1 to E2F5 are known to associate with proteins in the pRb-family of proteins while E2F6 and E2F7 are independent of pRb. ...

EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene. EID1 has been shown ... "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1". Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S ... 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. ... 2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623-35. doi:10.1016/j. ...

β-Glycerophosphate is an inhibitor of the enzyme serine-threonine phosphatase. It is often used in combination with other ... β-Glycerophosphate is also used to drive osteogenic differentiation of bone marrow stem cells in vitro. β-Glycerophosphate is ... used to buffer M17 media for Lactococcus culture in recombinant protein expression. "β-Glycerophosphate disodium salt hydrate ... "Protease and Phosphatase Inhibitors". Thermo Fisher Scientific. Retrieved 2018-05-30. Langenbach & Handschel (2013). "Effects ...

Noggin, a developmental protein, inhibits chondrogenesis by preventing condensation and differentiation of mesenchymal cells. ... Sox9 and Nkx3.2 induce each other in a positive feedback loop where Nkx3.2 inactivates a Sox9 inhibitor. This loop is supported ... Bone morphogenetic proteins are growth factors released during embryonic development to induce condensation and determination ... PTHrP acts as a patterning molecule, determining the position in which the chondrocytes initiate differentiation. Research is ...

... while activation of a GAP results in inactivation of the cognate G-protein. Guanosine nucleotide dissociation inhibitors (GDI) ... Small GTPases regulate a wide variety of processes in the cell, including growth, cellular differentiation, cell movement and ... Therefore, a G-protein can be switched on and off. GTP hydrolysis is accelerated by GTPase activating proteins (GAPs), while ... They are a type of G-protein found in the cytosol that are homologous to the alpha subunit of heterotrimeric G-proteins, but ...

The Cyclin-Dependent Kinase Inhibitor p57(Kip2) Regulates Cell Cycle Exit, Differentiation, and Migration of Embryonic Cerebral ... a motor protein that affects intercellular movement such as protein sorting and the process of cell division. Another protein ... DAB1 is a regulator protein downstream of the reelin receptors. This protein is located inside cells residing in the ... Cyclin-dependent kinase inhibitor 1C, or p57, also affects corticogenesis. It has been shown the p57 induces cells to exit from ...

... , a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces ... Low p27Kip1 expression can lead to tumor de-differentiation, increased penetration through the gastric wall, lymph node ... Thus, the human Cdk inhibitor p27Kip1 is a potential tumor suppressor protein. If its expression is reduced, the result might ... Page of Sic1 at yeastgenome.org (Protein pages needing a picture, Cell cycle, Saccharomyces cerevisiae genes, Proteins). ...

In addition to Myc, Smads are also involved in the downregulation of Inhibitor of DNA Binding (ID) proteins. IDs are ... potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein ... Thus, the two proteins could be caught in a "vicious cycle" of regulation. Pin1 causes both itself and Smad2 to be associated ... Therefore, downregulating ID proteins is a pathway by which TGF-B signaling could arrest the cell cycle. In a DNA microarray ...

June 2005). "An inhibitor of Bcl-2 family proteins induces regression of solid tumours". Nature. 435 (7042): 677-81. Bibcode: ... Differentiation. 16 (3): 360-367. doi:10.1038/cdd.2008.137. PMID 18806758. S2CID 24538054. Oltersdorf T, Elmore SW, Shoemaker ... This compound is part of a group of BH3 mimetic small molecule inhibitors (SMI) that target these Bcl-2 family proteins, but ... These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its ...

BCL-6 proteins repress genes involved in terminal differentiation and promote proliferation by blocking expression of a cell- ... cycle inhibitor (p27KIP1). BCL-6 is also an inhibitor of cellular senescence. Cellular senescence is a programmed response that ... 14-3-3 proteins exert anti-apoptotic activity by interfering with the function of BH3-only proteins and has been validated as a ... Pro-apoptotic proteins include Bax and Bak. Anti-apoptotic proteins include Bcl-2, Bcl-XL, Bcl-w, Mcl-1. When anti-apoptotic ...

... levels of myostatin up-regulate a cyclin-dependent kinase inhibitor called p21 and thereby inhibit the differentiation of ... The proteins responsible for signaling the activation of satellite cells are called mitogens. A mitogen is a small protein that ... One of the first roles described for IGF-1 was its involvement in the proliferation and differentiation of satellite cells. In ... The disruption in myofiber integrity is seen in increased plasma levels in muscle proteins. The death of myofibers drives a ...

... a protein initiating bone differentiation". The Journal of Biological Chemistry. 264 (23): 13377-13380. doi:10.1016/S0021-9258( ... For example, BMP4 and its inhibitors noggin and chordin help regulate polarity of the embryo (i.e. back to front patterning). ... BMP: The What and the Who BMPedia - the Bone Morphogenetic Protein Wiki Bone+Morphogenetic+Proteins at the U.S. National ... Spinal Fusion and Bone Morphogenetic Protein Reddi AH (1997). "Bone morphogenetic proteins: an unconventional approach to ...

... soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation". Eur J Biochem ... 1999). "Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis". J. Biol. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... 1996). "Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis". J. ...

Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS). CSF1R is a ... Overall, CSF1R inhibitors have favorable safety profiles with limited toxicity. CSF1R inhibitors such as PLX5622 are widely ... protein, an inhibitor of pro-apoptotic caspase-9. CSF1R signaling in mature osteoclasts promotes survival by stimulating mTOR/ ... CSF1R, the protein encoded by the CSF1R gene is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor ...

The differentiation of N2a cells is caused by activation of the mitogen-activated protein kinase/extracellular-signal regulated ... It does so by activating Akt while inactivating glycogen synthase kinase-3β (GSK-3β), an inhibitor of the Akt pathway. Emodin ... while inhibition of the Akt pathway will not prevent LA-induced differentiation. LA causes differentiation through the ... inhibit differentiation of N2a cells that are differentiated through serum-withdrawal differentiation. HDL does so through ...

Inhibitors of these ligands prevents mesoderm formation and these proteins show a graded distribution along the dorsal/ventral ... These proteins are known to be ligands for the Notch protein. GLP-1, a Notch protein, is also required for specification of the ... mom-2 is a member of the Wnt family of proteins (i.e. the signal) and mom-5 is a member of the frizzled family of proteins (i.e ... Wnt proteins were not necessary to specify the axis, but examination of other proteins in the Wnt pathway led to the discovery ...

... with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation". Cell Death Differ. 15 (5): 859-66. doi: ... "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 ... Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of ... Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1998). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of ...

... with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation". Cell Death and Differentiation. 15 (5): ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... Polyubiquitin-C is a protein encoded by the UBC gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with ... Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (August 2008). "Protein phosphatase 4 negatively regulates LPS cascade by ...

One example is the BMP (bone morphogenetic protein,) which has an important role in ameloblast differentiation. When ... Follistatin, a BMP inhibitor, is over expressed in the epithelium of developing teeth, the ameloblasts do not differentiate and ... Their differentiation from preameloblasts (whose origin is from inner enamel epithelium) is a result of signaling from the ... The differentiation from preameloblasts to ameloblasts occurs during the first stage of amelogenesis, called the pre-secretory ...

"Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease ... purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". European ... This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, ... The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR ...

"Developing irreversible inhibitors of the protein kinase cysteinome". Chemistry & Biology. 20 (2): 146-159. doi:10.1016/j. ... JAK3 is crucial in transmitting signals from cytokines that are responsible for either T-cell proliferation, differentiation, ... Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3 ... Initially, tofacitinib was thought to be a selective JAK3 inhibitor, but later was found to be a potent inhibitor of JAK1 and ...

Cryptic family protein 1B is a protein that in humans is encoded by the CFC1B gene. Cryptic family protein 1B acts as a ... and a block on the differentiation of cardiac myocyte,. both of which lead to embryonic death. Cripto's functions have been ... Expression levels of cripto are associated with resistance to EGFR inhibitors. Teratocarcinoma-derived growth factor 1 GRCh38: ... It has been associated with the translation of an extracellular protein for this pathway. The extracellular protein which ...

... , as other junctional proteins could be used as a marker of epithelial differentiation, and as a diagnostic marker to ... "Histone deacetylase inhibitors up-regulate the expression of tight junction proteins". Molecular Cancer Research. 2 (12): 692- ... Moreover, cingulin forms a complex with JAM-A, a tight junction membrane protein. Most of cingulin protein interactions are ... "The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4". PLOS ...

Inactivation of cyclin D is triggered by several cyclin-dependent kinase inhibitor protein (CKIs) like the INK4 family (e.g. ... Inhibition of cyclin D via inactivation or degradation leads to cell cycle exit and differentiation. ... Cyclins are eukaryotic proteins that form holoenzymes with cyclin-dependent protein kinases (Cdk), which they activate. The ... Drosophila and many other organisms only have one cyclin D protein. In mice and humans, two more cyclin D proteins have been ...

A small molecule inhibitor (GSK-J1) has been developed to inhibit the jumonji domain of KDM6 histone demethylase family to ... Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. KDM6B was found to be expressional increased ... during cardiac and endothelial differentiation of murine embryonic stem cells. ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 17, Human proteins, All ...

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene. Members of the ID family of helix- ... Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells ... "Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein". Deed RW, Jasiok M, Norton JD (Apr ... Inhibitor of DNA-binding protein ENSG00000117318 GRCh38: Ensembl release 89: ENSG00000283060, ENSG00000117318 - Ensembl, May ...

... bone morphogenetic proteins, growth and differentiation factors, and Müllerian inhibitor subfamily. TGF-β signaling plays an ... The second is the helix-loop-helix (HLH) region, which facilitates protein-protein interactions. Also contained with the AhR ... also known as hepatitis B virus X-associated protein 2 (XAP2), AhR interacting protein (AIP), and AhR-activated 9 (ARA9). The ... The AhR protein contains several domains critical for function and is classified as a member of the basic helix-loop-helix/Per- ...

... differentiation, mitosis, cell survival or apoptosis. cIAP1 is as well implicated in innate immunity. When NOD-like receptors ... cIAP1 (also named BIRC2) is the abbreviation for a human protein, cellular inhibitor of apoptosis protein-1. It belongs to the ... cIAP1 is an inhibitor of apoptosis protein. It directly ubiquitinates RIP1 and induces constitutive RIP1 ubiquitination in ... Pu Xia; Yanfei Qi (2012). "Cellular Inhibitor of Apoptosis Protein-1 (cIAP1) Plays a Critical Role in β-Cell Survival under ...

miR-181 could directly target hepatic transcriptional regulators of differentiation (like homeobox 2 CDX2 and 6 GATA proteins ... Tamoxifen acts as an anti-estrogen (inhibitor) in breast tissue, but as an estrogen (stimulating agent) in cholesterol ... "The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation". Nature Cell Biology. 8 (3 ... miR-181 expression has a reverse correlation with Tcl1 protein expression. mir-181 a and b are over-expressed and act as bad ...