β-Glycerophosphate is an inhibitor of the enzyme serine-threonine phosphatase. It is often used in combination with other ... β-Glycerophosphate is also used to drive osteogenic differentiation of bone marrow stem cells in vitro. β-Glycerophosphate is ... used to buffer M17 media for Lactococcus culture in recombinant protein expression. "β-Glycerophosphate disodium salt hydrate ... "Protease and Phosphatase Inhibitors". Thermo Fisher Scientific. Retrieved 2018-05-30. Langenbach & Handschel (2013). "Effects ...

EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene. EID1 has been shown ... "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1". Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S ... 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. ... 2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623-35. doi:10.1016/j. ...

The Cyclin-Dependent Kinase Inhibitor p57(Kip2) Regulates Cell Cycle Exit, Differentiation, and Migration of Embryonic Cerebral ... a motor protein that affects intercellular movement such as protein sorting and the process of cell division. Another protein ... DAB1 is a regulator protein downstream of the reelin receptors. This protein is located inside cells residing in the ... Cyclin-dependent kinase inhibitor 1C, or p57, also affects corticogenesis. It has been shown the p57 induces cells to exit from ...

EP300 interacting inhibitor of differentiation 2, also known as EID2 is a human gene. The protein encoded by this gene may ... v t e (Articles with short description, Short description is different from Wikidata, Protein pages needing a picture, Genes on ... This inhibitory effect on gene expression can be explained by EID-2's ability to associate with and inhibit the ... a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD". Gene. 318: 35-43. doi:10.1016/j. ...

... , a protein, is a stoichiometric inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces ... Low p27Kip1 expression can lead to tumor de-differentiation, increased penetration through the gastric wall, lymph node ... Thus, the human Cdk inhibitor p27Kip1 is a potential tumor suppressor protein. If its expression is reduced, the result might ... Page of Sic1 at yeastgenome.org (Protein pages needing a picture, Cell cycle, Saccharomyces cerevisiae genes, Proteins). ...

"Fas-mediated apoptosis in neuroblastoma requires mitochondrial activation and is inhibited by FLICE inhibitor protein and Bcl-2 ... Differentiation. 16 (3): 360-367. doi:10.1038/cdd.2008.137. PMID 18806758. S2CID 24538054. Oltersdorf T, Elmore SW, Shoemaker ... These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ...

This gene targets the cyclin-dependent kinase inhibitor, p21, and causes cell differentiation, cell cycle arrest in G1, and ... Bax protein, and cytochrome C. The tumor suppressor gene p53 is also important in the cell cycle regulation of K562 cells. ... Many factors and components play a role in the cell cycle of K562 cells in terms of growth, cell differentiation, and apoptosis ... Cell differentiation is induced by the deacetylase activity in these "undifferentiated progenitor cells," which alters the ...

... is an inhibitor of paracellular permeability. In celiac disease, one pathway that allows fragments of gliadin ... The responsible region was located near the carboxyl terminus of the toxin protein. This region coincided with a peptide ... This leads to the induction of myeloid differentiation factor 88 (MYD88) and the release of zonulin into the lumen. Zonulin ... The eight amino acid sequence in this region was shared with zonulin, an endogenous protein involved in tight junction ...

... soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation". Eur J Biochem ... 1999). "Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis". J. Biol. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... 1996). "Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis". J. ...

Inhibitors of these ligands prevents mesoderm formation and these proteins show a graded distribution along the dorsal/ventral ... These proteins are known to be ligands for the Notch protein. GLP-1, a Notch protein, is also required for specification of the ... Wnt proteins were not necessary to specify the axis, but examination of other proteins in the Wnt pathway led to the discovery ... PAR proteins are responsible for partitioning these determinants in the early embryo. These proteins are located at the ...

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene. The protein encoded by ... 2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain ... inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, ... inhibitor gamma". Collins SP, Uhler MD (1997). "Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor ...

Halperin DS, Pan C, Lusis AJ, Tontonoz P (February 2013). "Vestigial-like 3 is an inhibitor of adipocyte differentiation". ... Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene. Vestigial like family member 4 GRCh38 ... Zhou W, Chen H, Zhang L (March 2009). "The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and ... a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation". The Journal of Biological ...

... bone morphogenetic proteins, growth and differentiation factors, and Müllerian inhibitor subfamily. TGF-β signaling plays an ... The second is the helix-loop-helix (HLH) region, which facilitates protein-protein interactions. Also contained with the AhR ... The AhR protein contains several domains critical for function and is classified as a member of the basic helix-loop-helix/Per- ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ...

December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". ... The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein ... May 1998). "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation". The ... E2F1 to E2F5 are known to associate with proteins in the pRb-family of proteins while E2F6 and E2F7 are independent of pRb. ...

"The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation". Nature Cell Biology. 8 (3 ... Tamoxifen acts as an anti-estrogen (inhibitor) in breast tissue, but as an estrogen (stimulating agent) in cholesterol ... miR-181 expression has a reverse correlation with Tcl1 protein expression. mir-181 a and b are over-expressed and act as bad ... miR-181a has been shown to play a role in the lineage differentiation in the hematopoietic system. miR-181a expression is ...

Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity". Cell Death and Differentiation. 9 (1): 20-6. ... Protein HtrA2, also known as Omi, is a mitochondrially-located serine protease. The human protein Serine protease HTRA2, ... "Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2". The Journal of Biological ... "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins". ...

Inhibitor of DNA-binding/differentiation proteins, also known as ID proteins comprise a family of proteins that heterodimerize ... Differentiation+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Enzyme inhibitors, Protein ... By inhibiting the formation of E-protein dimers that promote differentiation, ID proteins can regulate the timing of ... ID proteins can bind E-proteins, preventing them from binding bHLH proteins and halting transcription, a case often seen in ...

... with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation". Cell Death Differ. 15 (5): 859-66. doi: ... "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 ... Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). "Assignment of human inhibitor of apoptosis protein (IAP) genes ... is a protein that in humans is encoded by the BIRC2 gene. cIAP1 is a member of the Inhibitor of Apoptosis family that inhibit ...

... proteins BRD2, BRD3, BRD4, and BRDT, and prevent protein-protein interaction between BET proteins and acetylated histones and ... to affect the differentiation of oligodendrocyte progenitor cells.: 4.1 RVX-208 ABBV-744 LY294002 (some PI3K and BRD2, BRD3, ... BET inhibitors have been described that are able to discriminate between the first and second bromodomains of BET proteins (BD1 ... Examples include use of BET inhibitors in combination with γ-secretase inhibitors for T cell acute lymphoblastic leukemia and ...

... , as other junctional proteins could be used as a marker of epithelial differentiation, and as a diagnostic marker to ... "Histone deacetylase inhibitors up-regulate the expression of tight junction proteins". Molecular Cancer Research. 2 (12): 692- ... Moreover, cingulin forms a complex with JAM-A, a tight junction membrane protein. Most of cingulin protein interactions are ... "The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4". PLOS ...

Additionally, the sonic hedgehog protein has been shown to block activity of the retinoblastoma protein, thereby inducing cell ... Several Notch signaling pathway inhibitors, including the gamma secretase inhibitor LY3056480, are being studied for their ... has been shown to be a master regulator in the differentiation of inner and outer hair cells. This discovery has allowed ... The cell cycle inhibitor p27kip1 (CDKN1B) has also been found to encourage regrowth of cochlear hair cells in mice following ...

This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca ... In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation. GRCh38: Ensembl release 89: ... Caldesmon is a protein that in humans is encoded by the CALD1 gene. Caldesmon is a calmodulin binding protein. Like calponin, ... This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and ...

"Blood-based protein biomarkers for stroke differentiation: A systematic review". Proteomics Clin Appl. 11 (9-10). doi:10.1002/ ... Activated protein C-protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI). It ... Another complex related to APC-PCI is the activated protein C-α1-antitrypsin (APCAT) complex. Merlini PA, Ardissino D (1995). " ... v t e v t e (Coagulation system, Protein complexes, All stub articles, Biochemistry stubs, Hematology stubs). ...

... s (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily ... Levine A, Brivanlou A (2006). "GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos". Development. 133 (2 ... Chen C, Ware S, Sato A, Houston-Hawkins D, Habas R, Matzuk M, Shen M, Brown C (2006). "The Vg1-related protein Gdf3 acts in a ... Cunningham N, Jenkins N, Gilbert D, Copeland N, Reddi A, Lee S (1995). "Growth/differentiation factor-10: a new member of the ...

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. The protein encoded by this gene ... This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. A ... Inhibitor of DNA-binding protein GRCh38: Ensembl release 89: ENSG00000115738 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-Protein ...

Suzuki Y, Nakabayashi Y, Takahashi R (July 2001). "Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein ... It is now being shown that caspase-3 may play a role in embryonic and hematopoietic stem cell differentiation. The Proteolysis ... One means of caspase inhibition is through the IAP (inhibitor of apoptosis) protein family, which includes c-IAP1, c-IAP2, XIAP ... Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R (July 2001). "X-linked inhibitor of apoptosis protein (XIAP) inhibits ...

Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/β-Catenin and Protein ... 2016) Small molecule inhibitors of Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy ... He demonstrated the "CXXC5-Dvl protein-protein interaction (PPI)" as a target for development of agents enhancing wound healing ... played a key role in unveiling the structure of lactose repressor protein(LacI), which was one of the most interested proteins ...

"Peptide based Molecules as Protein-Protein Interaction Inhibitors: Tools for Chemical Genetics and Therapy". Current Chemical ... Cell Death and Differentiation. 23 (4): 707-722. doi:10.1038/cdd.2015.133. PMC 4986638. PMID 26494468.{{cite journal}}: CS1 ... Protein-Protein interaction Regulators, edited by Siddhartha Roy & Haian Fu. 2021. Published by Royal Society of Chemistry, UK ... USA and Protein-Protein interaction Regulators published by Royal Society of Chemistry, UK. He has guided around 30 scholars in ...

... levels of myostatin up-regulate a cyclin-dependent kinase inhibitor called p21 and thereby inhibit the differentiation of ... The proteins responsible for signaling the activation of satellite cells are called mitogens. A mitogen is a small protein that ... One of the first roles described for IGF-1 was its involvement in the proliferation and differentiation of satellite cells. In ... The disruption in myofiber integrity is seen in increased plasma levels in muscle proteins. The death of myofibers drives a ...

"Developing irreversible inhibitors of the protein kinase cysteinome". Chemistry & Biology. 20 (2): 146-159. doi:10.1016/j. ... JAK3 is crucial in transmitting signals from cytokines that are responsible for either T-cell proliferation, differentiation, ... Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3 ... Initially, tofacitinib was thought to be a selective JAK3 inhibitor, but later was found to be a potent inhibitor of JAK1 and ...