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*  Glucagon-like peptide 1 receptor
"Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1". Proc. Natl. ...
*  Incretin
Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Incretins are released after ... Drucker's laboratory that studies incretins Drucker DJ, Nauck MA (November 2006). "The incretin system: glucagon-like peptide-1 ... Incretins, especially GIP and GLP-1 secreted, respectively, by K and L cells in the gut are also important" (Rang and Dale's ... Amori RE, Lau J, Pittas AG (July 2007). "Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta ...
*  Dipeptidyl peptidase-4 inhibitor
"Pancreatic Safety of Incretin-Based Drugs - FDA and EMA Assessment - NEJM". Monami M, Dicembrini I, Mannucci E (January 2014 ... The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn ... "Marked expansion of exocrine endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and ...
*  Albiglutide
Liu, J; Li, L; Deng, K; Xu, C; Busse, JW; Vandvik, PO; Li, S; Guyatt, GH; Sun, X (8 June 2017). "Incretin based treatments and ... Albiglutide acts as an agonist at the GLP-1 receptor, which makes it a type of incretin mimetic. This causes an increase of ...
*  Sitagliptin
"www.merck.com" (PDF). Olansky L (2010). "Do incretin-based therapies cause acute pancreatitis?". J Diabetes Sci Technol. 4 (1 ... Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP ...
*  Anti-diabetic medication
Incretins are insulin secretagogues. The two main candidate molecules that fulfill criteria for being an incretin are glucagon- ... permanent dead link] Amori RE, Lau J, Pittas AG (2007). "Efficacy and safety of incretin therapy in type 2 diabetes: systematic ... They have all the incretins actions except stimulation of insulin secretion. As of 2007[update], pramlintide is the only ... Dipeptidyl peptidase-4 (DPP-4) inhibitors increase blood concentration of the incretin GLP-1 by inhibiting its degradation by ...
*  European Association for the Study of Diabetes
Incretin Study Group; EASD Islet Study Group; European Diabetes Epidemiology Group (EDEG); Diabetes and Nutrition Study Group ( ...
*  Glucagon-like peptide-1
"Diabetes and Intestinal Incretin Hormones: A New Therapeutic Paradigm" at medscape.com (slide 36) Toft-Nielsen MB, Madsbad S, ... Deacon CF, Holst JJ (2009). "Immunoassays for the incretin hormones GIP and GLP-1". Best Pract Res Clin Endocrinol Metab. 23 (4 ... doi:10.1016/S1262-3636(08)73397-4. Seino Y, Fukushima M, Yabe D (2010). "GIP and GLP-1, the two incretin hormones: Similarities ... Gautier JF, Choukem SP, Girard J (2008). "Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes". ...
*  Daniel J. Drucker
Baggio, L. L.; Drucker, D. J. (2007). "Biology of Incretins: GLP-1 and GIP". Gastroenterology. 132 (6): 2131-57. doi:10.1053/j. ... Drucker, D. J. (2006). "The biology of incretin hormones". Cell Metabolism. 3 (3): 153-65. doi:10.1016/j.cmet.2006.01.004. PMID ... Drucker, D. J.; Nauck, M. A. (2006). "The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 ...
*  Gastric inhibitory polypeptide
GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins. GIP is derived from ... Kim W, Egan JM (Dec 2008). "The role of incretins in glucose homeostasis and diabetes treatment". Pharmacological Reviews. 60 ( ... Efendic S, Portwood N (2004). "Overview of incretin hormones". Hormone and Metabolic Research. 36 (11-12): 742-6. doi:10.1055/s ...
*  Hyperlipidemia
"Postprandial hyperlipidemia, endothelial dysfunction and cardiovascular risk: Role of Incretins". Cardiovascular Diabetology " ...
*  Exenatide
"IN RE: INCRETIN MIMETICS PRODUCTS LIABILITY LITIGATION" (PDF). USJP. United States Judicial Panel on Multidistric Litigation. ... Tushuizen ME, Bunck MC, Pouwels PJ, van Waesberghe JH, Diamant M, Heine RJ (2006). "Incretin mimetics as a novel therapeutic ... In March 2013, the FDA issued a Drug Safety Communication announcing investigations into incretin mimetics due to findings by ... "FDA investigating reports of possible increased risk of pancreatitis and pre-cancerous findings of the pancreas from incretin ...
*  Dipeptidyl peptidase-4
It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the ... thereby prolonging incretin effect in vivo. A new coronavirus related to SARS, named Middle East respiratory syndrome ...
*  Glucagon-like peptide-1 receptor agonist
... s also known as GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 ... Forsmark, CE (2016). "Incretins, Diabetes, Pancreatitis and Pancreatic Cancer: What the GI specialist needs to know". ... "Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis". BMJ (Clinical ...
*  Organoid
"Intestinal organoids for assessing nutrient transport, sensing and incretin secretion". Scientific Reports. 5: 16831. doi: ... drug transport and secretion of incretin hormones. This is of great relevance in the context of malabsorption diseases as well ...
*  Saxagliptin
DPP-4 is an enzyme that breaks down incretin hormones. As a DPP-4 inhibitor, saxagliptin slows down the breakdown of incretin ... "IN RE: INCRETIN MIMETICS PRODUCTS LIABILITY LITIGATION" (PDF). USJP. United States Judicial Panel on Multidistric Litigation. ... It is this increase in incretin hormones that is responsible for the beneficial actions of saxagliptin, including increasing ... Because incretin hormones are more active in response to higher blood sugar levels (and are less active in response to low ...
*  Vildagliptin
"Pancreatic Safety of Incretin-Based Drugs - FDA and EMA Assessment - NEJM". New England Journal of Medicine. 370 (9): 794-7. ... "Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia ... "Both agencies agree that assertions concerning a causal association between incretin-based drugs and pancreatitis or pancreatic ...
*  Liraglutide
Liu, J; Li, L; Deng, K; Xu, C; Busse, JW; Vandvik, PO; Li, S; Guyatt, GH; Sun, X (8 June 2017). "Incretin based treatments and ... Liraglutide (NN2211) is a derivative of human incretin (metabolic hormone) glucagon-like peptide-1 (GLP-1) that is used as a ... Liraglutide is a once-daily injectable derivative of the human incretin (metabolic hormone) glucagon-like peptide-1 (GLP-1), ... "Pancreatic Safety of Incretin-Based Drugs-FDA and EMA Assessment-NEJM". The New England Journal of Medicine. 370 (9): 794-7. ...
*  Manitoba Centre for Health Policy
"Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. - PubMed - NCBI". ncbi.nlm.nih.gov. Retrieved 2016 ... "Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study. - PubMed - NCBI". ncbi.nlm.nih. ...
*  Glucokinase
It is suspected that these cells are involved in incretin functions. Because insulin is one of, if not the most important, ... It seems likely that responses to incoming glucose during digestion play a role in the incretin amplification of insulin ...
*  RIMS2
2002). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. 276 (49): 46046-53 ... Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. United States. 276 (49): 46046-53. doi:10.1074/jbc. ...
*  GPR119
... has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor ...
*  RAPGEF4
In fact, incretin-based diabetes therapies are currently used in clinical practice worldwide; development of Epac2-selective ... Rim2 complex in incretin-potentiated insulin secretion". The Journal of Biological Chemistry. 276 (49): 46046-53. doi:10.1074/ ... "Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion". Diabetes. 64 (4): 1262-72. ... of Epac2 knockout mice indicate that Epac-mediated signaling is required for potentiation of insulin secretion by incretins ( ...
*  GPR120
"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120". Nat. Med. 11 (1): 90-4. doi:10.1038/ ...
*  Enteroendocrine cell
L cells secrete glucagon-like peptide-1, an incretin, pancreatic peptide YY3-36, oxyntomodulin and glucagon-like peptide-2. L ... Drucker DJ, Nauck MA (2006). "The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 ... K cells secrete gastric inhibitory peptide, an incretin, which also promotes triglyceride storage. ...