Cellular adoptive immunotherapy
... is a type of immunotherapy. Immune cells such as T-cells are usually isolated from patients for ... This therapy has shown to be more effective in treating solid tumors than other cellular adoptive immunotherapies such as CAR T ... The primary types of cellular adoptive immunotherapies are T cell therapies. Other therapies include CAR-T therapy, CAR-NK ... Main article: see Cancer immunotherapy The final destination of cellular adoptive therapies is to create cellular products that ...
Adoptive cell transfer
Adoptive Transfer at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Adoptive Immunotherapy at the U.S. ... Gattinoni L, Powell DJ, Rosenberg SA, Restifo NP (May 2006). "Adoptive immunotherapy for cancer: building on success". Nature ... Rosenberg SA, Restifo NP (April 2015). "Adoptive cell transfer as personalized immunotherapy for human cancer". Science. 348 ( ... Adoptive cell transfer (ACT) is the transfer of cells into a patient. The cells may have originated from the patient or from ...
Autologous immune enhancement therapy
September 2000). "Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial ... June 2002). "Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced ... "Adoptive immunotherapy of cancer: accomplishments and prospects". Cancer Treat Rep. 68 (1): 233-55. PMID 6362866. Yang Q, ... AIET in NCRM Immunotherapy in Malaysia AIET experience by Nilai Cancer Centre, Malaysia A patient blog: AIET help cure sarcoma ...
William Coley
Chang AE, Shu S. (1996). "Current status of adoptive immunotherapy of cancer". Critical Reviews in Oncology/Hematology. 22 (3 ... "Immunotherapy in the Twentieth Century: William Coley and Lloyd J. Old, CancerTherapyAdvisor.com, 15 March 2017 "Eminent ... Today, Coley is recognized as the Father of Cancer Immunotherapy for his contributions to the science. William Coley was born ... Hobohm, U (Oct 2001). "Fever and cancer in perspective". Cancer Immunology, Immunotherapy. 50 (8): 391-396. doi:10.1007/ ...
Steven Rosenberg
Rosenberg has pioneered the use of adoptive immunotherapy. Rosenberg graduated from the Bronx High School of Science. He ... He pioneered the development of immunotherapy that has resulted in the first effective immunotherapies and the development of ... "Trailblazing Researchers in Immunotherapy Selected to Receive Americas Most Distinguished Prize in Medicine". www.amc.edu. " ... His research has focused on the immunotherapy of cancer. 1992 Golden Plate Award of the American Academy of Achievement 2011 ...
Zinc finger nuclease treatment of HIV
"Genetic engineering of T cells for adoptive immunotherapy". Immunologic Research. 42 (1-3): 166-181. doi:10.1007/s12026-008- ...
Tumor-infiltrating lymphocytes
Restifo NP, Dudley ME, Rosenberg SA (March 2012). "Adoptive immunotherapy for cancer: harnessing the T cell response". Nature ... TIL adoptive cell therapy is now a routine regimen in centers across the world, including MD Anderson Cancer Center, where the ... In Adoptive T cell transfer therapy, TILs are expanded ex vivo from surgically resected tumors that have been cut into small ... Immunotherapy Doubts Fading in GI Cancers. April 2016 Syn NL, Teng MW, Mok TS, Soo RA (December 2017). "De-novo and acquired ...
Cancer immunotherapy
Other modes of enhancing [adoptive] immuno-therapy include targeting so-called intrinsic checkpoint blockades e.g. CISH. Many ... What is Cancer Immunotherapy Association for Immunotherapy of Cancer Society for Immunotherapy of Cancer "And Then There Were ... Adoptive T cell therapy is a form of passive immunization by the transfusion of T-cells (adoptive cell transfer). They are ... Restifo NP, Dudley ME, Rosenberg SA (March 2012). "Adoptive immunotherapy for cancer: harnessing the T cell response". Nature ...
Melanoma
Rosenberg SA, Restifo NP (April 2015). "Adoptive cell transfer as personalized immunotherapy for human cancer". Science. 348 ( ... Ongoing research is looking at treatment by adoptive cell transfer. Adoptive cell transfer refers to the application of pre- ... In clinical research, adoptive cell therapy and gene therapy, are being tested. Two kinds of experimental treatments developed ... The therapy combination of dabrafenib and trametinib has a 3-year PFS of 23%, and 5-year PFS of 13%. Immunotherapy is aimed at ...
Nicholas P. Restifo
Epub ahead of print] Restifo NP, Dudley ME, Rosenberg SA (March 2012). "Adoptive immunotherapy for cancer: harnessing the T ... "Adoptive cell transfer as personalized immunotherapy for human cancer". Science. 348 (6230): 62-68. Bibcode:2015Sci...348...62R ... Restifo is a pioneer in the field of cancer immunotherapy with a focus on the use of T cells in the treatment of malignancy. ... Restifo has been a pioneer in the use of T cell-based immunotherapy. Restifo was born July 24, 1960, in Columbus, Ohio. He grew ...
Tumor antigen
Cancer immunotherapy Restifo, NP; Dudley, ME; Rosenberg, SA (Mar 22, 2012). "Adoptive immunotherapy for cancer: harnessing the ... Coulie PG, Hanagiri T, Takanoyama M: From Tumor Antigens to Immunotherapy. Int J Clin Oncol 6:163, 2001. Chapter on tumor ...
Antonio Siccardi
"Adoptive immunotherapy by avidin-driven cytotoxic T lymphocyte-tumor bridging". Cancer Research. 60 (15): 4211-5. PMID 10945632 ...
Immunotherapy
August 2009). "Adoptive immunotherapy of lung cancer with immobilized anti-TCRgammadelta antibody-expanded human gammadelta T- ... while immunotherapies that reduce or suppress are classified as suppression immunotherapies. Immunotherapy is under preliminary ... Doskali M, Tanaka Y, Ohira M, Ishiyama K, Tashiro H, Chayama K, Ohdan H (March 2011). "Possibility of adoptive immunotherapy ... Immunotherapy may produce long-term benefits. Immunotherapy is partly effective in some people and ineffective in others, but ...
Adoptive immunity
... adoptive transfer adoptive immunization adoptive immunotherapy Adoptive cell therapy adoptive tolerance Rosenberg, SA; Restifo ... NP; Yang, JC; Morgan, RA; Dudley, ME (2008). "Adoptive cell transfer: a clinical path to effective cancer immunotherapy". ... Adoptive immunity acts in a host after their immunological components are withdrawn, their immunological activity is modified ... 1993). "Adoptive immunity." [Dictionary of Terms in Immunoglogy], 3rd ed. Osaka: Saishin-Igakusha, Ltd., p. 510. ISBN 4-914909- ...
Telomerase
Barsov EV (March 2011). "Telomerase and primary T cells: biology and immortalization for adoptive immunotherapy". Immunotherapy ... Immunotherapy successfully treats some kinds of cancer, such as melanoma. This treatment involves manipulating a human's immune ... It must be combined with surgery, radiation, chemotherapy or immunotherapy. Cells may reduce their telomere length by only 50- ... Patel KP, Vonderheide RH (June 2004). "Telomerase as a tumor-associated antigen for cancer immunotherapy". Cytotechnology. 45 ( ...
Primary immunodeficiency
May 2016). "Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes". The Journal of ...
CAR T cell
"Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?". Nature Clinical Practice. Oncology. 3 (12 ... Adoptive transfer of T cells expressing CARs is a promising anti-cancer therapeutic, because CAR-modified T cells can be ... Jin C, Fotaki G, Ramachandran M, Nilsson B, Essand M, Yu D (July 2016). "Safe engineering of CAR T cells for adoptive cell ... The premise of CAR T immunotherapy is to modify T cells to recognize cancer cells in order to more effectively target and ...
Tumor antigens recognized by T lymphocytes
A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes ". Science. 233: 1318-1321. Wu R., ... Adoptive transfer of TILs can increase the survival of melanoma patients when it is used as an adjuvant therapy, i.e. after a ... Adoptive transfer involves either collecting from patients intratumoral or blood T cells, stimulate them in vitro against ... Adoptive TIL transfer in the adjuvant setting for melanoma: long-term patient survival ". Journal of Immunology Research. 2014 ...
Tissue-resident memory T cell
"The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer". Cells. 10 (9): 2234. doi:10.3390/ ... Whereas large fraction of TILs are TRM cells, they are candidates for solid cancer immunotherapy. TRM cells infiltrated in ... Immune checkpoint therapy and tumor-infiltrating lymphocytes (TIL) therapy are cancer immunotherapy strategies whose principle ...
Cytokine-induced killer cell
Jäkel, Clara E; Schmidt-Wolf, Ingo GH (July 2014). "An update on new adoptive immunotherapy strategies for solid tumors with ... "Feasibility and safety of adoptive immunotherapy with CIK cells after cord blood transplantation". Biology of Blood and Marrow ... Data highlight the potentiality of this novel immunotherapy strategy where a nonspecific cytotoxic cell population can be ... Natural killer cell Natural killer T cell Lymphokine-activated killer cell Interleukin Cancer immunotherapy Schmidt-Wolf, IG; ...
Checkpoint inhibitor
Adoptive cell transfer Cancer immunotherapy Chimeric antigen receptor Immune checkpoint Pardoll DM (March 2012). "The blockade ... Other modes of enhancing [adoptive] immunotherapy include targeting so-called intrinsic checkpoint blockades. Many of these ... The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ... CISH knock out in T cells increased PD-1 expression and the adoptive transfer of CISH knock out T cells synergistically ...
T memory stem cell
August 2011). "Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice". Clinical ... Studies on adoptive cell therapy in mouse melanoma model revealed a significant linear correlation between the differentiation ... Wang F, Cheng F, Zheng F (August 2022). "Stem cell like memory T cells: A new paradigm in cancer immunotherapy". Clinical ... This strategy can be particularly suitable for generating virus-specific TSCM cells for adoptive cell therapy to prevent or ...
James S. Economou
"Multifunctional T cell analyses to study response and progression in adoptive cell transfer immunotherapy". Cancer Discovery. 3 ... Economou's research interests in tumor immunology include dendritic cell vaccination, DNA vaccines and adoptive cell therapy ...
Interleukin 15
March 2006). "Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors". Nature ... Ahmad A, Ahmad R, Iannello A, Toma E, Morisset R, Sindhu ST (July 2005). "IL-15 and HIV infection: lessons for immunotherapy ... IL-15 SA is currently being evaluated for antiviral and anticancer activities, in addition to enhancing immunotherapy and ... Jakobisiak M, Golab J, Lasek W (April 2011). "Interleukin 15 as a promising candidate for tumor immunotherapy". Cytokine & ...
ALECSAT
The latter method is utilized for ALECSAT to treat cancer by adoptive T-cell immunotherapy. Refer to the adjacent diagram for a ... Research on adoptive transfer in melanoma patients laid the groundwork for companies focusing on adoptive transfer research in ... In a study run at the University de la Sante, the adoptive transfer of cloned T cells in "in vitro immunization" caused ... "Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in melanoma patients is followed by increased frequencies of ...
NK-92
Several phase 1 clinical trials have been performed by experts in the field of adoptive immunotherapy of cancer. Hans ... interleukin 2-independent natural killer cell lines suitable for adoptive cellular immunotherapy". Human Gene Therapy. 10 (8): ... Klingemann H, Boissel L, Toneguzzo F (2016). "Natural Killer Cells for Immunotherapy - Advantages of the NK-92 Cell Line over ... Paul S, Lal G (2017). "The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy". ...
Cancer immunology
"Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies ... Daniyan AF, Brentjens RJ (June 2017). "Immunotherapy: Hiding in plain sight: immune escape in the era of targeted T-cell-based ... This phenomenon was proven to happen as a result of immunotherapies of cancer patients. CD8+ cytotoxic T cells are a ... Li G, Wong AJ (September 2008). "EGF receptor variant III as a target antigen for tumor immunotherapy". Expert Review of ...
Immunotransplant
... lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy. Curr ... Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. J Immunol 2007; ... Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 ... Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with ...
Molecular oncology
"The Role of Checkpoint Inhibitors and Cytokines in Adoptive Cell Based Cancer Immunotherapy with Genetically Modified T Cells ... The second issue with the CAR-T immunotherapy approach is that it can cause cytokine release syndrome. This is when an excess ... Many types of immunotherapies exist including bone marrow transplants, antibody therapies, and various manipulations of host ... CAR-T cells can also be combined with cytokines to improve the efficacy of the immunotherapy method. Cytokines are messenger ...
Transcription activator-like effector nuclease
Adoptive T-cell Immunotherapies". Cancer Research. 75 (18): 3853-64. doi:10.1158/0008-5472.CAN-14-3321. PMID 26183927. Boissel ... "A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy". Molecular Therapy. 23 (9): 1507-18. doi: ...