Daëron M, Jaeger S, Du Pasquier L, Vivier E (August 2008). "Immunoreceptor tyrosine-based inhibition motifs: a quest in the ... An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly ... ITIMs can also work in conjunction with Immunoreceptor tyrosine-based switch motifs(ITSM) in order to activate ITIM-bearing ... Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 ...

Daëron M, Jaeger S, Du Pasquier L, Vivier E (August 2008). "Immunoreceptor tyrosine-based inhibition motifs: a quest in the ... Immunoreceptor tyrosine-based inhibitory motifs) in their cytosolic region. These act to down-regulate signaling pathways ... Immunoreceptor tyrosine-based activation motifs). Some, however, like Siglec-14, contain positive amino acid residues that help ... "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by ...

"Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs". Nature ... In contrast to inhibition of apoptosis, several effectors appear to induce programmed cell death. For instance, EHEC effectors ... Bacterial Effector Proteins and their domains/motifs (from Paul Dean's lab) T3DB - A database of Type 3 Secretion System (T3SS ... Once a pathogen genome has been sequenced, effectors can be predicted based on protein sequence similarity, but such ...

Bellón T, Kitzig F, Sayós J, López-Botet M (Apr 2002). "Mutational analysis of immunoreceptor tyrosine-based inhibition motifs ... and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells ...

Activating receptors do not have the immunoreceptor tyrosine-base inhibition motif (ITIM) characteristic of inhibitory ... KIR inhibitory receptors signal through their immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic domain ... an adaptor molecule containing a negatively charged residue as well as immunoreceptor tyrosine-based activation motifs (ITAM). ... their ITIMs are tyrosine phosphorylated and protein tyrosine phosphatases, including SHP-1, are recruited. Inhibition occurs ...

Inhibitory molecules NKG2A and its splice variant NKG2B contain immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the ... NKG2E and its splice variant NKG2H do not have an activating immunoreceptor tyrosine-based activation motifs (ITAMs) in their ... ITAMs, included in DAP-12, on the other hand, recruite the Src homology domain containing kinases Syk (spleen tyrosine kinase) ... Raulet DH (October 2003). "Roles of the NKG2D immunoreceptor and its ligands". Nature Reviews. Immunology. 3 (10): 781-90. doi: ...

A common feature of members of all KIR is the presence of immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their ... All of these signaling molecules contain immunoreceptor tyrosine-based activated motifs (ITAMs), which are phosphorylated and ... of such receptors is the presence of noncovalently linked subunits that contain immunoreceptor tyrosine-based activation motifs ... KARs and KIRs can have tyrosine containing activatory or inhibitory motifs in the intracellular part of the receptor molecule ( ...

Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the ... The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in ... Based on these results, Pfizer voluntarily withdrew gemtuzumab ozogamicin from the market in mid-2010, but was reintroduced to ... inhibition of cellular activity. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or ...

... a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is ... Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta- ... a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is ... Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing ...

... a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is ... Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta- ... Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing ... PILRalpha recruits PTPN6 and PTPN1 via interactions of its ITIM motifs. PILRalpha is also used by some viruses, notably HSV-1, ...

Binding SHIP1 to phosphorylated immunoreceptor tyrosine-based inhibition motifs (ITIM) of FcγRIIB inhibits the activation of B ... Nevertheless, SHIP1 may also bind to partially phosphorylated immunoreceptor tyrosine-based activation motifs (ITAM) of some ... but contains a proline-rich region that forms the motif for binding SH3 domain and also contains sequence containing tyrosine ... phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation". The Journal ...

"The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc ... Both forms contain the Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) in their cytoplasmic regions. The extracellular ... Inhibition of the MAP kinase pathway, together with the anti-apoptotic kinase Akt can negatively affect proliferation and ... Horejs-Hoeck J, Hren A, Mudde GC, Woisetschläger M (July 2005). "Inhibition of immunoglobulin E synthesis through Fc gammaRII ( ...

"The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc ... Prasad N, Topping RS, Decker SJ (2003). "Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5 ... Habib T, Hejna JA, Moses RE, Decker SJ (July 1998). "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/ ... Habib T, Hejna JA, Moses RE, Decker SJ (1998). "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 ...

... identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs ... Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". ...

... a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than ... 2007). "Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like ...

... identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs ... and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells ... 2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition". Blood. ...

... identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs ... "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing ... "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing ... and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on monocytic ...

... recognition motif, the immunoreceptor tyrosine-based inhibitory motif (ITIM) and the immunoreceptor tyrosine-based switch motif ... For example, this is the case of gallbladder cancer where BTLA+ CD8+ T cells are associated with inhibition of anticancer ... The reason is that through ITIM it recruits either SHP-1 or SHP-2 which act as phosphatases and dephosphorylate tyrosine which ... On the other hand, it also possesses the Grb-2 recognition motif which, when recognized by a Grb-2 protein, promotes activation ...

This serves not only for inhibition and regulation of signalling pathways related to ITAM-based signalling, but also for ... An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in ... The motif contains a tyrosine separated from a leucine or isoleucine by any two other amino acids, giving the signature YxxL/I ... The tyrosine residues within these motifs become phosphorylated by Src family kinases following interaction of the receptor ...

Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to ... expressed by B-cell and plasma cell precursors is a candidate that induces apoptosis as well as inhibition of B-cell receptor ( ... In addition, both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM), which some scientists have ...

... events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) ... Qiu W, Cobb RR, Scholz W (May 1998). "Inhibition of p130cas tyrosine phosphorylation by calyculin A". Journal of Leukocyte ... of inhibitory signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs ( ... channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its ...

... and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells ... 2017). "Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior". Frontiers in Aging ... LILBR2 plays a critical role in the inhibition of axonal regeneration and functional recovery after brain injury. However, ...

A FcRγ chain with ITAM (immunoreceptor tyrosine-based activation motif) domain is associated with the transmembrane domain. The ... which includes two inhibition motifs (ITIMs), which can block tyrosine domain when activated. A ligand of Lair-1 receptor is ... Integrin α1β1 binds to collagen via the MIDAS motif in the α subunit I domain. It preferentially binds collagens IV, VI and ... Unlike other tyrosine-kinase receptors, maximal activation of receptors occurs 18 hours after collagen stimulation. They ...

... with chimeric receptors to recognize and kill cancer cells have employed immunoreceptor tyrosine-based activation motifs (ITAMs ... to account for CTLA-4 inhibition of T-cell responses to antigen. His research also showed that a mutant form of the immune cell ... 1998) The CD4 receptor is complexed to a T-cell specific tyrosine kinase (pp58) in detergent lysates from human T lymphocytes. ... 1989) The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc. ...

... and represents a motif (I/VXXYXXL) known as an immunoreceptor tyrosine-based inhibitory motif (ITIM). FcγRIIB1 and FcγRIIB2 ... The abrogation of ITAM activation signaling is caused by inhibition of protein tyrosine kinases of Src family, and by ... signals within their cells through an important activation motif known as an immunoreceptor tyrosine-based activation motif ( ... Binding of ligand to FcγRIIB leads to phosphorylation of the tyrosine of the ITAM motif. This modification generates the ...

... a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is ... "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell ... "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor ... "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine ...

... via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph ... The mechanism involves inhibition of ZAP70 phosphorylation and its association with CD3ζ. PD-1 signaling attenuates PKC-θ ... "SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell ... April 2019). "Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in ...

For example, in T cells, Lck and Fyn (Src family kinases) phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs ... The inhibition of PLCγ1 is linked to a decrease in tumor growth and metastasis. PLCγ1 is acting as a vital part in stopping ... The SH2 domains bind phosphorylated tyrosine residues on target proteins via their FLVR sequence motifs, activating the ... PLCG1 can be activated by receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases. For example, when activated, ...

... in this sequence are polar in nature and are considered to be a part of the Immunoreceptor Tyrosine-based Inhibitory Motif (ITM ... Specifically, this inhibition is in part due to the SIYSTL motif at the C-terminus of the protein, which is in the ... This motif is dense with Tyrosine residues, some of which are phosphorylated. The phosphorylation on these residues play the ... It function is based on its specialized structure, which contains many specialized motifs and sequences that allow its ...

Motifs are intrinsic or in the associated adaptor subunits. Immunoreceptor tyrosine-based activation motifs (ITAMs) are short ... It has been shown that inhibition of tyrosine phosphatases induces phosphorylation in NTRs and signalling even without ligand ... bind to cytoplasmic tyrosine phosphatases. Immunoreceptor Tyrosine-based Switch Motifs (ITSMs) with the signature TxYxx(I/V) ... Inhibitory signals are transduced by Immunoreceptor tyrosine-based inhibitory motifs (ITIMs) of the signature (S/I/V/L)xYxx(I/V ...