*  Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
It has variable CD20 expression and unmutated immunoglobulin variable region genes. Castleman disease (CD) is a ... These plasmablasts express IgM-immunoglobulin light chains, most often of lambda subtype. These plasmablasts can give rise to a ... The plasmablasts do not show rearranged immunoglobulin genes, and typically lack EBV infection. The disease predominantly ...
*  Somatic hypermutation
During B cell division the immunoglobulin variable region DNA is transcribed and translated. The introduction of mutations in ... Somatic hypermutation involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike ... These regions correspond to the complementarity determining regions; the sites involved in antigen recognition on the ... "DNA polymerase-eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes". Nat. Immunol. 2: 537-541. doi: ...
*  IGKC
Bentley DL, Rabbits TH (1981). "Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene ... Hieter PA, Maizel JV, Leder P (1982). "Evolution of human immunoglobulin kappa J region genes". J. Biol. Chem. 257 (3): 1516-22 ... 1981). "Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments". Cell ... Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains ...
*  Antibody
... involves the generation of a unique immunoglobulin variable region. The variable region of each immunoglobulin heavy or light ... Each heavy chain has two regions, the constant region and the variable region. The constant region is identical in all ... heavy chains μ and ε have a constant region composed of four immunoglobulin domains. The variable region of the heavy chain ... The variable parts of an antibody are its V regions, and the constant part is its C region. The Ig monomer is a "Y"-shaped ...
*  CD300C
"Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate". Nat. Immunol. 3 (12 ... "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor ...
*  SIRPB1
Cannon JP; Haire RN; Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions ... 2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res ... and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to ...
*  List of MeSH codes (D12.776.124)
... immunoglobulin fab fragments MeSH D12.776.124.486.485.680.650.500 -- immunoglobulin variable region MeSH D12.776.124.486. ... immunoglobulin fab fragments MeSH D12.776.124.790.651.680.650.500 -- immunoglobulin variable region MeSH D12.776.124.790. ... immunoglobulin variable region MeSH D12.776.124.486.485.797.180 -- complementarity determining regions MeSH D12.776.124.486. ... immunoglobulin constant regions MeSH D12.776.124.486.485.538.249 -- immunoglobulin fab fragments MeSH D12.776.124.486.485.538. ...
*  List of MeSH codes (G06)
... immunoglobulin variable region MeSH G06.184.603.060.425.160 --- complementarity determining regions MeSH G06.184.603.060.440 ... locus control region MeSH G06.184.603.080.689.650 --- operator regions (genetics) MeSH G06.184.603.080.689.675 --- promoter ... File "2006 MeSH Trees".) MeSH G06.184.154.147 --- allosteric site MeSH G06.184.154.290 --- bay region (chemistry) MeSH G06.184. ... matrix attachment regions MeSH G06.184.603.080.689 --- regulatory sequences, nucleic acid MeSH G06.184.603.080.689.330 --- ...
*  Mir-650 microRNA precursor family
Das, S. (2009). "Evolutionary Origin and Genomic Organization of Micro-RNA Genes in Immunoglobulin Lambda Variable Region Gene ... miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene. There is direct ... 2012). "MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic ... "The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light ...
*  [email protected]
"Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". ... IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations ... 1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within ... [email protected] Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp ...
*  J. Donald Capra
Pascual, V.; Capra, J. D. (1991). "Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and ... "Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes". The Journal of ... His contributions to immunology have focused on the molecular features of antibody variable regions, including key discoveries ... Somatic recombination generates the essential arginine at the junction of the variable and joining regions". Proceedings of the ...
*  Index of biochemistry articles
... immunoglobulin - immunoglobulin joining region - immunoglobulin variable region - immunologic receptor - immunology - In vivo ... fab immunoglobulin - facilitated diffusion - factor VIII - FADH - FADH2 - Fat - Fatty acid - fc immunoglobulin - fc receptor - ... heavy-chain immunoglobulin - Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus ... gamma-chain immunoglobulin - gamma-delta T-cell antigen receptor - gastrin - gastrointestinal hormone receptor - gastrula - Gel ...
*  V(D)J recombination
For example, the human immunoglobulin heavy chain region contains 2 Constant (Cμ and Cδ) gene segments and 44 Variable (V) gene ... and variable (V) regions), which are encoded by genes on three loci: The immunoglobulin heavy locus ([email protected]) on chromosome 14, ... "The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus". The Journal of Experimental ... All of these processing events result in an antigen-binding region that is highly variable, even when the same gene segments ...
*  Activation-induced cytidine deaminase
... "variable" region than other regions of the genome that are known to be subject to AID activity. This is also true of artificial ... A recent publication suggests that high AID activity at a few non-immunoglobulin targets is achieved when transcription on ... It is thought that the formation of these DSBs in either the switch regions or the Ig variable region can lead to CSR or GC, ... Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW (2002). "Internal IgH class switch region deletions are position- ...
*  [email protected]
1999). "The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus". J. Exp. Med. 188 (11 ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ... This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J ( ... Buluwela L, Rabbitts TH (1989). "A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region ...
*  PCBP2
"Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated ... noncoding region: identification by automated liquid chromatography-tandem mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 93 ... untranslated region of the androgen receptor messenger RNA". J. Biol. Chem. 277 (30): 27183-92. doi:10.1074/jbc.M202883200. ... untranslated region of erythropoietin messenger RNA". Blood. 93 (6): 2111-20. PMID 10068686. Wang Z, Day N, Trifillis P, ...
*  LAG3
... in chronic lymphocytic leukemia cells is associated with unmutated immunoglobulin variable heavy chain region (IGHV) gene and ... which belongs to immunoglobulin (Ig) superfamily, comprises a 503-amino acid type I transmembrane protein with four ... associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down- ... associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down- ...
*  Alpha-1-B glycoprotein
The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. Patients ... There is a large segment of amino acids from position 297 to 400 that is not shown to be an immunoglobulin domain. However, a ... Ultimately, alpha-1B glycoprotein seems to be primarily composed of four immunoglobulin domains. The alpha-1-glycoprotein is ... BLAST alignment of just the amino acids from 297-400 does illustrate that the latter sequence is indeed a fourth immunoglobulin ...
*  CD8A
"The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions". Cell. 40 (3 ... Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ...
*  T. J. Hamblin
... depending on whether the immunoglobulin heavy chain variable region genes contain somatic mutations. If they do the survival of ...
*  Organization and expression of immunoglobulin genes
... the light chain variable region (V), joining region (J), and constant region (C) gene segments. The variable region of light is ... 1979). Cloned pairs of variable region genes for immunoglobulin heavy-chains isolated from a clone library of the entire mouse ... The variable region rearrangements happen in an orderly sequence in the bone marrow. Usually, the assortment of these gene ... As a result, "a functional variable region gene of a light chain contains two coding segments that are separated by a non- ...
*  MLIP (gene)
"The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is ... restricted by short third complementarity-determining regions but not by limited gene segment usage". Blood. 97 (5): 1511-3. ...
*  Marginal zone B-cell
Dunn-Walters, DK; Isaacson, PG; Spencer, J (1995). "Analysis of mutations in immunoglobulin heavy chain variable region genes ... This region contains multiple subtypes of macrophages, dendritic cells, and the MZ B cells; it is not fully formed until 2 to 3 ... The MZ B cells within this region typically express high levels of IgM, CD21, CD1, CD9 with low to negligible levels of ... In humans the splenic marginal zone B cells have evidence of somatic hypermutation in their immunoglobulin genes, indicating ...
*  Immunoglobulin class switching
During class switching, the constant region of the immunoglobulin heavy chain changes but the variable regions, and therefore ... During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy ... In addition to the highly repetitive structure of the target S regions, the process of class switching needs S regions to be ... Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains ...
*  Elizabeth Press
Press's work provided the first evidence that immunoglobulin heavy chains had variable regions similar to those observed in ... light chains, and identified a particularly variable segment, now known as complementarity-determining region 3. Her research ... Press, EM; Hogg, NM (23 August 1969). "Comparative study of two immunoglobulin G Fd-fragments". Nature. 223 (5208): 808-10. doi ...
*  Pembrolizumab
... is an immunoglobulin G4, with a variable region against the human programmed cell death 1 receptor, a humanized ...