"Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". ... IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations ... 1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within ... IGH@ Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp ...

"Immunoglobulin Heavy Chain Variable, Diversity, and Joining Region Gene Rearrangement". National Cancer Institute Thesaurus. ... and J are rearranged to encode the variable region, resulting in a fraction of functional genes with a productive V(D)J region ... The variable domain of the B-cell antigen receptor is encoded by the V, (D), and J gene segments, the recombination of which ... Allelic exclusion of immunoglobulin (Ig) heavy chain and light chain genes in B cells forms the genetic basis for the presence ...

Pascual, V.; Capra, J. D. (1991). Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and ... "Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes". The Journal of ... His contributions to immunology have focused on the molecular features of antibody variable regions, including key discoveries ... Somatic recombination generates the essential arginine at the junction of the variable and joining regions". Proceedings of the ...

380 It has variable CD20 expression and unmutated immunoglobulin variable region genes.: 380 : 513 Castleman disease (CD) is a ... These plasmablasts express IgM-immunoglobulin light chains, most often of lambda subtype. These plasmablasts can give rise to a ... The plasmablasts do not show rearranged immunoglobulin genes,: 380 : 513 and typically lack EBV infection. The disease ...

... involves the generation of a unique immunoglobulin variable region. The variable region of each immunoglobulin heavy or light ... In the bone marrow, each developing B cell will assemble an immunoglobulin variable region by randomly selecting and combining ... Only the constant region of the antibody heavy chain changes during class switching; the variable regions, and therefore ... The antibody's variable region binds to allergic antigen, for example house dust mite particles, while its Fc region (in the ε ...

During B cell division the immunoglobulin variable region DNA is transcribed and translated. The introduction of mutations in ... Somatic hypermutation involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike ... These regions correspond to the complementarity-determining regions; the sites involved in antigen recognition on the ... "DNA polymerase-eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes". Nat. Immunol. 2 (6): 537-541. ...

"Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate". Nat. Immunol. 3 (12 ... "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor ...

"Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions". Proceedings of the ... Two most studied cases of allelic exclusion are monoallelic expression of immunoglobulins in B and T cells and olfactory ... Pernis B, Chiappino G, Kelus AS, Gell PG (November 1965). "Cellular localization of immunoglobulins with different allotypic ...

"Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions". Proc. Natl. Acad. Sci. U. ... Nishizawa also introduced tunnel injection in 1958, and invented the varicap (variable capacitance diode) in 1959. Lasers In ...

Cannon JP; Haire RN; Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions ... 2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res ... and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to ...

Immunoglobulins have two regions: the constant region and the variable region. The constant region is involved in effector ... Anti-immunoglobulin antibodies may bind to either the variable or constant region of the immunoglobulin. Anti-immunoglobulin ... One immunoglobulin only has one type of light chain. Each light chain has both a constant and a variable region. It is critical ... Specifically, anti-immunoglobulin antibodies are created by B-cells as antibodies to bind to other immunoglobulins. ...

They are formed by light and heavy chain of the variable region of an immunoglobulin. The two chains are linked by a flexible ... They mostly consist of a heavy and light chain of the variable region of immunoglobulin. Recombinant antibodies have many ... "Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae". Microbial Cell ... "Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin". Nature Biotechnology. 25 (11): ...

Bentley DL, Rabbits TH (1981). "Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene ... Hieter PA, Maizel JV, Leder P (1982). "Evolution of human immunoglobulin kappa J region genes". J. Biol. Chem. 257 (3): 1516-22 ... 1981). "Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments". Cell ... Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains ...

... the light chain variable region (V), joining region (J), and constant region (C) gene segments. The variable region of light is ... 1979). "Cloned pairs of variable region genes for immunoglobulin heavy-chains isolated from a clone library of the entire mouse ... The variable region rearrangements happen in an orderly sequence in the bone marrow. Usually, the assortment of these gene ... As a result, "a functional variable region gene of a light chain contains two coding segments that are separated by a non- ...

"Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain". Proceedings of the National Academy ... The conserved regions of the U1 RNA thus include sequences complementary to the stop codons. These observations enabled ... Thus, new genes were assembled from exon modules that coded for functional domains, folding regions, or structural elements ... These were delimited by regions containing stop signals, the messages to terminate construction of the polypeptide chain, and ...

The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. Patients ... There is a large segment of amino acids from position 297 to 400 that is not shown to be an immunoglobulin domain. However, a ... Ultimately, alpha-1B glycoprotein seems to be primarily composed of four immunoglobulin domains. The alpha-1-glycoprotein is ... alignment of just the amino acids from 297 to 400 does illustrate that the latter sequence is indeed a fourth immunoglobulin ...

"Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain". Proceedings of the National Academy ... non-coding regions of RNA) and splicing back together exons (coding regions). For nuclear-encoded genes, splicing occurs in the ... Upstream (5'-ward) from the AG there is a region high in pyrimidines (C and U), or polypyrimidine tract. Further upstream from ... The word intron is derived from the terms intragenic region, and intracistron, that is, a segment of DNA that is located ...

"Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain". Proceedings of the National Academy ... The word intron is derived from the term intragenic region, i.e., a region inside a gene. The term intron refers to both the ... for intragenic regions) - alternating with regions which will be expressed - exons." (Gilbert 1978) The term intron also refers ... for intragenic regions) - alternating with regions which will be expressed - exons." (Gilbert 1978) Gilbert W (February 1978 ...

Das S (May 2009). "Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region ... miR-650 has further been reported to target a homologous DNA region in the promoter region of the NDRG2 gene. There is direct ...

"The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions". Cell. 40 (3 ... Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ...

"Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated ... noncoding region: identification by automated liquid chromatography-tandem mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 93 ... untranslated region of the androgen receptor messenger RNA". J. Biol. Chem. 277 (30): 27183-92. doi:10.1074/jbc.M202883200. ... untranslated region of erythropoietin messenger RNA". Blood. 93 (6): 2111-20. doi:10.1182/blood.V93.6.2111.406k24_2111_2120. ...

1999). "The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus". J. Exp. Med. 188 (11 ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ... This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J ( ... Buluwela L, Rabbitts TH (1989). "A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region ...

During class switching, the constant region of the immunoglobulin heavy chain changes but the variable regions do not, and ... During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy ... In addition to the highly repetitive structure of the target S regions, the process of class switching needs S regions to be ... Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains ...

"CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic ... Stevenson became interested in cancer immunology: the use of Immunoglobulin (antibodies) to attack cancer cells. She focussed ...

"Variable regions of heavy and light polypeptide chains of the same gammaG-immunoglobulin molecule". Proceedings of the National ... can produce many different antibody proteins with similar antibody constant regions and divergent antibody variable regions. ... Cummingham, B.; Gottlieb, P.; Konigsberg, W.; Edelman, G. (1968). "The covalent structure of a human gamma G-immunoglobulin. V ... "The covalent structure of an entire gammaG immunoglobulin molecule". Proceedings of the National Academy of Sciences of the ...

"Variable regions of heavy and light polypeptide chains of the same gammaG-immunoglobulin molecule". Proceedings of the National ... Gottlieb, Paul David (1972). "The variability of immunoglobulins". elibrary.ru: 1. Kobler, John (1977). The Rockefeller ... "The covalent structure of a human gamma G-immunoglobulin. V. Partial amino acid sequence of the light chain". Biochemistry. 7 ( ... "The covalent structure of an entire gammaG immunoglobulin molecule". Proceedings of the National Academy of Sciences of the ...

... consists of both an immunoglobulin-like variable domain and an immunoglobulin-like constant domain in the extracellular region ...

... depending on whether the immunoglobulin heavy chain variable region genes contain somatic mutations. If they do, the survival ...

"Design and construction of a hybrid immunoglobulin domain with properties of both heavy and light chain variable regions". ... In molecular biology, a framework region is a subdivision of the variable region (Fab) of the antibody. The variable region is ... The framework region makes up about 85% of the variable region. Located on the tips of the Y-shaped molecule, the framework ... The framework regions are highly conserved regions of the variable portion of the antibody. The evolutionary reason for the ...

Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment ...