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*  Helios Murialdo
"Mutants Defective in Immunoglobulin Kappa Chain Synthesis Have Novel Rearrangements Associated with Kappa Genes". Proc. Natl. ... He also worked on the factors that control immunoglobulin gene expression, the structure of the genes and their rearrangement ...
*  DNA polymerase lambda
Bertocci B, De Smet A, Berek C, Weill JC, Reynaud CA (August 2003). "Immunoglobulin kappa light chain gene rearrangement is ... Whereas pol μ is important for heavy-chain rearrangements, pol λ seems to be more important for light-chain rearrangements. The ... and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo". Immunity. 25 (1): 31-41. doi: ...
*  DNA polymerase mu
Bertocci B, De Smet A, Berek C, Weill JC, Reynaud CA (August 2003). "Immunoglobulin kappa light chain gene rearrangement is ... Like TdT, pol μ participates in V(D)J recombination, but only during heavy chain rearrangements. This is distinct from pol λ, ... which is involved in light chain rearrangements. In polymerase mu mutant mice, hematopoietic cell development is defective in ... and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo". Immunity. 25 (1): 31-41. doi: ...
*  IGL@
Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P (1981). "Human immunoglobulin kappa light-chain genes are deleted or rearranged ... 1982). "Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes". J. Exp. Med. 155 (5 ... Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of ... immunoglobulin lambda constant 1 (Mcg marker) IGLC2 - immunoglobulin lambda constant 2 (Kern-Oz- marker) IGLC3 - immunoglobulin ...
*  MDX-1097
... targets kappa free immunoglobulin light chains which are found on the surface of some kappa light chain-restricted ... "Characterization of a unique conformational epitope on free immunoglobulin kappa light chains that is recognized by an antibody ... Hutchinson, A. T.; Jones, D. R.; Raison, R. L. (2015). "Preclinical and clinical development of an anti-kappa free light chain ... "Free Ig light chains interact with sphingomyelin and are found on the surface of myeloma plasma cells in an aggregated form". ...
*  IGKC
Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains ... within the Immunoglobulin kappa locus, IGK@. "Human PubMed Reference:". "Entrez Gene: IGKC immunoglobulin kappa constant". ... The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The ... Klobeck HG, Combriato G, Zachau HG (1984). "Immunoglobulin genes of the kappa light chain type from two human lymphoid cell ...
*  Index of biochemistry articles
... kappa opioid receptor - kappa-chain immunoglobulin - karyoplasm - karyotype - kelvin - keratin - kinase - kinesin - kinetic ... immunoglobulin - immunoglobulin joining region - immunoglobulin variable region - immunologic receptor - immunology - In vivo ... heavy-chain immunoglobulin - Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus ... gamma-chain immunoglobulin - gamma-delta T-cell antigen receptor - gastrin - gastrointestinal hormone receptor - gastrula - Gel ...
*  IGK@
"Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed ... The immunoglobulin kappa locus contains the following genes: IGKC: immunoglobulin kappa constant IGKJ@: immunoglobulin kappa ... Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light ... chains of antibodies (or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) ...
*  Immunoglobulin light chain
There are two types of light chain in humans: kappa (κ) chain, encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2 ... immunoglobulin). A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. ... The immunoglobulin light chain genes in tetrapods can be classified into three distinct groups: kappa (κ), lambda (λ), and ... "Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative ...
*  Plasma cell dyscrasia
Rather, they overexpress a monoclonal, aberrant free κ (i.e. kappa) or λ (i.e., lambda) immunoglobulin light chain. For ... a free κ chain in great excess of a λ chain or a free λ chain in great excess of a κ chain; and d) free γ, δ, or μ heavy chains ... Myeloma protein toxicities include: Monoclonal free light chains, free heavy chains, or a mixture of these chains can deposit ... www.uptodate.com/contents/pathogenesis-of-immunoglobulin-light-chain-al-amyloidosis-and-light-and-heavy-chain-deposition- ...
*  YY1
... that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site". Proceedings of the National ...
*  Serum free light-chain measurement
There are two types of immunoglobulin light chain produced in humans, designated by the Greek letters kappa (κ) and lambda (λ ... There is approximately 40% excess immunoglobulin light-chain production over immunoglobulin heavy-chain synthesis. Possibly ... An abnormal light-chain ratio has been defined as a kappa/lambda chain ratio of less than 0.26 or more than 1.65. In 2009, the ... Kappa free-light chains are normally monomeric, while lambda free-light chains tend to be dimeric, joined by disulphide bonds. ...
*  Antibody
In mammals there are two types of immunoglobulin light chain, which are called lambda (λ) and kappa (κ). A light chain has two ... heavy chains μ and ε have a constant region composed of four immunoglobulin domains. The variable region of the heavy chain ... two identical heavy chains and two identical light chains connected by disulfide bonds. Each chain is composed of structural ... The variable region of each immunoglobulin heavy or light chain is encoded in several pieces-known as gene segments (subgenes ...
*  Raji cell
... but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a ... Both kappa genes and one lambda gene are rearranged. These findings indicate either that translocation may occur as a separate ... Pepsin digestion of immunoglobulin fractions from four SLE sera caused a reduction in SLE IgG binding to undigested Raji cells ... A test for the detection of soluble immunoglobulin (Ig)G-antigen complexes. Raji cells are a line EBV-transformed lymphocytes ...
*  Bence Jones protein
They can be kappa (most of the time) or lambda. The light chains can be immunoglobulin fragments or single homogeneous ... A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular ... The proteins are immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. ... "Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains ...
*  Serum protein electrophoresis
Immunoglobulins consist of heavy chains, (IgA, IgM, IgG, IgE and IgD) and light chains (kappa and lambda). A normal gamma zone ... Note that immunoglobulins may be also be found in other zones; IgA typically migrates in the beta-gamma zone, and in particular ... The immunoglobulins or antibodies are generally the only proteins present in the normal gamma region. Of note, any protein ... A broad "swell-like" manner (wide) indicates polyclonal immunoglobulin production. If it is elevated in an asymmetric manner or ...
*  Waldenström's macroglobulinemia
The light chain of the monoclonal protein is usually the kappa light chain. At times, patients with Waldenström's ... Immunoelectrophoresis and immunofixation studies help identify the type of immunoglobulin, the clonality of the light chain, ... Results from characterization studies of urinary immunoglobulins indicate that light chains (Bence Jones protein), usually of ... WM is characterized by having high levels of a circulating antibody, immunoglobulin M (IgM), which is made and secreted by the ...
*  V(D)J recombination
The kappa (κ) and lambda (λ) chains of the immunoglobulin light chain loci rearrange in a very similar way, except that the ... containing the gene segments for the immunoglobulin heavy chain. The immunoglobulin kappa (κ) locus (IGK@) on chromosome 2, ... containing the gene segments for the remainder of the immunoglobulin light chain. Each heavy chain and light chain gene ... Translation of the spliced mRNA for either the kappa or lambda chains results in formation of the Ig κ or Ig λ light chain ...
*  Nivolumab
The gamma 1 heavy chain is 91.8% unmodified human design while the kappa light chain is 98.9%. PD-1 was first shown to be an ... Nivolumab is a fully human monoclonal immunoglobulin G4 antibody to PD-1. ...
*  Protein L
In humans and mice, most antibody molecules contain kappa (κ) light chains and the remainder have lambda (λ) light chains. ... Binding of mouse immunoglobulins is restricted to those having VκI light chains. Given these specific requirements for ... Protein L is only effective in binding certain subtypes of kappa light chains. For example, it binds human VκI, VκIII and VκIV ... Akerström B, Björck L (November 1989). "Protein L: an immunoglobulin light chain-binding bacterial protein. Characterization of ...
*  Humoral immune deficiency
... kappa chain deficiency, isolated IgG subclass deficiency, IgA with IgG subsclass deficiency, selective immunoglobulin A ... Hyper-IgM syndromes Normal numbers of B cells with isotype or light chain deficiencies: heavy chain deletions, ... μ-Heavy chain deficiency, l 5 deficiency, Igα deficiency, BLNK deficiency, thymoma with immunodeficiency B cells low but ... Measure serum immunoglobulin levels B cell count Family medical history Treatment for B cell deficiency(humoral immune ...
*  Eculizumab
It is an immunoglobulin G-kappa (IgGκ) consisting of human constant regions and murine complementarity-determining regions ... The compound contains two 448-amino acid heavy chains and two 214-amino acid light chains, and has a molecular weight of ... grafted onto human framework light and heavy chain variable regions. ...
*  ICD-10 Chapter III: Diseases of the blood and blood-forming organs, and certain disorders involving the immune mechanism -...
Other immunodeficiencies with predominantly antibody defects Kappa light chain deficiency (D80.9) Immunodeficiency with ... Selective deficiency of immunoglobulin A (IgA) (D80.3) Selective deficiency of immunoglobulin G (IgG) subclasses (D80.4) ... Selective deficiency of immunoglobulin M (IgM) (D80.5) Immunodeficiency with increased immunoglobulin M (IgM) (D80.6) Antibody ... Nonfamilial hypogammaglobulinaemia Agammaglobulinaemia with immunoglobulin-bearing B-lymphocytes Common variable ...
*  Primary immunodeficiency
... kappa chain deficiency, isolated IgG subclass deficiency, IgA with IgG subclass deficiency, selective immunoglobulin A ... immunoglobulin replacement therapy in the form of intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG) may ... Hyper-IgM syndromes Normal numbers of B cells with isotype or light chain deficiencies: heavy chain deletions, ... For instance, an antibody deficiency can be diagnosed in the presence of low immunoglobulins, recurrent infections and failure ...
*  Monoclonal antibody therapy
Taking human gene sequences from the kappa light chain and the IgG1 heavy chain results in antibodies that are approximately 65 ... Omalizumab inhibits human immunoglobulin E (IgE) and is useful in moderate-to-severe allergic asthma. Alzheimer's disease (AD) ... and the light chain (~25kDa). The two types of light chains are kappa (κ) and lambda (λ). By cleavage with enzyme papain, the ... The heavy and light chains of human IgG proteins are expressed in structural polymorphic (allotypic) forms. Human IgG allotype ...
*  Organization and expression of immunoglobulin genes
The light chain can be either kappa,κ or lambda,λ. This process takes place at the level of mRNAs processing. Random ... Antibody (or immunoglobulin) structure is made up of two heavy-chains and two light-chains. These chains are held together by ... Here at this stage, Pre-B cell, mμ heavy chain and surrogate light chain are formed. The final rearrangement of the light chain ... The kappa and lambda light chains undergo rearrangements of the V and J gene segments. In this process, a functional Vlambda ...