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*  List of MeSH codes (D12.776.124)
... immunoglobulin fab fragments MeSH D12.776.124.486.485.797.590 -- immunoglobulin joining region MeSH D12.776.124.486.485.900 -- ... immunoglobulin fab fragments MeSH D12.776.124.790.651.797.590 -- immunoglobulin joining region MeSH D12.776.124.790.651.900.120 ... complementarity determining regions MeSH D12.776.124.486.485.680.650.500.590 -- immunoglobulin joining region MeSH D12.776. ... complementarity determining regions MeSH D12.776.124.790.651.680.650.500.590 -- immunoglobulin joining region MeSH D12.776. ...
*  Index of biochemistry articles
... immunoglobulin - immunoglobulin joining region - immunoglobulin variable region - immunologic receptor - immunology - In vivo ... fab immunoglobulin - facilitated diffusion - factor VIII - FADH - FADH2 - Fat - Fatty acid - fc immunoglobulin - fc receptor - ... heavy-chain immunoglobulin - Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus ... gamma-chain immunoglobulin - gamma-delta T-cell antigen receptor - gastrin - gastrointestinal hormone receptor - gastrula - Gel ...
*  Enhancer (genetics)
"A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes". Cell ... Other enhancer regions drive eve expression in 6 other stripes in the embryo. Establishing body axes is a critical step in ... In genetics, an enhancer is a short (50-1500 bp) region of DNA that can be bound by proteins (activators) to increase the ... Silencers and enhancers may be in close proximity to each other or may even be the same region only differentiated by the ...
*  IGHV@
"Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". ... Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene. IGHV is the immunoglobulin heavy ... IGH@ Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp ... 1986). "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain ...
*  List of MeSH codes (D12.776)
... immunoglobulin joining region MeSH D12.776.377.715.548.680.650.750 - tuftsin MeSH D12.776.377.715.548.680.660 - immunoglobulin ... immunoglobulin fab fragments MeSH D12.776.377.715.548.797.590 - immunoglobulin joining region MeSH D12.776.377.715.548.900 - ... immunoglobulin constant regions MeSH D12.776.377.715.548.538.249 - immunoglobulin fab fragments MeSH D12.776.377.715.548.538. ... immunoglobulin fab fragments MeSH D12.776.377.715.548.680.650.500 - immunoglobulin variable region MeSH D12.776.377.715.548.680 ...
*  IGH@
... the fused D-J exon of this partially rearranged D-J region is then joined to a V segment. The rearranged V-D-J region ... immunoglobulin genes: IGHJ1, IGHJ2, IGHJ3, IGHJ4, IGHJ5, IGHJ6 Symbols for constant region (C) immunoglobulin genes: Heavy ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ... Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the ...
*  Antibody
... involves the generation of a unique immunoglobulin variable region. The variable region of each immunoglobulin heavy or light ... The variable domain exon is rejoined through a process called non-homologous end joining (NHEJ) to the desired constant region ... Each heavy chain has two regions, the constant region and the variable region. The constant region is identical in all ... and a hinge region for added flexibility; heavy chains μ and ε have a constant region composed of four immunoglobulin domains. ...
*  IGK@
... or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. ... immunoglobulin kappa constant IGKJ@: immunoglobulin kappa joining group IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5 IGKV@: immunoglobulin ... Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light ... These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins. The immunoglobulin kappa locus ...
*  Immunoglobulin heavy constant alpha 1
... one variable region, and three variable regions. As a major class of immunoglobulin in body secretions, IgA plays a role in ... a typical tertiary structure of the immunoglobulin fold class. The two beta sheets that comprise each beta-sandwich are joined ... The Ig alpha-1 chain C region is contained on the first of the constant regions of IgA, and is composed of an amino acid ... Immunoglobulin heavy constant alpha 1 is a immunoglobulin gene with symbol IGHA1. It encodes a constant (C) segment of ...
*  Chromosome 22 (human)
IGLJ3 encoding protein Immunoglobulin lambda joining 3 LINC00899 encoding protein Long intergenic non-protein coding RNA 899 ... gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively ... the 22q11 locus contains the subgenes for immunoglobulin light chain lambda: Interestingly, the immunoglobulin lambda light ... var: Variable region; stalk: Stalk. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp ...
*  IGL@
... immunoglobulin lambda constant 7 IGLJ@ - joining group IGLJn - immunoglobulin lambda joining n IGLJ1, IGLJ2, IGLJ3, IGLJ6, ... Immunoglobulin lambda locus, also known as IGL@, is a region on human chromosome 22 that contains genes for the lambda light ... immunoglobulin lambda constant 1 (Mcg marker) IGLC2 - immunoglobulin lambda constant 2 (Kern-Oz- marker) IGLC3 - immunoglobulin ... This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining ...
*  Diphtheria toxin
Processing The leader region is cleaved during secretion. Proteolytic nicking separates A and B subunits, which remain joined ... it is a subclass of immunoglobulin-like fold. The R domain binds to a cell surface receptor, permitting the toxin to enter the ...
*  V(D)J recombination
This D-J recombination is followed by the joining of one V gene segment, from a region upstream of the newly formed DJ complex ... For example, the human immunoglobulin heavy chain region contains 2 Constant (Cμ and Cδ) gene segments and 44 Variable (V) gene ... This process can involve either the joining of the Dβ1 gene segment to one of six Jβ1 segments or the joining of the Dβ2 gene ... The immunoglobulin kappa (κ) locus (IGK@) on chromosome 2, containing the gene segments for part of the immunoglobulin light ...
*  Secretory component
The secretory component is a component of immunoglobulin A (IgA). Secretory component is a proteolytic cleavage product of the ... Secretory components wrap around two IgA units joined by a J chain protein fragment, resulting in a >--< configuration, with ... each of the two antigen binding regions of the two constituent y-shaped antibodies exposed. One identified function of ... Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up ...
*  Organization and expression of immunoglobulin genes
These include: the light chain variable region (V), joining region (J), and constant region (C) gene segments. The variable ... These are a short leader (L) exon, a noncoding sequence (intron), a joined VJ segment, a second intron, and the constant region ... The segments joined due to signals generated RSSs that flank each V, D, and J segments. Only genes flank by 12 -bp that join to ... 1979). Cloned pairs of variable region genes for immunoglobulin heavy-chains isolated from a clone library of the entire mouse ...
*  Immunoglobulin G
The various regions and domains of a typical IgG are depicted in the figure to the left. The Fc regions of IgGs bear a highly ... The IgG3, though of relatively low affinity, allows IgG-mediated defences to join IgM-mediated defences in clearing foreign ... The structure of the hinge regions (region 6 in the diagram) contributes to the unique biological properties of each of the ... Even though there is about 95% similarity between their Fc regions, the structure of the hinge regions is relatively different ...
*  Complementarity-determining region
Complementarity-determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors ... and joining (J) regions. CDR3 is the most variable. The tertiary structure of an antibody is important to analyze and design ... Since most sequence variation associated with immunoglobulins and T cell receptors are found in the CDRs, these regions are ... Framework region Hypervariable region Abbas AK and Lichtman AH (2003). Cellular and Molecular Immunology (5th ed.). Saunders, ...
*  IGLJ3
Immunoglobulin lambda joining 3 is a protein that in humans is encoded by the IGLJ3 gene. "Human PubMed Reference:". "Entrez ... "V-region and class specific RT-PCR amplification of human immunoglobulin heavy and light chain genes from B-cell lines". ... Immunoglobulin lambda joining 3". Paul E, Iliev AA, Livneh A, Diamond B (December 1992). "The anti-DNA-associated idiotype 8.12 ... Combriato G, Klobeck HG (June 1991). "V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light ...
*  Non-homologous end joining
This process couples "variable" (V), "diversity" (D), and "joining" (J) regions, which when assembled together create the ... Schatz DG, Baltimore D (April 1988). "Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into ... Komori T, Okada A, Stewart V, Alt FW (August 1993). "Lack of N regions in antigen receptor variable region genes of TdT- ... Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous ...
*  Immunoglobulin class switching
... α or ε constant region gene segment. The free ends of the DNA are rejoined by a process called non-homologous end joining (NHEJ ... During class switching, the constant region of the immunoglobulin heavy chain changes but the variable regions, and therefore ... In addition to the highly repetitive structure of the target S regions, the process of class switching needs S regions to be ... During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy ...
*  Serum free light-chain measurement
There is approximately 40% excess immunoglobulin light-chain production over immunoglobulin heavy-chain synthesis. Possibly ... In addition, the first 23 amino acids of the 1st variable domain framework region have a number of variations known as ... Kappa free-light chains are normally monomeric, while lambda free-light chains tend to be dimeric, joined by disulphide bonds. ... Immunoglobulin light chains that are circulating in serum in a free (unbound) state are called free light chains (FLCs). ...
*  T-cell receptor
Each chain is composed of two extracellular domains: Variable (V) region and a Constant (C) region, both of Immunoglobulin ... both involving a somewhat random joining of gene segments to generate the complete TCR chain). Likewise, generation of the TCR ... The Constant region is proximal to the cell membrane, followed by a transmembrane region and a short cytoplasmic tail, while ... The residues in these variable domains are located in two regions of the TCR, at the interface of the α- and β-chains and in ...
*  Genome instability
In a pre-B cell, the region consists of all V, D, and J segments. During development of the B cell, a specific V, D, and J ... Since immunoglobulins are essential to a lymphocyte and highly expressed to increase detection of antigens, c-myc is then also ... by non-homologous end joining). In addition, DNA damages can also give rise to epigenetic alterations during DNA repair. Both ... The protein coding regions of the human genome, collectively called the exome, constitutes only 1.5% of the total genome. As ...
*  Platelet membrane glycoprotein
In the absence of fibrinogen, the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex. ... The β1 subunit has four cysteine-rich regions and a structure similar to other β-integrins. The interaction with collagen leads ... Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. It is an important collagen ... Calpain cleaves aggregin, and thus allows for joining of the two subunits. Deficiency in the IIb / IIIa complex is described as ...
*  Immunoglobulin M
J chain (J for joining) was discovered as a covalently bonded component of polymeric IgA and IgM . J chain is a small (~137 ... Overall, the IgM constant region has a "mushroom-like" structure, where the Cµ2-Cµ3 domains are a disk analogous to the head of ... Immunodeficiency with hyper-immunoglobulin M Immunoglobulin M deficiency "Immunoglobulin M". The American Heritage Dictionary ... Immunoglobulin M at the US National Library of Medicine Medical Subject Headings (MeSH) Immunoglobulin M Deficiency Reference ...
*  Elizabeth Press
Press's work provided the first evidence that immunoglobulin heavy chains had variable regions similar to those observed in ... Press was 19 years old when the Second World War started, and joined the Women's Royal Naval Service (WRNS, "the Wrens"). After ... On 1 October 1955, Press joined Rodney Porter's research group at the National Institute for Medical Research, Mill Hill, ... Press, EM; Hogg, NM (23 August 1969). "Comparative study of two immunoglobulin G Fd-fragments". Nature. 223 (5208): 808-10. doi ...