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*  CD79B
... molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. It is ... is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491-8. PMID 8419481. ... 1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187-92. doi ... surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are ...
*  CD79A
Association of the CD79a/b heterodimer with the immunoglobulin heavy chain is required for surface expression of the BCR and ... complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes". Journal of Immunology. 148 (2): ... The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B- ... Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (Aug 1991). "The B-cell antigen receptor of the five immunoglobulin ...
*  Immunoglobulin E
... (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is ... Understanding of this structure (which is atypical of other isotypes in that it is highly bent and asymmetric) and of the ... Although IgE is typically the least abundant isotype-blood serum IgE levels in a normal ("non-atopic") individual are only 0.05 ... Presence of a unique immunoglobulin as a carrier of reaginic activity". J. Immunol. 97 (1): 75-85. PMID 4162440. Johansson SG, ...
*  Index of immunology articles
D Immunoglobulin E Immunoglobulin G Immunoglobulin heavy chain Immunoglobulin light chain Immunoglobulin M Immunoglobulin Y ... antibody-mediated degradation Intravascular immunity Intrinsic immunity IRGs ISCOM Isoantibodies Isoantigen Isograft Isotype ( ... Immunofixation Immunogen Immunogenetics Immunogenicity Immunoglobulin A Immunoglobulin class switching Immunoglobulin ...
*  Adaptive immune system
Another isotype, shark IgW, is related to mammalian IgD. TCRs, both α/β and γ/δ, are found in all animals from gnathostomes to ... Antibodies (also known as immunoglobulin, Ig), are large Y-shaped proteins used by the immune system to identify and neutralize ... Th2 also produce Interleukin 4, which facilitates B cell isotype switching. In general, Th2 responses are more effective ... which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen ...
*  CD40 (protein)
As a result of this net stimulation, the B cell can undergo division, antibody isotype switching, and differentiation to plasma ... Impaired immunoglobulin class switching and germinal center formation". Immunity. 1 (3): 167-178. doi:10.1016/1074-7613(94) ... to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin ...
*  Superantigen
SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and ... Immunoglobulin pools are able to neutralize specific antibodies and prevent T-cell activation. Synthetic antibodies and ... When the structure of individual SAg domains has been compared to other immunoglobulin-binding streptococcal proteins (such as ... "The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching". Int. Immunol ...
*  Fragment crystallizable region
In IgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second ... Fcab fragments can be inserted into a full immunoglobulin by swapping the Fc region, thus obtaining a bispecific antibody (with ... ISBN 0-8493-6078-1. Stadlmann J, Pabst M, Kolarich D, Kunert R, Altmann F (2008). "Analysis of immunoglobulin glycosylation by ... the Fc region of immunoglobulins has been engineered to contain an antigen-binding site. This type of antigen-binding fragment ...
*  Polyclonal antibodies
This induces the B-lymphocytes to produce IgG immunoglobulins specific for the antigen. This polyclonal IgG is purified from ... isotype), complement fixing nature] of the antibodies to be made. Immunization and phlebotomies are stress associated and, at ... They are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope. ...
*  CD154
A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM ... "T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells ... the B cell can undergo rapid cellular division to form a germinal center where antibody isotype switching and affinity ...
*  Antiganglioside antibodies
1993). "Antiglycolipid antibodies, immunoglobulins and paraproteins in motor neuron disease: a population based case-control ... García Guijo C, García-Merino A, Rubio G (1995). "Presence and isotype of anti-ganglioside antibodies in healthy persons, motor ...
*  Recombination-activating gene
AKA isotype switching) and somatic hypermutation (AKA affinity maturation). Current studies have indicated that RAG-1 and RAG-2 ... encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell ...
*  Malaria vaccine
Research shows that if immunoglobulin is taken from immune adults, purified and then given to individuals who have no ... Adjuvants are crucial in affecting the specificity and isotype of the necessary antibodies. They are thought to be able to ...
*  Humoral immunity
Immunoglobulins are glycoproteins in the immunoglobulin superfamily that function as antibodies. The terms antibody and ... germinal center formation and isotype switching, affinity maturation and memory cell generation. It also refers to the effector ... Each immunoglobulin class differs in its biological properties and has evolved to deal with different antigens. Antibodies are ... immunoglobulin are often used interchangeably. They are found in the blood and tissue fluids, as well as many secretions. In ...
*  Avian immune system
Kramer and Cho have shown immunoglobulins in both the egg white and in the embryo. Maternal IgA and IgM get transferred to the ... and a T cell sublineage that expresses a different receptor isotypes (TCR3) generated exclusively in the thymus. Homologues of ... Ratcliffe MJH, Lisilla O, Pink JRL, Vainio O (2005). "Avian B cell precusors: surface immunoglobulin expression is an early, ...
*  CD23
... , also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy ... "Molecular structure of human lymphocyte receptor for immunoglobulin E". Cell. 47 (5): 657-65. doi:10.1016/0092-8674(86)90508-8 ...
*  Hybridoma technology
By using culture supernatant or a purified immunoglobulin preparation, further analysis of a potential monoclonal antibody ... k isotype). This monoclonal antibody shows specific immuno-cytochemical staining of nucleoli. Tissues and tumours can be ...
*  DNA vaccination
DNA immunization can be used to bias the TH profile of the immune response and thus the antibody isotype, which is not possible ... Each type has distinctive patterns of lymphokine and chemokine expression, specific types of immunoglobulins, patterns of ... Feltquate, D.M.; Heaney, S; Webster, RG; Robinson, HL (March 1, 1997). "Different T helper cell types and antibody isotypes ...
*  Activation-induced cytidine deaminase
A recent publication suggests that high AID activity at a few non-immunoglobulin targets is achieved when transcription on ... Scherer, F; Navarrete, MA; Bertinetti-Lapatki, C; Boehm, J; Schmitt-Graeff, A; Veelken, H (January 2016). "Isotype-switched ... The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes in B ... It is involved in the initiation of three separate immunoglobulin (Ig) diversification processes: Somatic hypermutation (SHM), ...
*  POEMS syndrome
Many of the signs and symptoms in POEMS syndrome are due at least in part to the release of an aberrant immunoglobulin, i.e. a ... typically an IgG or IgA isotype (occurs in nearly 100% of cases; in >95% of instances the myeloma proteins contain a λ chain ... or immunoglobulins by the syndrome's neoplastic cells and/or the response of the immune system to the neoplasm. ...
*  Ipilimumab
... , which is an IgG1 isotype, and tremelimumab (from Pfizer) which is an IgG2 isotype. On December 10, 2007, Bristol- ... "A new member of the immunoglobulin superfamily--CTLA-4". Nature. 328 (6127): 267-70. doi:10.1038/328267a0. PMID 3496540. Harper ...
*  T helper cell
A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM ... "T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells ...
*  Tanox
... in an isotype-specific fashion. This migis approach ("migis" is an acronym for "mIg isotype-specific") was supported by the ... an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis". Clin Pharmacol Ther. 62 (6 ... of the transmembrane anchor peptides at the C-termini of the five isotypes of heavy chains of the five classes of mIg's vary ... implications in isotype-specific regulation". Biotechnology (N Y). 9 (1): 53-6. doi:10.1038/nbt0191-53. PMID 1370037. Peng C, ...
*  Schistosomiasis vaccine
2007). "Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with ... Efficacy Testing of Sm-p80-Based Vaccine in a Nonhuman Primate Model of Schistosoma mansoni Infection and Immunoglobulin G and ...
*  Passive immunity
Immunoglobulin G (IgG) is the only antibody isotype that can pass through the human placenta, and is the most common antibody ... Immunoglobulin therapy continued to be a first line therapy in the treatment of severe respiratory diseases until the 1930s, ... Immune globulin or immunoglobulin has been used to both prevent and treat reactivation of the herpes simplex virus (HSV), ... In 1953, human vaccinia immunoglobulin (VIG) was used to prevent the spread of smallpox during an outbreak in Madras, India, ...