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*  CD79B
... molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. It is ... is identical in B cell and plasma cell lines producing all the human Ig isotypes". J. Immunol. 150 (2): 491-8. PMID 8419481. ... 1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)". Genomics. 16 (1): 187-92. doi ... surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are ...
*  Antibody
The co-expression of both of these immunoglobulin isotypes renders the B cell ready to respond to antigen. B cell activation ... While most of these early studies focused on IgM and IgG, other immunoglobulin isotypes were identified in the 1960s: Thomas ... Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation of a unique immunoglobulin ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ...
*  IgG deficiency
... of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes ... IgG3 deficiency is not usually encountered without other concomitant immunoglobulin deficiencies, and IgG4 deficiency is very ... IgG deficiency (Selective deficiency of immunoglobulin G) is a form ... with normal total IgG and IgM immunoglobulins and other components of the immune system being at normal levels. These ...
*  Isotype (immunology)
In immunology, the immunoglobulin (Ig) isotype (class) is encoded by the constant region segments of the immunoglobulin gene ... Immunoglobulin Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ... Isotype expression reflects the maturation stage of a B cell. Naive B cells express IgM and IgD isotypes with unmutated ... IgD isotypes are expressed on naive B cells as they leave bone marrow and populate secondary lymphoid organs. The levels of ...
*  Basophil activation
Immunoglobulin E (IgE) is a class of antibody (or immunoglobulin "isotype") that has only been found in mammals. It plays an ...
*  Besilesomab
It binds to an immunoglobulin, IgG1 isotype. SCINTIMUN has been used since 1992 mainly in Hungary, Czech Republic, and ...
*  List of MeSH codes (D12.776.124)
... immunoglobulin isotypes MeSH D12.776.124.486.485.114.619.026 -- immunoglobulin a MeSH D12.776.124.486.485.114.619.026.030 -- ... immunoglobulin isotypes MeSH D12.776.124.790.651.114.619.026 -- immunoglobulin a MeSH D12.776.124.790.651.114.619.026.030 -- ... immunoglobulin g MeSH D12.776.124.486.485.114.619.393.522 -- immunoglobulin gamma-chains MeSH D12.776.124.486.485.114.619.393. ... immunoglobulin g MeSH D12.776.124.790.651.114.619.393.522 -- immunoglobulin gamma-chains MeSH D12.776.124.790.651.114.619.393. ...
*  CTLA-4
Most patients develop reduced levels of at least one immunoglobulin isotype, and have low CTLA4 protein expression in T ... CTLA4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal ... "A new member of the immunoglobulin superfamily--CTLA-4". Nature. 328 (6127): 267-70. doi:10.1038/328267a0. PMID 3496540. ... is based on an individual's clinical condition and may include standard management for autoimmunity and immunoglobulin ...
*  Biovest
... with an IgG isotype with each treatment vaccine produced to correspond with the patient's tumor immunoglobulin isotype. Of 40 ... Among 35 patients with IgM tumor isotype receiving BiovaxID manufactured with an IgM isotype, median time to relapse after ... 25 had tumors with IgM isotype and 15 had tumors with IgG isotype. Two of the patients in the vaccinated treatment/control ... Among 40 patients with IgG tumor isotype receiving BiovaxiD manufactured with an IgG isotype, median time to relapse after ...
*  Immunoglobulin light chain
Das S, Nikolaidis N, Klein J, Nei M (2008). "Evolutionary redefinition of immunoglobulin light chain isotypes in tetrapods ... The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed ... and σ isotypes preceded the radiation of tetrapods. The σ isotype was lost after the evolution of the amphibian lineage and ... The immunoglobulin light chain genes in tetrapods can be classified into three distinct groups: kappa (κ), lambda (λ), and ...
*  Immunoglobulin heavy chain
"Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary ... The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). A typical antibody is ... There are five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. They define classes of immunoglobulins: IgG, ... Identification and expression of a previously unknown isotype, immunoglobulin Z". Nature Immunology. 6 (3): 295-302. doi: ...
*  Rheumatoid factor
Although predominantly encountered as IgM, rheumatoid factor can be of any isotype of immunoglobulins, i.e. IgA, IgG, IgM, IgE ... 25 (2): 4. Hermann, E; Vogt, P; Müller, W (1986). "Rheumatoid factors of immunoglobulin classes IgA, IgG and IgM: Methods of ... Restricted IgM Rheumatoid Factor Responses From More Mature Anti-Citrullinated Protein Antibody-Associated or Isotype-Switched ...
*  Immunoglobulin class switching
... , also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a ... "Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes". The Journal ... such as from the isotype IgM to the isotype IgG. During this process, the constant-region portion of the antibody heavy chain ... Immunoglobulin genes undergo legitimate repair in human B cells not only after cis- but also frequent trans-class switch ...
*  IGK@
"Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed ... The immunoglobulin kappa locus contains the following genes: IGKC: immunoglobulin kappa constant IGKJ@: immunoglobulin kappa ... Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light ... These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins. ...
*  Immunoglobulin E
... (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is ... Understanding of this structure (which is atypical of other isotypes in that it is highly bent and asymmetric) and of the ... Although IgE is typically the least abundant isotype-blood serum IgE levels in a normal ("non-atopic") individual are only 0.05 ... Presence of a unique immunoglobulin as a carrier of reaginic activity". J. Immunol. 97 (1): 75-85. PMID 4162440. Johansson SG, ...
*  Allotype (immunology)
Allotype Idiotype Isotype "THE STRUCTURE AND FUNCTION OF IMMUNOGLOBULINS - ANTIBODIES". Retrieved 2009-05-19. Immunoglobulin ... In immunology, an immunoglobulin allotype is the allele of the antibody chains found in the individual. The word allotype comes ... Thus allotype refers to the idea that each immunoglobulin has unique sequences particular to the individual's genome that ...
*  Primary immunodeficiency
... one or more isotypes of immunoglobulin are decreased or don't function properly. These proteins, generated by plasma cells, ... immunoglobulin replacement therapy in the form of intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG) may ... For instance, an antibody deficiency can be diagnosed in the presence of low immunoglobulins, recurrent infections and failure ... Milder forms of primary immunodeficiency, such as selective immunoglobulin A deficiency, are fairly common, with random groups ...
*  B-cell receptor
The B-cell receptor is composed of two parts: A membrane-bound immunoglobulin molecule of one isotype (IgD, IgM, IgA, IgG, or ... amplitude and duration of BCR activation can be influenced by a specific immunoglobulin structure, the expression adaptor ...
*  Immunoglobulin M
... also termed classes or isotypes - IgM, IgD, IgG, IgE and IgA. Immunoglobulins are produced by vertebrate animals as part of the ... Immunodeficiency with hyper-immunoglobulin M Immunoglobulin M deficiency "Immunoglobulin M". The American Heritage Dictionary ... Immunoglobulin M at the US National Library of Medicine Medical Subject Headings (MeSH) Immunoglobulin M Deficiency Reference ... The immunoglobulin C domains interact with other physiological components, eg cellular immunoglobulin receptors and the ...
*  Proteus penneri
"A proteolytic enzyme secreted by Proteus mirabilis degrades immunoglobulins of the immunoglobulin A1 (IgA1), IgA2, and IgG ... isotypes". Infect Immun. 58 (6): 1979-85. PMC 258753 . PMID 2111288. Swenson, JM; Hindler J A, Peterson L R. (1999). Murray, P. ... Secretory immunoglobulins of the IgA class are produced by mucous tissue and are particularly resistant to enzymatic breakdown ...
*  Germinal center
... the B cell receives critical signals to undergo isotype switching (also called immunoglobulin class switching) and to commence ...
*  Nephelometry (medicine)
For example the total levels of antibodies isotypes or classes: Immunoglobulin M, Immunoglobulin G, and Immunoglobulin A. It is ...
*  Social genomics
... immunoglobulin G). This pattern of up-regulated pro-inflammatory transcription coupled with down-regulated anti-viral ... is associated with the down-regulation of anti-viral gene products including interferon type 1 and specific antibody isotypes ( ...
*  Cryoglobulinemia
... type III cases associated with the expression of low levels of a one or more isotypes of circulating monoclonal immunoglobulin( ... immunoglobulin components or immunoglobulins with structures that do not fit into any classifications in the cryoglobulins of ~ ... promotes cell death by apoptosis in cells accumulating immunoglobulins) in patients with monoclonal immunoglobulin-induced ... Non-IgM monoclonal immunoglobulin-based cases of cryoglobulinemic disease are less commonly associated with other B-cell ...
*  Immunoglobulin A
IgA exists in two isotypes, IgA1 and IgA2. They are both heavily glycosylated proteins. While IgA1 predominates in serum (~80 ... Immunoglobulin A (IgA, also referred to as sIgA) is an antibody that plays a crucial role in the immune function of mucous ... Immunoglobulin A at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal Medicine portal. ... The IgA dimeric form is the most prevalent and is also called secretory IgA (sIgA). sIgA is the main immunoglobulin found in ...
*  DNA vaccination
DNA immunization can be used to bias the TH profile of the immune response and thus the antibody isotype, which is not possible ... Each type has distinctive patterns of lymphokine and chemokine expression, specific types of immunoglobulins, patterns of ... Feltquate, D.M.; Heaney, S; Webster, RG; Robinson, HL (March 1, 1997). "Different T helper cell types and antibody isotypes ...
*  IGHM
2002). "Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple ... "Entrez Gene: IGHM immunoglobulin heavy constant mu". Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing ... Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... Dorai H, Gillies SD (1989). "The complete nucleotide sequence of a human immunoglobulin genomic C mu gene". Nucleic Acids Res. ...