*  Immunoglobulin heavy chain
These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually ... The heavy chain doesn't always have to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain in the absence of ... Heavy chains α and γ have approximately 450 amino acids. Heavy chains μ and ε have approximately 550 amino acids. Each heavy ... heavy chain that is present in all jawed fish and is the heavy chain for what is thought to be the primordial immunoglobulin. ...
*  ETV6
Immunoglobulin heavy chain gene IGH; g) enzyme genes TTL (adds and removes tyrosine residues on α-tubulin), GOT1 (an Aspartate ... transaminase), and ACSL6 (a Long-chain-fatty-acid-CoA ligase); h) transporter gene ARNT (binds to ligand-bound aryl hydrocarbon ...
*  [email protected]
Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the [email protected] gene. IGHV is the immunoglobulin heavy ... [email protected] Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp ... Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain ... 2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain ...
*  Enhancer (genetics)
The first discovery of a eukaryotic enhancer was in the immunoglobulin heavy chain gene in 1983. This enhancer, located in the ... "A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene ... "A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes". Cell ... "Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus". Science. 221 (4611): 663-5. PMID 6306772. ...
*  IGHD
2006). "Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire ... "Entrez Gene: IGHD immunoglobulin heavy constant delta". Shin SU, Wei CF, Amin AR, et al. (1992). "Structural and functional ... 1982). "Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD". ... genomic sequence of the delta heavy chain". Science. 228 (4700): 733-7. doi:10.1126/science.3922054. PMID 3922054. " ...
*  ARID3A
Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF (Jun 2006). "Induction of immunoglobulin heavy-chain transcription ... "Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer". Molecular Cancer. 6: 23. doi: ...
*  J. Donald Capra
Pascual, V.; Capra, J. D. (1991). "Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and ... "Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes". The Journal of ... Hurley, C. K.; Shaw, S.; Nadler, L.; Schlossman, S.; Capra, J. D. (1982). "Alpha and beta chains of SB and DR antigens are ... Hasemann, C. A.; Capra, J. D. (1990). "High-level production of a functional immunoglobulin heterodimer in a baculovirus ...
*  Tasuku Honjo
"Organization of the constant-region gene family of the mouse immunoglobulin heavy chain". Cell. 28 (3): 499-506. doi:10.1016/ ... He succeeded in cDNA clonings of IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain in 1986, and ... Ishida, Y; Agata, Y; Shibahara, K; Honjo, T (1992). "Induced expression of PD-1, a novel member of the immunoglobulin gene ...
*  G-quadruplex
It has been suggested that quadruplex formation plays a role in immunoglobulin heavy chain switching. As cells have evolved ... and in allowing programmed recombination of immunologlobin heavy genes and the pilin antigenic variation system of the ...
*  Thyroglobulin
Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein". J. Biol. ... Thyroglobulin has been shown to interact with Binding immunoglobulin protein. GRCh38: Ensembl release 89: ENSG00000042832 - ... possible cleavage of the polypeptide chain at the tyrosine donor site". FEBS Lett. 242 (2): 414-8. doi:10.1016/0014-5793(89) ...
*  TFE3
... binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991 ... a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics. 11 (2): 374-8. doi: ... Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A ... "bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3 ...
*  V(D)J recombination
The immunoglobulin heavy locus ([email protected]) on chromosome 14, containing the gene segments for the immunoglobulin heavy chain. The ... containing the gene segments for the remainder of the immunoglobulin light chain. Each heavy chain and light chain gene ... chains of the immunoglobulin light chain loci rearrange in a very similar way, except that the light chains lack a D segment. ... For example, the human immunoglobulin heavy chain region contains 2 Constant (Cμ and Cδ) gene segments and 44 Variable (V) gene ...
*  Susumu Tonegawa
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene ...
*  HOXC4
"The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. ...
*  [email protected]
... immunoglobulin genes: Heavy chain alpha (IgA): IGHA1, IGHA2 Heavy chain gamma (IgG): IGHG1, IGHG2, IGHG3, IGHG4 Heavy chain ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ... Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the ... IGHE Heavy chain mu (IgM): IGHM [email protected] "Human PubMed Reference:". "Entrez Gene: IGH immunoglobulin heavy locus". "Gene Family: ...
*  Receptor editing
3. Kleinfield R, Hardy RR, Tarlinton, D (1986). 'Recombination between an expressed immunoglobulin heavy-chain gene and a ... They can avoid apoptosis by modifying the sequence of light chain V and J genes (components of the antigen receptor) so that it ...
*  Organization and expression of immunoglobulin genes
Antibody (or immunoglobulin) structure is made up of two heavy-chains and two light-chains. These chains are held together by ... Here at this stage, Pre-B cell, mμ heavy chain and surrogate light chain are formed. The final rearrangement of the light chain ... a partial rearrangement of the heavy-chain gene occurs which is followed by complete rearrangement of heavy-chain gene. ... 1979). Cloned pairs of variable region genes for immunoglobulin heavy-chains isolated from a clone library of the entire mouse ...
*  IGHA2
Toraño A, Putnam FW (Feb 1978). "Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the ... Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Flanagan JG, Rabbitts TH (Dec 1982). "Arrangement of human immunoglobulin heavy chain constant region genes implies ... "Human PubMed Reference:". "Entrez Gene: IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker)". Kerr MA (Oct 1990). "The ...
*  IGHM
1973). "Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin". Science. 182 (4109): 287-91. doi: ... Rabbitts TH, Forster A, Milstein CP (1982). "Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta ... Neale GA, Kitchingman GR (1991). "mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region ... Fang T, Smith BP, Roman CA (2001). "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain ...
*  IL1RAPL2
1994). "Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to ...
*  Heavy chain disease
The defect in the immunoglobulins presumably arises during somatic hypermutation. Deletion of the N-terminal part of the heavy ... gamma chain disease (Franklin's disease) mu chain disease delta chain disease The most common type of heavy chain disease is ... These heavy chain disease proteins have various deletions, mainly in their amino-terminal part, which causes the heavy chains ... Franklin's disease (gamma heavy chain disease) It is a very rare B-cell lymphoplasma cell proliferative disorder which may be ...
*  Serum free light-chain measurement
There is approximately 40% excess immunoglobulin light-chain production over immunoglobulin heavy-chain synthesis. Possibly ... Immunoglobulin light chains that are circulating in serum in a free (unbound) state are called free light chains (FLCs). ... Each immunoglobulin light-chain molecule contains approximately 220 amino acids in a single polypeptide chain that is folded to ... so under normal conditions no light chains pass beyond the proximal tubules. If immunoglobulin light chains are produced in ...
*  DNAJC3
It was shown that loss of the BiP (immunoglobulin heavy-chain binding protein) co-chaperone DNAJC3 leads to diabetes mellitus ...
*  Immunoglobulin class switching
... the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy chain stays the same ( ... Naïve mature B cells produce both IgM and IgD, which are the first two heavy chain segments in the immunoglobulin locus. After ... During class switching, the constant region of the immunoglobulin heavy chain changes but the variable regions, and therefore ... the process of class switching needs S regions to be first transcribed and spliced out of the immunoglobulin heavy chain ...
*  Pathophysiology of multiple sclerosis
They are the following immunoglobulins: Ig γ-1 (chain C region), Ig heavy chain V-III (region BRO) and Ig-κ-chain (C region) ... 2014). "A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM ... There is also an overexpression of IgG-free kappa light chain protein in both CIS and RR-MS patients, compared with control ... "Cerebrospinal fluid immunoglobulin G promotes oligodendrocyte progenitor cell migration. ;;J Neurosci Res.;; 2004 Aug 1;77(3): ...
*  LILRA3
... free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles Cluster of differentiation "Human ... immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is ... Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), ... Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and ...