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*  Serum protein electrophoresis
Immunoglobulins consist of heavy chains, (IgA, IgM, IgG, IgE and IgD) and light chains (kappa and lambda). A normal gamma zone ... Note that immunoglobulins may be also be found in other zones; IgA typically migrates in the beta-gamma zone, and in particular ... The immunoglobulins or antibodies are generally the only proteins present in the normal gamma region. Of note, any protein ... C-reactive protein is found in between the beta and gamma zones producing beta/gamma fusion. IgA has the most anodal mobility ...
*  IGHG2
... of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 ... Hofmann T, Parr DM (Nov 1979). "A note of the amino acid sequence of residues 381--391 of human immunoglobulins gamma chains". ... Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Ig gamma-2 chain C region is a protein that in humans is encoded by the IGHG2 gene. "Human PubMed Reference:". "Entrez Gene: ...
*  IGHE
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". Dna. 1 (1): 11-8. doi: ... Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence ... "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". ...
*  IGHG4
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Ig gamma-4 chain C region is a protein that in humans is encoded by the IGHG4 gene. "Human PubMed Reference:". "Entrez Gene: ... Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". Dna. 1 (1): 11-8. doi: ... Partial amino acid sequence of the constant region of a gamma 4 chain". The Biochemical Journal. 117 (1): 33-47. PMC 1178827 . ...
*  IGHA2
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Toraño A, Putnam FW (Feb 1978). "Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the ... Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". Dna. 1 (1): 11-8. doi: ... of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, ...
*  IGHG3
1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma ... "Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis". Biochemistry. 19 ( ... Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene. "Human PubMed Reference:". Alexander A, ... "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)". Michaelsen TE, Frangione B, Franklin EC (1977). " ...
*  Index of biochemistry articles
... gamma-chain immunoglobulin - gamma-delta T-cell antigen receptor - gastrin - gastrointestinal hormone receptor - gastrula - Gel ... immunoglobulin - immunoglobulin joining region - immunoglobulin variable region - immunologic receptor - immunology - In vivo ... heavy-chain immunoglobulin - Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus ... kappa-chain immunoglobulin - karyoplasm - karyotype - kelvin - keratin - kinase - kinesin - kinetic energy - kinetics - knock- ...
*  FCAR
"Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for ... while outside-in signaling caused by ligand binding depends on FcαRI association with the Fc receptor gamma chain (FcR γ-chain ... However, this chain alone cannot perform signaling in response to IgA binding, and FcαRI must associate with a dimeric form of ... The priming of FcαRI to be able to bind IgA does not depend on FcαRI association with the FcR γ-chain, but does depend on ...
*  FCGR1A
"Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for ... and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): ... the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599-606. PMID ... High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene. FCGR1A has been ...
*  Otelixizumab
The heavy chains are humanized γ1 (gamma-1) chains from rats, making otelixizumab an immunoglobulin G1. The light chains are ... As a monoclonal antibody, otelixizumab consists of two heavy chains and two light chains. ... More specifically, otelixizumab targets the epsilon chain of CD3. Data suggest that the drug works by blocking the function of ... chimeric human/rat λ (lambda) chains. Bolt, S., Routledge, E., Lloyd, I., Chatenoud, L., Pope, H., Gorman, S., Clark, M. & ...
*  IGHM
"Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch ... 1988). "Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes". ... Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... Dolby TW, Devuono J, Croce CM (1981). "Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B ...
*  IGHG1
1971). "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide ... 1971). "The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide ... Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene. "Human PubMed Reference:". "Entrez Gene: ... The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain ...
*  Nivolumab
... is a fully human monoclonal immunoglobulin G4 antibody to PD-1. The gamma 1 heavy chain is 91.8% unmodified human ... design while the kappa light chain is 98.9%. PD-1 was first shown to be an immune checkpoint in 2000. Nivolumab was created by ...
*  List of MeSH codes (D12.776.124)
... immunoglobulin epsilon-chains MeSH D12.776.124.486.485.705.500.380 -- immunoglobulin gamma-chains MeSH D12.776.124.486.485.705. ... immunoglobulin epsilon-chains MeSH D12.776.124.790.651.705.500.380 -- immunoglobulin gamma-chains MeSH D12.776.124.790.651.705. ... immunoglobulin g MeSH D12.776.124.486.485.114.619.393.522 -- immunoglobulin gamma-chains MeSH D12.776.124.486.485.114.619.393. ... immunoglobulin g MeSH D12.776.124.790.651.114.619.393.522 -- immunoglobulin gamma-chains MeSH D12.776.124.790.651.114.619.393. ...
*  IGH@
... immunoglobulin genes: Heavy chain alpha (IgA): IGHA1, IGHA2 Heavy chain gamma (IgG): IGHG1, IGHG2, IGHG3, IGHG4 Heavy chain ... Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ... Buluwela L, Rabbitts TH (1989). "A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region ...
*  IGKC
"The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain". Biochemistry. 9 (16): ... Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains ... The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The ... Klobeck HG, Combriato G, Zachau HG (1984). "Immunoglobulin genes of the kappa light chain type from two human lymphoid cell ...
*  International Classification of Diseases for Oncology
... lymphadenopathy M9768/1 T-gamma lymphoproliferative disease M9769/1 Immunoglobulin deposition disease Systemic light chain ... M9762/3 Heavy chain disease, NOS Alpha heavy chain disease Mu heavy chain disease Gamma heavy chain disease Franklin disease ... gamma-delta) cell lymphoma Hepatosplenic T-cell lymphoma M9717/3 Intestinal T-cell lymphoma Enteropathy type T-cell lymphoma ...
*  Immune repertoire
The 6 main types are: immunoglobulins (2), and T cell receptors (4). Immunoglobulin proteins consist of 2 parts, a light chain ... and a heavy chain. T cell receptors come in 4 types, labelled alpha, beta, gamma and delta. In an organism, each of the 6 types ... 2006) estimated repertoire for TCR gamma genes, in CD8+CD45RO+ memory T cells in blood, as 40,000-100,000 sub-types, in 3 ... either immunoglobulin or T cell receptor. In most vertebrates, immune systems have 6 key types of proteins, which help the ...
*  Antibody
In mammals there are two types of immunoglobulin light chain, which are called lambda (λ) and kappa (κ). A light chain has two ... Possible classes of heavy chains in antibodies include alpha, gamma, delta, epsilon, and mu, and they define the antibody's ... heavy chains μ and ε have a constant region composed of four immunoglobulin domains. The variable region of the heavy chain ... two identical heavy chains and two identical light chains connected by disulfide bonds. Each chain is composed of structural ...
*  Waldenström's macroglobulinemia
Immunoelectrophoresis and immunofixation studies help identify the type of immunoglobulin, the clonality of the light chain, ... An M component with beta-to-gamma mobility is highly suggestive of Waldenström's macroglobulinemia. ... Results from characterization studies of urinary immunoglobulins indicate that light chains (Bence Jones protein), usually of ... The light chain of the monoclonal protein is usually the kappa light chain. At times, patients with Waldenström's ...
*  Schnitzler syndrome
The immunoglobulins may show up in the urine as Bence Jones proteins. Signs of inflammation are often present: these include an ... It almost always has light chains of the κ-type. A variant in which IgG is raised has been described, which appears to be ten ... Blood tests show a high concentration of specific gamma-globulins (monoclonal gammopathy) of the IgM type. ...
*  Elizabeth Press
Press's work provided the first evidence that immunoglobulin heavy chains had variable regions similar to those observed in ... FLEISCHMAN, JB; PORTER, RR; PRESS, EM (August 1963). "THE ARRANGEMENT OF THE PEPTIDE CHAINS IN GAMMA-GLOBULIN". The Biochemical ... The structural studies on antibodies were essential in the chain of scientific discoveries which led to the development of ... Her studies on antibodies were important in determining the chain structure, and particularly the observation that more than ...
*  T-cell receptor
The intersection of these specific regions (V and J for the alpha or gamma chain; V, D, and J for the beta or delta chain) ... Each chain is composed of two extracellular domains: Variable (V) region and a Constant (C) region, both of Immunoglobulin ... chain and a beta (β) chain (encoded by TRA and TRB, respectively), whereas in 5% of T cells the TCR consists of gamma and delta ... generation of the TCR gamma chain involves VJ recombination, whereas generation of the TCR delta chain occurs by VDJ ...
*  Heavy chain disease
... gamma chain disease (Franklin's disease) mu chain disease delta chain disease The most common type of heavy chain disease is ... "Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain". Blood. 115 (2): 282-8. ... Franklin's disease (gamma heavy chain disease) It is a very rare B-cell lymphoplasma cell proliferative disorder which may be ... Wahner-Roedler DL, Witzig TE, Loehrer LL, Kyle RA (2003). "Gamma-heavy chain disease: review of 23 cases". Medicine (Baltimore ...
*  List of MeSH codes (G04)
... gamma-chain t-cell antigen receptor MeSH G04.610.626.398 --- genes, immunoglobulin MeSH G04.610.626.454 --- immunoglobulin ... heavy chain MeSH G04.610.626.320.501.450 --- immunoglobulin class switching MeSH G04.610.626.320.601 --- gene rearrangement, b- ... alpha-chain t-cell antigen receptor MeSH G04.610.626.325.211 --- gene rearrangement, beta-chain t-cell antigen receptor MeSH ... immunoglobulin km allotypes MeSH G04.610.626.510 --- immunoglobulin idiotypes MeSH G04.610.626.580 --- major histocompatibility ...
*  HCONDELs
510 of these identified hCONDELs were then validated computationally with 39 of these being validated by polymerase chain ... locus and the growth arrest and DNA-damage-inducible protein GADD45 gamma (GADD45G) locus suggest a role in deletions that ... and near genes encoding fibronectin-type-III-or CD80-like immunoglobulin C2-set domains. Of the 510 identified hCONDELs, only ... using the genome-wide comparison method however validation of these predicated regions of deletions through polymerase chain ...