Loading...
*  Monoclonal antibody therapy
... the Fab (fragment-antigen binding) part can be separated from the Fc (fragment constant) part of the molecule. The Fab ... Omalizumab inhibits human immunoglobulin E (IgE) and is useful in moderate-to-severe allergic asthma. Alzheimer's disease (AD) ... Jefferis R, Lefranc MP (July-August 2009). "Human immunoglobulin allotypes: possible implications for immunogenicity". MAbs. 1 ... Immunoglobulin G (IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of ...
*  Cap formation
If the antibody is non-crosslinking (such as a Fab antibody fragment), the bound antibody is uniformly distributed. This can be ... 1971). "Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by an anti-immunoglobulin ...
*  List of MeSH codes (D12.776.124)
... immunoglobulin fab fragments MeSH D12.776.124.486.485.538.500 -- immunoglobulin fc fragments MeSH D12.776.124.486.485.538. ... immunoglobulin fab fragments MeSH D12.776.124.790.651.538.500 -- immunoglobulin fc fragments MeSH D12.776.124.790.651.538. ... immunoglobulin fragments MeSH D12.776.124.486.485.680.650 -- immunoglobulin fab fragments MeSH D12.776.124.486.485.680.650.500 ... immunoglobulin fab fragments MeSH D12.776.124.486.485.797.590 -- immunoglobulin joining region MeSH D12.776.124.486.485.900 -- ...
*  Digoxin immune fab
DigiFab is a sterile, lyophilized preparation of digoxin-immune ovine Fab (monovalent) immunoglobulin fragments. It is prepared ... papain is used to cleave the antibody into Fab and Fc fragments) should not use ovine digoxin immune fab. Because it is ... digesting it with papain and isolating the digoxin-specific Fab fragments by affinity chromatography. These antibody fragments ... Digoxin immune fab or Digoxin-specific antibody is an antidote for overdose of digoxin. It is made from immunoglobulin ...
*  Fragment antigen-binding
The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin ... The F(ab')2 fragment can be split into two Fab' fragments by mild reduction. The variable regions of the heavy and light chains ... which is only half the size of the Fab fragment, yet retains the original specificity of the parent immunoglobulin. Fc region ... The antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one ...
*  Abciximab
... is made from the Fab fragments of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet ... Abciximab (previously known as c7E3 Fab), a glycoprotein IIb/IIIa receptor antagonist manufactured by Janssen Biologics BV and ...
*  IGLL1
1996). "Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and ... Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene. IGLL1 has also recently been ... 1989). "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human ... 1991). "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B ...
*  Digoxin toxicity
The primary treatment of digoxin toxicity is digoxin immune fab, which is an antibody made up of anti-digoxin immunoglobulin ... "Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Final report of ... Fab dose can be determined by two different methods. First method is based on the amount of digoxin ingested whereas the second ... Treatment of severe toxicity is with digoxin-specific antibody fragments. Its use is recommended in those who have a serious ...
*  Immunoglobulin heavy constant alpha 1
Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain ... Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain ... Immunoglobulin heavy constant alpha 1 is a immunoglobulin gene with symbol IGHA1. It encodes a constant (C) segment of ... Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes. IgA shows the same ...
*  List of MeSH codes (D12.776)
... immunoglobulin fab fragments MeSH D12.776.377.715.548.538.500 - immunoglobulin fc fragments MeSH D12.776.377.715.548.538. ... immunoglobulin fragments MeSH D12.776.377.715.548.680.650 - immunoglobulin fab fragments MeSH D12.776.377.715.548.680.650.500 ... immunoglobulin fab fragments MeSH D12.776.377.715.548.797.590 - immunoglobulin joining region MeSH D12.776.377.715.548.900 - ... immunoglobulin fc fragments MeSH D12.776.377.715.548.680.660.249 - cd4 immunoadhesins MeSH D12.776.377.715.548.680.660.500 - ...
*  Antibody
This region of the antibody is called the Fab (fragment, antigen-binding) region. It is composed of one constant and one ... Somatic recombination of immunoglobulins, also known as V(D)J recombination, involves the generation of a unique immunoglobulin ... Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain ... The membrane-bound form of an antibody may be called a surface immunoglobulin (sIg) or a membrane immunoglobulin (mIg). It is ...
*  Fragment crystallizable region
This type of antigen-binding fragment is called Fcab. Fcab fragments can be inserted into a full immunoglobulin by swapping the ... Fab region Protein tag Janeway, CA, Jr.; et al. (2001). Immunobiology (5th ed.). Garland Publishing. ISBN 0-8153-3642-X. ... "Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu ... The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors ...
*  IGKC
1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253-64. doi: ... Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains ... 2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321- ... The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The ...
*  Snake antivenom
... two Fab fragments and one Fc fragment. An antibody can also be digested by pepsin to produce two fragments: a F(ab')2 fragment ... Whole antibody products consist of the entire antibody molecule, often immunoglobulin G (IgG), whereas antibody fragments are ... The fragment antigen-binding (Fab fragment) is a region on an antibody that binds to antigens, such as venoms. The molecular ... or Fab, is the selective antigen binding region. An antibody, such as IgG, can be digested by papain to produce three fragments ...
*  Antigen-antibody interaction
In an antibody, the Fab (fragment, antigen-binding) region is formed from the amino-terminal end of both the light and heavy ... "Immunoglobulins- antigen-antibody reactions and selected tests". Microbiology and Immunology. University of South Carolina ... chains of the immunoglobulin polypeptide. This region called V (variable) domain is composed of amino acid sequences that ...
*  IGHG1
1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253-64. doi: ... Ellison JW, Berson BJ, Hood LE (1982). "The nucleotide sequence of a human immunoglobulin C gamma1 gene". Nucleic Acids Res. 10 ... 2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321- ... Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of ...
*  Biosensor
In one approach to overcome these limitations, recombinant binding fragments (Fab, Fv or scFv) or domains (VH, VHH) of ... Skrlec, K; Strukelj, B; Berlec, A (Jul 2015). "Non-immunoglobulin scaffolds: a focus on their targets". Trends Biotechnol. 33 ( ... Crivianu-Gaita, V; Thompson, M (Nov 2016). "Aptamers, antibody scFv, and antibody Fab' fragments: An overview and comparison of ... This strategy is also valid for antibody fragments. However, in the absence of specific structural data, other strategies must ...
*  Protein L
Single chain variable fragments (scFv) and Fab fragments also bind to Protein L. Despite this wide binding range, Protein L is ... immobilize or detect immunoglobulins. Each of these immunoglobulin-binding proteins has a different antibody binding profile in ... Binding of mouse immunoglobulins is restricted to those having VκI light chains. Given these specific requirements for ... Unlike Protein A and Protein G, which bind to the Fc region of immunoglobulins (antibodies), Protein L binds antibodies through ...
*  Fcab
"Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu ... This type of antibodies are therefore able to recognise two different antigens, one at their Fab region and a second one at the ... This antibody fragment is part of the modular antibody technology of F-star Biotechnology Ltd. Wozniak-Knopp G, Bartl S, Bauer ... Fcabs are antibodies fragments engineered from the constant region of an antibody (Fc). In naturally occurring antibodies (such ...
*  SpAB protein domain
... and Fab (the Ig fragment responsible for antigen recognition). The native state of the B domain, deviates a lot since its inter ... Protein A contains five highly homologous immunoglobulin (Ig)-binding domains in tandem (designated domains E, D, A, B and C), ... "Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: ... It does this though SpAB binding to the Fc fragment of IgG. The B domain of SpA (SpAB) consists of three a-helices which are ...
*  Single-domain antibody
... and even smaller than Fab fragments (~50 kDa, one light chain and half a heavy chain) and single-chain variable fragments (~25 ... these are called VHH fragments. Cartilaginous fishes also have heavy-chain antibodies (IgNAR, 'immunoglobulin new antigen ... An alternative approach is to split the dimeric variable domains from common immunoglobulin G (IgG) from humans or mice into ... A single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is an antibody fragment consisting of a single ...
*  Creative Biolabs
Fab construction is a complex technique as Fab fragments contain both variable domains and constant regions. The same heavy and ... "Dextran as a Generally Applicable Multivalent Scaffold for Improving Immunoglobulin-Binding Affinities of Peptide and ... "Therapeutic anti-IgE monoclonal antibody single chain variable fragment (scFv) safety and immunomodulatory effects after one ... light variable chains used for scFv construction can be used in the construction of Fab. Construction of pre-made phage display ...
*  Fc receptor
When IgG molecules, specific for a certain antigen or surface component, bind to the pathogen with their Fab region (fragment ... Two types of FcεR are known: the high-affinity receptor FcεRI is a member of the immunoglobulin superfamily (it has two Ig-like ... It is composed of two extracellular Ig-like domains, and is a member of both the immunoglobulin superfamily and the multi-chain ... Its name is derived from its binding specificity for a part of an antibody known as the Fc (Fragment, crystallizable) region. ...
*  Synthetic antibody
The ability to manipulate the antibody genes makes it possible to generate new antibodies and antibody fragments, such as Fab ... Affimer binders have been produced to a large number of targets including ubiquitin chains, immunoglobulins and C-reactive ... Synthetic antibodies include recombinant antibodies, nucleic acid aptamers and non-immunoglobulin protein scaffolds. As a ... or from non-immunoglobulin protein scaffolds / peptide aptamers, into which hypervariable loops are inserted to form the ...
*  Protein A
It binds the heavy chain within the Fc region of most immunoglobulins and also within the Fab region in the case of the human ... Deisenhofer J (April 1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment ... "Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: ... Protein A can bind with strong affinity to the Fc portion of immunoglobulin of certain species as shown in the below table. In ...
*  Index of biochemistry articles
... fab immunoglobulin - facilitated diffusion - factor VIII - FADH - FADH2 - Fat - Fatty acid - fc immunoglobulin - fc receptor - ... peptide fragment - peptide initiation factor - peptide receptor - peptide termination factor - peripheral membrane protein - ... immunoglobulin - immunoglobulin joining region - immunoglobulin variable region - immunologic receptor - immunology - In vivo ... heavy-chain immunoglobulin - Hela cell - helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus ...
*  Papain
An antibody digested by papain yields three fragments: two 50 kDa Fab fragments and one 50kDa Fc fragment. The papain-digested ... In immunology, papain is known to cleave the Fc (crystallisable) portion of immunoglobulins (antibodies) from the Fab (antigen- ...