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*  IGHE
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence ... "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell ... "Human PubMed Reference:". "Entrez Gene: IGHE immunoglobulin heavy constant epsilon". Venkitaraman AR, Williams GT, Dariavach P ...
*  Regeneron
Trap technology involves fusing two distinct fully human receptor components and a fully human immunoglobulin-G constant region ...
*  2F5 antibody
"The immunoglobulin CH1 constant region modulates antigen binding affinity and functional activities of the broadly neutralizing ... Fab and Immunoglobulin G Forms) to Its gp41 Epitope Reveals a Strong Influence of the Immunoglobulin Fc Region on Affinity". ... 2F5 then binds to this epitope and its constant region interacts with the viral lipid membrane, which neutralizes the virus. ... suggesting the constant region is important to neutralization. This also indicates, as Fab is much smaller than IgG, that ...
*  IGHG2
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell ... "Human PubMed Reference:". "Entrez Gene: IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)". Connell GE, Parr DM, Hofmann ... "The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein". Canadian Journal of ...
*  IGHG4
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell ... Partial amino acid sequence of the constant region of a gamma 4 chain". The Biochemical Journal. 117 (1): 33-47. PMC 1178827 . ... "Human PubMed Reference:". "Entrez Gene: IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)". McLean GR, Nakouzi A, ...
*  List of MeSH codes (D12.776.124)
... immunoglobulin constant regions MeSH D12.776.124.486.485.538.249 -- immunoglobulin fab fragments MeSH D12.776.124.486.485.538. ... immunoglobulin constant regions MeSH D12.776.124.486.485.680.745 -- immunoglobulin idiotypes MeSH D12.776.124.486.485.705 -- ... immunoglobulin constant regions MeSH D12.776.124.790.651.680.745 -- immunoglobulin idiotypes MeSH D12.776.124.790.651.705.500 ... immunoglobulin fab fragments MeSH D12.776.124.486.485.797.590 -- immunoglobulin joining region MeSH D12.776.124.486.485.900 -- ...
*  IGKC
1981). "Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments". Cell ... Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains ... Hieter PA, Maizel JV, Leder P (1982). "Evolution of human immunoglobulin kappa J region genes". J. Biol. Chem. 257 (3): 1516-22 ... Bentley DL, Rabbits TH (1981). "Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene ...
*  IGHA2
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region ... Flanagan JG, Rabbitts TH (Dec 1982). "Arrangement of human immunoglobulin heavy chain constant region genes implies ... "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell ... "Human PubMed Reference:". "Entrez Gene: IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker)". Kerr MA (Oct 1990). "The ...
*  IGL@
1982). "Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes". J. Exp. Med. 155 (5 ... constant group IGLC1 - immunoglobulin lambda constant 1 (Mcg marker) IGLC2 - immunoglobulin lambda constant 2 (Kern-Oz- marker ... IGLC3 - immunoglobulin lambda constant 3 (Kern-Oz+ marker) IGLC7 - immunoglobulin lambda constant 7 IGLJ@ - joining group IGLJn ... Immunoglobulin lambda locus, also known as IGL@, is a region on human chromosome 22 that contains genes for the lambda light ...
*  Antibody
... and a hinge region for added flexibility; heavy chains μ and ε have a constant region composed of four immunoglobulin domains. ... Each heavy chain has two regions, the constant region and the variable region. The constant region is identical in all ... involves the generation of a unique immunoglobulin variable region. The variable region of each immunoglobulin heavy or light ... This region of the antibody is called the Fab (fragment, antigen-binding) region. It is composed of one constant and one ...
*  Tasuku Honjo
"Organization of the constant-region gene family of the mouse immunoglobulin heavy chain". Cell. 28 (3): 499-506. doi:10.1016/ ... Ishida, Y; Agata, Y; Shibahara, K; Honjo, T (1992). "Induced expression of PD-1, a novel member of the immunoglobulin gene ...
*  Immunoglobulin class switching
During class switching, the constant region of the immunoglobulin heavy chain changes but the variable regions, and therefore ... removing unwanted μ or δ heavy chain constant region exons and allowing substitution of a γ, α or ε constant region gene ... During this process, the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy ... In addition to the highly repetitive structure of the target S regions, the process of class switching needs S regions to be ...
*  IGH@
Buluwela L, Rabbitts TH (1989). "A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region ... Flanagan JG, Rabbitts TH (1983). "Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary ... IGHJ6 Symbols for constant region (C) immunoglobulin genes: Heavy chain alpha (IgA): IGHA1, IGHA2 Heavy chain gamma (IgG): ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ...
*  IGHG3
1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma ... "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)". Michaelsen TE, Frangione B, Franklin EC (1977). " ... Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene. "Human PubMed Reference:". Alexander A, ... Structure of the Fc fragment of immunoglobulin G3". Biochem. Biophys. Res. Commun. 71 (4): 907-14. doi:10.1016/0006-291X(76) ...
*  Immunoglobulin heavy constant alpha 1
The Ig alpha-1 chain C region is contained on the first of the constant regions of IgA, and is composed of an amino acid ... Immunoglobulin heavy constant alpha 1 is a immunoglobulin gene with symbol IGHA1. It encodes a constant (C) segment of ... Complete nucleotide sequences for the alpha-1 heavy chain constant region and the allelic alpha-2 heavy chain regions were ... one variable region, and three variable regions. As a major class of immunoglobulin in body secretions, IgA plays a role in ...
*  Single-chain variable fragment
This protein retains the specificity of the original immunoglobulin, despite removal of the constant regions and the ... Single-chain variable fragments lack the constant Fc region found in complete antibody molecules, and, thus, the common binding ... but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected ... This can be done by producing a single peptide chain with two VH and two VL regions, yielding tandem scFvs. Another possibility ...
*  F-star
... monoclonal antibodies using a modular combinatorial approach that engineers the Fc constant region of an immunoglobulin into a ... "Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu ...
*  Isotype (immunology)
In immunology, the immunoglobulin (Ig) isotype (class) is encoded by the constant region segments of the immunoglobulin gene ... IgA antibodies are divided into two subclasses that differ in the size of their hinge region. IgA1 has a longer hinge region ... Immunoglobulin Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH) Overview at University of South ... antibody class in the serum and it is divided into 4 subclasses based on differences in the structure of the constant region ...
*  CSR
... a process that changes the constant region of an immunoglobulin Control/Status Register, a register in central processing units ...
*  Pilus
Recombination genes of pili code for variable (V) and constant (C) regions of the pili (similar to immunoglobulin diversity). ... which are 9-10 monomers residing in coding regions of the donor DNA. Specific recognition of DUSs is mediated by a type IV ...
*  T-cell receptor
... region and a Constant (C) region, both of Immunoglobulin superfamily (IgSF) domain forming antiparallel β-sheets. The Constant ... Each locus can produce a variety of polypeptides with constant and variable regions. When the TCR engages with antigenic ... followed by a transmembrane region and a short cytoplasmic tail, while the Variable region binds to the peptide/MHC complex. ... The residues in these variable domains are located in two regions of the TCR, at the interface of the α- and β-chains and in ...
*  V(D)J recombination
For example, the human immunoglobulin heavy chain region contains 2 Constant (Cμ and Cδ) gene segments and 44 Variable (V) gene ... Primary transcript (unspliced RNA) is generated containing the VDJ region of the heavy chain and both the constant mu and delta ... The immunoglobulin kappa (κ) locus (IGK@) on chromosome 2, containing the gene segments for part of the immunoglobulin light ... regions), which are encoded by genes on three loci: The immunoglobulin heavy locus (IGH@) on chromosome 14, containing the gene ...
*  Immunoglobulin heavy chain
Each heavy chain has two regions: a constant region (which is the same for all immunoglobulins of the same class but differs ... immunoglobulin domains but also have a hinge region for added flexibility. Heavy chains μ and ε have a constant region composed ... a variable region that differs between different B cells, but is the same for all immunoglobulins produced by the same B cell ... The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). A typical antibody is ...
*  Eculizumab
It is an immunoglobulin G-kappa (IgGκ) consisting of human constant regions and murine complementarity-determining regions ... grafted onto human framework light and heavy chain variable regions. The compound contains two 448-amino acid heavy chains and ...
*  Fragment crystallizable region
"Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu ... they are constant rather than variable. The Fc region is, therefore, sometimes incorrectly termed the "fragment constant region ... The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors ... IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2-4) in each polypeptide chain. The Fc regions of ...
*  Chromosome 7 (human)
gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively ... protein 196 TRBC1 encoding protein T cell receptor beta constant 1 TRBC2 encoding protein T cell receptor beta constant 2 TRIL ... encoding protein Poliovirus receptor related immunoglobulin domain containing RADIL: ras-associating and dilute domain- ... is designated as the Williams syndrome critical region. This region includes more than 20 genes, and researchers believe that ...