"Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells". J Biol Chem. 276 (19): 16223 ... Int J Biochem Cell Biol. 34 (5): 487-504. doi:10.1016/S1357-2725(01)00156-X. PMID 11906820. "Entrez Gene: ESAM endothelial cell ... Endothelial cell-selective adhesion molecule is a protein that in humans is encoded by the ESAM gene. GRCh38: Ensembl release ... 2002). "A transmembrane tight junction protein selectively expressed on endothelial cells and platelets". J. Biol. Chem. 277 ( ...
"A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains". Nature. 308 (5955): ... T cells expressing this receptor are referred to as α:β (or αβ) T cells, though a minority of T cells express an alternate ... However, T-cell activation on a single cell level can be characterised by a digital switch-like response, meaning the T cell is ... The ability of T cells to ignore healthy cells but respond when these same cells express a small number of foreign pMHCs is ...
Schwaber, J.; Cohen, E. P. (1973). "Human x mouse somatic cell hybrid clone secreting immunoglobulins of both parental types". ... The term "dendritic cell" is coined by Ralph M. Steinman working with Zanvil A. Cohn. The term "Norrmalmstorgssyndromet", ... Steinman, R. M.; Cohn, Z. A. (1973). "Identification of a Novel Cell Type in Peripheral Lymphoid Organs of Mice: I. Morphology ... August - Production of monoclonal antibodies involving human-mouse hybrid cells is first described by Jerrold Schwaber. ...
Human x mouse somatic cell hybrid clone secreting immunoglobulins of both parental types. Nature. 1973 Aug 17;244(5416):444-7. ... The hybrid cells continued secretion of mouse immunoglobulin and initiate synthesis and secretion of human immunoglobulin." The ... They fused "mouse myeloma cells secreting immunoglobulin of known specificity and human peripheral blood lymphocytes not ... In 1973 he described, with Edward Cohen, a method of producing antibodies involving human-mouse hybrid cells, or hybridomas. ...
Schwaber J, Cohen EP (August 1973). "Human x mouse somatic cell hybrid clone secreting immunoglobulins of both parental types ... similar to a cancer cell). This mixture of cells is then diluted and clones are grown from single parent cells on microtitre ... is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this ... single cell amplification from various B cell populations and single plasma cell interrogation technologies. Different from ...
1994). "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin ... This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two ... 1996). "A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and ... 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function ...
"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and ... Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene. Killer cell ... 2006). "Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis". Scand. J. Rheumatol. 35 (2): 124-7 ... "Entrez Gene: KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4". Döhring C, Samaridis J ...
"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and ... Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene. Killer cell ... "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". ... 1995). "Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes". J. Immunol. 155 (5): 2306-10. PMID ...
1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- ... Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene. Killer cell ... "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". ... "Entrez Gene: KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2". Wagtmann N, Biassoni R ...
"Molecular clones of the p58 Natural Killer cell receptor reveal immunoglobulin-related molecules with diversity in both the ... Members of the IgSF family include the human killer cell immunoglobulin-like receptor (KIR) and the Immunoglobulin-like ... Because NK cells target self cells, they have an intricate mechanism by which they differentiate self and non-self cells in ... Because natural killer cells target virally infected host cells and tumor cells, inhibitory KIR receptors are important in ...
... but is the same for all immunoglobulins produced by the same B cell or B cell clone. The variable domain of any heavy chain is ... The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In human genome, the IgH ... There are five types of mammalian immunoglobulin heavy chain: γ, δ, α, μ and ε. They define classes of immunoglobulins: IgG, ... Cell. 153 (6): 1379-93. doi:10.1016/j.cell.2013.04.049. PMC 4007204. PMID 23746848. Fish heavy chain and light chain genes[full ...
A new technology allowed for heavy and light chain immunoglobulin genes to be amplified from human B cells and cloned into ... In 2008, this method was refined with a greater ability to sort cells and clone, which led to the discovery of more human ... In order to find the moment when most antitoxins in the blood cells of the horses is produced, frequent blood samples were ... Above the rouleaux formation which contained the red blood cells, the serum was visible. The color of the serum varied from ...
Striebich CC, Falta MT, Wang Y, Bill J, Kotzin BL (October 1998). "Selective accumulation of related CD4+ T cell clones in the ... Wang X, Stollar BD (November 1999). "Immunoglobulin VH gene expression in human aging". Clinical Immunology. 93 (2): 132-42. ... Mahoney JA, Ntolosi B, DaSilva RP, Gordon S, McKnight AJ (March 2001). "Cloning and characterization of CPVL, a novel serine ... "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ ...
"Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in ... Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals ... family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell ... Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D (Jul 2001). "The cell polarity protein ...
Boles KS, Mathew PA (Feb 2001). "Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 ... Murphy JJ, Hobby P, Vilarino-Varela J, Bishop B, Iordanidou P, Sutton BJ, Norton JD (Feb 2002). "A novel immunoglobulin ... The surface antigen CD319 (SLAMF7) is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma. In ... Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC". Frontiers in Bioscience. ...
From 2001 to 2003, Jones positionally cloned the T-cell immunoglobulin mucin (TIM) gene family and demonstrated the genetic ... McIntire, Jennifer Jones (2001). Identification of Tapr, a T cell and Airway Phenotype Regulatory locus, and positional cloning ... Her doctoral advisor was Dale Umetsu [Wikidata]. Jones' dissertation in 2001 was titled, Identification of Tapr, a T cell and ... Cell biologists, American molecular biologists, Women molecular biologists, Women oncologists, Cancer researchers). ...
"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and ... Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene. Killer-cell ... "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". ... "Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1". Boyson JE, Erskine R, ...
1996). "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, ... Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It ... "Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell ... Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ...
"Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas". Proc. ... Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... 1988). "Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes". ... "Entrez Gene: IGHM immunoglobulin heavy constant mu". Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing ...
... a group of genetically identical eosinophils derived from a significantly mutated ancestor cell. The clone may prove to be ... IgG4-related disease or Immunoglobulin G4-related disease is a condition dacryoadenitis, sialadenitis, lymphadentitis, and ... CD7 positive T cells, CD3 negative, CD4 positive T cells, or CD3 positive, CD4 negative, CD8 negative T cells) and is thought ... These cytokines may be released by the diseased cells or the diseased cells may cause the release of these cytokines by non- ...
It plays an essential role in the final differentiation of B cells into immunoglobulin-secreting cells, as well as inducing ... cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal. 10 (10): 2821-32. doi:10.1002/ ... Interleukin 8 is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells ... T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, ...
... immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model". J. Virol. 75 (23 ...
Synthetic (recombinant or cell-clone) human immunoglobulins can now be made, and for several reasons (including the risk of ... known as antibodies or immunoglobulins. This was first performed (and is still sometimes performed) by taking blood from a ...
... cells and screened for clones with useful properties like high binding specificity. The selected protein is multiplied in ... and the hinge region of an immunoglobulin G1 (IgG1). Genetically modified cells produce SMIPs as antibody-like dimers, which ... They are largely built from parts of antibodies (immunoglobulins), and like them have a binding site for antigens that could be ... A large number of different hinge regions and effector domains are taken from libraries of immunoglobulins, and the combined ...
... immunoglobulins derived from the same B lymphocyte clone, propagated in continuous cell lines Biomedicines: obtained from ...
Myeloma is a malignancy of plasma cells. Plasma cells produce immunoglobulins, which are commonly called antibodies. There are ... When someone has myeloma, a malignant clone, a rogue plasma cell, reproduces in an uncontrolled fashion, resulting in ... A myeloma protein is an abnormal antibody (immunoglobulin) or (more often) a fragment thereof, such as an immunoglobulin light ... When there is a malignant clone, there is usually overproduction of a single antibody, resulting in a "spike" on the normal ...
"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for ... immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is ... Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), ... "Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3". Jones DC, Kosmoliaptsis ...
"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for ... Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene. This ... 2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition". Blood. ... The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin ...
"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for ... The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a ... and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells". European ... Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene. This ...
"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for ... and KIR2DL4 in antigen presenting cells, NK cells, and T cells". FASEB Journal. 19 (6): 662-4. doi:10.1096/fj.04-1617fje. PMID ... March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature ... The expression of LILRB4 on monocytic myeloid leukemia cells supports infiltration and inhibits T cell proliferation. Multiple ...
"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for ... March 2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nature ... "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Human ... The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a ...