Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci U S A. 2004;101: ... The research group of Sollid identified the sequence of immunodominant gluten peptides recognized by T cells of celiac disease ... the group of Chaitan Khosla he solved the x-ray crystal structure of HLA-DQ2.5 with a bound deamidated gluten T-cell epitope. ...

Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of ...

In the absence of the immunodominant head domain, isolated portions of the HA stalk that include the FI6 epitope and have ... Using protein engineering and adjuvants to focus the immune system on the FI6 epitope may be the critical next step along the ... A more important clinical implication of this work is the identification of a universal neutralizing epitope in the HA stalk at ... we would first have to determine whether the influenza virus could quickly mutate the epitope targeted by FI6 and escape ...

... immunodominant epitopes MeSH D23.050.550.750 - immunoglobulin idiotypes MeSH D23.050.705.115 - antigens, human platelet MeSH ... epitopes, b-lymphocyte MeSH D23.050.550.402 - epitopes, t-lymphocyte MeSH D23.050.550.480 - haptens MeSH D23.050.550.480.097 - ...

"Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to ... April 1994). "T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from ... "Defective presentation of MHC class I-restricted cytotoxic T-cell epitopes in Burkitt's lymphoma cells". Int. J. Cancer. 68 (2 ...

Mapping of immunodominant regions in antigens or whole proteomes Seromarker discovery Monitoring of clinical trials Profiling ... A peptide microarray (also commonly known as peptide chip or peptide epitope microarray) is a collection of peptides displayed ... 2009). "Development of a novel peptide microarray for large-scale epitope mapping of food allergens". Journal of Allergy and ... 2011). "Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals". Journal of ...

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A ... Pastan has developed methods to make active RITs in which the major B cell and T cell epitopes have been identified and ... Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. ...

An immunodominant >900 kDa protein, known as GP900, localizes to the apical end of sporozoites and in micronemes of merozoites ... In vitro, hyperimmune sera, as well as antibodies directed at specific epitopes on the GP900 protein, inhibit the invasion of C ... Many are immunodominant, and antibodies against select domains block invasion of host cells.[citation needed] "DPDx - ...

2020). "Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma". PLOS ONE. 15 (9): e0238089. Bibcode: ... October 2020). "Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients". Cellular & ... November 2020). "Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity". Science. ... June 2020). "Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients". ...

The amino-acid sequence of CSP consists of an immunodominant central repeat region flanked by conserved motifs at the N- and C ... amino acid sequence of repetitive epitope". Science. 225 (4662): 628-630. doi:10.1126/science.6204384. ISSN 0036-8075. PMID ... "Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium ...

DNA Cloning of Plasmodium falciparum Circumsporozoite Gene: Amino Acid Sequence of Repetitive Epitope. V Enea, J Ellis, F ... 1988 Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to ...

... but yet maintains the epitopes present in this immunogenic protein. Other relevant virulence genes regulated by PhoP are ... tuberculosis is their ability to keep the genetic repertoire encoding immunodominant antigens absent in BCG., whereas ...

Shimoda S, Nakamura M, Ishibashi H, Hayashida K, Niho Y (1995). "HLA DRB4 0101-restricted immunodominant T cell autoepitope of ... Kobayashi H, Kokubo T, Takahashi M, Sato K, Miyokawa N, Kimura S, Kinouchi R, Katagiri M (1998). "Tyrosinase epitope recognized ...

The procedure of identifying an antibody's binding sites (epitopes) on the target protein is referred to as "epitope mapping." ... creation of quick serodiagnostic tests and efficient vaccines is made possible by the identification of certain immunodominant ... Maier RH, Maier CJ, Rid R, Hintner H, Bauer JW, Onder K (April 2010). "Epitope mapping of antibodies using a cell array-based ... Due to their various epitopes, antibodies have gained interest in both basic and clinical research. The foundation of antibody ...

Neutralizing antibodies target epitopes on the receptor-binding domain. Most COVID-19 vaccine development efforts in response ... "The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS- ... Its extensive glycosylation can serve as a glycan shield that hides epitopes from the immune system. Due to the outbreak of ... Antibodies to the SARS-CoV and SARS-CoV-2 spike proteins have been identified that target epitopes on the receptor-binding ...

Portner A, Scroggs RA, Naeve CW (April 1987). "The fusion glycoprotein of Sendai virus: sequence analysis of an epitope ... but has inserted sequence encoding immunodominant antigen of Mycobacterium tuberculosis. The safety and immunogenicity of this ... Macher BA, Beckstead JH (1990-01-01). "Distribution of VIM-2 and SSEA-1 glycoconjugate epitopes among human leukocytes and ...