*  Immunodominance
The immunodominant epitope will be a BCR that has a particular 'goldilocks' amount of affinity for its epitope determined by ... where immunodominant epitopes will curtail immune responses against non-dominant epitopes. Antigen-presenting cells such as ... As the immunodominant epitope is mutated and/or lost in the cancer, the immune response no longer has Immunodominance also has ... Immunodominant epitopes vary from person to person. This phenomenon is due to the variability of HLA types, which make up the ...
*  Tropheryma whipplei
Liang Z, La Scola B, Raoult D (January 2002). "Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei". Clin. ...
*  Dipeptidyl peptidase-4
"On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease". Advances in ...
*  Molecular mimicry
From these examples, it is clear that the search for candidate mimic epitopes must extend beyond the immunodominant epitopes of ... This is also known as "cross-reactivity" between self antigen of the host and immunodominant epitopes of the pathogen. An ... The prerequisite for molecular mimicry to occur is thus the sharing of the immunodominant epitope between the pathogen and the ... Either the linear amino acid sequence or the conformational fit of the immunodominant epitope may be shared between the ...
*  IFI30
... of γ-Interferon-inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes ...
*  FOXE3
2010). "The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead ...
*  POLR3C
Kuwana M, Kimura K, Kawakami Y (2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by ...
*  Ruth Sonntag Nussenzweig
"TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite ... "Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites." Vaccine. 2011 Oct 6;29( ...
*  Antigen
T cell responses typically are directed against a relatively few immunodominant epitopes, although in some cases (e.g., ... Antigenic escape Antitoxin Conformational epitope Epitope Linear epitope Magnetic immunoassay Neutralizing antibody Original ... Using the "lock and key" metaphor, the antigen can be seen as a string of keys (epitopes) each of which matches a different ... Immunodominant antigens - Antigens that dominate (over all others from a pathogen) in their ability to produce an immune ...
*  Dihydrolipoyl transacetylase
Recent evidence has suggested that peptides within the catalytic site may present the immunodominant epitopes recognized by the ... Braun S, Berg C, Buck S, Gregor M, Klein R (Feb 2010). "Catalytic domain of PDC-E2 contains epitopes recognized by ... These antibodies are detectable in the sera of PBC patients and vary greatly with regards to epitope specificity from patient ... "Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic ...
*  Hsp90
Prediction and validation of the immunodominant epitope/s of HSP90 beta protein has been demonstrated using sera from infertile ... A polyclonal antibody generated to the immunodominant epitope- EP6 confirms similar biochemical and cellular immunoreactivity ... The decapeptide EP6 (380-389)is a major immunogenic epitope of HSP90 followed by EP1 (1-12) and EP8 (488-498). Knowledge of ... The study might generate new tools for the detection of disease-inducing epitopes and a possible therapeutic intervention. ...
*  West Nile fever
Hall, RA; Broom AK; Hartnett AC; Howard MJ; Mackenzie JS (February 1995). "Immunodominant epitopes on the NS1 protein of MVE ...
*  HLA-DO
... and β-subunits which interacts with HLA-DM in order to fine tune immunodominant epitope selection. As elucidated by studies ... "A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for ...
*  Collagen, type XVII, alpha 1
Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of ...
*  List of MeSH codes (D23)
... immunodominant epitopes MeSH D23.050.550.750 --- immunoglobulin idiotypes MeSH D23.050.705.115 --- antigens, human platelet ... epitopes, b-lymphocyte MeSH D23.050.550.402 --- epitopes, t-lymphocyte MeSH D23.050.550.480 --- haptens MeSH D23.050.550.480. ...
*  Antigen-presenting cell
These epitopes are termed immunodominant. APCs naturally have a role in fighting tumors, via stimulation of B and cytotoxic T ... The internalized antigen is digested into smaller peptides containing epitopes, which are then presented to T cells by the MHC ... In MHC class I and class II molecules, only certain epitopes of an internalized peptide can be presented. ...
*  Deepak T. Nair
Crystal structure of an antibody bound to an immunodominant peptide epitope: novel features in peptide-antibody recognition. J ... be a convergence of both epitope and paratope conformations in an antibody response against a flexible immunodominant epitope ( ... Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response. J Immunol. 2002 Mar 1; ... a computational analysis of the conformational propensities of native and retro-inverso versions of B-cell and T-cell epitopes ...
*  Malaria vaccine
It also does not contain any immunodominant T-cell epitopes.[citation needed] In 2015, researchers used a repetitive antigen ... display technology to engineer a nanoparticle that displayed malaria specific B cell and T cell epitopes. The particle ...
*  Allen Steere
This outcome has been associated with an immunodominant T cell epitope of outer-surface protein A (OspA) of the spirochete. ...
*  DNA vaccination
CTL responses can be raised against immunodominant and immunorecessive CTL epitopes, as well as subdominant CTL epitopes, in a ... This may prove to be a useful tool in assessing CTL epitopes and their role in providing immunity. Cytotoxic T-cells recognise ... Strings of minigenes (or MHC class I epitopes) from different pathogens raise cytotoxic T-cell responses to some pathogens, ... However, DNA immunization-induced antibodies show greater affinity to native epitopes than recombinant protein-induced ...
*  Ira Pastan
Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A ... Pastan has developed methods to make active RITs in which the major B cell and T cell epitopes have been identified and ... Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. ...
*  HLA-A11
"Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to ... April 1994). "T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from ... "Defective presentation of MHC class I-restricted cytotoxic T-cell epitopes in Burkitt's lymphoma cells". Int. J. Cancer. 68 (2 ...
*  MAGEA3
2003). "Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen ... 2006). "A newly identified MAGE-3-derived, HLA-A24-restricted peptide is naturally processed and presented as a CTL epitope on ...
*  HLA-DQ2
The immunodominant site for DQ2.5 is on α2-gliadin. The site is a protease resistant 33mer that has 6 overlapping DQ2.5 ... Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM (July 2005). "Refining the rules of gliadin T cell epitope ... DQ2.2 however can present less pathogenic epitopes such as proteolytic peptides of gamma-gliadin. This appears to be the ... "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease". Proc Natl Acad Sci USA. 101 (12): ...
*  FI6 (antibody)
In the absence of the immunodominant head domain, isolated portions of the HA stalk that include the FI6 epitope and have ... Using protein engineering and adjuvants to focus the immune system on the FI6 epitope may be the critical next step along the ... A more important clinical implication of this work is the identification of a universal neutralizing epitope in the HA stalk at ... we would first have to determine whether the influenza virus could quickly mutate the epitope targeted by FI6 and escape ...
*  Peptide microarray
Mapping of immunodominant regions in antigens or whole proteomes Seromarker discovery Monitoring of clinical trials Profiling ... A peptide microarray (also commonly known as peptide chip or peptide epitope microarray) is a collection of peptides displayed ... 2009). "Development of a novel peptide microarray for large-scale epitope mapping of food allergens". Journal of Allergy and ... 2011). "Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals". Journal of ...