Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in ... "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern ...

... degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance". Immunity. ... Moreover recognition of phosphatidylserine also helps to control adaptive immune system by clearing phosphatidylserine ... which leads to reduced antigen presentation leading to increased toleration of tumor by the immune system. Therefore there are ... "Bimodal regulation of T cell-mediated immune responses by TIM-4". International Immunology. 20 (5): 695-708. doi:10.1093/intimm ...

The tolerance that immune cells normally have to host tissues can be lost, resulting in permanent damage to host cells. Studies ... Blocking antibodies have been described as a mechanism for HSV-1 to evade the immune system. Blocking antibodies can be used in ... Media related to Blocking antibodies at Wikimedia Commons (Commons category link is on Wikidata, Immune system, Reagents for ... These new treatments are not without side-effects and immune-related adverse events have been observed in a variety of patients ...

Abnormalities in the maternal immune system and insufficiency of gestational immune tolerance seem to play major roles in pre- ... As natural killer cells are intimately involved in placentation and placentation involves a degree of maternal immune tolerance ... seemed to lack sufficient levels of the seminal immune factors necessary to induce immunological tolerance in their partners. ... Immune factors may also play a role. Testing for pre-eclampsia is recommended throughout pregnancy via measuring a woman's ...

These have included publications on induction of secretory immune responses, oral tolerance and on immunological aspects of the ... "Salivary Antibodies and Systemic Tolerance in Mice after Oral Immunization with Bacterial Antigens", Annals of the New York ... Challacombe, S J; Tomasi, T B (1 December 1980). "Systemic tolerance and secretory immunity after oral immunization" (PDF). ...

... and altered immune tolerance. There is limited evidence to guide possible approaches to reducing autumn exacerbations, but ... Many of these genes are related to the immune system or modulating inflammation. Even among this list of genes supported by ... Psychological stress may worsen symptoms - it is thought that stress alters the immune system and thus increases the airway ... There may also be involvement of other components of the immune system, including cytokines, chemokines, histamine, and ...

Furthermore, expression of TGF-β is also correlated with immune tolerance and may help shield cancer cells from immune ...

... inducing active gestational immune tolerance. There are significantly improved outcomes when women are exposed to seminal ...

In the intestinal tract the immune system must have tolerance to the normal intestinal flora, yet respond to pathogenic ... Immune cells as well as lymphoid tissue, including lymphoid nodules and capillaries, may be present. Smooth muscle fibers may ... The lamina propria's richness in macrophages and lymphoid cells makes it a key place for immune responses to occur. It forms ... Because the epithelium is often under external stress and is somewhat delicate, the lamina propria hosts many immune cells. ...

He won a Nobel Prize in 1960 for predicting acquired immune tolerance and he developed the theory of clonal selection. Burnet ... Burnet noted that his contributions to immune tolerance were strictly theoretical: My part in the discovery of acquired ... immune tolerance and somatic hypermutation as a mechanism in antibody production. The clonal selection theory became one of the ... and by extension the idea of immune tolerance. He proposed that if in embryonic life expendable cells from a genetically ...

Injections with GAD65 in ways that induce immune tolerance have been shown to prevent type 1 diabetes in rodent models. In ... Dalakas MC, Fujii M, Li M, Lutfi B, Kyhos J, McElroy B (December 2001). "High-dose intravenous immune globulin for stiff-person ... Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO (November 1993). "Immune response to glutamic acid decarboxylase ... "Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes". Nature. 366 (6450): ...

Her major scientific contributions are in the areas of T cell immune tolerance, T cell memory and development of ...

... is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance". FEBS Lett. 579 (3 ... "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins ... and axotrophin/MARCH-7 in transplantation tolerance". Int. Immunopharmacol. 6 (13-14): 1993-2001. doi:10.1016/j.intimp.2006.09. ...

This expanded immune tolerance persists in both mother and offspring after birth and allows microchimeric cells to be retained ... After giving birth, about 50-75% of women carry fetal immune cell lines. Maternal immune cells are also found in the offspring ... Moreover, fetal immune cells have also been frequently found in breast cancer stroma as compared to samples taken from healthy ... These changes in immune responses during pregnancy extend to maternal components specific to fetal antigens, because of feto- ...

... being studied is in altering the protein structure of the allergen to decrease immune response but still induce tolerance. ... For example, drugs that inhibit IgE-mediated signaling pathways can be used in addition to OIT to reduce immune response. In 1 ... FAHF-2, a Chinese herbal mixture, has shown positive effects on the immune system and has been shown to protect mice from ... In desensitization immunotherapy the aim is to induce or restore tolerance to the allergen by reducing its tendency to induce ...

As a researcher his main lines are immunopathogenesis of diffuse connective tissue diseases, immune tolerance and autoimmunity ...

... a potential immune tolerance-escaping factor. Anti-mitochondrial, anti-centromere and anti-p62 antibodies are also found in ( ...

Nevertheless, it was found, that application of some HSPs into patients is able to induce immune tolerance and treat autoimmune ... But gp96 immune function could be peptide-independent, because it is involved in proper folding of many immune receptors, like ... With the exception of SRA, which down-regulates immune response. Heat-shock proteins can be secreted from immune cells or ... It was used in autologous manner in clinical studies for gp96 and hsp70, but in vitro this works for all immune-relevant HSPs. ...

In addition, they have been found to secrete chemokines that alter the immune response and promote tolerance of the new tissue ... Destruction of the immune system by the HIV is driven by the loss of CD4+ T cells in the peripheral blood and lymphoid tissues ... However, the immune system is vulnerable to degradation upon the pathogenesis of disease, and because of the critical role that ... The transplanted cells also generate an immune response that helps to kill off the cancer cells; this process can go too far, ...

... sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to ... The immune response varies among the gut regions. The immune deficiency (IMD) pathway responds to bacterial infections and is ... In aged animals, immune responses may over-shoot, possibly harming the host and favoring colonization with pathogens (e.g. ... In the middle and posterior midgut, other genes such as the receptor PGRP-LB, which down-regulates the IMD immune response, are ...

... putting a higher demand on gestational immune tolerance in order to avoid an immune reaction toward the fetus. Some mice ... Methods to artificially stimulate gestational immune tolerance towards a xeno-fetus include intercurrently introducing a ... However, other mice experiments indicate that an immune response towards xeno-fetuses does not belong to classical cytotoxic T ... On the other hand, immune suppression with ciclosporin has shown no effect for this purpose. Pre-transfer immunization with ...

This self-tolerance means that lymphocytes should not incite an immune response against human cellular antigens. Sometimes, ... This defence mechanism produces antibodies (large glycoproteins) in response to an immune stimulus. Many cells of the immune ... The immune response to RNP may be caused by the presentation of the nuclear components on the cell membrane in apoptotic blebs ... These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to ...

Dendritic cells also play a role in peripheral tolerance, which contributes to prevention of auto-immune disease. Prior to ... den Haan JM, Arens R, van Zelm MC (December 2014). "The activation of the adaptive immune system: cross-talk between antigen- ... Antigen-presenting cells are vital for effective adaptive immune response, as the functioning of both cytotoxic and helper T ... Some cancer therapies involve the creation of artificial APCs to prime the adaptive immune system to target malignant cells. ...

HDFN represents a breach of immune privilege for the fetus or some other form of impairment of the immune tolerance in ... "Acute hemolytic transfusion reactions may be either immune-mediated or nonimmune-mediated. Immune-mediated hemolytic ... It works by binding any fetal red blood cells with the D antigen before the mother is able to produce an immune response and ... Immune-mediated hemolytic reactions caused by IgG, Rh, Kell, Duffy, or other non-ABO antibodies typically result in ...

... of an immune reaction towards the embryo or fetus that could otherwise arise from insufficient gestational immune tolerance. ... She may also provide immune protection against diseases by passing of IgG antibodies to the embryo or fetus. Artificial supply ...

The goal is to activate the immune cells by lifting self-tolerance checkpoints that are restraining T cells to attack tumor ... Most of them are targeting immune checkpoints (CTLA-4, PD1/PD-L1, ...) . The only oligoclonal antibody treatment against immune ... Targeting immune cells regulation checkpoints : inhibition of T regulatory cells downregulatory effects (e.g. using antagonist ... 1982: Combination of two antibodies to enhance the immune response against viruses. 2000's: Several research teams came up with ...

A common feature of immune factors in causing recurrent pregnancy loss appears to be a decreased maternal immune tolerance ... Williams Z (September 2012). "Inducing tolerance to pregnancy". The New England Journal of Medicine. 367 (12): 1159-61. doi: ... However, in vitro fertilization does not improve maternal-fetal tolerance imbalances.[citation needed] There is significant, ...

MHC class II thus mediates immunization to-or, if APCs polarize Th0 cells principally to Treg cells, immune tolerance of-an ... In a transplant procedure, as of an organ or stem cells, MHC molecules themselves act as antigens and can provoke immune ... MHC is the tissue-antigen that allows the immune system (more specifically T cells) to bind to, recognize, and tolerate itself ... The presentation of pathogen-derived proteins results in the elimination of the infected cell by the immune system. Diversity ...

Bluestone headed the Immune Tolerance Network,[needs update][third-party source needed] a consortium of over 1000 scientists to ... and as a leader of the well-known Immune Tolerance Network. But Bluestone is also well known in the business world, having ... as Director of the Immune Tolerance Network. In June 2008 Dr. Bluestone served as interim vice chancellor of research... In ... San Francisco Diabetes Center and the Immune Tolerance Network and is AW and Mary Clausen Distinguished Professor of Medicine, ...

... intended to break immune tolerance to certain disease specific proteins. It is hypothesized that receptor mediated uptake of ... Initial clinical results for Provenge in 2000 showed immune responses supporting the expected mode-of-action, as well as a PSA ... Dendreon has explored approaches to obtaining tumour-specific antigen targets under the theory that the immune system may be ... The company successfully brought to market the first approved cell-based immune therapy, Provenge, for the treatment of ...