*  Immune tolerance
... Network International Conference on Immune Tolerance Immune tolerance at the US National Library of Medicine ... Immune tolerance is important for normal physiology. Central tolerance is the main way the immune system learns to discriminate ... Immune tolerance, or immunological tolerance, or immunotolerance, is a state of unresponsiveness of the immune system to ... see Immune response). Tolerance is classified into central tolerance or peripheral tolerance depending on where the state is ...
*  Short course immune induction therapy
Immune tolerance is maintained by central and peripheral tolerance. During central tolerance, T-cells are selected in the ... Immune tolerance can be defined as the ability of the immune system to distinguish between self and non-self, or harmless and ... While autoimmunity is thought to result from the breakdown of central and peripheral tolerance, an undesirable immune responses ... These strategies employed the use of soluble peptide tolerance and oral peptide tolerance to great efficacy in experimental ...
*  Immune tolerance in pregnancy
... or gestational/maternal immune tolerance is the absence of a maternal immune response against (in ... and a chronic insufficient tolerance may cause infertility. Other examples of insufficient immune tolerance in pregnancy are Rh ... The increased immune tolerance is believed to be a major contributing factor to an increased susceptibility and severity of ... immune tolerance towards) the fetus and placenta during pregnancy, which thus may be viewed as unusually successful allografts ...
*  Phagocyte
CS1 maint: Multiple names: authors list (link) Steinman, Ralph M. (2004). "Dendritic Cells and Immune Tolerance". The ... The first type of tolerance is central tolerance, that occurs in the thymus. T cells that bind (via their T cell receptor) to ... The second type of immunological tolerance is peripheral tolerance. Some self reactive T cells escape the thymus for a number ... This process is called tolerance. Dendritic cells also promote immunological tolerance, which stops the body from attacking ...
*  Regulatory T cell
The contribution of these populations to self-tolerance and immune homeostasis is less well defined. Foxp3 can be used as a ... Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008). "Regulatory T cells and immune tolerance". Cell. 133 (5): 775-87. doi:10.1016 ... The immune system must be able to discriminate between self and non-self. When self/non-self discrimination fails, the immune ... Sakaguchi S (2004). "Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune ...
*  Clonal deletion
It is one method of immune tolerance. Frank Macfarlane Burnet proposed autoreactive cells would be terminated before maturation ... Thus, the host develops a tolerance for this antigen, or a self tolerance. B and T lymphocytes are tested for their affinity ... Central tolerance prevents B and T lymphocytes from reacting to self. Thus, clonal deletion can help protect individuals ... This prevents recognition and destruction of self host cells, making it a type of negative selection or central tolerance. ...
*  Andrew Stimpson
... this is a type of immune tolerance. The more specific and sensitive RT-PCR test for HIV's genome does not appear to have been ...
*  History and naming of human leukocyte antigens
For more information please see immune tolerance). Where this goes wrong is when tissues are transferred to another person. ... In generating an immune response to an antigen, the B-cells go through a process of maturation, from surface IgM production, to ... These cells were later found to be one of two types of immune cells, the T-cells (named for their origin, the thymus). The ... The biggest weakness in Burnet's theory was that he had no explanation for how the body selected for immune cells that only ...
*  AOAH
Lu M, Varley AW, Munford RS (2013). "Persistently active microbial molecules prolong innate immune tolerance in vivo". PLOS ... 2012). "Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA ... The LPS-exposed mice develop strikingly high titers of polyclonal antibodies, prolonged hepatomegaly, and innate immune " ... "tolerance" that gives them slow and inadequate responses to bacterial challenge. AOAH has been highly conserved through ...
*  Kari Nadeau
Nadeau's laboratory is working on scientific investigations of immune tolerance. Areas of research include: Primary immune ... During this time, she also did a postdoctoral fellowship in human immune tolerance mechanisms in asthma and allergy.[citation ... NIH 2014 National Scientific Committee of the Immune Tolerance Network, NIH 2015 Elected into American Society of Clinical ... Environmental effects on tolerance - Ambient air pollution, specifically polycyclic aromatic hydrocarbons found in diesel ...
*  Java mouse-deer
Once acquired, individuals with BVDV can gain lifelong immune tolerance. Java mouse-deer is currently categorized as "Data ...
*  C. Garrison Fathman
Co-Chairman of the Autoimmunity Committee of the Immune Tolerance Network; Naomi M. Kanof Award for Distinguished Achievement ... He was instrumental in helping develop the Human Immune Monitoring Center at Stanford University. Dr. Fathman received his M.D ... The Human Immune Monitoring Center - Research - Institute for Immunity, Transplantation and Infection - Stanford University ... Chairman NIH Immunological Sciences and Hyper-accelerated Award/Mechanisms in Immune Disease Study Sections, HHMI Review Panel ...
*  Rupert E. Billingham
Together they demonstrated immune tolerance as proposed by Frank Macfarlane Burnet. Burnet and Medawar received the Nobel Prize ...
*  Rh disease
It may thus be regarded as insufficient immune tolerance in pregnancy. Generally rhesus disease becomes worse with each ... Fetal blood (or umbilical cord blood) The direct Coombs test is used to confirm that the fetus or neonate has an immune ... The use of Rh immune globulin to prevent the disease in babies of Rh negative mothers has become standard practice, and the ... The mother has an intramuscular injection of anti-Rh antibodies (Rho(D) immune globulin). This is done so that the fetal rhesus ...
*  Walter and Eliza Hall Institute of Medical Research
Macfarlane developed the ideas of clonal selection and acquired immune tolerance. Later, Professor Donald Metcalf discovered ... with its scientists making important discoveries in the control of immune system responses, cell cycle regulation and malaria. ... that he was awarded the Nobel Prize for Medicine in 1960 with Sir Peter Medawar for the discovery of immunological tolerance. ...
*  Immunotherapy
Immune tolerance therapies seek to reset the immune system so that the body stops mistakenly attacking its own organs or cells ... Immune suppression dampens an abnormal immune response in autoimmune diseases or reduces a normal immune response to prevent ... "The immune tolerance network: a new paradigm for developing tolerance-inducing therapies". The Journal of Allergy and Clinical ... Other drugs modulate immune responses. The body naturally does not launch an immune system attack on its own tissues. ...
*  Pregnancy
The main reason for this success is increased immune tolerance during pregnancy. Immune tolerance is the concept that the body ... 1-4. doi:10.1007/0-387-34944-8. ISBN 978-0-387-34944-2. Williams, Zev (2012-09-20). "Inducing Tolerance to Pregnancy". New ... This is from factors including underdeveloped lungs of newborns, infection due to underdeveloped immune system, feeding ... is able to not mount an immune system response against certain triggers. Pregnancy is typically broken into three periods, or ...
*  Cancer immunology
Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM (Oct 2002). "Immune tolerance after delivery of dying cells to ... Kim R, Emi M, Tanabe K (May 2007). "Cancer immunoediting from immune surveillance to immune escape". Immunology. 121 (1): 1-14 ... He reasoned, the immune system would be able to play a factor via a 'bystander effect' in eradicating chemotherapy-resistant ... Syn, Nicholas L; Teng, Michele W L; Mok, Tony S K; Soo, Ross A. "De-novo and acquired resistance to immune checkpoint targeting ...
*  Type 1 regulatory T cells (Tr1 cells)
... a new mechanism of peripheral immune tolerance". Cellular & Molecular Immunology. 12 (5): 566-571. doi:10.1038/cmi.2015.44. ... The suppressing and tolerance-inducing effect of Tr1 cells is mediated mainly by cytokines. The other mechanism as cell to cell ... Cytolysis indirectly suppresses immune response by reducing numbers of myeloid-origin antigen presenting cells. Tr 1 cells are ... Tr1 cells are self or non-self antigen specific and their key role is to induce and maintain peripheral tolerance and suppress ...
*  Thymocyte
2015) Fezf2 Orchestrates a Thymic Programs of Self-Antigen Expression for Immune Tolerance. Cell 163, 975 - 987 Thymus ... If these peripheral tolerance mechanisms also fail, autoimmunity may arise. Thymus transplantation results in that T cells are ... If T cells bearing these T cell receptors were to enter the periphery, they would be capable of activating an immune response ... Additional mechanisms of peripheral tolerance active in the periphery exist to silence these cells such as anergy, deletion, ...
*  Sandra Saouaf
"Mechanisms of peripheral immune tolerance: Conversion of the immune to the unresponsive phenotype". Immunologic Research. 28 (3 ... December 1990). "Mechanisms of Autoimmunity in the Context of T-Cell Tolerance: Insights from Natural and Transgenic Animal ... Gupta, Sudhir; Paul, William E.; DeFranco, Anthony; Perlmutter, Roger (2013). Mechanisms of Lymphocyte Activation and Immune ...
*  Testicle
Mature sperm (and their antigens) arise long after immune tolerance is established in infancy. Therefore, since sperm are ... The function of the blood-testis barrier (red highlight in diagram above) may be to prevent an auto-immune reaction. ... Thus, the blood-testis barrier may reduce the likelihood that sperm proteins will induce an immune response, reducing fertility ... Injection of sperm antigens causes inflammation of the testis (auto-immune orchitis) and reduced fertility. ...
*  Furin
Expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin has been shown to interact ... "T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance". Nature. 455 (7210): ...
*  Galectin-1
... is thought to play a role in creating immune tolerance in pregnancy. Galectin-1 is expressed by the endometrial ... Munoz-Suano A, Hamilton AB, Betz AG (May 2011). "Gimme shelter: the immune system during pregnancy". Immunol. Rev. 241 (1): 20- ...
*  Jeanne Lusher
Immune tolerance induction in the treatment of paediatric haemophilia A patients with factor VIII inhibitors. Haemophilia 2000; ... Nephrotic syndrome as a complication of immune tolerance in hemophilia B. Blood 1997;89:1115-6. DiMichele D. Inhibitor ... Lusher, along with other researchers, successfully used recombinant factor VIII concentrates for immune tolerance induction in ... 1- Immune Thrombocytopenic Purpura: Lusher and Zuelzer presented a comprehensive description of the natural history of ITP in ...
*  Gameplay of Stars!
Higher racial tolerances will result in more worlds available for colonization, and that the colonies will generally be more ... and tri-immune-HE. HG emphasises empire size, with high population growth rate and high rates of planet habitability. The Claim ... Each race has a defined tolerance for an environment's gravity, temperature and radiation levels dissimilar to their natural ...
*  John O'Shea (biologist)
2008). "T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance". Nature. 455 ... tolerance and homeostasis in immune cells. The section also studies patients with primary immunodeficiency and autoinflammatory ... O'Shea was awarded two US Patents related to Janus Family Kinases and identification of immune modulators (7,070,972, and ... Ghoreschi, Kamran; Laurence, Arian; o'Shea, John J. (2009). "Janus kinases in immune cell signaling". Immunological Reviews. ...