Loading...
*  Hydroxylation
Proline hydroxylation is also a vital component of hypoxia response via hypoxia inducible factors. In some cases, proline may ... multi-subunit enzymes prolyl 4-hydroxylase, prolyl 3-hydroxylase and lysyl 5-hydroxylase, respectively. These reactions require ... 17α-Hydroxylase Cholesterol 7 alpha-hydroxylase Dopamine β-hydroxylase Phenylalanine hydroxylase Tyrosine hydroxylase Nelson, D ... ISBN 1-57259-153-6.[page needed] Holmgren, Steven K; Bretscher, Lynn E; Taylor, Kimberly M; Raines, Ronald T (1999). "A ...
*  Von Hippel-Lindau tumor suppressor
The most researched of these targets is hypoxia inducible factor 1a (HIF1a), a transcription factor that induces the expression ... In hypoxic conditions, HIF1A subunits accumulate and bind to HIFB. This heterodimer of HIF is a transcription factor that ... In the normal cell with active VHL protein, HIF alpha is regulated by hydroxylation in the presence of oxygen. When iron, 2- ... Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ (April 2003). "Effect of ascorbate on the activity of hypoxia-inducible factor in ...
*  HIF1AN
Dann CE, Bruick RK, Deisenhofer J (2003). "Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl ... alpha subunit inhibitor". Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002). "Asparagine hydroxylation of the HIF ... "Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin ... "Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha". J. ...
*  HIF1A
The human HIF1A gene encodes for the alpha subunit, HIF1A of the transcription factor hypoxia-inducible factor (HIF1). HIF1A ... "Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit ... is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It ... Liu, X (2014). "Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent ...
*  List of MeSH codes (D12.776.930)
... core binding factor alpha 2 subunit MeSH D12.776.930.155.200.300 -- core binding factor alpha 3 subunit MeSH D12.776.930.316. ... hypoxia-inducible factor 1, alpha subunit MeSH D12.776.930.125.750.590 -- myod protein MeSH D12.776.930.125.750.595 -- myogenic ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.155.200.100 -- core binding factor alpha 1 subunit MeSH D12.776. ... nf-e2 transcription factor, p45 subunit MeSH D12.776.930.323.500.500 -- hepatocyte nuclear factor 1-alpha MeSH D12.776.930.323. ...
*  List of MeSH codes (D12.776.260)
... alpha subunit MeSH D12.776.260.103.750.590 -- myod protein MeSH D12.776.260.103.750.595 -- myogenic regulatory factor 5 MeSH ... hypoxia-inducible factor 1, ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.235. ... nf-e2 transcription factor, p45 subunit MeSH D12.776.260.262.500.500 -- hepatocyte nuclear factor 1-alpha MeSH D12.776.260.262. ... hepatocyte nuclear factor 3-alpha MeSH D12.776.260.950.249.750 -- hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 ...
*  Hydroxyproline
Hydroxylation of proline has been shown to be involved in targeting Hypoxia-inducible factor (HIF) alpha subunit (HIF-1 alpha) ... 2001). "Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation". Science. ... Under normoxia (normal oxygen conditions) EGLN1[1] protein hydroxylates the proline at the 564 position of HIF-1 alpha, which ...
*  Hypoxia in fish
Saydur (2007), "Molecular cloning, characterization and expression of two hypoxia-inducible factor alpha subunits, HIF-1α and ... after approximately one week and is therefore likely under genetic control of hypoxia inducible factor hypoxia inducible factor ... Research in mammals has implicated hypoxia inducible factor (HIF) as a key regulator of gene expression changes in response to ... "Evolution and Regulation of the Downstream Gene of Hypoxia-Inducible Factor-1α in Naked Carp (Gymnocypris przewalskii) from ...
*  HIF3A
"Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit". Drevytska T, Gavenauskas B, Drozdovska S, Nosar V, Dosenko V, ... It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At ... hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 ... "Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha". ...
*  EGLN1
Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2), or prolyl hydroxylase domain-containing protein 2 (PHD2), is an enzyme ... In normoxia, HIF alpha subunits are marked for the ubiquitin-proteasome degradation pathway through hydroxylation of proline- ... Ozer A, Wu LC, Bruick RK (2005). "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF ... 2006). "Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger ...
*  EPAS1
... enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ... It is a type of hypoxia-inducible factor, a group of transcription factors involved in body response to oxygen level. The gene ... "Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein". The Journal of ... "A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is ...
*  Pacak-Zhuang syndrome
Mutations in the genes encoding alpha subunits of hypoxia-inducible factors (HIF-alpha) have not previously been identified in ... Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction. J Natl Cancer Inst 2013; 105 ... Ocular Manifestations of Hypoxia-Inducible Factor-2A Paranglioma-Somatostatinoma-Polycythemia Syndrome. J Opthal 2014. DOI: ... neurofibromatosis 1 (NF1), or von Hippel-Lindau (VHL) disease. ...
*  Hypoxia-inducible factors
... family of transcription factors. The alpha and beta subunit are similar in structure and both contain the following domains: N- ... Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular ... "Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases". Current ... Chen H, Li J, Liang S, Lin B, Peng Q, Zhao P, Cui J, Rao Y (March 2017). "Effect of hypoxia-inducible factor-1/vascular ...
*  N-alpha-acetyltransferase 10
... does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF". The Journal of ... N-alpha-acetyltransferase 10 (NAA10) also known as NatA catalytic subunit Naa10 and arrest-defective protein 1 homolog A (ARD1A ... "Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis". Journal of ... inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha ...
*  EGLN2
The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen ... the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this ... 2004). "Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors". J. Cell. Biochem. 92 (3): 491-501. doi:10.1002/jcb ... modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343-9. doi:10.1016/ ...
*  Hydrogen potassium ATPase
... adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes". Pharmacol Res. 76: 157- ... ATP4A ATPase H+/K+ transporting alpha subunit Chourasia, M.; Sastry, G. M.; Sastry. G. N. (2005). "Proton binding sites and ... The H+/K+ ATPase β subunit stabilizes the H+/K+ ATPase α subunit and is required for function of the enzyme. The β subunit ... The α subunit also has a phosphorylation site (Asp385). The gene ATP4B encodes the β subunit of the H+/K+ ATPase, which is an ~ ...
*  HIF-1 alpha IRES
The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of ... "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia ... The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap- ... and hypoxia". Mol Biol Cell. 13 (5): 1792-1801. doi:10.1091/mbc.02-02-0017. PMC 111144 . PMID 12006670. Page for HIF-1 alpha ...
*  EP300
This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in ... "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene ... "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5367- ... "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and ...
*  P4HA2
"The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases". J ... The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer". J Biol Chem. 272 (28): 17342-8. doi: ... a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one ... "Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. ...
*  Procollagen-proline dioxygenase
Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond ... Helaakoski, T; Vuori, K; Myllylä, R; Kivirikko, K. I.; Pihlajaniemi, T (1989). "Molecular cloning of the alpha-subunit of human ... Smith, T. G.; Robbins, P. A.; Ratcliffe, P. J. (2008). "The human side of hypoxia-inducible factor". British Journal of ... Karuppagounder, S. S.; Ratan, R. R. (2012). "Hypoxia-inducible factor prolyl hydroxylase inhibition: Robust new target or ...
*  PSMA7
This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important ... Proteasome subunit alpha type-7 also known as 20S proteasome subunit alpha-4 is a protein that in humans is encoded by the ... As a component of alpha ring, proteasome subunit alpha type-7 contributes to the formation of heptameric alpha rings and ... This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits ...
*  Chromosome 11 (human)
Srp receptor alpha subunit TAF1D: TATA box binding protein associated factor RNA polymerase 1 subunit D TALDO1 encoding protein ... tumor protein 53 inducible protein 11 TRAPPC4: trafficking protein particle complex subunit 4 TRPT1: tRNA 2'-phosphotransferase ... hypoxia upregulated protein 1 IFITM2 encoding protein Interferon induced transmembrane protein 2 IFT46: intraflagellar ... tectorin alpha (nonsyndromic deafness) TH: tyrosine hydroxylase THRSP: thyroid hormone inducible hepatic protein THYN1: ...
*  MTORC1
Under hypoxic conditions, hypoxia inducible factor one alpha (HIF1A) will stabilize and activate transcription of REDD1, also ... Once the initiation complex is assembled at the 5' cap of mRNA, it will recruit the 40S small ribosomal subunit that is now ... Cytokines like tumor necrosis factor alpha (TNF-alpha) can induce mTOR activity through IKK beta, also known as IKK2. IKK beta ... Upon growth factor binding to the adjacent receptor tyrosine kinase, the adaptor protein GRB2 binds with its SH2 domains. This ...
*  Ras subfamily
Roy Blum; yoel kloog (2005). "Ras Inhibition in Glioblastoma Down-regulates Hypoxia-Inducible Factor-1, Causing Glycolysis ... as opposed to other G-domain-containing proteins such as the alpha subunit of heterotrimeric G proteins. Residue 61 is ... Specifically, it is a single-subunit small GTPase, which is related in structure to the Gα subunit of heterotrimeric G proteins ... Ras contains six beta strands and five alpha helices: It consists of two domains, a G domain of 166 amino acids, about 20kDa, ...
*  IDH2
... which accumulates and leads to hypoxia-inducible factor 1α degradation, as well as changes in epigenetics and extracellular ... a partially unraveled alpha helix in the semi open form, and an alpha helix in the active form. The mitochondrial form of IDH2 ... It is a homodimer in which each subunit has a Rossmann fold, and a common top domain of interlocking β sheets. Mtb IDH-1 is ... The mitochondrial form of IDH, like most isoforms, is a homodimer, in which two identical monomer subunits form one unit. The ...
*  Trimeric autotransporter adhesin
... as it activates of NF-κB as well as hypoxia-inducible factor 1. The head domain of BadA is more complex than other TAAs. It is ... Structure: The neck domain is a homotrimer, where three of the same subunits associate. All three subunits are arranged in such ... Hence, the stalk domains can be considered alpha helical coiled-coils that deviate from the standard model due to their unusual ... In essence, they are virulence factors, factors that make the bacteria harmful and infective to the host organism. TAAs are ...
*  Mdm2
"Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha". Genes & Development. 14 (1): ... Bálint E, Bates S, Vousden KH (July 1999). "Mdm2 binds p73 alpha without targeting degradation". Oncogene. 18 (27): 3923-9. doi ... "ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA ... In addition, MDM2 has p53-independent transcription factor-like effects in nuclear factor-kappa beta (NFκB) activation. ...