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*  Hyperalgesia
Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues. Opioid-induced hyperalgesia may ... Where hyperalgesia has been produced by chronic high doses of opioids, reducing the dose may result in improved pain management ... Hyperalgesia can be experienced in focal, discrete areas, or as a more diffuse, body-wide form. Conditioning studies have ... Hyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergic response. This ...
*  Neuropathic pain
Davis AM, Inturrisi CE (1999). "d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia". J. ...
*  TRPV1
This manifests as an increased sensitivity to painful stimuli (hyperalgesia) or pain sensation in response to non-painful ... "Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice". PLoS One. 8 (12): e81228. doi: ... "The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans". ... likewise activate TRPV1 and may thereby contribute to tactile hyperalgesia and allodynia (see Hepoxilin#Pain perception). ...
*  Hyperalgesia (album)
"Victorian Halls released Hyperalgesia @ Bottom Lounge". The Deli Magazine. 19 May 2015. Retrieved 30 June 2017. "Hyperalgesia ... Hyperalgesia is the second full-length studio album by American alternative rock band Victorian Halls from Chicago, Illinois, ...
*  Opioid-induced hyperalgesia
... or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia is a phenomenon ... Opioid-induced hyperalgesia has also been criticized as overdiagnosed among chronic pain patients, due to poor differential ... Ketamine, a NMDA antagonist, has been shown to prevent the extended use of opioid in post-operative hyperalgesia when it is ... "Opioid-Induced Hyperalgesia (OIH)". Revista Brasileira de Anestesiologia. 60: 639-647. DuPen, Anna; Shen, Danny; Ersek, Mary ( ...
*  Brain-derived neurotrophic factor
Shu XQ, Mendell LM (July 1999). "Neurotrophins and hyperalgesia". Proceedings of the National Academy of Sciences of the United ...
*  Opioid
... induced hyperalgesia more commonly occurs with chronic use or brief high doses but some research suggests that it may ... Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity ... Wilson GR, Reisfield GM (2003). "Morphine hyperalgesia: a case report". Am J Hosp Palliat Care. 20 (6): 459-61. doi:10.1177/ ... Side effects such as hyperalgesia and allodynia, sometimes accompanied by a worsening of neuropathic pain, may be consequences ...
*  Rostral ventromedial medulla
Pretreatment with MK-801 significantly reduced SP induced hyperalgesia. Intrathecal MK-801 also blocked hyperalgesia resulting ... Allodynia and hyperalgesia were experimentally induced by administration of CCK into the RVM. Spinal administration of SB- ... Behavioral hyperalgesia in inflammatory pain states is closely correlated with phosphorylation of spinal NMDA receptors. To ... Injection of the CCK-saporin conjugate also reversed allodynia and hyperalgesia in a nerve injury model, producing the same ...
*  EMA401
Increased AT2R activity causes hyperalgesia. AT2R antagonist EMA401 inhibits the downstream effects of AT2R activation, ... both reversing and/or preventing potentiation that causes hyperalgesia. AngII increases neuronal excitability to TRPV1 channel ...
*  Allodynia
Coutaux A, Adam F, Willer JC, Le Bars D (2005). "Hyperalgesia and allodynia: peripheral mechanisms". Joint Bone Spine. 72 (5): ... Allodynia is different from hyperalgesia, an extreme, exaggerated reaction to a stimulus which is normally painful. There are ...
*  Lipoxin
... and inflammation-based pain and hyperalgesia. Lipoxins have protective effects in animal models of infection-based inflammation ...
*  Nociceptor
Normally hyperalgesia ceases when inflammation goes down, however, sometimes genetic defects and/or repeated injury can result ... This is commonly known as hyperalgesia. Inflammation is one common cause that results in the sensitization of nociceptors. ...
*  Opioid rotation
Opioid-induced hyperalgesia Kraychete, Durval Campos; Sakata, Rioko Kimiko. "Use and Rotation of Opioids in Chronic Non- ...
*  Nav1.8
Evidence for a link between PGE2 and hyperalgesia comes from an antisense deoxynucleotide knockdown of Nav1.8 in the DRG of ... Lai J, Porreca F, Hunter JC, Gold MS (2004). "Voltage-gated sodium channels and hyperalgesia". Annual Review of Pharmacology ... Therefore, Nav1.8 contributes to hyperalgesia (increased sensitivity to pain) and allodynia (pain from stimuli that do not ... hyperalgesia). The increased levels of nerve growth factor and tumour necrosis factor-α (TNF-α) causes the upregulation of ...
*  SIB-1757
It has anti-hyperalgesia effects in animals. SIB-1757 along with other mGluR5 antagonists has been shown to have ...
*  Sérgio Henrique Ferreira
His studies on the basic mechanisms involved in the development of inflammatory hyperalgesia led to the discovery that a select ... II-Prostaglandins hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. ... Bradykinin initiates cytokine mediated inflammatory hyperalgesia. Brazilian Journal of Pharmacological Sciences. vol. 110, p. ... group made a relevant contribution to the role of bradykinin and of cytokines in the development of inflammatory hyperalgesia. ...
*  Failed back syndrome
Sommer C, Schäfers M, Marziniak M, Toyka KV (June 2001). "Etanercept reduces hyperalgesia in experimental painful neuropathy". ...
*  Algophobia
People suffering from this probably have hyperalgesia. The Fear of Pain Questionnaire (currently the FPQ-III) has been used to ...
*  Hemopressin
The original Hp peptide reduces sensitivity to painful stimuli in an experimental model of hyperalgesia. Hp also reduces food ... March 2005). "Antinociceptive action of hemopressin in experimental hyperalgesia". Peptides. 26 (3): 431-6. doi:10.1016/j. ...
*  Plerixafor
"CXCR4 Signaling Mediates Morphine-induced Tactile Hyperalgesia". Brain, Behavior, and Immunity. 25 (3): 565-73. doi:10.1016/j. ... of CXCR4 signalling by plerixafor has also unexpectedly been found to be effective at counteracting opioid-induced hyperalgesia ...
*  Μ-opioid receptor
DuPen A, Shen D, Ersek M (September 2007). "Mechanisms of opioid-induced tolerance and hyperalgesia". Pain Management Nursing. ...
*  Dorsal root ganglion
Syriatowicz, J. P.; Hu, D.; Walker, J. S.; Tracey, D. J. (1999). "Hyperalgesia due to nerve injury: Role of prostaglandins". ... a compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia) which further supports a role for HT ...
*  Mechanosensation
Hyperalgesia which remains in the initial area is known as primary hyperalgesia, and hyperalgesia which extends to a large area ... Hyperalgesia to mechanical stimuli extends to a large area around the initial location of the stimulus, while hyperalgesia to ... which is a chemical commonly used to induce hyperalgesia. Secondary hyperalgesia is believed to be caused by a magnified spinal ... Primary hyperalgesia probably relies on a central mechanism. It is argued that MIAs, or C-MiHi primary afferents, are crucial ...
*  Nocebo
... hyperalgesia is believed to involve the activation of cholecystokinin receptors. In a paper, Stewart-Williams and Podd ... For example, precisely the same inert agents can produce analgesia and hyperalgesia, the first of which, from this definition, ... Stewart-Williams & Podd (2004), p.326 Colloca, L; Benedetti, F (Oct 2007). "Nocebo hyperalgesia: how anxiety is turned into ... Verbal suggestion can cause hyperalgesia (increased sensitivity to pain) and allodynia (perception of a tactile stimulus as ...
*  Complex regional pain syndrome
Pöyhiä R, Vainio A (January 2006). "Topically administered ketamine reduces capsaicin-evoked mechanical hyperalgesia". The ... or hyperalgesia after a nerve injury, not necessarily limited to the distribution of the injured nerve Evidence at some time of ... or hyperalgesia (an exaggerated sense of pain) disproportionate to the inciting event Evidence at some time of edema, changes ... mechanical hyperalgesia) and showed a "significantly increased activation" of not just the S1 cortex (contralateral), S2 ( ...