Hydroxyurea (HU) is a small molecule drug that inhibits the enzyme ribonucleotide reductase (RNR), preventing the catalysis of ... Koç A, Wheeler LJ, Mathews CK, Merrill GF (January 2004). "Hydroxyurea arrests DNA replication by a mechanism that preserves ... Xu YJ, Singh A, Alter GM (November 2016). "Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α- ... Platt OS (March 2008). "Hydroxyurea for the treatment of sickle cell anemia". The New England Journal of Medicine. 358 (13): ...
He was prescribed an unusual combination therapy: didanosine, indinavir and hydroxyurea. Hydroxyurea was the most unusual of ... Gibbs MA, Sorensen SJ (January 2000). "Hydroxyurea in the treatment of HIV-1". The Annals of Pharmacotherapy. 34 (1): 89-93. ...
Newton HB (2007). "Hydroxyurea chemotherapy in the treatment of meningiomas". Neurosurg Focus. 23 (4): E11. doi:10.3171/foc-07/ ... A 2007 study of whether hydroxyurea has the capacity to shrink unresectable or recurrent meningiomas is being further evaluated ...
In the early 1980s a team led by Charache began testing a few patients at Hopkins to see if hydroxyurea, a cancer drug, would ... They found that hydroxyurea treatment could increase recipients' blood levels of hemoglobin F, a form of hemoglobin primarily ... Subsequent investigation of the beneficial effects hydroxyurea in people with sickle cell disease has revealed multiple ... Agrawal, Rohit Kumar; Patel, Rakesh Kantilal; Shah, Varsha; Nainiwal, Lalit; Trivedi, Bhadra (June 2014). "Hydroxyurea in ...
Platt OS (Mars 2008). «Hydroxyurea for the treatment of sickle cell anemia». N. Engl. J. Med. 358 (13): 1362-9.. ... Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia». N. Engl. J. Med. 332 (20): 1317-22. ISSN 0028- ... Hydroxyurea (medac)[endre , endre wikiteksten]. Det fyrste godkjende lækjemiddelet for årsakshandsaming av sigdcelleanemi, ... Hydroxyurea var tidlegare brukt som cellegift, og det er attlete over langtidsverknadane. Risikoen har likevel vist seg å vere ...
Tripathi, K; Mor, V; Bairwa, NK; Del Poeta, M; Mohanty, BK (2012). "Hydroxyurea treatment inhibits proliferation of ...
Hydroxyurea is the only FDA approved drug for thalassemia. Patients who took 10 mg/kg of hydroxyurea everyday for a year had ... Thalassemia patients who do not respond well to blood transfusions can take hydroxyurea or thalidomide, and sometimes a ... Keikhaei, Bijan (2015). "Clinical and Haematological Effects of Hydroxyurea in β -Thalassemia Intermedia Patients". Journal of ... The combination of thalidomide and hydroxyurea resulted in hemoglobin levels increasing significantly in transfusion-dependent ...
The hydroxyurea arm had a lower likelihood of myelofibrosis, arterial thrombosis, and bleeding, but it had a slightly higher ... July 2005). "Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia". N. Engl. J. Med. 353 (1): 33-45. doi ... Anagrelide can be useful in times when hydroxyurea proves ineffective. Common side effects are headache, diarrhea, unusual ... Stopping anagrelide (and switching patients to hydroxyurea) appeared to reverse the degree of marrow fibrosis. Thus, patients ...
Extremely high platelet counts can be treated with hydroxyurea (a cytoreducing agent) or anagrelide (Agrylin). In Janus kinase ... "Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia". NEJM. 353 (1): 33-45. doi:10.1056/NEJMoa043800. ...
Inhibition of the enzyme by hydroxyurea, hydroxylamine, and acetohydroxamic acid". J Biol Chem. 240: 2407-2414. PMID 14304845. ...
There are also reports of hydroxyurea as a rare cause. In season 6 of House MD in the episode 12 titled Remorse, House ...
Hydroxycarbamide (hydroxyurea) was shown effective in mouse models and subsequently commercially researched by Novo Nordisk, ... Grzeschik SM, Ganta M, Prior TW, Heavlin WD, Wang CH (August 2005). "Hydroxyurea enhances SMN2 gene expression in spinal ... placebo-controlled trial of hydroxyurea in spinal muscular atrophy". Neurology. 75 (24): 2190-7. doi:10.1212/WNL. ...
For example, it is used to prepare the drug hydroxyurea. It is also used for the heat treatment of metals (e.g., Ferritic ...
Brawley, Otis W. (2008-06-17). "National Institutes of Health Consensus Development Conference Statement: Hydroxyurea Treatment ... hydroxyurea treatment for sickle cell disease." "Introduction to special issue: advancing the ethics of community-based ... "NIH consensus development statement on hydroxyurea treatment for sickle cell disease". NIH Consensus and State-of-the-science ... "NIH consensus development statement on hydroxyurea treatment for sickle cell disease." "National Institutes of Health Consensus ...
Examples of substances under this schedule: Testolactone, Hydroxyurea, Carbutamide, Primidone etc. Schedule H: The drug label ...
Hydroxyurea had previously been used as a chemotherapy agent, and some concern exists that long-term use may be harmful, but ... Hydroxyurea and phlebotomy combined may be more effective than transfusion and chelation combined in terms of pain, life- ... Hydroxyurea, also known as hydroxycarbamide, probably reduces the frequency of painful episodes and the risk of life- ... Other measures may include blood transfusion and the medication hydroxycarbamide (hydroxyurea). A small percentage of people ...
The primary treatment consists of anagrelide or hydroxyurea to lower platelet levels. Congenital amegakaryocytic ...
This is usually with a "cytoreductive agent" (hydroxyurea, also known as hydroxycarbamide). The tendency of some practitioners ... While hydroxyurea is considered safer in this aspect, there is still some debate about its long-term safety. In the past, ...
Rodgers G. "Hydroxyurea and other disease-modifying therapies in sickle cell disease". UpToDate. Archived from the original on ...
"1-{4-[3-(4-Fluorophenoxy)phenyl]-3-butyn-2-yl}-1-hydroxyurea". chemspider.com. Retrieved 24 December 2015. CS1 maint: ...
Hydroxyurea is also used to treat certain types of cancer and blood disorders. Aphidocolin is a fungus-derived tetracyclic ... Hydroxyurea decreases the production of dNTPs by inhibiting the enzyme ribonucleotide reductase. This serves to halt DNA ... "Hydroxyurea Arrests DNA Replication by a Mechanism That Preserves Basal dNTP Pools". Journal of Biological Chemistry. 279 (1): ...
Najean Y, Rain JD (1997). "Treatment of polycythemia vera: the use of hydroxyurea and piprobroman in 292 patients under the age ... Dexamethasone, alpha-interferon and hydroxyurea (also known as hydroxycarbamide) may play a role. Lenalidomide and thalidomide ... the development of myelofibrosis following these disorders may be accelerated by the oral chemotherapy drug hydroxyurea. The ...
The drugs hydroxyurea and Motexafin gadolinium interfere with the action of this enzyme. Elledge SJ, Zhou Z, Allen JB (March ... "Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea". The Journal of Biological ...
Patients may receive hydroxyurea to induce the protective effects of increased fetal hemoglobin production. They may also ...
... to try Hydroxyurea, a drug used to treat blood cancer, to treat her sickle cell disease. The treatment worked and Hydroxyurea ...
Only cytotoxic drugs such as busulfan, hydroxyurea or interferon-alpha (rIFN-α) were utilized. Even though the first Bcr-Abl TK ...
Sakano K, Oikawa S, Hasegawa K, Kawanishi S (November 2001). "Hydroxyurea induces site-specific DNA damage via formation of ... and hydroxyurea (induces DNA base oxidation). UV light also induced competence in L. pneumophila. Charpentier et al. suggested ...
Sakano, K; Oikawa, S; Hasegawa, K; Kawanishi, S (2001). "Hydroxyurea induces site-specific DNA damage via formation of hydrogen ... and hydroxyurea (causes oxidation of DNA bases). Charpentier et al. also showed that UV irradiation induces competence in L. ...