Hydroxyproline
2S,4R)-4-Hydroxyproline, or L-hydroxyproline (C5H9O3N), is an amino acid, abbreviated as Hyp or O, e.g., in Protein Data Bank. ... Hydroxyproline is also found in the walls of oomycetes, fungus-like protists related to diatoms. (2S,4S)-cis-4-Hydroxyproline ... Hydroxyproline differs from proline by the presence of a hydroxyl (OH) group attached to the gamma carbon atom. Hydroxyproline ... Hydroxyproline is found in few proteins other than collagen. For this reason, hydroxyproline content has been used as an ...
4-hydroxyproline epimerase
Other names in common use include hydroxyproline epimerase, hydroxyproline 2-epimerase, and L-hydroxyproline epimerase. This ... In enzymology, a 4-hydroxyproline epimerase (EC 5.1.1.8) is an enzyme that catalyzes the chemical reaction trans-4-hydroxy-L- ... Adams E, Norton IL (May 1964). "Purification and properties of inducible hydroxyproline 2-epimerase from Pseudomonas". The ... The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase. ...
Skp1-protein)-hydroxyproline N-acetylglucosaminyltransferase
... hydroxyproline Thus, the two substrates of this enzyme are UDP-N-acetylglucosamine and Skp1-protein-hydroxyproline, whereas its ... Skp1-hydroxyproline GlcNAc-transferase, and UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase. CM; Morris, HR; Panico, M ... Teng-Umnuay P, van der Wel H, West CM (1999). "Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the ... The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:[Skp1-protein]-hydroxyproline N-acetyl-D-glucosaminyl- ...
Trans-L-3-hydroxyproline dehydratase
The enzyme trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) catalyzes the chemical reaction trans-L-3-hydroxyproline ⇌ {\ ... This enzyme is also called trans-L-3-hydroxyproline hydro-lyase. Ramaswamy SG (1983). "Conversion of 3-hydroxyproline to ... The systematic name of this enzyme class is trans-L-3-hydroxyproline hydro-lyase (Δ1-pyrroline-2-carboxylate-forming). ...
Non-proteinogenic amino acids
Hydroxyproline. This imino acid differs from proline due to a hydroxyl group on carbon 4. Hypusine. This amino acid is obtained ... and in hydroxyproline the hydroxylation of proline is critical for maintaining connective tissues. Another example is the ...
1-Pyrroline-5-carboxylate dehydrogenase
Adams E, Goldstone A (December 1960). "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta ...
Pyrroline-5-carboxylate reductase
"Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta1-pyrroline-3-hydroxy-5-carboxylate". The ...
Arabinogalactan protein
Specific sets of hydroxyproline O-β-galactosyltransferases, β-1,3-galactosyltransferases, β-1,6-galactosyltransferases, α- ... Proline residues in the protein backbone can be hydroxylated to Hydroxyproline (O) depending on the surrounding amino acids. ... Ogawa-Ohnishi, Mari; Matsubayashi, Yoshikatsu (2015-03-01). "Identification of three potent hydroxyproline O- ... and Analysis of Hydroxyproline-Rich Glycoproteins". Plant Physiology. 153 (2): 485-513. doi:10.1104/pp.110.156554. ISSN 0032- ...
Amino acid
For example, hydroxyproline , is synthesised from proline. Another example is selenomethionine). Non-proteinogenic amino acids ... Hydroxyproline, generated by hydroxylation of proline, is a major component of the connective tissue collagen. Hypusine in the ... while hydroxyproline is made by a post translational modification of proline. Microorganisms and plants synthesize many ...
Procollagen-proline dioxygenase
This particular enzyme catalyzes the formation of (2S, 4R)-4-hydroxyproline, a compound that represents the most prevalent post ... Prolyl hydroxylase catalyzes the formation of hydroxyproline. The modification has a significant impact on the stability of ... Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen". Biochemical and Biophysical Research ... 4-hydroxyproline + succinate + CO2 The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two ...
Organic azide
Shaffer, Karl J.; Taylor, Carol M. (2006-08-01). "β-Glycosides of Hydroxyproline via an Umpolung Approach". Organic Letters. 8 ...
Aldehyde dehydrogenase 4 family, member A1
1974). "Defective hydroxyproline metabolism in type II hyperprolinemia". Biochemical Medicine. 10 (4): 329-36. doi:10.1016/0006 ... "Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline". J. Clin. ...
Imino acid
"An assay for hydroxyproline and proline on one sample and a simplified method for hydroxyproline". Analytical Biochemistry. 63 ... The only proteinogenic amino acid of this type is proline, although the related non-proteinogenic amino acids hydroxyproline ... Stout, E.R.; Fritz, G.J. (1966). "Role of Oxygen Fixation in Hydroxyproline Biosynthesis by Etiolated Seedlings". Plant ... Myhill, D.; Jackson, D.S. (1963). "Separation of proline and hydroxyproline using thin-layer chromatography". Analytical ...
TULP1
"Entrez Gene: TULP1 tubby like protein 1". Powles TJ, Rosset G, Leese CL, Bondy PK (1977). "Early morning hydroxyproline ...
HOGA1
The protein is one of the enzymes (4-hydroxy-2-oxoglutarate aldolase) involved in metabolism of hydroxyproline to glyoxylate. ... The enzyme overactivity can form excessive glyoxylate from hydroxyproline. Glyoxylate is catabolised to oxalate, resulting in ...
Mannan-binding lectin
The core-specific lectin contains hydroxyproline, hydroxylysine, and glucosylgalactosylhydroxylysine residues". J Biol Chem. ...
Hydroxylation
Collagen consists of both 3‐hydroxyproline and 4‐hydroxyproline residues. Hydroxylation occurs at the γ-C atom, forming ... This is due to the fact that collagen makes up about 25-35% of the protein in our bodies and contains a hydroxyproline at ... hydroxyproline (Hyp), which stabilizes the secondary structure of collagen due to the strong electronegative effects of oxygen ...
Alkanolamine
Two amino acids are alkanolamines, formally speaking: serine and hydroxyproline. Veratridine and veratrine Tropane alkaloids ...
ELOB
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline ... hydroxyproline recognition in signaling". Science. 296 (5574): 1886-9. Bibcode:2002Sci...296.1886M. doi:10.1126/science.1073440 ... "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL". Nature. 417 (6892): 975-8. Bibcode:2002Natur. ...
Paget's disease of bone
Pyridinoline Elevated levels of serum and urinary hydroxyproline are also found. Bone scans are useful in determining the ...
CUL2
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline ...
HIF1A
... hydroxyproline recognition in signaling". Science. 296 (5574): 1886-9. Bibcode:2002Sci...296.1886M. doi:10.1126/science.1073440 ... "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL". Nature. 417 (6892): 975-8. doi:10.1038/ ...
Secondary amino acid
In nature, proline, hydroxyproline, pipecolic acid and sarcosine are well-known secondary amino acids. Proline is the only ... In protein, hydroxyproline is incorporated into protein by hydroxylation of proline. Pipecolic acid, a heavier analog of ... Ninhydrin tests of proline and hydroxyproline give yellow results. In enzymology, a N-methyl-L-amino-acid oxidase is an oxidase ...
ELOC
... hydroxyproline recognition in signaling". Science. 296 (5574): 1886-9. doi:10.1126/science.1073440. PMID 12004076. S2CID ...
Kininogen 1
Kato H, Matsumura Y, Maeda H (May 1988). "Isolation and identification of hydroxyproline analogues of bradykinin in human urine ...
Eyespot (wheat)
Wheat cells also release hydroxyproline glycoprotein (HRGP) in their cell walls. Secretion of HRGP is dependent on the signal ...
Abdominal fascia
X-Pro dipeptidase
This enzyme catalyses the following chemical reaction Hydrolysis of Xaa!Pro dipeptides; also acts on aminoacyl-hydroxyproline ...
Collagen
... the latter tend to have similar proline and hydroxyproline contents to mammals. The lower proline and hydroxyproline contents ... Proline or hydroxyproline constitute about 1/6 of the total sequence. With glycine accounting for the 1/3 of the sequence, this ... The most common motifs in the amino acid sequence of collagen are glycine-proline-X and glycine-X-hydroxyproline, where X is ... Hydroxyproline derived from proline Hydroxylysine derived from lysine - depending on the type of collagen, varying numbers of ...
Von Hippel-Lindau tumor suppressor
... hydroxyproline recognition in signaling". Science. 296 (5574): 1886-9. Bibcode:2002Sci...296.1886M. doi:10.1126/science.1073440 ...