... (2,5-dihydroxyphenylacetic acid) is a phenolic acid usually found in Arbutus unedo (strawberry-tree) honey. ... Accumulation of excess homogentisic acid and its oxide, named alkapton, is a result of the failure of the enzyme homogentisic ... "Homogentisic Acid: A Phenolic Acid as a Marker of Strawberry-Tree (Arbutus unedo) Honey". J. Agric. Food Chem. 47 (10): 4064- ... 2-dioxygenase further degrades homogentisic acid to yield 4-maleylacetoacetic acid. Paolo Cabras; Alberto Angioni; Carlo ...
Huong, DT; Kamperdick, C; Sung, TV (2004). "Homogentisic Acid Derivatives from Miliusa balansae". Journal of Natural Products. ...
... is produced by Elbs persulfate oxidation of o-Coumaric acid. Homogentisic acid Gentisic acid Cain, J ... 2,5-Dihydroxycinnamic acid is a hydroxycinnamic acid. It is an isomer of caffeic acid. ... Hydroxycinnamic acids, Hydroquinones, Vinylogous carboxylic acids, All stub articles, Aromatic compound stubs). ...
It is derived from the oxidative dimerization of homogentisic acid. It has been both widely and falsely reported that ... Like its orange-colored analog norhipposudoric acid, hipposudoric acid functions both as a natural sunscreen and as an ... Hipposudoric acid is a red pigment found in the skin secretions of the hippopotamus; although the secretions are often known as ... "Properties of the enzyme responsible to the synthesis of hipposudoric and norhipposudoric acids, the pigments in the red sweat ...
... the body accumulates an intermediate substance called homogentisic acid in the blood and tissues. Homogentisic acid and its ... The homogentisic acid is converted to the related substance benzoquinone acetic acid which forms polymers that resemble the ... the HGD enzyme cannot metabolize the homogentisic acid (generated from tyrosine) into 4-maleylacetoacetate, and homogentisic ... The accumulating homogentisic acid causes damage to cartilage (ochronosis, leading to osteoarthritis) and heart valves, as well ...
"Nonenzymic oxidation of p-hydroxyphenylpyruvic acid with singlet oxygen to homogentisic acid. A model for the action of p- ... "The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid". The Biochemical ... The HPPD reaction occurs through a NIH shift and involves the oxidative decarboxylation of an α-oxo acid as well as aromatic ... but it is known that the site consists of an iron ion surrounded by amino acids extending inward from beta sheets (with the ...
4-hydroxyphenylpyruvate dioxygenase converts a tyrosine byproduct called 4-hydroxyphenylpyruvate to homogentisic acid. ... Articles with short description, Short description is different from Wikidata, Amino acid metabolism disorders, Autosomal ...
... is a syndrome caused by the accumulation of homogentisic acid in connective tissues. The condition was named after ... Ochronosis occurs because of deposition of phenols (such as homogentisic acid and hydroquinone) as plaques in the matrix of ... Amino acid metabolism disorders, Autosomal recessive disorders, Skin conditions resulting from errors in metabolism). ...
"The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid". Biochem. J. 49 (5 ... Dicarboxylic acids, Beta-keto acids, Enones, All stub articles, Alkene stubs, Biochemistry stubs). ... Fumarylacetoacetic acid (fumarylacetoacetate) is an intermediate in the metabolism of tyrosine. It is formed through the ...
Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. It is an ... Alpha-keto acids, Propionic acids, Hydroxy acids, All stub articles, Biochemistry stubs). ... 4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acid phenylalanine. The aromatic side ... gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ...
Buildup of homogentisic acid can result in heart valve damage, kidney stones and damage to cartilage in the body. Pantothenate ... the α-keto acid of methionine, and formic acid. However, ARD from Klebsiella oxytoca catalyzes an additional reaction when ... For instance, carbon-carbon bond cleavage, fatty acid hydroperoxidation, carbon-sulfur bond cleavage, and thiol oxidation are ... Amino Acids. 41 (1): 91-102. doi:10.1007/s00726-010-0518-2. PMC 3136866. PMID 20195658. Solomon EI, Brunold TC, Davis MI, ...
Nitisinone inhibits the conversion of 4-OH phenylpyruvate to homogentisic acid by 4-Hydroxyphenylpyruvate dioxygenase, the ... Patients received amino acid supplements lacking tyrosine and phenylalanine, most often by drinking a specially engineered ... Tyrosinemia type I is a genetic disorder that disrupts the metabolism of the amino acid tyrosine, resulting in damage primarily ... SA inhibits the enzyme 5-ALA dehydratase which converts aminolevulinic acid (5-ALA) into porphobilinogen, a precursor to ...
... (homogentisic acid oxidase, homogentisate oxidase, homogentisicase) is an enzyme which catalyzes ... His365 binds to Glu341 via hydrogen bonding to stabilize the amino acid side chains. Homegentisate 1,2 dioxygenase is involved ... more specifically in the breakdown of the amino acids tyrosine and phenylalanine. HGD appears in the metabolic pathway of ...
Alkaptonuria: Metabolic disorder which promotes the accumulation of homogentisic acid in the body and may cause brown colour ... In the late 17th century, many people reached out to barbers, who used a file to file down the teeth before applying an acid ... It also contains acid-buffering components that makes baking soda biologically antibacterial at high concentrations and capable ... Although this effect is not as damaging as phosphoric acid etch, the increased irregularity of the teeth surface makes the ...
Biosynthesis starts with formation of the closed-ring part of the molecule as homogentisic acid (HGA). The side chain is ... The Shikimate pathway generates the chromanol ring from the Homogentisic Acid (HGA) and the MEP pathway produces the ... Vitamin E is fat soluble, so dietary supplement products are usually in the form of the vitamin, esterified with acetic acid to ... for humans or domesticated animals convert the phenol form of the vitamin to an ester using either acetic acid or succinic acid ...
... alkaptonurics produce homogentisic acid stones, and iminoglycinurics produce stones of glycine, proline, and hydroxyproline. ... Reducing the pH to 5.0 decreases the solubility of uric acid to less than 8 mg/100 mL. The formation of uric-acid stones ... The mainstay for medical management of uric acid stones is alkalinization (increasing the pH) of the urine. Uric acid stones ... "Effect of addition of calcium hydroxide to foods rich in oxalic acid on calcium and oxalic acid metabolism , Request PDF". ...
More specifically, inhibition of HPPD prevents the formation of a breakdown product, homogentisic acid, which in turn is a key ... an enzyme in plants that breaks down the amino acid tyrosine into molecules that are then used by plants to create other ... is an enzyme found in both plants and animals which catalyzes the catabolism of the amino acid tyrosine. Preventing the ... that the urine of rats treated with III showed elevated levels of both p-hydroxyphenylpyruvate and p-hydoxyphenyllactic acids. ...
Homogentisic acid 4-Hydroxymandelic acid 5-Methoxysalicylic acid Norcantharidin Orsellinic acid Quinolacetic acid ... The molecular formula C8H8O4 (molar mass : 168.15 g/mol, exact mass : 168.042259 u) may refer to: Dehydroacetic acid 3,4- ... Trihydroxyacetophenones Gallacetophenone (2,3,4-trihydroxyacetophenone) 2,4,6-Trihydroxyacetophenone Vanillic acid This set ...
... a metabolic disorder in which a patient accumulates homogentisic acid in connective tissues and which can be identified by ...
... and homogentisic acid (alkaptonuria) creates a false positive. As color of the obtained precipitate can be used to infer the ... This is due to the possibility of a reaction in which the presence of other reducing substances such as ascorbic acid, drugs ( ... However, sucrose indirectly produces a positive result with Benedict's reagent if heated with dilute hydrochloric acid prior to ...
... skin discoloration and connective tissue damage from the accumulation of homogentisic acid). Combination therapy-using ... "Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne". Cochrane ... Mild peels include those using glycolic acid, lactic acid, salicylic acid, Jessner's solution, or a lower concentration (20%) ... Azelaic acid may cause skin irritation. It is less effective and more expensive than retinoids. Azelaic acid also led to worse ...
... for patients with Tyrosinemia type 1 as it prevents the formation of 4-Maleylacetoacetic acid and fumarylacetoacetic acid, ... Alkaptonuria is caused when an enzyme called homogentisic dioxygenase (HGD) is faulty, leading to a buildup of homogenisate. ...
... homogentisic acid MeSH D02.241.223.601.521 - homovanillic acid MeSH D02.241.223.601.600 - methylphenidate MeSH D02.241.223.601. ... quinic acid MeSH D02.241.511.852 - shikimic acid MeSH D02.241.511.902 - sugar acids MeSH D02.241.511.902.107 - ascorbic acid ... edetic acid MeSH D02.241.081.038.455 - egtazic acid MeSH D02.241.081.038.581 - iodoacetic acid MeSH D02.241.081.038.581.400 - ... hexuronic acids MeSH D02.241.081.844.915.400.500 - iduronic acid MeSH D02.241.081.901.177 - aconitic acid MeSH D02.241.081.901. ...