The role of homocysteine as a risk factor for cardiovascular disease is suggested to be mediated by homocysteine down- ... an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical because it is also a marker of ... 2006). "Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease". N Engl J Med. 354 (15): 1567-77. doi:10.1056 ... Polyphenol antioxidants also play a role in down-regulating homocysteine. With raised levels of ADMA seemingly to be associated ...
... and two studies have found higher levels of plasma homocysteine in PEX patients, or elevated homocysteine concentrations in ... 2007). "Homocysteine in tear fluid of patients with pseudoexfoliation glaucoma". J Glaucoma. 16 (2): 234-9. doi:10.1097/IJG. ... Vessani RM, Ritch R, Liebmann JM, Jofe M (2003). "Plasma homocysteine is elevated in patients with exfoliation syndrome". Am J ... Scientists believe that elevated levels of plasma homocysteine are a risk factor for cardiovascular disease, ...
Also including the vitamin B12)-related amino acid homocysteine. These values (except Hemoglobin in plasma) are for total blood ... "Homocysteine". www.thedoctorsdoctor.com. Derived from molar values using molar massof 135 g/mol Derived from mass values using ...
Elevated levels of homocysteine, a toxic 'natural' amino acid. Benign or malignant primary bone tumors are rare causes of hip ...
The source of the methyl group is S-adenosyl-L-methionine and S-adenosyl-L-homocysteine is generated as a side product. In ... Choline and folate, interacting with vitamin B12, act as methyl donors to homocysteine to form methionine, which can then go on ... It also works as a substrate for the BHMT-enzyme, which methylates homocysteine to methionine. This is a S-adenosylmethionine ( ... Choline deficiency thus leads to elevated homocysteine levels and decreased SAM levels in blood. Choline occurs in foods as a ...
Hohman, R.J.; Guitton, M.C.; Véron, M. (1984). "Purification of S-adenosyl-l-homocysteine hydrolase from Dictyostelium ... Kajander, EO; Raina, AM (1981). "Affinity-chromatographic purification of S-adenosyl-L-homocysteine hydrolase. Some properties ...
Bleich S, Degner D, Bandelow B, von Ahsen N, Rüther E, Kornhuber J (August 2000). "Plasma homocysteine is a predictor of ... Chronic consumption of alcohol may result in increased plasma levels of the toxic amino acid homocysteine; which may explain ... 2001). "Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the 'French ... March 2006). "Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine ...
... where the activated homoserine or serine is fused to a cysteine or homocysteine forming cystathionine. A similar compound is ... homocysteine, methionine and ethionine possess the thiol equivalents. The selenol equivalents are selenocysteine, ...
... is involved in maintaining normal circulating levels of homocysteine; in riboflavin deficiency, homocysteine levels ... from homocysteine. Riboflavin deficiency appears to impair the metabolism of the dietary mineral, iron, which is essential to ...
Plasma homocysteine concentration and coronary artery disease in Asian Indians. J Assoc Physicians India. 2002 Oct;50:1229-31. ...
Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ (May 2002). "Homocysteine, B vitamin status, and cognitive ...
Bönsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S (Dec 2004). "Homocysteine associated genomic DNA hypermethylation in ...
Note that homocysteine can also be converted to methionine by the folate-independent enzyme betaine-homocysteine ... 677TT (but not 677CC/CT) individuals with lower plasma folate levels are at risk for elevated plasma homocysteine levels. In ... It does not result in thermolabile MTHFR and does not appear to affect homocysteine levels. It does, however, affect the ... 5-Methyltetrahydrofolate is used to convert homocysteine (a potentially toxic amino acid) to methionine by the enzyme ...
Homocysteine is an amino acid whose levels correlated with heart disease. However, a 2010 study showed that lowering ... homocysteine by nearly 30 percent had no effect on heart attack or stroke. Priming studies claim that decisions can be ...
Homocysteine (a putative cardiovascular risk factor) mounts an oxidative attack on DDAH to form a mixed disulfide, inactivating ... Stühlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP (November 2001). "Homocysteine impairs the nitric oxide synthase ... By oxidizing a sulfhydryl moiety critical for DDAH activity, homocysteine and other risk factors cause ADMA to accumulate and ...
This differs from the process in yeast, where sulfide must be incorporated first in homocysteine then converted in two steps to ... This happens through the transsulfuration pathway and the methylation of homocysteine. Both cysteine and methionine are sulfur- ...
Pařízková M, Andel R, Lerch O, Marková H, Gažová I, Vyhnálek M, Hort J, Laczó J (2017). "Homocysteine and Real-Space Navigation ...
SAM is converted to S-Adenosyl homocysteine (SAH) during this process. The breaking of the SAM-methyl bond and the formation of ... DNA adenine S-adenosyl-L-homocysteine + DNA 6-methylaminopurine m6A was primarily found in prokaryotes until 2015 when it was ... Catechol-O-methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate-homocysteine ...
High levels of homocysteine also result in hypermethylation of CpG islands in the promoter region of the estrogen receptor ... August 2003). "Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease". ... One proposed mechanism behind this global hypomethylation is elevated homocysteine levels causing hyperhomocysteinemia, a known ... High plasma levels of homocysteine inhibit DNA methyltransferases, which causes hypomethylation. Hypomethylation of DNA affects ...
... homocysteine is an amino acid and metabolite of methionine; increased levels of homocysteine can lead to homocystinuria(see ... Homocysteine, a compound that SDH combines with Serine to create cystathionine, also noncompetitively inhibits the action of ... Studies have shown that homocysteine reacts with SDH's PLP coenzyme to create a complex. This complex is devoid of coenzyme ... Hurd RW, Hammond EJ, Wilder BJ (March 1981). "Homocysteine induced convulsions: enhancement by vitamin B6 and inhibition by ...
High blood levels of the amino acid homocysteine is associated with premature atherosclerosis; whether elevated homocysteine in ... Clarke R, Halsey J, Bennett D, Lewington S (February 2011). "Homocysteine and vascular disease: review of published results of ... Lonn E (September 2007). "Homocysteine in the prevention of ischemic heart disease, stroke and venous thromboembolism: ... the homocysteine-lowering trials". Journal of Inherited Metabolic Disease. 34 (1): 83-91. doi:10.1007/s10545-010-9235-y. PMID ...
Wald DS, Law M, Morris JK (Nov 2002). "Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis". ... Additionally, it is crucial to maintain low homocysteine levels for the proper functioning of various pathways and for ... The isozymes differ in their ability to efficiently degrade methionine, homocysteine, and cysteine. E. histolytica MGL is ... Stipanuk MH (2004). "Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine". Annual ...
This enzyme converts the S-adenosyl homocysteine into the compound homocysteine. Homocysteine may be converted back to ... This enzyme starts the next step in the process, converting S-adenosylmethionine to a compound called S-adenosyl homocysteine. ...
It is related to homocysteine, a by-product of methionine metabolism. Grandes, P; Kq, KQD; Morino, P; Cuénod, M; Streit, P ( ...
Zhu BT (October 2002). "On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis". Histology ...
Biosynthetically, cystathionine is generated from homocysteine and serine by cystathionine beta synthase (upper reaction in the ... Cystathionine is produced by the transsulfuration pathway which converts homocysteine into cystathionine. Cystathionine is then ...
Kokame K, Kato H, Miyata T (1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential ...
De La Haba G, Cantoni GL (March 1959). "The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine". ... This enzyme catalyses the following chemical reaction S-adenosyl-L-homocysteine + H2O ⇌ L-homocysteine + adenosine The enzyme ... is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine. ...
Oct 2005). "Homocysteine and cognitive performance in the Framingham offspring study: age is important". Am J Epidemiol. 162 (7 ... These and further risk factors, such as homocysteine, were gradually discovered over the years. The Framingham Heart Study, ... Sundström J, Vasan RS (2005). "Homocysteine and heart failure: a review of investigations from the Framingham Heart Study". ... for homocysteine and vitamin B12 levels) in participants of the Framingham Heart Study. Because of these exciting genomic ...
Homocysteine: elevated levels of total homocysteine (tHcy) an amino acid are an independent risk factor for silent stroke, even ... 2001). "Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people". Stroke: A Journal of ... Vermeer, SE; Van Dijk, EJ; Koudstaal, PJ; Oudkerk, M; Hofman, A; Clarke, R; Breteler, MM (2002). "Homocysteine, silent brain ... 2008). "Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter ...