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*  Methylenetetrahydrofolate reductase deficiency
MTHFR is the rate-limiting enzyme in the methyl cycle, which includes the conversion of homocysteine into methionine. Defects ... In common forms of MTHFR deficiency, elevated plasma homocysteine levels have sometimes been treated with Vitamin B12 and low ... Although this treatment significantly decreases the serum levels of homocysteine, this treatment is not thought to improve ... or= 40 micromol/liter). The Hordaland Homocysteine Study". Journal of Clinical Investigation. 98 (9): 2174. PMC 507663 . Clarke ...
*  Folate deficiency
High homocysteine levels in the blood can lead to vascular injuries by oxidative mechanisms which can contribute to cerebral ... Additionally, a defect in homocysteine methyltransferase or a deficiency of B-12 may lead to a so-called "methyl-trap" of ... The significance of folic acid and homocysteine". Pol Merkur Lekarski. 26 (152): 136-41. PMID 19388520. ... leading to an accumulation of homocysteine (hyperhomocisteinemia) and to impaired metabolism of neurotransmitters (especially ...
*  Homocysteine
... MS Spectrum Homocysteine at Lab Tests Online Homocysteine: analyte monograph - The Association for Clinical ... Homocysteine exists at neutral pH values as a zwitterion. Homocysteine is not obtained from the diet. Instead, it is ... Homocysteine also acts as an allosteric antagonist at Dopamine D2 receptors. Homocysteine levels are typically higher in men ... Homocysteine can cyclize to give homocysteine thiolactone, a five-membered heterocycle. Because of this "self-looping" reaction ...
*  Homocysteine methylase
... may refer to: Homocysteine S-methyltransferase 5-methyltetrahydropteroyltriglutamate-homocysteine S- ...
*  Homocysteine desulfhydrase
In enzymology, a homocysteine desulfhydrase (EC 4.4.1.2) is an enzyme that catalyzes the chemical reaction L-homocysteine + H2O ... Other names in common use include homocysteine desulfurase, L-homocysteine hydrogen-sulfide-lyase, and (deaminating). This ... The systematic name of this enzyme class is L-homocysteine hydrogen-sulfide-lyase (deaminating 2-oxobutanoate-forming). ... the two substrates of this enzyme are L-homocysteine and H2O, whereas its 3 products are hydrogen sulfide, NH3, and 2- ...
*  Homocysteine S-methyltransferase
... homocysteine methylase, homocysteine methyltransferase, homocysteine transmethylase, L-homocysteine S-methyltransferase, S- ... Other names in common use include S-adenosylmethionine homocysteine transmethylase, S-methylmethionine homocysteine ... S-adenosylmethionine-homocysteine transmethylase, and S-adenosylmethionine:homocysteine methyltransferase. This enzyme ... In enzymology, a homocysteine S-methyltransferase (EC 2.1.1.10) is an enzyme that catalyzes the chemical reaction S- ...
*  S-Adenosyl-L-homocysteine
... (SAH) is an amino acid derivative used in several metabolic pathways in most organisms. It is an ... BioCYC E.Coli K-12 Compound: S-adenosyl-L-homocysteine. ...
*  Thetin-homocysteine S-methyltransferase
Other names in common use include dimethylthetin-homocysteine methyltransferase, and thetin-homocysteine methylpherase. KLEE WA ... In enzymology, a thetin-homocysteine S-methyltransferase (EC 2.1.1.3) is an enzyme that catalyzes the chemical reaction ... MAW GA (1956). "Thetin-homocysteine transmethylase; a preliminary manometric study of the enzyme from rat liver". Biochem. J. ... MAW GA (1958). "Thetin-homocysteine transmethylase; some further characteristics of the enzyme from rat liver". Biochem. J. 70 ...
*  Betaine-homocysteine S-methyltransferase
In the field of enzymology, a betaine-homocysteine S-methyltransferase also known as betaine-homocysteine methyltransferase ( ... Pajares MA, Pérez-Sala D (December 2006). "Betaine homocysteine S-methyltransferase: just a regulator of homocysteine ... "Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase". J. Biol. Chem. 283 (14): ... Betaine Homocysteine Methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 2.1.1.5 ...
*  S-adenosyl-L-homocysteine hydrolase
... responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is a ... S-adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, ... Sganga MW, Aksamit RR, Cantoni GL, Bauer CE (1992). "Mutational and nucleotide sequence analysis of S-adenosyl-L-homocysteine ...
*  5-Methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
Homocysteine is coordinated to a zinc ion, as initially suggested by spectroscopy and mutagenesis . Pejchal, Robert; Ludwig, ... The systematic name of this enzyme class is 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase. Other ... In enzymology, a 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC 2.1.1.14) is an enzyme that ... The role of zinc in the methylation of homocysteine". J. Am. Chem. Soc. 120: 8410-8416. doi:10.1021/ja980581g. Molecular and ...
*  S-Adenosyl methionine
This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled ... that use SAM-e as a substrate produce S-adenosyl homocysteine as a product. S-adenosyl homocysteine is a strong negative ... Finkelstein J, Martin J (2000). "Homocysteine". Int J Biochem Cell Biol. 32 (4): 385-9. doi:10.1016/S1357-2725(99)00138-7. PMID ...
*  Gluten-sensitive enteropathy-associated conditions
Prolactin - deficiency (childhood). homocysteine - excess. Megaloblastic anemia (MA) is associated with GSE and is believed to ...
*  Phosphatidylethanolamine N-methyltransferase
Robinson, Killian H. (2001). "Homocysteine and coronary artery disease". In Carmel, Ralph; Jacobsen, Ralph Carmel. Homocysteine ... PEMT is also a significant source and regulator of plasma homocysteine, which can be secreted or converted to methionine or ... High levels of homocysteine are linked to cardiovascular disease and artherosclerosis, particularly coronary artery disease. ... Refsum H, Ueland PM, Nygård O, Vollset SE (1998). "Homocysteine and cardiovascular disease". Annual Review of Medicine. 49: 31- ...
*  Epigenetics of diabetes Type 2
Homocysteine is an intermediate that is responsible for maintaining methylation reactions in critical metabolic processes. It ... This reaction is a critical step in the conversion of homocysteine to methionine. The resulting product is a methyl donor that ... CS1 maint: Uses authors parameter (link) Miguel, A, L Jose, and Maria I Amores-Sanchez (2001). "Roles of homocysteine in cell ... After examining Type 2 diabetes patients, it was found that levels of homocysteine were exceptionally high when compared to ...
*  Methionine
Homocysteine can be converted to cysteine. (5) Cystathionine-β-synthase (a PLP-dependent enzyme) combines homocysteine and ... Adenosylhomocysteinase converts SAH to homocysteine. There are two fates of homocysteine: it can be used to regenerate ... this step is performed by homocysteine methyltransferase or betaine-homocysteine S-methyltransferase.) Although mammals cannot ... Homocysteine can also be remethylated using glycine betaine (NNN-trimethyl glycine, TMG) to methionine via the enzyme betaine- ...
*  Peter H. Lin
"Homocysteine/Hypertension & Vascular Lesion Formation". www.labome.org. Retrieved 2008-03-09. ...
*  Bleomycin hydrolase
Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. Another of its activities is ... "Protective Mechanisms against Homocysteine Toxicity". The Journal of Biological Chemistry. 281: 22485-22492. doi:10.1074/jbc. ...
*  Folate
Increased homocysteine level suggests tissue folate deficiency but homocysteine is also affected by vitamin B12 and vitamin B6 ... homocysteine, in a reaction catalyzed by homocysteine methyltransferase. These reactions are important because a defect in ... May 2010). "Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate ... Varela-Moreiras G, Murphy MM, Scott JM (May 2009). "Cobalamin, folic acid, and homocysteine". Nutr. Rev. 67 Suppl 1: S69-72. ...
*  S-Methylmethionine
The coproduct is S-adenosyl homocysteine. The biological roles of S-methylmethionine are not well understood. Speculated roles ...
*  Genetic testing
... intrauterine fetal demise Homocysteine Venous thrombosis; increased plasma homocysteine levels PAI-1 gene mutation Independent ...
*  Transmethylation
Deficiencies of vitamin B12 or folate cause increased levels of circulating homocysteine. Elevated homocysteine is a risk ... An example of transmethylation is the recovery of methionine from homocysteine. In order to sustain sufficient reaction rates ... Methylation Carmel R, Green R, Rosenblatt DS, Watkins D (2003). "Update on cobalamin, folate, and homocysteine". Hematology Am ... delivers methyl groups to form the active methyl form of vitamin B12 that is required for methylation of homocysteine. ...
*  Jasvinder K Gambhir
Gambhir, J. K. (2000). "Homocysteine metabolism in health and disease". Indian heart journal. 52 (7 Suppl): S9-15. PMID ... Her works spans across numerous fields such as nephropathy, estrogen deficiency effects, lipoproteins, homocysteine and ...
*  Vegan nutrition
Krajčovičová-Kudláčková, M.; Blažíček, P.; Kopčová, J.; Béderová, A.; Babinská, K. (2000). "Homocysteine Levels in Vegetarians ...
*  Vegetarian nutrition
VeganHealth.org: B12 and Chronic Disease: Homocysteine. Retrieved 26 April 2007. Mozafar, A. (1994). "Enrichment of some B- ... Krajčovičová-Kudláčková, M.; Blažíček, P.; Kopčová, J.; Béderová, A.; Babinská, K. (2000). "Homocysteine Levels in Vegetarians ... lower homocysteine levels, lower risk of high blood pressure, and lower risk of type 2 diabetes. Despite a widespread belief ...