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*  MEIS1
Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the ... "Toward a complete human genome sequence". Genome Research. 8 (11): 1097-108. Nov 1998. doi:10.1101/gr.8.11.1097. PMID 9847074. ... Wang Y, Yin L, Hillgartner FB (Jun 2001). "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid ... This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing ...
*  Homeobox protein Nkx-2.5
CSX, the human homolog of murine Csx, has a homeodomain sequence identical to that of Csx and is expressed only in the heart, ... Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Oct 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors ... Kasahara H, Izumo S (Jan 1999). "Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of ... "Homeodomain factor Nkx2-5 in heart development and disease". Cold Spring Harbor Symposia on Quantitative Biology. 67: 107-14. ...
*  Homeobox
The homeodomain binds DNA in a sequence-specific manner. However, the specificity of a single homeodomain protein is usually ... Homeodomain proteins show a preference for the DNA sequence 5'-ATTA-3'; sequence-independent binding occurs with significantly ... Homeodomain proteins are found in eukaryotes . Through the HTH motif, they share limited sequence similarity and structural ... Such complexes have a much higher target specificity than a single homeodomain protein. Homeodomains are encoded both by genes ...
*  EMX2
Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ (2001). "Characterization of the homeodomain gene EMX2: sequence conservation ... The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) ... 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40-5. doi:10.1038/ ... 2004). "Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons ...
*  Selection and amplification binding assay
Finally the sequence CAATC was identified as the consensus binding sequence for Quox1 homeodomain. By combining the power of ... Sequence the DNA: After final step of selection and electrophoresis, clone the DNA into a cloning vector and sequence it. ... It is also possible to identify the binding site even if both the protein and sequence is not known. Blackwell TK, Weintraub H ... The radio labeled probe was incubated with 25 pmol of purified Quox1 homeodomain fusion protein in binding buffer for EMSA. The ...
*  HOXB2
"A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the ... Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase ... The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression ... and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". The Journal of Biological ...
*  Regional differentiation
All homeotic genes share a segment of protein with a similar sequence and structure called the homeodomain (the DNA sequence is ... It activates the expression of Squint (a Nodal related signaling protein aka ndr1) and Bozozok (a homeodomain transcription ...
*  Kathleen Matthews (biochemist)
"Multiple Intrinsically Disordered Sequences Alter DNA Binding by the Homeodomain of the Drosophila Hox Protein Ultrabithorax". ...
*  EMX homeogene
... the homeodomain is responsible for binding to target DNA sequences to regulate transcription. Cecchi C, Boncinelli E (August ...
*  PRRX1
"Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins". Mol. Cell. Biol. 15 (6): 3318-26 ... Cserjesi P, Lilly B, Bryson L, Wang Y, Sassoon DA, Olson EN (August 1992). "MHox: a mesodermally restricted homeodomain protein ... May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315-21. doi:10.1038/ ... "Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor". Science. 257 (5073 ...
*  IRX1
... encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in ... The homeodomain belongs to the TALE (three amino acid loop extension) class of homeodomains, and is characterized by the ... The IRO motif is a region downstream of the homeodomain that is found only in members of the Iroquois-class homeodomain ... Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by ...
*  ISL1
"Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]". ... This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeodomain. The encoded ... "Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1)". Gay F, Anglade I, Gong Z, Salbert G (October 2000). " ... Gay F, Anglade I, Gong Z, Salbert G (2001). "The LIM/homeodomain protein islet-1 modulates estrogen receptor functions". Mol. ...
*  Hox gene
... all homeodomain-containing transcription factors bind essentially the same DNA sequence. The sequence bound by the homeodomain ... The DNA sequence bound by the homeodomain protein contains the nucleotide sequence TAAT, with the 5' terminal T being the most ... The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the ... This sequence is conserved in nearly all sites recognized by homeodomains, and probably distinguishes such locations as DNA ...
*  IKBKG
... consists of the region from T735 to E745 of the IKK-β subunit fused with a sequence derived from the Antennapedia homeodomain ... The NBD peptide was designed by identifying the amino acid binding sequence on IKK-α and IKK-β to which NEMO binds. A small ... Galgóczy P, Rosenthal A, Platzer M (June 2001). "Human-mouse comparative sequence analysis of the NEMO gene reveals an ... "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287-92. ...
*  Homeosis
Thus, the 60 amino acid DNA binding protein domain was named the homeodomain, while the 180 bp nucleotide sequence encoding it ... McGinnis, W; Levine, MS; Hafen, E; Kuroiwa, A; Gehring, WJ (1984). "A conserved DNA sequence in homoeotic genes of the ... the phenomenology of homeosis in animals was further elaborated by discovery of a conserved DNA binding sequence present in ...
*  Fuzzy complex
"Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila hox protein ultrabithorax". ... Interactions in fuzzy complexes are usually mediated by short motifs,. Flanking regions are tolerant to sequence changes as ... roles of amino acid sequence, domain length, and charge density". J Biol Chem 284,(25): 16716-22. doi: M109.011288 [pii] ... "Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha". J Mol ...
*  ZEB2
... a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target ... class of homeodomain transcription factors. ZEB2 protein has 8 zinc fingers and 1 homeodomain. The structure of the homeodomain ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31-9 ... Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of ...
*  HMGB2
"The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic ... "Sequence of human HMG2 cDNA". Nucleic Acids Research. 19 (23): 6643. doi:10.1093/nar/19.23.6643. PMC 329240 . PMID 1754403. " ... and p73-dependent sequence-specific transactivation from the human Bax gene promoter". The Journal of Biological Chemistry. 277 ...
*  Msh homeobox 2
His mutation in the N-terminal arm of the MSX2 homeodomain stabilizes DNA binding without altering nucleotide sequence ... DNA Sequence. 8 (1-2): 87-92. doi:10.3109/10425179709020891. PMID 9522127. Newberry EP, Latifi T, Towler DA (Aug 1999). "The ... "A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis". Cell. 75 ( ... "DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2". Biochemical and ...
*  Ctenophora
NISC Comparative Sequencing Program (2010). "The homeodomain complement of the ctenophore Mnemiopsis leidyi suggests that ... Several more recent studies comparing complete sequenced genomes of ctenophores with other sequenced animal genomes have also ... In agreement with the latter point, the analysis of a very large sequence alignment at the metazoan taxonomic scale (1,719 ... Pang, K.; Ryan, J. F.; NISC Comparative Sequencing Program; Mullikin, J. C.; Baxevanis, A. D.; Martindale, M. Q. (2010). " ...
*  List of model organisms
NISC Comparative Sequencing Program (2010). "The homeodomain complement of the ctenophore Mnemiopsis leidyi suggests that ... The genome of this particular cultivar will not be sequenced in the near future, but sequencing of its wild species Nicotiana ... Arabidopsis was the first plant to have its genome sequenced. Its genome sequence, along with a wide range of information ... Phage lambda Phi X 174 - its genome was the first ever to be sequenced. The genome is a circle of 11 genes, 5386 base pairs in ...
*  VSX2
"Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)". "Toward a complete human genome sequence". Genome Res. ... 2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601-7. doi:10.1038/nature01348. PMID ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... Dorval KM, Bobechko BP, Ahmad KF, Bremner R (2005). "Transcriptional activity of the paired-like homeodomain proteins CHX10 and ...
*  CUL4A
Sequence alignment studies showed that there is a highly conserved "LEXE" motif within helix one of the homeodomain. When ... The HOXA9 degron lies within the homeodomain, which is crucial for DNA binding. ... "CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein". The EMBO Journal. 22 (22): 6057-67. doi: ...
*  POU domain
In proteins a POU-specific domain is always accompanied by a homeodomain. Despite of the lack of sequence homology, 3D ... There is a surprisingly high degree of amino acid sequence conservation (37%-42%) of POU homeodomains to the transcriptional ... POU (pronounced 'pow') is a family of proteins that have well-conserved homeodomains. The acronym POU is derived from the names ... Johnson WA, Hirsh J (Feb 1990). "Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in ...
*  Drosophila embryogenesis
Bicoid has a DNA-binding homeodomain that binds both DNA and the nanos mRNA. Bicoid binds a specific RNA sequence in the 3' ...
*  Chromosome 7 (human)
... family with sequence similarity 185 member A FAM200A: family with sequence similarity 200 member A FBXO24: F-box only protein ... putative homeodomain transcription factor 2 PLOD3: procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 POM121: POM121 ... "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157-64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID ... DNA sequence and biology". Science. 300 (5620): 767-72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961 ...
*  PHF1
The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc ... This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. ... "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". ...