... class of homeodomain transcription factors. ZEB2 protein has 8 zinc fingers and 1 homeodomain. The structure of the homeodomain ... Bürglin, TR, Affolter, M, (2015). "Homeodomain proteins: an update". Chromosoma. 125 (3): x. doi:10.1007/s00412-015-0543-8. PMC ... Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a ... a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target ...
homeodomain proteins, which are encoded by homeobox genes, are transcription factors. Homeodomain proteins play critical roles ... Gehring WJ, Affolter M, Bürglin T (1994). "Homeodomain proteins". Annual Review of Biochemistry. 63: 487-526. doi:10.1146/ ... "Homeodomain proteins: an update". Chromosoma. 125 (3): 497-521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.. ... TAD is domain of the transcription factor that binds other proteins such as transcription coregulators. Proteins containing ...
2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274-8. doi: ... Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene. This gene is a member of the paired box (PAX ... Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 ... PAX1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
The homeodomain binds DNA in a sequence-specific manner. However, the specificity of a single homeodomain protein is usually ... These genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure ... Such complexes have a much higher target specificity than a single homeodomain protein. Homeodomains are encoded both by genes ... Conservation of codomains suggests a common eukaryotic ancestry for TALE and non-TALE homeodomain proteins. Proteins containing ...
Gehring WJ, Affolter M, Bürglin T (1994). "Homeodomain proteins". Annual Review of Biochemistry. 63: 487-526. doi:10.1146/ ... Homeo domain 3.1.1 Family: Homeo domain only; includes Ubx 3.1.2 Family: POU domain factors; includes Oct 3.1.3 Family: Homeo ... Cdx protein family DNA-binding protein Inhibitor of DNA-binding protein Nuclear receptor, a class of ligand activated ... Bürglin TR, Affolter M (June 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497-521. doi:10.1007/s00412-015- ...
... protein has 7 zinc fingers and 1 homeodomain. The structure of the homeodomain shown on the right. Mutations of the gene ... Dillner NB, Sanders MM (January 2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen ... Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497-521. doi:10.1007/s00412-015- ... Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) ...
SREB proteins are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. These proteins ... proteins. However, in contrast to E-box-binding HLH proteins, an arginine residue is replaced with tyrosine making them capable ... SREBP precursors are retained in the ER membranes through a tight association with SCAP and a protein of the INSIG family. ... Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA ...
Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. Changes in the ... They encode homeodomain proteins which interact with Hox and other homeotic genes to initiate segment-specific gene regulation ... The proteins do not bind directly to the DNA, rather, they interact with other regulatory proteins which are already bound to ... Mannervik M (April 1999). "Target genes of homeodomain proteins". BioEssays. 21 (4): 267-70. doi:10.1002/(SICI)1521-1878(199904 ...
... family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several ... Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.[5][6] ... 2000). "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription". J. Biol. ... 2004). "A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during ...
Analysis of Pitx2 homeodomain protein activities". J. Biol. Chem. 273 (32): 20066-72. doi:10.1074/jbc.273.32.20066. PMID ... Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene. PROP1 has both DNA-binding and ... "Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor". Osorio MG, Kopp P, Marui S, et al. (2000). " ... GeneReviews/NCBI/NIH/UW entry on PROP1- Related Combined Pituitary Hormone Deficiency (CPHD) PROP1 protein, human at the US ...
The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern ... Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene. Homeobox-containing genes are thought to ... Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): ... EN1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
Schaefer LK, Wang S, Schaefer TS (2001). "Functional interaction of Jun and homeodomain proteins". J. Biol. Chem. 276 (46): ... Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene. This gene belongs to the homeobox family of ... Shi X, Yang X, Chen D, Chang Z, Cao X (1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein ... "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its ...
"The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co- ... "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis ... "The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis ... Topisirovic I, Culjkovic B, Cohen N, Perez JM, Skrabanek L, Borden KL (Feb 2003). "The proline-rich homeodomain protein, PRH, ...
paired-like homeodomain 1 is a protein that in humans is encoded by the PITX1 gene.[5][6][7] ... "Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1". Virology. 306 (1): ... This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of ... "Entrez Gene: PITX1 paired-like homeodomain transcription factor 1".. *^ Philippi A, Tores F, Carayol J, Rousseau F, Letexier M ...
"The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent ... Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.[5][6][7] ... HOXC11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase ... Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene. In vertebrates, the genes encoding the ... Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A ... HOXA11 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase ... Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene. This gene is a member of the Antp homeobox ... "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the ... HOXB2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
"Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J. Biol. Chem ... Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene. This gene belongs to the homeobox family of ... Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX Homeodomain Proteins Block CBP Histone Acetyltransferase Activity ... The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively ...
"AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448- ... Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene. In vertebrates, the genes encoding the ... Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase ... Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A ...
Hansen LP, Crabtree GR (Apr 1993). "Regulation of the HNF-1 homeodomain proteins by DCoH". Current Opinion in Genetics & ... "Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein". Science. 254 (5039): 1762-7. ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... Sourdive DJ, Transy C, Garbay S, Yaniv M (Apr 1997). "The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha- ...
Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C (Jun 2003). "HOXB13 homeodomain protein is cytoplasmic throughout ... Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene. This gene is a member of the Antp homeobox ... Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase ... "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". ...
Shen WF, Krishnan K, Lawrence HJ, Largman C (2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity ... Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene. This gene is a member of the Abd-B homeobox ... "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its ... "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its ...
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase ... Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. This gene is a member of the ... HOXD10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence- ...
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein ... Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the ... Analysis of Pitx2 homeodomain protein activities". The Journal of Biological Chemistry. 273 (32): 20066-72. doi:10.1074/jbc. ... This protein is involved in the development of the eye, tooth and abdominal organs. This protein acts as a transcriptional ...
Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. The protein encoded by this gene is a ... "Entrez Gene: HOP homeodomain-only protein". Kook H, Epstein JA (October 2003). "Hopping to the beat. Hop regulation of cardiac ... a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". The Journal of Biological Chemistry ... a novel atypical 73 amino acid K50-homeodomain protein, during mouse development". Mechanisms of Development. 119. 119 Suppl 1 ...
Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[5][6][7] ... 1989). "Complementary homeo protein gradients in developing limb buds". Genes Dev. 3 (5): 641-50. doi:10.1101/gad.3.5.641. PMID ... HOXD8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) ... "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339-47. PMC ...