Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC (2008). "Identification of Holliday junction resolvases from humans and ... Lorenz A, West SC, Whitby MC (2010). "The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a ... The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that ... GEN1, Holliday junction 5' flap endonuclease is a protein that in humans is encoded by the GEN1 gene. This gene encodes a ...

West, Stephen C. (1 June 2009). "The search for a human Holliday junction resolvase". Biochemical Society Transactions. ...

RuvC is the resolvase, which cleaves the Holliday junction. RuvC proteins have been shown to form dimers in solution and its ... therefore resolving Holliday junctions in either a horizontal or vertical manner. RecBCD "RuvA - Holliday junction ATP- ... Holliday+Junction+Resolvases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with ... thereby resolving the Holliday junction. RuvA is a DNA-binding protein that binds Holliday junctions with high affinity. The ...

The SLX1-SLX4 complex acts as a Holliday junction resolvase. As such, the complex cleaves the links between two homologous ... 10 July 2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): ...

Górecka, K. M.; Komorowska, W.; Nowotny, M. (2013). "Crystal structure of RuvC resolvase in complex with Holliday junction ... RuvA is a tetramer and binds to the DNA at the Holliday junction when it is in the open X form. The protein binds in a way that ... The protein is a dimer, and will bind to the Holliday junction when it takes on the stacked X form. The protein has ... The ions determine which structure the Holliday junction will adopt, as they play a stabilizing role. When the ions are absent ...

In molecular biology, the protein domain, Ydc2 (also known as SpCce1), is a Holliday junction resolvase from the fission yeast ... "Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2". EMBO J. 20 (23): 6601-11. doi:10.1093/ ... capable of resolving Holliday junctions into separate DNA duplexes by cleaving DNA after 5'-CT-3, and 5'-TT-3, sequences. The ... White MF, Lilley DM (1998). "Interaction of the resolving enzyme YDC2 with the four-way DNA junction". Nucleic Acids Res. 26 ( ...

Connector domain, which is similar in structure to Holliday junction resolvase ruvC. Core domain, which is composed of two ...

It is normally found as a standalone domain in bacterial and viral Holliday Junction Resolvases (HJR). FAN1 does not exhibit ... It usually cleaves about 5 nucleotides from a junction. FAN1 will also incise at splayed arms, three way junctions, and 3' ... any activity on Holliday Junction (HJ) substrates. A subdomain of SAP consisting of six α helices connected to the VRR_Nuc ...

"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63-77. doi: ...

July 2009). "Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases". ... which is responsible for the assembly of a Holliday junction resolvase in the role of DNA repair and maintenance. SLX4IP has ... "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63-77. doi: ... "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63-77. doi: ...

2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell. 138 (1): 63-77. ...

In addition to the discovery of cellular Holliday junction resolvases, West was the first to purify the human RAD51 protein ( ... His laboratory discovered that the Holliday junction resolvase activities of MUS81 and GEN1 are regulated so that they act late ... where he discovered eukaryotic Holliday junction resolvases (yeast Yen1 and human GEN1). The identification of GEN1 was the ... He was also the first to show that RuvA and RuvB are motor proteins that mediate Holliday junction branch migration. His ...

... also known as Holliday junction resolvase, Holliday junction endonuclease, Holliday junction-cleaving endonuclease, Holliday ... This process is known as Holliday junction resolution. The Holliday junction is a structure that forms during genetic ... A Holliday junction resolvase enzyme has also been identified in archaea in Pyrococcus furiosus cells - it is encoded by a gene ... Agmon N, Yovel M, Harari Y, Liefshitz B, Kupiec M (September 2011). "The role of Holliday junction resolvases in the repair of ...

CCCGT sequence is related to the archaeal Holliday junction resolvase family". Nucleic Acids Res. 35 (7): 2377-89. doi:10.1093/ ...

The CX3 complex associates with Holliday junction resolvase activity, probably in a role of stabilizing gene conversion tracts ...

Holliday junctions were identified, although as of 2004 the identification of mammalian Holliday junction resolvases remained ... four-arm junctions similar to Holliday junctions appear in some functional RNA molecules. Immobile Holliday junctions, with ... Holliday junctions are thus components of many such DNA structures. As isolated Holliday junction complexes are too flexible to ... Holliday junctions can be resolved by four different pathways that account for essentially all Holliday junction resolution in ...

The CX3 complex was shown to associate with Holliday junction resolvase activity, probably in a role of stabilizing gene ...

The CX3 complex was shown to associate with Holliday junction resolvase activity, probably in a role of stabilizing gene ... Liu Y, Masson JY, Shah R, O'Regan P, West SC (January 2004). "RAD51C is required for Holliday junction processing in mammalian ...

"Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous ... since it resolves intermediates in this process termed Holliday junctions. H. pylori mutants that are defective in RuvC have ... esophagus-stomach junction). The treatment for this cancer is highly aggressive with even localized disease being treated ... disrupts tight junctions and causes apoptosis), and certain phospholipases. Cytotoxin associated gene CagA can also cause ...

... holliday junction resolvases MeSH D08.811.739.500 - integrases MeSH D08.811.739.500.667 - transposases MeSH D08.811.739.500. ... holliday junction resolvases MeSH D08.811.277.352.335.350.500 - micrococcal nuclease MeSH D08.811.277.352.335.375 - ... holliday junction resolvases MeSH D08.811.277.352.355.325.500 - micrococcal nuclease MeSH D08.811.277.352.355.350 - ... transposon resolvases MeSH D08.811.739.900 - vdj recombinases MeSH D08.811.797.500 - ribonuclease p MeSH D08.811.797.750 - rna ...

Holliday junction resolvases, Piwi and Argonaute proteins, various exonucleases, and the spliceosomal protein Prp8. RNases H ...

... which may constitute a signal for the Holliday junction resolvase and DNA replication. The transcriptional patterns of SIRV1 ... "Holliday junction resolving enzymes of archaeal viruses SIRV1 and SIRV2". Journal of Molecular Biology. 309 (5): 1067-76. doi: ...

For many years, it was thought that when the Holliday junction intermediate was formed, the branch point of the junction (where ... This further cleavage or 'resolvation' is done by a special group of enzymes called Resolvases. RuvC is just one of these ... During genetic recombination, a Holliday junction is formed between the two strands of DNA and a double-stranded break in a DNA ... This reaction synthesizes the Holliday junction discussed earlier. In this fashion, opposite DNA strands are joined. Subsequent ...

The pathway leading to a CO involves a double Holliday junction (DHJ) intermediate. Holliday junctions need to be resolved for ... The MUS81-MMS4 endonuclease, although a minor resolvase for CO formation in S. cerevisiae, is crucial for limiting chromosome ... Constantinou A, Chen XB, McGowan CH, West SC (Oct 2002). "Holliday junction resolution in human cells: two junction ... "Human Mus81-associated endonuclease cleaves Holliday junctions in vitro". Molecular Cell. 8 (5): 1117-27. doi:10.1016/S1097- ...

Mutants of S. cerevisiae defective in CO recombination at the level of Holliday junction resolution were found to efficiently ... "Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase". Cell. 149 (2): 334-47 ... Double mutants deleted for both MLH3 (major pathway) and MMS4 (which is necessary for a minor Holliday junction resolution ... The MSH4/MSH5 complex binds and stabilizes double Holliday junctions and promotes their resolution into crossover products. An ...

The pathway leading to a CO involves a double Holliday junction (DHJ) intermediate. Holliday junctions need to be resolved for ... "Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase". Cell. 149 (2): 334-47 ... double-strand break resection and resolution of double Holliday junctions". Mol. Cell. 40 (6): 1001-15. doi:10.1016/j.molcel. ...

1). Strand exchange then proceeds via a crossed strand intermediate analogous to the Holliday junction in which only one pair ... Famous serine recombinases include enzymes such as gamma-delta resolvase (from the Tn1000 transposon), Tn3 resolvase (from the ... Holliday, R. (1964). "A mechanism for gene conversion in fungi" (PDF). Genetics Research. 5 (2): 282-304. doi:10.1017/ ... The now classical members gamma-delta and Tn3 resolvase, but also new additions like φC31-, Bxb1-, and R4 integrases, cut all ...

MLH1-MLH3 binds specifically to Holliday junctions and may act as part of a larger complex to process Holliday junctions during ... "Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase". Cell. 149 (2): 334-47 ... The pathway leading to a CO involves a double Holliday junction (DHJ) intermediate. Holliday junctions need to be resolved for ... Meiotic CO requires resolution of Holliday junctions through actions of the MLH1-MLH3 heterodimer. The MLH1-MLH3 heterodimer is ...

... -MLH3 binds specifically to Holliday junctions and may act as part of a larger complex to process Holliday junctions during ... "Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase". Cell. 149 (2): 334-47 ... The pathway leading to a CO involves a double Holliday junction (DHJ) intermediate. Holliday junctions need to be resolved for ... Meiotic CO requires resolution of Holliday junctions through actions of the MLH1-MLH3 heterodimer. The MLH1-MLH3 heterodimer is ...

... or Holliday junction joint molecules, the latter being subsequently resolved as crossovers (COs) (see Figure). The several ... "Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase". Cell. 149 (2): 334-47 ...