High mobility group box-1 (HMGB-1) proteins as important mediators in thrombus formation. Coronary sinus thrombosis as a severe ...

"Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes". Molecular Biology of ... High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by ... This gene encodes a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are ... "High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in ...

... proteins are part of broader group of proteins referred to as High Mobility group chromosomal (HMG) proteins. This larger ... Both HMGB and HMGN are associated with the mitotic chromosome. The interactions of all HMGs with chromatin is highly dynamic, ... Once occupied one protein cannot displace the other. However both proteins are not permanently associated to the nucleosomes ... In the case of HMGN proteins, Protein kinase C (PKC) can phosphorylate the serine amino acids in the nucleosome binding domain ...

After transcription, the rDNA region has to protected from any damage, it suggested HMGB proteins play a major role in ... The nucleosome contains over 120 direct protein-DNA interactions and several hundred water-mediated ones. Direct protein - DNA ... which binds to newly synthesized H3 and H4 proteins. The old H3 and H4 proteins retain their chemical modifications which ... Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. DNA must be compacted into ...

... hmgb proteins MeSH D12.776.660.235.400.600.300 - hmgb1 protein MeSH D12.776.660.235.400.600.600 - hmgb2 protein MeSH D12.776. ... hmga proteins MeSH D12.776.660.235.400.500.100 - hmga1a protein MeSH D12.776.660.235.400.500.200 - hmga1b protein MeSH D12.776. ... MeSH D12.776.660.235.400.400 - hmgn proteins MeSH D12.776.660.235.400.400.200 - hmgn1 protein MeSH D12.776.660.235.400.400.300 ... telomeric repeat binding protein 1 MeSH D12.776.660.235.700.875 - telomeric repeat binding protein 2 MeSH D12.776.660.352. ...

... a sensor protein (PRRs), an adaptor (ASC) and an effector (caspase-1). Generally, inflammasome-forming NLR proteins share a ... molecules such as HMGB-1, ATP and DNA, out of the cell. These molecules recruit more immune cells and further perpetuate the ... Some non-NLR proteins like absent in melanoma 2 (AIM2) and pyrin can also be activated and form inflammasomes. Also, non- ... AIM2 protein can recognise viral DNA in cytoplasm and form AIM2 inflammasome, which then triggers by a caspase-1 dependent ...

HMG-box proteins are found in a variety of eukaryotic organisms. They were originally isolated from mammalian cells, and named ... contains an AT-hook domain HMGA1 HMGA2 HMGB - contains a HMG-box domain HMGB1 HMGB2 HMGB3 HMGB4 HMGN - contains a nucleosomal ... Antibodies to HMG proteins are found in patients with autoimmune diseases. The SRY gene on the Y Chromosome, responsible for ... A member of the HMG family of proteins, HMGB1, has also been shown to have an extracellular activity as a chemokine, attracting ...

HMGB and HMGN proteins. HMGA1-GFP fusion proteins are highly dynamic in vivo (determined using FRAP analysis), but in contrast ... High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene. This gene encodes a non- ... "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y". Molecular and ... HMGA1 proteins are quite small (~10-12 kDa) and basic molecules, and consist of three AT-hooks with the RGRP (Arg-Gly-Arg-Pro) ...

HMGB-1, a growth factor which promotes chondrocyte division while receptors for advanced glycation products (RAGE) mediated ... After Wnt14 is initiated, phosphorylation of the β-Catenin that would normally mark the protein for destruction is suppressed ... a protein which inhibits cartilage differentiation. These preferences are important since mature cartilage tissue is avascular ... is favored in an environment with high compressive force and low partial oxygen pressure which combine to inhibit protein 3, ...

In humans, the UBTF gene encodes a 764 amino acid protein and is located on chromosome 17 at position q21.31. In mice, UBTF is ... Hamdane N, Herdman C, Mars J, Stefanovsky V, Tremblay MG, Moss T (Sep 2015). "Depletion of the cisplatin targeted HMGB-box ... Seither P, Iben S, Thiry M, Grummt I (2001). "PAF67, a novel protein that is associated with the initiation-competent form of ... Upstream binding transcription factor (UBTF), or upstream binding factor (UBF), is a protein that in humans is encoded by the ...

... hmgb proteins MeSH D12.776.664.235.400.600.300 - hmgb1 protein MeSH D12.776.664.235.400.600.600 - hmgb2 protein MeSH D12.776. ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... fusion proteins, gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, ...

HMGB-1 and other players". Apoptosis. 15 (9): 1098-113. doi:10.1007/s10495-010-0478-8. PMID 20198437. S2CID 12729066. Han, CZ; ... lactoferrin and antibiotic proteins. Degranulation of these into the phagosome, accompanied by high reactive oxygen species ... and cationic proteins such as defensins. Other antimicrobial peptides are present in these granules, including lactoferrin, ...