RA is strongly associated with genes of the inherited tissue type major histocompatibility complex (MHC) antigen. HLA-DR4 is ... The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex is the human ... June 2005). "Association of rheumatoid arthritis with HLA-DR1 and HLA-DR4 in Hungary". Annals of the New York Academy of ... Risk alleles within the HLA (particularly HLA-DRB1) genes harbor more risk than other loci. The HLA encodes proteins that ...

"Strong association between IgA nephropathy and HLA-DR4 antigen". Kidney Int. 22 (4): 377-82. doi:10.1038/ki.1982.185. PMID ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... "HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ... derived from IMGT/HLA Roudier J (2006). "HLA-DRB1 genes and extraarticular rheumatoid arthritis". Arthritis Research & Therapy ...

Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). ... Furthermore, the human leukocyte antigen involved in this condition are HLA-DQ2(DR3 (DQB*0201)) and HLA-DQ8(DR4 (DQB1*0302)), ... Moreover, autoantibodies reacting to specific antigens is common, in the immune system of an affected individual. In terms of ...

For example, it has been associated with human leukocyte antigens (HLA) HLA-DR4 and DRB1/DQA1, copy-number variations of ... HLA-DRB1*0405 in particular appears to play an important susceptibility role. If tested in the prodromal phase, cerebrospinal ... VKH is attributed, however, to aberrant T-cell-mediated immune response directed against self-antigens found on melanocytes. ... complement component 4, a variant IL-23R locus and with various other non-HLA genes. ...

... associated with the human leukocyte antigen HLA-DR4, is often called "Familial polymorphous light eruption of American Indians ... Photosensitivity with HIV infection List of human leukocyte antigen alleles associated with cutaneous conditions Hydroa ...

Persons having the HLA-DR4 type of human leucocyte antigen appear to have a higher risk of PMR. No specific test exists to ...

"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... DQ8 increases the risk for rheumatoid arthritis and is linked to the primary risk locus for RA, HLA-DR4. DR4 also plays an ... HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... "HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations". Tissue Antigens. 59 (5): 397-406. doi:10.1034/j.1399- ...

... is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4 (only 1-3% ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ... DR3 is genetically linked to HLA-DR52, DRB3*02:02 allele, and HLA-DQ2 (DQ2.5). derived from IMGT/HLA Wiencke K, Karlsen TH, ...

... (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes. DR6 serological ... derived from IMGT/HLA DR12 - 3%, DR11 - 3% DR5-2% DR12 - 6%, DR11 - 7% DR5-4% DR1404 - 3% DR4 - 25% Shinomiya N, Nomura Y, ... HLA-DRB1*13 and HLA-DRB1*14 encode serotypes of DR6. ... HLA typing and clinical characteristics in Japan". Clin Immunol ... reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7. DR13 and DR14 share a ...

... hla-dr2 antigen MeSH D23.050.301.500.450.400.440.455 - hla-dr3 antigen MeSH D23.050.301.500.450.400.440.460 - hla-dr4 antigen ... hla-dr2 antigen MeSH D23.050.705.552.410.400.440.455 - hla-dr3 antigen MeSH D23.050.705.552.410.400.440.460 - hla-dr4 antigen ... hla-dr2 antigen MeSH D23.050.705.552.450.400.440.455 - hla-dr3 antigen MeSH D23.050.705.552.450.400.440.460 - hla-dr4 antigen ... hla-a antigens MeSH D23.050.301.500.450.370.372 - hla-a1 antigen MeSH D23.050.301.500.450.370.374 - hla-a2 antigen MeSH D23.050 ...

The risk is partially shared with the HLA-DR locus (DR3 and DR4 serotypes). Celiac1 is a genetic name for DQB1, the HLA DQB1* ... Major histocompatibility complex Human leukocyte antigen HLA-DQ ENSG00000206237, ENSG00000231286, ENSG00000206302, ... HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA ... Certain HLA-DQB1 alleles are also linked to a modest increased risk of multiple sclerosis. Other HLA-DQB1 alleles are ...

"Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis". Tissue Antigens. 58 (6): ... The DR4-DQA1*0303:DQB1*040X can be found at high frequencies in PNG highland groups but not DQ4.24. The DR*0405 and DR*410 are ... HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA ... Birol A, Anadolu R, Tutkak H, Gürgey E (2002). "HLA-class 1 and class 2 antigens in Turkish patients with pemphigus". Int J ...

HLA-DR13 is genetically linked to HLA-DR52 and HLA-DQ5 (HLA-DQ1) serotypes. derived from IMGT/HLA DR1404 - 3% DR4 - 25% ... DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens. ... HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. ... "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". ...

HLA class II histocompatibility antigen, DRB3-1 beta chain is a protein that in humans is encoded by the HLA-DRB3 gene. The ... 1987). "Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation ... Gorski J, Mach B (1986). "Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR ... 1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ...

DR4~DQ8). The full haplotype is (for relative distances) see Human leukocyte antigens: A*02:01 ~ C*05:01 ~ B*44:02 ~ DRB1*04:01 ... Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2. HLA-A*02 is one particular class I major ... HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the ... Tissue Antigens. 11 (2): 96-112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067. "HLA Nomenclature @ hla.alleles.org". ...

Ambrus M, Hernádi E, Bajtai G (May 1977). "Prevalence of HLA-A1 and HLA-B8 antigens in selective IgA deficiency". Clin. Immunol ... HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian ... HLA A1-B8 (Also:HL A1,8; HL A1,A8; HLA A1-Cw7-B8; HLA A*01-B*08, HLA A*0101-B*0801, HLA A*0101-Cw*0701-B*0801; HLA A*01:01-C*07 ... Müller C, Ehninger G, Goldmann S (2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over ...

"HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella". Tissue Antigens. ... the association appears not to extend beyond the HLA-B locus. A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 ... HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody ... antigens were first being described. The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 were ...

2005). "Association of rheumatoid arthritis with HLA-DR1 and HLA-DR4 in Hungary". Ann. N. Y. Acad. Sci. 1051 (1): 263-270. ... "HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic ... HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. Fernández MM, Guan R, ... HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among ...

... severe disease with the HLA-DR3 serotype and late-onset disease with the HLA-DR4 serotype. The diagnosis of autoimmune ... anti soluble liver antigen (SLA), liver-pancreas antigen (LP), and anti-mitochondrial antibody (AMA)) are of use, as is finding ... rare except for overlap syndromes with primary biliary cholangitis Anti-soluble liver antigen/liver pancreas antibody antigen ... "Expression of class I and class II major histocompatibility complex antigens on human hepatocytes". Hepatology. 8 (3): 449-454 ...

Sirén M, Sareneva H, Lokki M, Koskimies S (1996). "Unique HLA antigen frequencies in the Finnish population". Tissue Antigens. ... And DR3-DQ2/DR4-DQ8 individuals who have type 1 diabetes (late onset) are often mistaken for type-2 diabetes. DR3-DQ2 is ... HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). HLA ... Klemola T, Savilahti E, Koskimies S, Pelkonen P (1988). "HLA antigens in IgA deficient paediatric patients". Tissue Antigens. ...

... (A11) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody ... In autoimmune hepatitis, A11 has a synergistic effect, acting together with DR4 and DR3 to increase the odds of disease to over ... "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... Kim SJ, Choi IH, Dahlberg S, Nisperos B, Kim JD, Hansen JA (March 1987). "HLA and leprosy in Koreans". Tissue Antigens. 29 (3 ...

HLA-DRB4) is linked to the following HLADR serotypes (HLA-DRB1) allele groups: HLA-DR4 - DRB1*04 HLA-DR7 - DRB1*07 HLA-DR9 - ... Morita K, Moriuchi J, Inoko H, Tsuji K, Arimori S (1991). "HLA class II antigens and DNA restriction fragment length ... HLA-DR53 is an HLA-DR serotype that recognizes gene products of HLA-DRB4 locus. There are 13 alleles at this locus that encode ... derived from IMGT/HLA Lepage V, Douay C, Mallet C, et al. (1988). "Erythema multiforme is associated to HLA-Aw33 and DRw53". ...

... papain-solubilized fragments of the human class II MHC antigens HLA-DR1, HLA-DR2, HLA-DR3, HLA-DR4, HLA-DR7, and HLA-DR8 were ... Early work, elucidated the three-dimensional structures of the human class I MHC molecules of HLA-A2, HLA-A68, and HLA-B27. ... "Crystallization of HLA-DR antigens". Res. Immunol. 142 (5-6): 401-407. doi:10.1016/0923-2494(91)90038-k. PMID 1754711.{{cite ... "Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and ...

HLA DR3 is correlated strongly with Sjögren syndrome, myasthenia gravis, SLE, and DM Type 1. HLA DR4 is correlated with the ... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ... Molecular mimicry - An exogenous antigen may share structural similarities with certain host antigens; thus, ... T-cell-B-cell discordance - A normal immune response is assumed to involve B and T cell responses to the same antigen, even if ...

... and HLA-DQB1. The variation patterns associated with increased risk of type 1 diabetes are called HLA-DR3 and HLA-DR4-HLA-DQ8, ... About half of the disease's heritability is due to variations in three HLA class II genes involved in antigen presentation: HLA ... A pattern associated with reduced risk of type 1 diabetes is called HLA-DR15-HLA-DQ6. Large genome-wide association studies ... and/or exposure to an antigen. The remaining 10-30% of type 1 diabetics have β-cell destruction but no sign of autoimmunity; ...

... dirucotide safely delayed median time to disease progression for five years in progressive MS patients with HLA-DR2 or HLA-DR4 ... T cells producing receptors recognizing MBP fragments presented by the MHC molecules of antigen presenting cells seem to play a ... "Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with ...

The haplotype HLA-DR4-DQ3 appears to play a role in the pathogenic AAHA production. The alleles primarily recognized are HLA- ... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DR7 may also be associated with these antibodies and the common haplotype association is the HLA-DR53 serotype.[citation ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ...

... as patients with MCTD are associated with HLA-DR4 or HLA-DR2, meanwhile those with SLE are associated with HLA-DR3 and those ... an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA ... It has been associated with HLA-DR4. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody ... thus SLE is more likely in patients with HLA-DR3 and scleroderma in patients with HLA-DR5. The prevalence of MCTD is higher ...

Risk factors for developing antiphospholipid syndrome include: Genetic Markers: HLA-DR4, HLA-DR7, and HLA-DRw53 Race: Blacks, ... McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990). "Anti-phospholipid antibodies are directed against a complex antigen ... that use recombinant antigens will not have a false-positive result.[citation needed] In people without symptoms, no treatment ...

Kalish RA, Leong JM, Steere AC (July 1993). "Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and ... a technique which identifies antibodies in the serum directed against foreign antigen, in this case, B. burgdorferi, the ... "Immunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or ...