HLA A1-B8 haplotype
Ambrus M, Hernádi E, Bajtai G (May 1977). "Prevalence of HLA-A1 and HLA-B8 antigens in selective IgA deficiency". Clin. Immunol ... HLA A1-B8 (Also:HL A1,8; HL A1,A8; HLA A1-Cw7-B8; HLA A*01-B*08, HLA A*0101-B*0801, HLA A*0101-Cw*0701-B*0801; HLA A*01:01-C*07 ... A1-B8 serotype was associated with a number of diseases as "HL-A"' antigens were first being described. Among these were ... April 1990). "A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection ...
HLA-DR10
One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5. derived from IMGT/HLA White A, Rostom A (1994). "HLA antigens ... HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product. The serological reaction of DR10 is relatively ... HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. ... Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K (2006). "HLA-class II haplotype associations with ovarian ...
Neonatal alloimmune thrombocytopenia
"HLA-DRw52a is involved in alloimmunization against PL-A1 antigen". Human Immunology. 27 (2): 73-9. doi:10.1016/0198-8859(90) ... Platelet antigens are inherited from both mother and father. NAIT is caused by antibodies specific for platelet antigens ... HLA) allo-antibodies (which are expressed by platelets) to fetuses whose platelets express the corresponding antigens. NAIT ... is strongly associated with both HLA-DRB3*0101 and HLA-DQB1*0201". Human Immunology. 34 (2): 107-14. doi:10.1016/0198-8859(92) ...
HLA-Cw7
The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7. Arce-Gomez B, Jones EA, ... HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes ... "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... Tissue Antigens. 61 (5): 403-407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. (HLA-C alleles). ...
Adoptive cell transfer
Cancer-testes antigen MAGE-A3 is not known to be expressed in any normal tissues. However, targeting an HLA-A*0201-restricted ... Two patients died when treated with an HLA-A1-restricted MAGE-A3-specific TCR whose affinity was enhanced by a site-specific ... Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. Loss of B cells can be countered with ... Cancer-testis antigens are a family of intracellular proteins that are expressed during fetal development, but with little ...
HLA-A1
... (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody ... "HL-A"' antigens were first being described. The associations rapidly expanded to include 'HL-A8' HLA-B8, as the HLA A1 and B8 ... In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has ... "HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella". Tissue Antigens. ...
List of MeSH codes (D23)
... hla-a antigens MeSH D23.050.301.500.450.370.372 - hla-a1 antigen MeSH D23.050.301.500.450.370.374 - hla-a2 antigen MeSH D23.050 ... hla-a antigens MeSH D23.050.705.552.400.370.372 - hla-a1 antigen MeSH D23.050.705.552.400.370.374 - hla-a2 antigen MeSH D23.050 ... hla-a antigens MeSH D23.050.705.552.450.370.372 - hla-a1 antigen MeSH D23.050.705.552.450.370.374 - hla-a2 antigen MeSH D23.050 ... hla-a3 antigen MeSH D23.050.301.500.450.380 - hla-b antigens MeSH D23.050.301.500.450.380.383 - hla-b7 antigen MeSH D23.050. ...
HLA DR3-DQ2
HLA-DR3-DQ2 is found in HLA A1-B8-DR3-DQ2 haplotype in Northern Europeans (including the British Ilse, Ireland, Iceland). HLA ... Sirén M, Sareneva H, Lokki M, Koskimies S (1996). "Unique HLA antigen frequencies in the Finnish population". Tissue Antigens. ... Klemola T, Savilahti E, Koskimies S, Pelkonen P (1988). "HLA antigens in IgA deficient paediatric patients". Tissue Antigens. ... C regions of the HLA gene complex in northern and northwestern Europe. The linked haplotype is HLA A1-B8-DR3-DQ2 (AH8.1 in the ...
HLA-A36
... (A36) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody ... A36 is rare HLA-A allele group. A36 has a high false serotyping rate to A1. A36 is largely limited to Africa. Outside Africa, ... "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... Allele Query Form IMGT/HLA - European Bioinformatics Institute Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA ...
MAGEA1
1996). "HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA- ... 1995). "Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles". Mol. ... "Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E)". Takahashi K, Shichijo S, Noguchi M, et ... 2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959-63. PMID ...
A1
... a potent cytotoxic agent HLA-A1, a human leukocyte antigen serotype Proanthocyanidin A1, an A type proanthocyanidin Primary ... Look up A 1, A1, or a1 in Wiktionary, the free dictionary. A1, A-1, A01 or A.1. may refer to: A1, the Basic Language ... A-1 Skyraider Albastar A1, glider Model 3 A-1, an Aeronautical Products rotorcraft, see List of rotorcraft A1, a tyre code A1 ... A1 x J1, a British hip hop duo A1, an album by Ertuğ Ergin A1, an album by Tony Cetinski A One, an album by Ayumi Hamasaki A1 ( ...
HLA B7-DR15-DQ6
While there are some diseases associated with the haplotype, the frequency of association is less compared to A1::B8. HLA B7- ... June 2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6 ... Müller C, Ehninger G, Goldmann S (2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based on over ... HLA B7-DR15-DQ6 is a representation(by serotype) of a common HLA haplotype found in Western Eurasia. The haplotype can be ...
Cancer vaccine targeting CD4+ T cells
One patient simultaneously developed CD8+ T cells to HLA-A1-restricted peptide 168-176. The novel monitoring methodology used ... Even though CD4+ T cells are known to play a central role in regulating virtually all antigen-specific immune responses, the ... Using a cloning approach, one patient was shown to have a CD4+ T cell response to HLA-DR1-restricted peptide 267-282.[citation ... In addition, it is likely that protein vaccination leads to presentation of epitopes in the context of various HLA alleles, and ...
C4A
Complement component 4 Complement component 4B HLA A1-B8-DR3-DQ2 haplotype Complement system Complement deficiency ... The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha ... insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA ... Blood antigen systems, Complement system, All stub articles, Human chromosome 6 gene stubs). ...
Complement component 4B
Complement component 4 Complement component 4A HLA A1-B8-DR3-DQ2 haplotype Complement system Complement deficiency ... The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha ... "Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6". Nature. ...
HLA-DQ7
Waine GJ, Ross AG, Williams GM, Sleigh AC, McManus DP (1998). "HLA class II antigens are associated with resistance or ... B1*0301 and A1*03 haplotypes are found at relatively high frequencies in SE Asia and Austronesia, also indicating that it is ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ... HLA DQB1*0301 in Turks is associated with Thymoma but the risk may be associated with HLA class I loci. DQA1*0601:DQB1*0301 ( ...
KIR3DL2
1996). "A human killer inhibitory receptor specific for HLA-A1,2". J. Immunol. 156 (9): 3098-101. PMID 8617928. Pende D, ... 2005). "Investigation of killer cell immunoglobulin-like receptor gene diversity V. KIR3DL2". Tissue Antigens. 64 (3): 226-34. ... 1996). "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer ... Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition ...
HLA-DQ8
"Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab Emirates population". Tissue Antigens. 66 (2): ... Iberia has considerable A1/B1 equilibration suggesting independent sources from Africa. DQ8 along with a few other haplotypes ... HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 ... "HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations". Tissue Antigens. 59 (5): 397-406. doi:10.1034/j.1399- ...
HLA-A*02
... (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the ... The haplotype is considerably more equilibrated relative to A1-B8 and a possible reason is gene flow from iberia or the east ... Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2. HLA-A*02 is one particular class I major ... Tissue Antigens. 11 (2): 96-112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067. "HLA Nomenclature @ hla.alleles.org". ...
HLA-DQ2
This haplotype, HLA A1-B8-DR3-DQ2, is associated with diseases in which HLA-DQ2 has suspect involvement. Direct involvement of ... high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): ... HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA ... DQB1*0201 in Europe is frequently found in the HLA A1-B8-DR3-DQ2 haplotype.[citation needed] This allele is linked to several ...
MAGEA4
January 2006). "Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign ... Hillig RC, Coulie PG, Stroobant V, Saenger W, Ziegler A, Hülsmeyer M (July 2001). "High-resolution structure of HLA-A*0201 in ... Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene. This gene is a member of the MAGEA ... May 2006). "Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung ...
MAGEA3
2006). "Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic ... 2003). "Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen ... 2001). "Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis". Cancer Res. 61 (21): 7959-63. PMID ... Melanoma-associated antigen 3 (MAGE-A3) is a protein that in humans is encoded by the MAGEA3 gene. This gene is a member of the ...
Outline of immunology
MHC class I HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G MHC class II HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α ... Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... Obligate heterodimers of one alpha and one beta subunits Alpha subunits A1 A2 A3 A4 A5 A6 A7 A8 A9 A10 A11 AD AE AL (CD11a) AM ... T cells Antigen receptor - T cell receptor (TCR) Subunits - TRA@ / TRB@ / TRD@ / TRG@ Co-receptors CD8 (CD8α / CD8β) CD4 ...
Rubella
"HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella". Tissue Antigens. ... Increased susceptibility to infection might be inherited as there is some indication that HLA-A1 or factors surrounding A1 on ... In 1967, the molecular structure of rubella was observed under electron microscopy using antigen-antibody complexes by Jennifer ...
Paired receptors
"CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence". Journal of Experimental ... An overview and expression details on ggTREM-A1". Developmental & Comparative Immunology. 41 (3): 403-412. doi:10.1016/j.dci. ... Example pairs include: CD94/NKG2, expressed in NK and some T cells and interacts with the ligand HLA-E. Dendritic cell ... This family also interacts with surfactant protein D. The carcinoembryonic antigen-related cell adhesion (CEACAM) family ...
Complement component 4
... originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and ... Complement component 4A Complement component 4B HLA A1-B8-DR3-DQ2 haplotype Complement system Complement deficiency Sekar A, ... Using protein variants visualized by electrophoresis, the four structural genes were located between HLA-B and HLA-D. More ... Moreover, the two loci are linked to the HLA, or the human analog of the major histocompatibility complex (MHC) on the short ...
Human leukocyte antigen
It has been shown that high resolution HLA typing (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 and HLA-DPB1) may be relevant in ... While the DQ and DP encoding loci have fewer alleles, combinations of A1:B1 can produce a theoretical potential of 7,755 DQ and ... There are three major and three minor MHC class I genes in HLA. Major MHC class I HLA-A HLA-B HLA-C Minor genes are HLA-E, HLA- ... HLA-DP α-chain encoded by HLA-DPA1 locus β-chain encoded by HLA-DPB1 locus HLA-DQ α-chain encoded by HLA-DQA1 locus β-chain ...
Orexin
In humans, narcolepsy is associated with a specific variant of the human leukocyte antigen (HLA) complex. Furthermore, genome- ... Liu ZW, Gao XB (January 2007). "Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral ... Klein J, Sato A (September 2000). "The HLA system. Second of two parts". The New England Journal of Medicine. 343 (11): 782-6. ... wide analysis shows that, in addition to the HLA variant, people with narcolepsy also exhibit a specific genetic mutation in ...
Severe cutaneous adverse reactions
... predispositions are a consequence of the HLA allele and T-cell receptor variants that individuals express in their antigen ... interleukin 5 and annexin A1). DRESS syndrome: Key elements promoting tissue injury in the DRESS syndrome are: Th2 cells and ... They load processed peptides onto MHC class II (i.e. HLA-DM, HLA-DO, HLA-DP, HLA-DQ, or HLA-DR) proteins and thereon present ... Non-professional APC include all nucleated cells; these cells load the processed peptides onto MHC class I (i.e. HLA-A, HLA-B, ...
Intestine transplantation
T-lymphocytes are able to distinguish between self and non-self by recognizing human leukocyte antigens (HLA) bound to the ... doi:10.1097/01.sla.0000157265.85388.a1. PMC 1357064. PMID 15798462. Koletzko, Berthold; Goulet, Olivier; Hunt, Joanne; Krohn, ... In addition to HLA and PRA typing, the complete blood count (CBC), coagulation profile, complete metabolic panel, and ABO blood ... measures the proportion of the population to which a recipient will react via pre-existing antibodies to various HLA antigens; ...