"Murine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptase". Virus Research. 134 (1-2 ... "Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA". The EMBO Journal. 20 (6): 1449- ... "Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase". Science. 252 (5002): 88-95. doi:10.1126/science ... Reverse-transcriptase inhibitors that specifically inhibit the polymerase function of RT are in widespread clinical use, but ...
... of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase ... By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. ... Elvucitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI), developed by Achillion Pharmaceuticals, Inc ... for the treatment of HIV infection. Elvucitabine belongs to a class (group) ...
... (MKC-442) is a failed experimental agent for the treatment of HIV. It is a non-nucleoside reverse transcriptase ...
Tarrago-Litvak L, Andréola ML, Nevinsky GA, Sarih-Cottin L, Litvak S (May 1994). "The reverse transcriptase of HIV-1: from ... HIV reverse transcriptase is an enzyme for AIDS virus replication.[126] Telomerase is an unusual polymerase because it contains ... They include reverse transcriptase, which is a viral enzyme involved in the infection of cells by retroviruses, and telomerase ... Nugent CI, Lundblad V (April 1998). "The telomerase reverse transcriptase: components and regulation". Genes & Development. 12 ...
"Dynamic binding orientations direct activity of HIV reverse transcriptase". Nature. 453: 184-189. Bibcode:2008Natur.453..184A. ...
"Rationally Designed Dual Inhibitors of HIV Reverse Transcriptase and Integrase". Journal of Medicinal Chemistry. 50 (15): 3416- ... was coined in 2007 by University of Minnesota researchers who designed and synthesized a combination HIV reverse transcriptase ... "U of M researchers announce advance in treatment of HIV". 25 July 2007. Retrieved 25 July 2007. "Researchers Discover New ... "Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5". Bioorganic & Medicinal ...
... s are typically used to combat HIV. HIV treatments usually rely on targeting reverse transcriptases and ... able to inhibit HIV-1 infection by inhibiting reverse transcription without an apparent impairment of reverse transcriptase. ... Zinc ejectors were patented in 2008 and some have entered Phase I/II trials as a HIV drug. The HIV-1 nucleocapsid protein 7 ( ... Azodicarbonamide (ADA) was the first zinc ejector to go into clinical trial for treatment of HIV. ADA inhibits HIV by ...
... works by blocking reverse transcriptase, an enzyme crucial for the HBV to reproduce in the body. It is approved for ... "A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial". HIV Med. 3 (4): 229-38 ... It is an orally administered nucleotide analog reverse transcriptase inhibitor (ntRTI). It can be formulated as the pivoxil ... Trials of adefovir in patients with HIV have not shown any clear benefits. Adefovir was invented in the Institute of Organic ...
... is a cytidine nucleoside analog and nucleoside reverse transcriptase inhibitor. It was found to inhibit HIV-1 ... Dexelvucitabine is a failed experimental agent for the management of HIV infection. ... replication in vitro and during Phase II clinical trials, it was found to decrease mean viral load in patients with HIV.[ ...
1990). "Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte ... Two compounds, punicalin and punicacortein C, inhibited purified HIV reverse transcriptase. Hydrolysable tannins have shown ... HPLC determination Tannins, including gallo and ellagic acid (epigallitannins), are inhibitors of HIV replication. 1,3,4-Tri-O- ... galloylquinic acid, 3,5-di-O-galloyl-shikimic acid, 3,4,5-tri-O-galloylshikimic acid, punicalin, punicalagin inhibited HIV ...
Like other anti-HIV nucleoside analogs, it acts as a chain terminator by incorporation and inhibits viral reverse transcriptase ... It is of the reverse transcriptase inhibitor class. Didanosine was first described in 1975 and approved for use in the United ... Didanosine (ddI, DDI), marketed under the trade names Videx, is a medication used to treat HIV/AIDS. It is used in combination ... Its FDA approval helped bring down the price of zidovudine (AZT), the initial anti-HIV drug. [Source needed on pricing effect ...
Menéndez-Arias L (June 2008). "Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase". ... For example, azidothymidine (AZT) is a nucleoside analogue used to prevent and treat HIV/AIDS. The term nucleoside refers to a ... For example, azidothymidine is used in the treatment of HIV/AIDS. Some less selective nucleoside analogues can be used as ... This is common in nucleoside analogues used to treat HIV/AIDS. Biology Chromosome Gene Genetics Nucleic acid sequence ...
They show great potency in inhibiting the activity of HIV reverse transcriptase. Several compounds in this class are non- ... nucleoside reverse transcriptase inhibitors used clinically in the treatment of HIV/AIDS, notably etravirine and rilpivirine. ... dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase ... non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 ...
Ateviridine is non-nucleoside reverse transcriptase inhibitor that has been studied for the treatment of HIV. Preparation of ... 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors". Journal of Medicinal Chemistry. 37 (7): 999. doi: ... of the resulting amine with the imidazolide derivative of 5-Methoxy-3-indoleacetic acid affords the amide reverse transcriptase ... January 2000). "Concentration-targeted phase I trials of atevirdine mesylate in patients with HIV infection: dosage ...
... is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV ... who have evidence of viral replication and HIV-1 strains resistant to a non-nucleoside reverse transcriptase inhibitor (NNRTI) ... non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 ... Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Unlike the currently available agents in the class, ...
HIV uses reverse transcriptase to create a DNA copy of its RNA genome. HIV latency allows the virus to largely avoid the immune ... This latent reservoir of HIV may explain the inability of antiretroviral treatment to cure HIV infection. Viruses portal Slow ... In the field of HIV research, proviral latency in specific long-lived cell types is the basis for the concept of one or more ... Unfortunately, HIV in proviral latency is nearly impossible to target with antiretroviral drugs. Both proviral and episomal ...
Group VII: viruses possess double-stranded DNA genomes and replicate using reverse transcriptase. The hepatitis B virus can be ... The retroviruses are included in this group, of which HIV is a member. ...
... non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 isolates, clinical non-B subtype HIV-1 isolates ( ... Stampidine is an experimental nucleoside reverse transcriptase inhibitor (NRTI) with anti-HIV activity. It is a derivative of ... Uckun FM (February 2006). "Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity". ... Notably, stampidine reversed the effects of HIV exposure on the host transcriptome regardless of NRTI-sensitivity or RT ...
An example is the Merck and Dupont synthesis of Efavirenz, a potent HIV reverse transcriptase inhibitor. Lithium acetylide is ... However, the mechanism of how these additives reverse stereoselectivity is still being debated. There have been some challenges ...
... and include reverse transcriptase and integrase. Reverse transcriptase is the virally encoded RNA-dependent DNA polymerase. The ... They may also have additional accessory genes depending on the virus (e.g., for HIV-1: vif, vpr, vpu, nef) whose products are ... Reverse transcriptase also has RNaseH activity for destruction of the RNA-template. Integrase binds both the viral cDNA ... Reverse transcriptase RT encoded by the pol gene. Protein size 66000 Da. ...
Lilian A. Radesca, Young S. Lo, James R. Moore und Michael E. Pierce: Synthesis of HIV-1 Reverse Transcriptase Inhibitor DMP ... Der Wirkstoff bindet nicht-kompetitiv an die Reverse Transkriptase von HIV-I, nahe der Substratbindungsstelle für Nukleoside. ... Torre, D. et al. (2001): Nevirapine or efavirenz combined with two nucleoside reverse transcriptase inhibitors compared to ... Sheran, M. The NNRTIs efavirenz and nevirapine in the treatment of HIV. HIV Clin Trials. 6(3); 158-68; PMID 16192249. ...
A reverse transcriptase PCR (RT-PCR) is used for HIV and other RNA viruses. Branched DNA (quantiplex bDNA) tests use a molecule ...
HIV-1 reverse transcriptase complexed with different inhibitors, by Temiz and Bahar, 2002. - HIV-1 protease, by Micheletti et ...
1993). "Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E". The Journal of ... Later, they have been utilized to investigate the kinetic mechanisms of drugs inhibiting HIV-reverse transcriptase, and ... 1993). "Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E". Biochemistry. 32 (26): 6548-54 ...
Some notable drugs containing trifluoromethyl groups include efavirenz (Sustiva), an HIV reverse transcriptase inhibitor; ...
Reverse-transcriptase. inhibitors (RTIs). Nucleoside and. nucleotide (NRTI). *Nucleoside analogues/NRTIs: Abacavir (ABC)°# ... They were able to show that indinavir, when used with two other anti-HIV drugs, could significantly reduce the HIV viral load.[ ... Indinavir does not cure HIV/AIDS, but it can extend the length of a person's life for several years by slowing the progression ... It is normally used as one of the three drugs in a triple-combination therapy for the HIV virus.[1] ...