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*  Misconceptions about HIV/AIDS
Diagnosis of infection using antibody testing is a well-established technique in medicine. HIV antibody tests exceed the ... "Comparison of the sensitivity of four rapid assays for the detection of antibodies to HIV-1/HIV-2 during seroconversion". Clin ... these direct testing techniques have confirmed the validity of the antibody tests. Positive HIV antibody tests are usually ... are not caused by HIV, but rather result from the immunosuppression caused by HIV disease. As the immune system of an HIV- ...
*  HIV vaccine
... antibody-mediated) and cellular (mediated by T cells) immunity. Second, HIV isolates are themselves highly variable. HIV can be ... who found a way to attach HIV-fighting antibodies to immune cells, creating a HIV-resistant cell population. On July 16, 2012, ... Federal Domestic HIV/AIDS Resource HIVtest.org - Find an HIV testing site near you Potential HIV vaccine using adenoviridae ... Work with monoclonal antibodies (MAb) has shown or proven that the human body can defend itself against HIV, and certain ...
*  Long-term nonprogressor
... and/or HLA-B*2705 alleles and ability to exert control over HIV. Antibody production. All individuals with HIV make antibodies ... HIV uses CCR5 to enter these cells. It is believed that the Δ32 (delta 32) variant of CCR5 impairs HIV ability to infect cells ... Induction of broadly neutralizing antibodies in healthy individuals is a potential strategy for a preventive HIV vaccine, as is ... 2005). "HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication". ...
*  Timeline of early HIV/AIDS cases
... retroactive testing of the frozen blood serum indicated that 50 of the children had antibodies to a virus related to HIV. Arvid ... List of HIV-positive people History of HIV/AIDS Timeline of HIV/AIDS Nathan Wolf; Carl Zimmer; Michael Worobey; David Quammen ... The strain of HIV viruses most closely related to the lineage of HIV-1 subgroup M (responsible for the global pandemic) may ... In 2008, partial HIV viral sequences were identified from a specimen of lymph node collected from an adult female in Kinshasa, ...
*  Neutralizing antibody
They could block about two-thirds of a large panel of HIV strains. These antibodies did not bind to known epitopes, on Env, ... The difference between neutralizing antibodies and binding antibodies is that neutralizing antibodies neutralize the biological ... They described the exact viral component, or epitope that triggered the antibody. Six amino acids at the tip of HIV's surface ... bNAbs are stickier than other antibodies. HIV viruses have only about 10 trimers on the surface versus some 450 for influenza. ...
*  Nancy T. Chang
Tanox was also active in the development of TNX-355, an antibody for the treatment of HIV/AIDS. Nancy has said that she is ... Tanox was also active in the development of TNX-355, an antibody for the treatment of HIV/AIDS. In 2007, Tanox was sold to ... Nancy Chang's published research includes over 35 papers on topics including monoclonal antibodies and HIV. She has been ... Nancy was instrumental in developing the first diagnostic assay to detect HIV infection by employing a peptide segment of HIV ...
*  Microantibody
This antibody inactivates HIV in vitro. Single-domain antibody Heap CJ, Wang Y, Pinheiro TJ, Reading SA, Jennings KR, Dimmock ... Microantibodies can stop viruses such as HIV from infecting cells in vitro. Antibodies are produced naturally by the body and ... passive antibody exposes the body to foreign protein and although monoclonal antibodies can be humanized they can still invoke ... The use of whole, natural antibodies as medicines presents many problems: they can only be produced by live cells and this ...
*  Hermann Mucke (bioscientist)
Evaluation of an indirect immunofluorescence assay for the confirmation of HIV-1 antibody in U.S. blood donor sera. J Clin ... HIV-1 by the U.S. FDA approval on 5 February 1992. A human T-lymphotropic virus antibody test, developed by Mucke's team but ... Indications for the presence of antibodies cross-reactive with HTLVI/II, but not HIV, in patients with myelodysplastic sndrome ... He developed an indirect immunofluorescence assay for the detection of antibodies to the human immunodeficiency virus in human ...
*  CD81
Purified HIV produced by MOLT\HIV cells contains CD81. Anti-CD81 antibodies downregulate HIV production 3 fold, however the ... HIV gag proteins use tetraspanin enriched microdomains (containing minimally CD81, CD82, CD63) as a platform for virion ... Takahashi S, Doss C, Levy S, Levy R (1990). "TAPA-1, the target of an antiproliferative antibody, is associated on the cell ... It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan ...
*  Chang Yi Wang
Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. Proc. Natl. Acad. Sci. United States ... and a Synthetic AIDS Vaccine Targeting HIV HIV Receptors April 25, 2001 • London, England HIV Therapeutics: Searching for the ... First was the development of a synthetic peptide based HIV 1 test and later an HIV 1,2 diagnostic test for blood screening, ... International clinical trials of HIV vaccines: I. Phase I trial of an HIV-1 synthetic peptide vaccine in Bangkok, Thailand. ...
*  Entry inhibitor
b12 is an antibody against HIV found in some long-term nonprogressors. It has been found to bind to gp120 at the exact region, ... Pugach P, Ketas TJ, Michael E, Moore JP (August 2008). "Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 ... TNX-355, a monoclonal antibody that binds CD4 and inhibits the binding of gp120 PRO 140, a monoclonal antibody that binds CCR5 ... By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS. There are ...
*  Breast milk
"HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women ... It is rich in protein and antibodies that provide passive immunity to the baby (the baby's immune system is not fully developed ... Scalding it will prevent rancid taste at the expense of antibodies. It should be stored with airtight seals. Some plastic bags ... Human milk quenches the baby's thirst and hunger and provides the proteins, sugar, minerals, and antibodies that the baby needs ...
*  Global HIV Vaccine Enterprise
"Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions". PLoS Medicine. 4 (12): e348. doi:10.1371/journal. ... "Nipping HIV In the Bud", IAVI Report Volume 14 No. 1, New York, January-February 2010. IAVI. "Nipping HIV In the Bud", IAVI ... The Global HIV Vaccine Enterprise (the Enterprise) is an alliance of organizations formed to accelerate the search for an HIV ... Coordinating Committee of the Global HIV/AIDS Vaccine Enterprise (2005) The Global HIV/AIDS Vaccine Enterprise: Scientific ...
*  Susan Zolla-Pazner
This discovery led her to develop methods to generate anti-HIV human monoclonal antibodies (mAbs) from the blood cells of HIV- ... "A human monoclonal antibody specific for the V3 loop of HIV type 1 clade E cross-reacts with other HIV type 1 clades". AIDS ... She initiated systemic testing to enumerate CD4 and CD8 cells and antibodies in order to diagnose HIV infection and follow the ... She proposed quantifying the antibodies directed at the second and third variable loops (V2 and V3) of the HIV envelope protein ...
*  Antibody-dependent enhancement
"Traitors of the immune system-Enhancing antibodies in HIV infection: Their possible implication in HIV vaccine development". ... or antibody-dependent cellular cytotoxicity-mediating antibodies (ADCC) in the serum contains infection enhancing antibodies( ... ADE of infection has also been reported in HIV. Like DENV, non-neutralizing level of antibodies have been found to enhance the ... The interaction of anti-HIV antibodies with non-neutralizing complement exposed viruses also aid in binding of the virus and ...
*  Ortho Clinical Diagnostics
The test detects both HIV-1 and HIV-2 antibodies and the p24 antigen, and enables detection of HIV-1 acute infection earlier ... "Ortho Clinical Diagnostics Gets FDA Clearance for HIV Combo Test on Immunodiagnostic System". 360Dx.com. Retrieved 19 December ... 2017: FDA approves Ortho's HIV Combo test for the VITROS® immunodiagnostic system. ...
*  Phage display
... of human antibody Fab that bound tetanus toxin and the method was then extended to rapidly clone human anti-HIV-1 antibodies ... Antibody phage display was later used by Carlos F. Barbas at The Scripps Research Institute to create synthetic human antibody ... HUMIRA, an antibody to TNF alpha, was the world's first fully human antibody, which achieved annual sales exceeding $1bn. Below ... The invention of antibody phage display revolutionised antibody drug discovery. Initial work was done by laboratories at the ...
*  TIGIT
Blocking these pathways with novel targeted monoclonal antibodies synergistically rejuvenated HIV-specific CD8+ T cell ... This pathway can potentially be targeted to enhance killing of HIV infected cells during "Shock and Kill" HIV curative ... TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is ... Elevated TIGIT levels remained sustained even among those with undetectable viral loads and a large fraction of HIV-specific ...
*  Molecular mimicry
Antibodies are produced for the HIV-1 gp41 protein. These antibodies can cross-react with astrocytes within human CNS tissue ... HIV-1 gp41 is used to bind chemokines on the cell surface of the host so that the virion may gain entrance into the host. ... The HIV-1 virus has been shown to cause diseases of the central nervous system (CNS) in humans through a molecular mimicry ... A twelve amino acid sequence (Leu-Gly-Ile-Trp-Gly-Cys-Ser-Gly-Lys-Leu-Ile-Cys) on gp41 of the HIV-1 virus (immunodominant ...
*  C1QA
1994). "Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41". Clin. Exp. Immunol. 94 (3 ... 1995). "Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1". Immunology. 85 (2): 184 ... 1995). "HIV-1 rsgp41 depends on calcium for binding of human c1q but not for binding of gp120". Mol. Immunol. 32 (5): 371-4. ... 1994). "The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three ...
*  Hook effect
Examples include high levels of syphilis antibodies in HIV patients or high levels of cryptococcal antigen leading to false ... The antibody that fails to react is known as the blocking antibody and prevents the precipitating antibody from binding to the ... In this case, no sandwich can be formed by the capturing antibody, the antigen and the detection antibody. In this case, free ... However, if too many antibodies are present that can bind to the antigen, then the antigenic sites are coated by antibodies, ...
*  Mycoplasma penetrans
"High frequency of antibodies to Mycoplasma penetrans in HIV-infected patients". The Lancet. 340 (8831): 1312-1316. doi:10.1016/ ...
*  Julie McElrath
One of their key findings suggested the vaccines might spur some recipients to make antibodies that prevent HIV infection. ... and the NIAID HIV Vaccine Trials Network. HIV-DNA priming alters T-cell response to HIV-adenovirus vaccine even when responses ... Progress in HIV-1 vaccine development. Curr Opin HIV AIDS 8(4):326-32, 2013. S.M. Hammer, M.E. Sobieszczyk, H. Janes, S.T. ... Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus. J ...
*  CD11a
"Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent ... Chirmule N, Oyaizu N, Saxinger C, Pahwa S (1994). "Nef protein of HIV-1 has B-cell stimulatory activity". AIDS. 8 (6): 733-4. ... Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced ... Hildreth JE, Orentas RJ (1989). "Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation". ...
*  Dong-Pyou Han
... eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER. Retrovirology. 2014 Feb 6;11(1):16. Soltis, Andy ... On 1 July 2015 Han was sentenced to 57 months imprisonment for fabricating and falsifying data in HIV vaccine trials. He was ... Associated Press (2 July 2015). "Disgraced Iowa State scientist who faked 'revolutionary' HIV vaccine research by using RABBIT ... had added human blood components to rabbit blood to make it appear as though a vaccine he was working on had exhibited anti-HIV ...
*  Development of analogs of thalidomide
This enhances natural and antibody dependent cellular cytotoxicity. Lenalidomide and pomalidomide are about 100-1000 times more ... HIV-associated wasting syndrome, Crohn's disease, Kaposi's sarcoma, myelodysplastic syndrome and hematopoietic stem cell ...
*  International AIDS Vaccine Initiative
"Two New Antibodies Found to Cripple HIV," Theraclone Sciences news release. Sept. 3, 2009. Phogat, Sanjay. "Antibody ... PG9 and PG16 were the first new broadly neutralizing antibodies against HIV discovered in more than a decade and are the result ... Its Neutralizing Antibody Consortium is a network dedicated to discovering and understanding broadly neutralizing antibodies ... The organization takes a comprehensive approach to HIV and AIDS that supports existing HIV prevention and treatment programs ...