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*  HIST1H1B
Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene. Histones are basic nuclear proteins responsible for ... "Entrez Gene: HIST1H1B histone cluster 1, H1b". Ohe Y, Hayashi H, Iwai K (1990). "Human spleen histone H1. Isolation and amino ... The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher ... Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of ...
*  HIST1H2AC
Histone H2A type 1-C is a protein that in humans is encoded by the HIST1H2AC gene. Histones are basic nuclear proteins that are ... "Entrez Gene: HIST1H2AC histone cluster 1, H2ac". Ruddy DA, Kronmal GS, Lee VK, et al. (1997). "A 1.1-Mb transcript map of the ... The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher ... Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of ...
*  Histone
Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1/H5 are known as the linker histones. The core ... Histone variants Chromatin Gene silencing Genetics Histone acetyltransferase Histone deacetylases Histone methyltransferase ... The discovery of the H5 histone appears to date back to the 1970s, and it is now considered an isoform of Histone H1. Histones ... Archaeal histones may well resemble the evolutionary precursors to eukaryotic histones. Histone proteins are among the most ...
*  Histone methyltransferase
... s (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine ... Histone methyltransferase does so by modifying histones at certain sites through methylation. Methylation of histones is ... Histone-Modifying Enzymes Histone acetyltransferase (HAT) Histone deacetylase (HDAC) RNA polymerase control by chromatin ... Histone methylation plays an important role in epigenetic gene regulation. Methylated histones can either repress or activate ...
*  Histone octamer
The histone octamer interacts with the DNA through both its core histone folds and N-terminal tails. The histone fold interacts ... Heterodimers, or histone-only intermediates are formed from histone-fold domains. The formation of histone only-intermediates ... Each histone has both an N-terminal tail and a C-terminal histone-fold. Both of these key components interact with DNA in their ... Each histone in the octamer has an N-terminal tail that protrudes from the histone core. The tails play roles both in inter and ...
*  Histone acetyltransferase
There are five different histone proteins: H1, H2A, H2B, H3, and H4. A core histone is formed when two of each histone subtype ... Histone-modifying enzymes Histone deacetylase (HDAC) Histone methyltransferase (HMT) RNA polymerase control by chromatin ... Histone H1 locks the nucleosome complex together, and it is the last protein to bind in the complex. Histones tend to be ... Sas2 is also observed to acetylate H3K14 in vitro on free histones. Esa1 can also acetylate H3K14 in vitro on free histones as ...
*  Histone H2A
... is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histones are ... Other histone proteins: H1 H2B H3 H4 Histone H2A is composed of non-allelic variants. The term "Histone H2A" is intentionally ... There are five families of histones known to date; these histones are termed H1/H5, H2A, H2B, H3, and H4. H2A is considered a ... H2A utilizes a protein fold known as the 'histone fold.' The histone fold is a three-helix core domain that is connected by two ...
*  Histone methylation
... is a process by which methyl groups are transferred to amino acids of histone proteins that make up ... Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids in the histones ... The activities of histone methyltransferases are offset by the activity of histone demethylases. This allows for the switching ... "Epigenetic Regulation by Histone Methylation and Histone Variants." Molecular Endocrinology 19.3 (2005): 563. Print. Albert, ...
*  Histone H2B
Nucleosome Histone Chromatin Other histone proteins: Histone H1 Histone H2A Histone H3 Histone H4 Bhasin M, Reinherz EL, Reche ... Similar to other histone proteins, histone H2B has a distinct histone fold that is optimized for histone-histone as well as ... Two copies of histone H2B come together with two copies each of histone H2A, histone H3, and histone H4 to form the octamer ... histone H2B genes share a promoter region with sequences that code for histone H2A. While all genes in the histone cluster are ...
*  Histone H3
These are denoted as Histone H3.1, Histone H3.2, Histone H3.3, Histone H3.4 (H3T), Histone H3.5, Histone H3.X and Histone H3.Y ... Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a ... Acetylation of histone H3 occurs at several different lysine positions in the histone tail and is performed by a family of ... Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five ...
*  Histone H4
... is a 102 to 135 amino acid protein which shares a structural motif, known as the histone fold, formed from three a- ... Histone H4 H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a ... Histone H4 is one of the slowest evolving proteins, and there appear to be no known sequence variants of histone H4. However, ... These modifications may alter expression of genes located on DNA associated with its parent histone octamer. Histone H4 is an ...
*  Histone variants
macroH2A contains a histone fold domain and an extra, long C-terminal macro domain which can bind poly-ADP-ribose. This histone ... Histone variants are proteins that substitute for the core canonical histones (H3, H4, H2A, H2B) in nucleosomes in eukaryotes ... Histone H3.3 has been found to play an important role in maintaining genome integrity during the mammalian development. Histone ... "Histome: The Histone Infobase" is manually curated database of histone variants in humans and associated post-translational ...
*  Histone H1
nucleosome histone chromatin linker histone H1 variants Other histone proteins involved in chromatin: H2A H2B H3 H4 ... Histone H1 is one of the five main histone protein families which are components of chromatin in eukaryotic cells. Though ... Much has been learned about histone H1 from studies on purified chromatin fibers. Ionic extraction of linker histones from ... Khochbin S (June 2001). "Histone H1 diversity: bridging regulatory signals to linker histone function". Gene. 271 (1): 1-12. ...
*  Histone fold
A histone fold is a structurally conserved motif found near the C-terminus in every core histone sequence in a histone octamer ... The histone fold averages about 70 amino acids and consists of three alpha helices connected by two short, unstructured loops. ... When not in the presence of DNA, the core histones assemble into head-to-tail intermediates (H3 and H4 first assemble into ... 224 Arrents, G. & Mourdrianakis, E.N. (1995). The histone fold: A ubiquitous architectural motif utilized in DNA compaction and ...
*  Histone Database
The Histone Database is a comprehensive database of histone protein sequences including histone variants, classified by histone ... new histone fold family members". Nucleic Acids Res. PMID 9399877. Baxevanis AD, Landsman D (1997). "Histone and histone fold ... The creation of the Histone Database was stimulated by the X-ray analysis of the structure of the nucleosomal core histone ... Marino-Ramirez L, Hsu B, Baxevanis AD, Landsman D (2006). "The Histone Database: a comprehensive resource for histones and ...
*  Histone code
Histone Histone-Modifying Enzymes Jenuwein T, Allis C (2001). "Translating the histone code". Science. 293 (5532): 1074-80. doi ... Cellsignal.com Histone Modifications with function and attached references Histone Code Overview sheet Histone Modification ... 2011). "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification". Cell. 146 ( ... Structural determinants of histone recognition by readers, writers and erasers of the histone code are revealed by a growing ...
*  Histone deacetylase
Histone acetyltransferase (HAT) Histone deacetylase inhibitor Histone methyltransferase (HMT) Histone-modifying enzymes RNA ... Histone deacetylases remove those acetyl groups, increasing the positive charge of histone tails and encouraging high-affinity ... These are just some examples of constantly emerging non-histone, non-chromatin roles for HDACs. Histone deacetylase inhibitors ... allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA ...
*  Histone-modifying enzymes
"Examples of histone modifications in transcriptional regulation". Histone deacetylases Histone methyltransferase Histone ... Several distinct classes of enzyme can modify histones at multiple sites. The figure on the right enlists those histone- ... The nucleosome is composed of an octamer of the four core histones (H3, H4, H2A, H2B) around which 146 base pairs of DNA are ... There are at least eight distinct types of modifications found on histones (see the legend box on the top left of the figure). ...
*  Histone deacetylase 2
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein ... "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co- ... "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids Res ... "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 95 (7): ...
*  Anti-histone antibodies
An ELISA for detecting anti-histone antibodies is said to be positive when there is more than 25 units/ml anti-histone ... Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family. They are found in 50%-70% of ... Muller, Sylviane (2014). Chapter 23 - Histone Autoantibodies, In Autoantibodies (Third ed.). San Diego, CA. p. 195. ISBN ...
*  Histone deacetylase 5
... is an enzyme that in humans is encoded by the HDAC5 gene. Histones play a critical role in ... The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase ... Histone deacetylase 5 has been shown to interact with: BCL6, CBX5, GATA1, HDAC3, IKZF1, MEF2A, NRIP1, NCOR1, NCOR2, YWHAQ, and ... "Entrez Gene: HDAC5 histone deacetylase 5". McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves ...
*  Histone deacetylase inhibitor
... s (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylase. HDIs ... Histone deacetylase inhibition induces the accumulation of hyperacetylated nucleosome core histones in most regions of ... Based on their homology of accessory domains to yeast histone deacetylases, the 18 currently known human histone deacetylases ... through modulating that the acetylation/deactylation of histones and/or non-histone proteins such as transcription factors. ...
*  Non-histone protein
In chromatin, those proteins which remain after the histones have been removed, are classified as non-histone proteins. ... Scaffold proteins, DNA polymerase, Heterochromatin Protein 1 and Polycomb are common non-histone proteins. This classification ...
*  Linker histone H1 variants
... including H1 histones, with the aim of producing informative and easily searchable histone variant names. histone H1 histone ... oocyte specific variants Histone H1 differs strongly from the core histones. Rather than originating from archaeal histones, it ... H1 histones bind to the linker DNA exiting from the nucleosome particle, while the core histones (H2A, H2B, H3 and H4) form the ... Unlike core histones featuring a so-called histone fold, H1s typically have a short basic N-terminal domain, a globular domain ...
*  Histone acetylation and deacetylation
Histone acetyltransferase Histone deacetylase Histone methylation Acetylation Phosphorylation Nucleosome University, James D. ... These histone cores are composed of 8 subunits, two each of H2A, H2B, H3 and H4 histones. This protein complex forms a ... Unlike histone core proteins, histone tails are not part of the nucleosome core and are exposed to protein interaction. A model ... By deacetylating the histone tails, the DNA becomes more tightly wrapped around the histone cores, making it harder for ...