Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded ... January 2011). "Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at ... "Entrez Gene: Euchromatic histone-lysine N-methyltransferase 1". Retrieved 2012-03-04. Kleefstra T, Brunner HG, Amiel J, ... In addition to their role as histone lysine methyltransferases (HMTs), several studies have shown that G9A/GLP are also able to ...

... family of histone lysine methyltransferases (HKMTs) which methylate histone H3 on lysine 9, human SETD7 (also called SET7 or ... Histone lysine methyltransferases (HMTase) differ both in their substrate specificity for the various acceptor lysines as well ... Min J, Zhang X, Cheng X, Grewal SI, Xu RM (November 2002). "Structure of the SET domain histone lysine methyltransferase Clr4 ... Histone lysine methylation is part of the histone code that regulates chromatin function and epigenetic control of gene ...

L. Liu, S. Kimball, H. Liu, A. Holowatyj, Z.Q. Yang (2015). Genetic alterations of histone lysine methyltransferases and their ... It is a member of the histone lysine methyltransferase family. Overexpression of SETD5 is associated positively with ... encoding a methyltransferase in a 3p25 microdeletion syndrome critical region, cause intellectual disability. American Journal ...

Rose NR, Klose RJ (December 2014). "Understanding the relationship between DNA methylation and histone lysine methylation". ... Methyltransferase DNA methylation PRMT4 pathway Cell cycle regulated Methyltransferase Iyer LM, Zhang D, Aravind L (January ... Information about DNA methyltransferases and DNA methylation at epigeneticstation.com Data for a DNA methyltransferase (DNMT) ... TRDMT1 is the first RNA cytosine methyltransferase to be identified in human cells. DNMT3 is a family of DNA methyltransferases ...

"Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein". The Journal of Biological Chemistry. 289 (17 ... Upon binding to DNA, PRDM9 catalyzes trimethylation of Histone 3 at lysine 4 and lysine 36. As a result, local nucleosomes are ... Hayashi K, Yoshida K, Matsui Y (November 2005). "A histone H3 methyltransferase controls epigenetic events required for meiotic ... "A mouse speciation gene encodes a meiotic histone H3 methyltransferase". Science. 323 (5912): 373-5. Bibcode:2009Sci...323.. ...

Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene. GRCh38: Ensembl release 89: ... "SETD7 SET domain containing 7, histone lysine methyltransferase [ Homo sapiens (human) ]". Nagase T, Kikuno R, Hattori A, et al ... "Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase". Mol Cell. 8 (6): 1207-17. ... a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for ...

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene. The enzyme is a histone ... This histone modification is often abbreviated H4K20me1: H4 - type of histone K - symbol of lysine 20 - position of the lysine ... methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine ... a nucleosomal histone H4-lysine 20-specific methyltransferase". Current Biology. 12 (13): 1086-99. doi:10.1016/S0960-9822(02) ...

Histone-lysine N-methyltransferase 2A is the human homolog of trx. The table contains names of Drosophila TrxG members. ... HIstome Histone acetyltransferase Histone deacetylases Histone methyltransferase Histone-Modifying Enzymes Nucleosome PRMT4 ... The trithorax complex activates gene transcription by inducing trimethylation of lysine 4 of histone H3 (H3K4me3) at specific ... "E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases". EMBO J. 28 (20): 3185- ...

A particular interest has been the development of inhibitors for the histone-lysine methyltransferase enzymes in the Plasmodium ... "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases". Nature Chemical Biology. 9 (3): 136-137. doi: ... "Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in ...

Histone methyltransferases (HMT) are histone-modifying enzymes (e.g., histone-lysine N-methyltransferases and histone-arginine ... which targets the lysine tail region of the histone, Dot1 methylates a lysine residue in the globular core of the histone, and ... histone marks. Generally, the effect of a histone methyltransferase on gene expression strongly depends on which histone ... The class of lysine-specific histone methyltransferases is subdivided into SET domain-containing and non-SET domain-containing ...

EZH2: This gene's product, the EZH2 protein, is a histone-lysine N-methyltransferase. It thereby regulates the expression of ... CUDC-907, an inhibitor of PI3K and histone deacetylases, is being evaluated in two separate clinical trials for the treatment ...

... and MLL4-containing histone H3 lysine 4 methyltransferase complex". J. Biol. Chem. 282 (28): 20395-406. doi:10.1074/jbc. ...

... and MLL4-containing histone H3 lysine 4 methyltransferase complex". The Journal of Biological Chemistry. 282 (28): 20395-406. ... Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme ... This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in ... "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Molecular Cell. 23 (4): 607-18. doi: ...

... protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is ... "Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase". J Biol Chem. 280 (42): ... The trimethylation of lysine-36 of histone H3 (H3K36me3) is required in human cells for homologous recombinational repair and ... "SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability". Cell Rep. 7 ...

2007). "PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex". J. Biol. Chem. 282 (28 ... UTX has been linked with demethylation of lysine residues on histone, in particular H3K27, resulting in a gene de-repression, a ... 2007). "A histone H3 lysine 27 demethylase regulates animal posterior development". Nature. 449 (7163): 689-94. Bibcode: ... 2008). "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases". Proc. Natl. Acad. Sci. U. ...

... or three times by lysine methyltransferases. Protein methylation has been most studied in the histones. The transfer of methyl ... groups from S-adenosyl methionine to histones is catalyzed by enzymes known as histone methyltransferases. Histones that are ... Nakayama, J. -I.; Rice, J. C.; Strahl, B. D.; Allis, C. D.; Grewal, S. I. (2001). "Role of Histone H3 Lysine 9 Methylation in ... The most prevalent protein methylations affect arginine and lysine residue of specific histones. Otherwise histidine, glutamate ...

The ADD domain serves as an inhibitor of the methyltransferase domain until DNMT3A binds to the unmodified lysine 4 of histone ... "The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase". Nucleic Acids Research. 31 (9): 2305- ... "The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase". Nucleic Acids Research. 31 (9): 2305- ... "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids ...

... (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ... "Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression". PLOS ONE. 6 (11): e28171. ... An S, Yeo KJ, Jeon YH, Song JJ (2011). "Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its ... Tanaka Y, Katagiri Z, Kawahashi K, Kioussis D, Kitajima S (2007). "Trithorax-group protein ASH1 methylates histone H3 lysine 36 ...

2002). "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression". J Biol Chem. ... Louis University School of Medicine, where he identified the first histone H3 lysine 4 (H3K4) methylase in Saccharomyces ... 2007). "Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS". Cell. 131 (6): 1084-1096. doi ... Smith, E.; Shilatifard, A. (2010). "The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying ...

They modify mainly lysine on the ε-nitrogen and the arginine guanidinium group on histone tails. Lysine methyltransferases and ... methyltransferase DNA methyltransferase Histone methyltransferase 5-Methyltetrahydrofolate-homocysteine methyltransferase O- ... "Histone Lysine Methylation" Genetic pathways involving Histone Methyltransferases from Cell Signaling Technology Portal: ... 5 December 2010). "Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP ...

This complex has histone methyltransferase activity and primarily methylates histone H3 on lysine 27 (i.e. H3K27me3), a mark of ... SET domain with histone methyltransferase activity) and Rbbp4 (histone binding domain). PRC2 can bind to H3K27me3 and repress ... PRC1 also mono-ubiquitinates histone H2A on lysine 119 (H2AK119Ub1). These proteins are required for long term epigenetic ... "EZH2 methyltransferase and H3K27 methylation in breast cancer". International Journal of Biological Sciences. 8 (1): 59-65. doi ...

Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene. SETDB1 is also known as ... Histone-lysine N-methyltransferase SETDB1) at the PDBe-KB. This article incorporates text from the United States National ... associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". Biochem ... Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ (April 2002). "SETDB1: a novel KAP-1-associated histone H3, lysine 9- ...

This histone methyltransferase performs its biological activity by catalyzing the trimethylation of histone 3 lysine 27 ( ... Dudakovic, Amel (2015). "Epigenetic control of skeletal development by the histone methyltransferase Ezh2". J. Biol. Chem. 290 ...

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene. GRCh38: Ensembl release ... 2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene. 23 (30): 5242 ... 2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis. 27 (11): ... 2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593-9. doi: ...

Histone-lysine N-methyltransferase KMT5B is an enzyme that in humans is encoded by the KMT5B gene. The enzyme along with WHSC1 ... "KMT5B lysine methyltransferase 5B [ Homo sapiens (human) ]". Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, ... Tryndyak VP, Kovalchuk O, Pogribny IP (2006). "Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast ... cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl- ...

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene. This gene is a member of ... interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 ... Vandel L, Trouche D (2001). "Physical association between the histone acetyl transferase CBP and a histone methyl transferase ... "The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase". Nucleic Acids Res. 31 (9): 2305-12. ...

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene. In mice, EZH1 and EZH2 ... Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH (Nov 2008). "EZH1 mediates methylation on histone H3 lysine ... "EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair". Genes ... cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. EZH1 also complements ...

Histone-lysine N-methyltransferase SETMAR is an enzyme that in humans is encoded by the SETMAR gene. SETMAR contains a SET ... January 2011). "Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining". Proceedings of the ... domain that confers its histone methyltransferase activity, on Lys-4 and Lys-36 of Histone H3, both of which are specific tags ... and Function of SETMAR Protein Lysine Methyltransferase". Life. 11 (12): 1342. doi:10.3390/life11121342. PMC 8704517. PMID ...

Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene. This gene is related to the ... "The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis". Genes ... 2006). "Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity". ...

... it recruits the histone methyltransferase G9a. G9a then catalyzes repressive histone 3 lysine 9 dimethylation (H3K9me2) at ... BHLHE41 recruits the histone methyltransferase G9a and histone deacetylases HDAC1 and Sirt1 to mediate chromatin modifications ... represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism". The Journal of ... The proline at position 385 (384 according to the talk page) of BHLHE41 is located close to the C-terminal histone deacetylase- ...

"Histone-lysine N-methyltransferase, H3 lysine-9 specific 3". HIstome: The Histone Infobase. Retrieved 8 June 2018. Cloos PA, ... Histone methylation Histone methyltransferase Methyllysine "H3K9me2". HIstome: The Histone Infobase. Retrieved 8 June 2018. ... The carboxyl (C) terminal end of these histones contribute to histone-histone interactions, as well as histone-DNA interactions ... two histone methyltransferases that catalyze the dimethylation of Lys9 of histone H3 (H3K9me2) (Covington et al., 2011), a mark ...