... may refer to: Demethylase (Histone-H3)-lysine-36 demethylase This disambiguation page lists articles ... associated with the title Histone demethylase. If an internal link led you here, you may wish to change the link to point ...

JmjC domain-containing histone demethylase 1A, H3-K36-specific demethylase, histone-lysine (H3-K36) demethylase, histone ... histone-H3)-lysine-36+demethylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Histone-H3)-lysine-36 demethylase (EC 1.14.11.27, JHDM1A, ... Histone-H3)-lysine-36 demethylase contains iron(II). Tsukada Y ... Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (February 2006). "Histone demethylation by a family of ...

Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in ... LSD1 was the first histone demethylase to be discovered though more than 30 have since been described. This gene encodes a ... LSD1 (lysine-specific demethylase 1), through a FAD-dependent oxidative reaction, specifically removes histone H3K4me2 to ... "Entrez Gene: Lysine (K)-specific demethylase 1A". Rudolph T, Beuch S, Reuter G (August 2013). "Lysine-specific histone ...

Shen, Hongjie; Xu, Wenqi; Lan, Fei (2017). "Histone lysine demethylases in mammalian embryonic development". Experimental & ... such as histone modification and DNA methylation). Giving an analogy of his mother and her twin sister, he explains: Chance ... "histone modifications at most act as cogs in the machinery." Omission of transcription factors was viewed as an "overarching" ... "Only a talmudic-like reading can reveal a hint that something other than histone modifications are at play." It is now ...

The activities of histone methyltransferases are offset by the activity of histone demethylases. This allows for the switching ... It is necessary for the activities of both histone methyltransferases and histone demethylases to be regulated tightly. ... Histone code Histone acetylation and deacetylation Histone methyltransferase Methylation Methyllysine Genetic imprinting DNA ... Histone methylation is a process by which methyl groups are transferred to amino acids of histone proteins that make up ...

May 2011). "The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases". EMBO Reports. 12 (5): 463-469. doi: ... This leads to a hypermethylated state of DNA and histones, which results in different gene expression that can activate ...

Walport LJ, Hopkinson RJ, Schofield CJ (December 2012). "Mechanisms of human histone and nucleic acid demethylases". Curr. Opin ... "Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of ... histone and DNA demethylation), as well as sensors of energy metabolism. Many αKG-dependent dioxygenase also catalyse uncoupled ...

... including histone lysine demethylases. This leads to a hypermethylated state of DNA and histones, which results in different ... "The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases". EMBO Rep. 12 (5): 463-9. doi:10.1038/embor.2011.43 ...

May 2011). "The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases". EMBO Reports. 12 (5): 463-9. doi: ... 23 November 2010). "Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase ... "Highly selective inhibition of histone demethylases by de novo macrocyclic peptides". Nature Communications. 8 (1). doi:10.1038 ...

Benevolenskaya EV (August 2007). "Histone H3K4 demethylases are essential in development and differentiation". Biochem. Cell ... Histone Histone-modifying enzymes Jenuwein T, Allis C (2001). "Translating the histone code". Science. 293 (5532): 1074-80. ... Cellsignal.com Histone Modifications with function and attached references Histone Code Overview sheet Histone Modification ... 2011). "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification". Cell. 146 ( ...

Benevolenskaya EV (August 2007). "Histone H3K4 demethylases are essential in development and differentiation". Biochemistry and ... Histone variants Chromatin Gene silencing Genetics Histone acetyltransferase Histone deacetylases Histone methyltransferase ... Histones H2A, H2B, H3 and H4 are known as the core or nucleosomal histones, while histones H1/H5 are known as the linker ... Archaeal histones may well resemble the evolutionary precursors to eukaryotic histones. Histone proteins are among the most ...

Histone lysine demethylases possess a variety of domains that are responsible for histone recognition, DNA binding, methylated ... Mosammaparast N, Shi Y (2010). "Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases ... CXXC and C5HC2 zinc finger domains responsible for histone recognition and binding Histone lysine demethylases are classified ... Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu G, Li E, Chen T (Sep 2009). "KDM1B is a histone H3K4 demethylase required ...

"Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer ... The histone demethylases are of interest both with respect to their links to diseases, including cancer and inflammatory ... A current focus of the group is modification of histones, in particular oxygenase catalysed N-demethylation of histone ... "Targeting histone lysine demethylases - Progress, challenges, and the future". Biochimica et Biophysica Acta (BBA) - Gene ...

... encodes a histone H3K9 demethylase. In addition, the JMJD1c gene has a role in mouse spermatogenesis. In male homozygous ... It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the ...

They are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative ... Chang B, Chen Y, Zhao Y, Bruick RK (October 2007). "JMJD6 is a histone arginine demethylase". Science. 318 (5849): 444-7. ... Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an enzyme that in humans is encoded by the JMJD6 gene. This ... Klose RJ, Kallin EM, Zhang Y (September 2006). "JmjC-domain-containing proteins and histone demethylation". Nature Reviews ...

"Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467-81. doi:10.1016/j. ... Shin S, Janknecht R (August 2007). "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D". Biochemical and ... Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an ... Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene. KDM4D belongs to the alpha- ...

It functions as a trimethylation-specific demethylase, converting specific trimethylated histone on histone H3 lysine 9 and 36 ... "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467-81. doi:10.1016/j. ... Shin S, Janknecht R (August 2007). "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D". Biochemical and ... "Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity". Nature. 448 (7149): 87-91. Bibcode: ...

FBXL11/KDM2A is a histone H3 lysine 36 demethylase enzyme. The enzymatic activity of FBXL11/KDM2A relies on a conserved JmjC ... Pan D, Mao C, Zou T, Yao AY, Cooper MP, Boyartchuk V, Wang YX (2012). "The Histone Demethylase Jhdm1a Regulates Hepatic ... "CpG islands recruit a histone H3 lysine 36 demethylase". Molecular Cell. 38 (2): 179-90. doi:10.1016/j.molcel.2010.04.009. PMC ... Lysine-specific demethylase 2A (KDM2A) also known as F-box and leucine-rich repeat protein 11 (FBXL11) is an enzyme that in ...

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates ... Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu G, Li E, Chen T (Sep 2009). "KDM1B is a histone H3K4 demethylase required ... "A novel mammalian flavin-dependent histone demethylase". The Journal of Biological Chemistry. 284 (26): 17775-82. doi:10.1074/ ... Lysine (K)-specific demethylase 1B is a protein that in humans is encoded by the KDM1B gene. ...

There are also changes on the genetic and epigenetic level through the function of histone lysine demethylases (KDMs) and ten- ... Rotili D, Mai A (June 2011). "Targeting Histone Demethylases: A New Avenue for the Fight against Cancer". Genes & Cancer. 2 (6 ...

Lysine demethylase 8 is a protein that in humans is encoded by the KDM8 gene. This gene likely encodes a histone lysine ... "Entrez Gene: Lysine demethylase 8". Retrieved 2016-04-09. Suzuki T, Minehata K, Akagi K, Jenkins NA, Copeland NG (2006). "Tumor ... demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. ...

HMT (histone demethylase) inhibitors also act on histones. They prevent the demethylation of the H3K4 histone protein and open ... Histones are proteins that the DNA chromosome are wrapped around. Histones are present as an octamer (set of 8 proteins) and ... Thus, depending on which histone is modified and the exact process, histone modifications can either silence or promote gene ... Loss-of-function mutations at the gene encoding histone H3 methyltransferase, an important enzyme for epigenetic histone ...

"Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4". Cell Res. 20 (2): 154-65 ... "Entrez Gene: Lysine demethylase 7A". Retrieved 2016-04-09. Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, Zhang T, Zhu Q, Zhang K ... Lysine demethylase 7A is a protein that in humans is encoded by the KDM7A gene. GRCh38: Ensembl release 89: ENSG00000006459 - ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Lysine-specific demethylase 7A ( ...

"Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467-81. doi:10.1016/j. ... It functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated ... Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene. This gene is a member of the Jumonji ... and dimethylated lysine 9 on histone H3". Nature. 442 (7100): 307-11. Bibcode:2006Natur.442..307C. doi:10.1038/nature04837. ...

Klose, Rob (2010). "CpG islands recruit a histone H3 lysine 36 demethylase". Mol. Cell. 38 (2): 179-90. doi:10.1016/j.molcel. ... identifying a novel family of histone lysine demethylase enzymes. He then moved to the University of Oxford where, in 2008, he ... Klose, Rob (2007). "The retinoblastoma binding protein RBP2 is an H3K4 demethylase". Cell. 128 (5): 889-900. doi:10.1016/j.cell ... Klose, Rob (2007). "Regulation of histone methylation by demethylimination and demethylation". Nat Rev Mol Cell Biol. 8 (4): ...

"Hypoxia upregulates the histone demethylase JMJD1A via HIF-1". Biochemical and Biophysical Research Communications. 372 (4): ... Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene. This gene encodes a zinc finger protein that ... "Entrez Gene: Lysine demethylase 3A". Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y (May 2006 ... "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell. 125 (3): 483-495 ...

Stewart S, Tsun ZY, Izpisua Belmonte JC (November 2009). "A histone demethylase is necessary for regeneration in zebrafish". ... March 2011). "The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset". Nature. 471 ... It has been found that histone demethylation occurs at the site of the amputation, switching the zebrafish's cells to an " ...

Kim TD, Shin S, Janknecht R (February 2008). "Repression of Smad3 activity by histone demethylase SMCX/JARID1C". Biochemical ... The MH2 domain is also a binding platform for cytoplasmic anchors, DNA-binding cofactors, histone modifiers, chromatin readers ...

"Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA". Nature. 421 (6925): 859-63. Bibcode: ... AlkB homolog 1, histone H2A dioxygenase is a protein that in humans is encoded by the ALKBH1 gene. This gene encodes a homolog ... "Entrez Gene: AlkB homolog 1, histone H2A dioxygenase". Retrieved 2018-07-12. Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F ...

They then recruit histone modifying enzymes, histone deacetylases, histone methylases and histone demethylases. These enzymes ... then the histone methylase G9a can add methyl groups, while the histone demethylase lysine specific demethylase 1 (LSD1) can ... For example, histone deacetylase 1 (HDAC1) and HDAC2 can remove the activating mark histone 3 acetyl lysine 9 (H3K9Ac), ... Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y (December 2004). "Histone demethylation mediated by ...