1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". ... Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene. Histones are basic nuclear proteins that are ... 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. ... "Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T ...
1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". ... Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene. Histones are basic nuclear proteins that ... "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940-8. ... 2004). "Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo". Genes Dev. 18 ( ...
Arabidopsis NRP1 and NRP2 encode histone chaperones and are required for maintaining postembryonic root growth. The Plant Cell ...
He demonstrated the histone chaperone activity and the acetylation of chromatin transcription and these findings have been ... V Swaminathan; A Hari Kishore; KK Febitha; Tapas K Kundu (September 2005). "Human histone chaperone nucleophosmin enhances ... of histone acetyltransferases". Use of certain benzoic acid and benzamide compounds as modulators of enzymes histone ... "Inhibition of Histone Acetyltransferases by CTK7A and Mthods thereof". Method for inhibiting histone acetyltransferases by ...
"Structure and activity of the peptidyl-prolyl isomerase domain from the histone chaperone Fpr4 toward histone H3 proline ... Histone acetylation, or the addition of an acetyl group to histones, is facilitated by histone acetyltransferases (HATs) which ... Much like histone acetylation, histone phosphorylation neutralizes the positive charge on histones which induces euchromatin ... DNA Histone Nucleosome Chromatin Euchromatin Heterochromatin Histone acetylation and deacetylation Histone methylation Protein ...
"Chaperone Nap1 Shields Histone Surfaces Used in a Nucleosome and Can Put H2A-H2B in an Unconventional Tetrameric Form". ... The histone octamer interacts with the DNA through both its core histone folds and N-terminal tails. The histone fold interacts ... Heterodimers, or histone-only intermediates are formed from histone-fold domains. The formation of histone only-intermediates ... Each histone has both an N-terminal tail and a C-terminal histone-fold. Each of these key components interacts with DNA in its ...
Although the vertebrate chaperone HJURP and the yeast chaperone Scm3 have diverged, their N-terminal domains show striking ... Although certain histone modifications at centromeres seem to serve a purpose-for example, contributing to a higher order ... On the other hand, frogs and chickens have domains in their chaperones that are not at all shared with that of yeast. Hence, ... However, even though the CENPA histone variant is in fact conserved, there is a surprisingly large amount of diversity in the ...
During the assembly of regular nucleosomal arrays, these nucleoplasmins transfer the DNA to them by binding to the histones. ... Nucleoplasmin, the first identified molecular chaperone is a thermostable acidic protein with a pentameric structure. The ... Tejun S, Yaozhou Z (2007). "Nucleoplasmin, an Important Nuclear Chaperone". Chinese Journal of Biochemistry and Molecular ... the archetypal molecular chaperone". Seminars in Cell Biology. 1 (1): 11-17. PMID 1983266. Rice P, Garduño R, Itoh T, Katagiri ...
Histones are important in the process of gene expression, and their positioning as determined by chaperone proteins is ... The chaperones also can change the conformation of the nucleosome as a whole. Modifications to histones, including acetylation ... She also proposed that histone-DNA bonds are weaker at points where less of the histone contacts the DNA, which was confirmed ... Luger has done significant studies of histones, researching the connection between their chaperone proteins and acetylation, as ...
... histone chaperone that execute a coordinating role in сhromatin remodeling. Teif VB, Rippe K (September 2009). "Predicting ... "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification". Cell. 146 (6): 1016 ... particularly in terms of the nucleosome histones H3 and H4 and the linker histone H1. Histone variants with two exons are ... The histone variant H2AX constitutes about 10% of the H2A histones in human chromatin. γH2AX (phosphorylated on serine 139 of ...
... which serve as molecular chaperone proteins for histone assembly into nucleosomes. The N-terminal domain of nucleoplasmins ... May 2006). "Structural insights into histone demethylation by JMJD2 family members". Cell. 125 (4): 691-702. doi:10.1016/j.cell ... Klose RJ, Zhang Y (April 2007). "Regulation of histone methylation by demethylimination and demethylation". Nature Reviews. ... October 2001). "The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly". ...
... complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone ... Histone deacetylase 2 (HDAC2) is an enzyme that in humans is encoded by the HDAC2 gene. It belongs to the histone deacetylase ... This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein ... March 2014). "Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the ...
Anwar A, Siegel D, Kepa JK, Ross D (Apr 2002). "Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone ... HSPA4 has been shown to interact with: APAF1 DNAJB1, HDAC1, HSF1, HSPBP1, Histone deacetylase 2, NAD(P)H dehydrogenase (quinone ... O'Keeffe B, Fong Y, Chen D, Zhou S, Zhou Q (Jan 2000). "Requirement for a kinase-specific chaperone pathway in the production ... Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF (Dec 1996). "A pathway of multi-chaperone interactions ...
Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, ... complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone ... The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone ... Histone deacetylase Histone deacetylase inhibitor GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, May 2017 GRCm38: ...
1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". ... Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene. Histones are basic nuclear proteins that are ... "Entrez Gene: HIST3H3 histone cluster 3, H3". Govin J, Caron C, Rousseaux S, Khochbin S (2005). "Testis-specific histone H3 ... 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol. Cell. ...
The formation of these features is the result of histone chaperones, HIRA and ASF1, whose chromatin remodeling activities here ... "The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases". ...
... and the histone code regulates histone-DNA interactions, the chaperone code controls how proteins are folded to produce a ... chaperone localization 4) chaperone-co-chaperone interaction. The Chaperone code is incredibly complex with multiple layers of ... Understanding the entire chaperone code-all the PTMs on all major chaperones, co-chaperones that control all aspects of life. ... Studies of the chaperone code may include: Level 1: Understanding the role and regulation of single PTMs on a single chaperone ...
Recent development of a reconstitution system has identified the histone chaperone FACT as an essential component of condensin ... indicating that the evolutionary origin of condensins precede that of histones. The fact that condensins I and II are widely ...
E2 SUMO-conjugating enzyme E3 ubiquitin ligases Flap endonuclease Helicases Histone acetyltransferase Histone chaperone Histone ... Milutinovic S, Zhuang Q, Szyf M (June 2002). "Proliferating cell nuclear antigen associates with histone deacetylase activity, ...
... is also a histone deacetylase inhibitor and chemical chaperone, leading respectively to research into its ... Sodium phenylbutyrate can act as a chemical chaperone, stabilising the mutant CFTR in the endoplasmic reticulum and allowing it ... Deriving from its activity as a histone deacetylase inhibitor, sodium phenylbutyrate is under investigation for use as a ... Chanoux RA, Rubenstein RC (17 July 2012). "Molecular Chaperones as Targets to Circumvent the CFTR Defect in Cystic Fibrosis". ...
... thereby allowing the misfolded protein cargo to be physically transported to chaperones and proteasomes for subsequent ... Histone acetyltransferase (HAT) Histone deacetylase inhibitor Histone methyltransferase (HMT) Histone-modifying enzymes RNA ... from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the DNA more ... Histone deacetylases remove those acetyl groups, increasing the positive charge of histone tails and encouraging high-affinity ...
Gurard-Levin ZA, Quivy JP, Almouzni G (2014). "Histone chaperones: assisting histone traffic and nucleosome dynamics". Annual ... To orchestrate this specialised loading there are CENPA-specific histone chaperones: HJURP in human, CAL1 in drosophila and ... The CENPA protein is a histone H3 variant which replaces one or both canonical H3 histones in a subset of nucleosomes within ... Sullivan KF, Hechenberger M, Masri K (November 1994). "Human CENP-A contains a histone H3 related histone fold domain that is ...
There are some chaperones which identify aggregates by recognizing their hydrophobic region. These chaperone may work as ... Histone deacetylase 6 is the protein that, in the deacetylase adaptor protein function, forms Lewy bodies (the regular wild- ... In cultured cells, when the production of misfolded proteins exceeds the capacity of the chaperone refolding system and the ... Gamerdinger, M; Kaya, AM; Wolfrum, U; Clement, AM; Behl, C (2011). "BAG3 mediates chaperone‐based aggresome‐targeting and ...
"Structure and Activity of the Peptidyl-Prolyl Isomerase Domain from the Histone Chaperone Fpr4 toward Histone H3 Proline ... allowing it to control the dissociation of SLBP from histone mRNA. This leads to Pin1 being able to affect histone mRNA decay. ... Histone H3 has an important lysine residue at the 36 position (also written K36) on the N-terminal tail which can be methylated ... Histones H2A and H2B also have multiple proline residues near amino acids that when modified affect the activity surrounding ...
Chuang JZ, Zhou H, Zhu M, Li SH, Li XJ, Sung CH (May 2002). "Characterization of a brain-enriched chaperone, MRJ, that inhibits ... Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone ... Linse S, Thalberg K, Knowles TP (2021). "The unhappy chaperone". QRB Discovery. Cambridge University Press. 2. doi:10.1017/qrd. ... November 2014). "Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub- ...
In histone acetylation and deacetylation, histone proteins are acetylated and deacetylated on lysine residues in the N-terminal ... The regulation of transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins by acetylation and ... The acetylation of STAT3 is catalyzed by histone acetyltransferase p300, and reversed by type 1 histone deacetylase. The lysine ... Typically, these reactions are catalyzed by enzymes with histone acetyltransferase (HAT) or histone deacetylase (HDAC) activity ...
Nucleophosmin has multiple functions: Histone chaperones Ribosome biogenesis and transport Genomic stability and DNA repair ... Lindström MS (2011). "NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling". Biochemistry ... this subtype of acute myelogenous leukemia include the refolding of the C-terminal domain using pharmalogical chaperones and ...
Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a ... Chaperones. 5 (2): 98-112. ISSN 1466-1268. PMC 312896. PMID 11147971. "Entrez Gene: DNAJA2 DnaJ (Hsp40) homolog, subfamily A, ... The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene ... novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546-56. doi:10.1128/MCB. ...
The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in ... Targeting the cancer chaperone HSP90. Jennifer R. Smith and Paul Workman. Drug Discovery Today: Therapeutic Strategies. Volume ... Belinostat is a histone deacetylase inhibitor (HDACi). TopoTarget expects to launch an initial regulatory study using ... and commercialization of a group of small molecules that inhibit histone deacetylase (HDAC) enzymes. One of these drugs- ...
By contributing to proper formation of spermatoproteasomes, α4s facilitates histone degradation at sites of meiotic DNA damage ... Sulistio YA, Heese K (March 2016). "The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease ... May 2013). "Reconfiguration of the proteasome during chaperone-mediated assembly". Nature. 497 (7450): 512-516. Bibcode: ... "Proteasome subunit α4s is essential for formation of spermatoproteasomes and histone degradation during meiotic DNA repair in ...