Both HLA class I and II alleles have been found to present these antigens. Some of these antigens are ubiquitously expressed in ... Major and Minor Histocompatibility Antigens to Non-Inherited Maternal Antigens (NIMA), Histocompatibility. INTECH. p. 146. ISBN ... Minor histocompatibility antigen (also known as MiHA) are peptides presented on the cellular surface of donated organs that are ... Minor histocompatibility antigens are due to normal proteins that are in themselves polymorphic in a given population. Even ...
... matching of MHC class I and MHC class II were observed. Human MHC class I and II are also called human leukocyte antigen (HLA ... MHC class I, MHC class II, and MHC class III. Among all those genes present in MHC, there are two types of genes coding for the ... MHC class II can be conditionally expressed by all cell types, but normally occurs only on "professional" antigen-presenting ... Zhu L, Ruan XD, Ge YF, Wan QH, Fang SG (June 2007). "Low major histocompatibility complex class II DQA diversity in the Giant ...
"Structure of the human class I histocompatibility antigen, HLA-A2". Nature. 329 (6139): 506-12. Bibcode:1987Natur.329..506B. ... Wang Z, Cao Y, Albino AP, Zeff RA, Houghton A, Ferrone S (February 1993). "Lack of HLA class I antigen expression by melanoma ... Saper MA, Bjorkman PJ, Wiley DC (May 1991). "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A ... β2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α1, α2, and α3 proteins which are ...
"Structure of the human class I histocompatibility antigen, HLA-A2". Nature. 329 (6139): 506-512. Bibcode:1987Natur.329..506B. ... Saper MA, Bjorkman PJ, Wiley DC (1991). "Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution ... the HLA-A2 human histocompatibility antigen. This work was published in 1987, first at 3.5Å resolution (PDB entry 1HLA) and ... "Awards - American Society for Histocompatibility and Immunogenetics". www.ashi-hla.org. "NIH Director's Pioneer Award". NIH ...
"Expression of class I and class II major histocompatibility complex antigens on human hepatocytes". Hepatology. 8 (3): 449-454 ... Czaja, Albert J.; Donaldson, Peter T. (August 2002). "Gender effects and synergisms with histocompatibility leukocyte antigens ... anti soluble liver antigen (SLA), liver-pancreas antigen (LP), and anti-mitochondrial antibody (AMA)) are of use, as is finding ... rare except for overlap syndromes with primary biliary cholangitis Anti-soluble liver antigen/liver pancreas antibody antigen ...
Desoye, G.; Dohr, G. A.; Ziegler, A. (1991). "Expression of human major histocompatibility (MHC) antigens on germ cells and ... In addition, HLA-G expresses oligosaccharides that are very different from those linked to other HLA class I molecules, so the ... These immune markers are also known as major histocompatibility complex (MHC) antigens or more specifically in humans as human ... Ljunggren, H. G.; Karre, K. (1990). "In search of "missing self"? MHC class I molecules and NK cell recognition". Immunol. ...
HLA class I histocompatibility antigen, A alpha chain) at the PDBe-KB. (Articles with short description, Short description ... "HLA-A major histocompatibility complex, class I, A [Homo sapiens (human)]". National Center for Biotechnology Information. U.S ... HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of human MHC ... "Major Histocompatibility Complex, Class I, A". Gene Cards. Weizmann Institute of Science. 7 November 2013. Retrieved 16 ...
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster ... The stable MHC class II + antigen complex is then presented on the cell surface. Without CLIP, MHC class II aggregates ... "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein ... "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens". Nucleic Acids Research ...
"The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens". Nature. 329 (6139): ... Enforcing the restriction that T cells are activated by peptide antigens only when the antigens are bound to self-MHC molecules ... "Antigen Presentation and Major Histocompatibility Complex". Reference Module in Biomedical Sciences: 90-98. doi:10.1016/B978-0- ... MHC-restricted antigen recognition, or MHC restriction, refers to the fact that a T cell can interact with a self-major ...
"Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line". J. Biol. Chem. ... Ultimately, papain-solubilized fragments of the human class II MHC antigens HLA-DR1, HLA-DR2, HLA-DR3, HLA-DR4, HLA-DR7, and ... Nathenson, S. G.; Davies, D. A. (1966). "Solubilization and partial purification of mouse histocompatibility antigens from a ... "Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and ...
"An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility ... complex class I proteins bind peptides with a blocked NH(2) terminus in vivo". The Journal of Experimental Medicine. 191 (12): ...
In different studies, rheumatoid arthritis is strongly linked to major histocompatibility complex (MHC) class II antigens. The ... depending on whether their TCR recognizes an MHC class I-presented antigen (CD8) or an MHC class II-presented antigen (CD4). It ... Antigens inside a cell are bound to class I MHC molecules, and brought to the surface of the cell by the class I MHC molecule, ... If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell ...
Class 2 major histocompatibility complex (MHC) antigens on macrophages are up-regulated at sites of VUE. Neutrophils should not ... Foetal macrophages in VUE proliferate and are activated as a result of the up-regulation of MHC class 2 antigen expression. ... Majority of the antigen-presenting cells were Hofbauer cells (macrophages) were of foetal origin. Perivillous monocyte- ... The trafficking of maternal lymphocytes responding to an antigen in the chronic deciduitis could activate and enter via the ...
HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also ... 1984). "Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes". Nature. 308 (5957): ... 1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475- ... 1987). "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes". J. ...
"Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain". Nucleic Acids Res ... HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. ... Parham P, Ohta T (1996). "Population biology of antigen presentation by MHC class I molecules". Science. 272 (5258): 67-74. ... 1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121-8. doi:10.1007/BF00211424. ...
HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA ... "Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain". Nucleic Acids Res ... Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha ... "Entrez Gene: HLA-DRA major histocompatibility complex, class II, DR alpha". Bénichou S, Benmerah A (2003). "[The HIV nef and ...
"The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody". The ... 2016 - The role of dendritic cell expressed CTLA-4 in Th immune polarization is first described 2016 - A third class of immune ... Antigen-Antibody binding hypothesis (John Marrack) 1940 - Identification of the Rh antigens (Karl Landsteiner and Alexander ... Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow- ...
"The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene". Proceedings of ... This association prepares the MHC class I for binding an antigen for presentation on the cell surface. A prolonged association ... the job of chaperoning the MHC class I protein while the tapasin links the complex to the transporter associated with antigen ... As newly synthesized MHC class I α-chains enter the endoplasmic reticulum, calnexin binds on to them retaining them in a partly ...
York IA, Rock KL (1996). "Antigen processing and presentation by the class I major histocompatibility complex". Annual Review ...
... a major histocompatibility complex class I antigen homolog". Cold Spring Harbor Symposia on Quantitative Biology. 54 (Pt 1): ... Story CM, Mikulska JE, Simister NE (December 1994). "A major histocompatibility complex class I-like Fc receptor cloned from ... "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to ... It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2- ...
2002). "HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand ... 2005). "Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1". Blood. ... "Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR". Tissue Antigens. 52 (4): 312 ... 2005). "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation". ...
... vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen- ... Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature 345:449-452. Moins- ... The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules. 1991. Eur J ... NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J ...
Major histocompatibility complex Human leukocyte antigen HLA-DP "Entrez Gene: HLA-DPA1 major histocompatibility complex, class ... Major histocompatibility complex, class II, DP alpha 1, also known as HLA-DPA1, is a human gene. The protein encoded by this ... Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha ... The class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It ...
iNKT cells recognize lipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like antigen ... a member of the CD1 family of antigen-presenting molecules, rather than peptide-major histocompatibility complexes (MHCs). As ... The best known antigen of iNKT cells is alpha-galactosylceramide (αGalCer), which is a synthetic form of a chemical purified ... The highly conserved TCR is made of Va24-Ja18 paired with Vb11 in humans, which is specific for glycolipid antigens. ...
Major histocompatibility complex Human leukocyte antigen HLA-DQ "Entrez Gene: HLA-DQB1 major histocompatibility complex, class ... Major histocompatibility complex, class II, DQ beta 3, also known as HLA-DQB3, is a human gene and also denotes the genetic ... While the overall sequence of the protein encoded by this gene is similar to other HLA class II beta chains, the translated ... "Mapping and nucleotide sequence of a new HLA class II light chain gene, DQB3". Immunogenetics. 30 (4): 243-9. doi:10.1007/ ...
Peptide antigens are displayed by the major histocompatibility complex class I (MHC) proteins on the surface of antigen- ... helping the virus propagate by preventing antigen presentation on the major histocompatibility complex. The proteasome ... Many MHC class I alleles prefer hydrophobic C-terminal residues, and the immunoproteasome complex is more likely to generate ... The strength of MHC class I ligand binding is dependent on the composition of the ligand C-terminus, as peptides bind by ...
... ceruloplasmin and class I major histocompatibility antigens". Experimental Cell Research. 143 (1): 91-102. doi:10.1016/0014- ...
... antigens. In B lymphocytes (B cells), interferon gamma stimulates antibody class switching. All of these cells have different, ... interferon gamma upregulates expression of macrophages and both types of Major Histocompatibility Complex (MHC) ... Dendritic cells phagocytose invaders; then they present the antigen on their surface to stimulate the acquired immune system ( ... These cells can differentiate into many subtypes once activated by antigen presenting cells (APCs) like dendrites. They divide ...
... tolerance can be established in vitro and in vivo for both MHC class I and II as well as minor histocompatibility antigens. ... This means that T-cells with a T-cell receptor specific to antigens presented on the veto cell, bind to the veto cell, and are ... Because veto cells can only suppress T-cell progenitors that are directed against antigens on the veto cells themselves, but ... Veto activity is thought to be a form of antigen-specific suppression that maintains continuous self-tolerance. Cells with veto ...
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 ... Class II molecules are constitutively expressed in professional antigen-presenting cells (APC: B lymphocytes, dendritic cells, ... "Entrez Gene: HLA-DRB1 major histocompatibility complex, class II, DR beta 1". Gregersen PK, Silver J, Winchester RJ (November ... The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer ...