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*  Histamine H2 receptor
Inhibition of neutrophil activation and chemotaxis H2-receptor antagonist GRCh38: Ensembl release 89: ENSG00000113749 - Ensembl ... Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The histamine receptor H2 belongs to the rhodopsin- ... "Entrez Gene: HRH2 histamine receptor H2". Maguire JJ, Davenport AP (29 November 2016). "H2 receptor". IUPHAR/BPS Guide to ... The drug betazole is an example of a histamine H2 receptor agonist. Histamine is a ubiquitous messenger molecule released from ...
*  Histamine H1 receptor
Horváth BV, Szalai C, Mándi Y, László V, Radvány Z, Darvas Z, Falus A (Nov 1999). "Histamine and histamine-receptor antagonists ... Brew OB, Sullivan MH (Sep 2001). "Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto- ... Histamine H1 receptors are activated by endogenous histamine, which is released by neurons that have their cell bodies in the ... While the best characterized function of the histamine system in the brain is regulation of sleep and arousal, histamine is ...
*  Cimetidine
Tagamet®: Discovery of Histamine H2-receptor Antagonists from American Chemical Society National Historic Chemical Landmarks. ... the first H2 receptor antagonist. Burimamide, a specific competitive antagonist at the H2 receptor, 100 times more potent than ... Cimetidine's mechanism of action as an antacid is as a histamine H2 receptor antagonist. Cimetidine is a potent inhibitor of ... Sivelle PC, Underwood AH, Jelly JA (March 1982). "The effects of histamine H2 receptor antagonists on androgen action in vivo ...
*  Metiamide
... is a histamine H2 receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate ... Durant, G. J.; Emmett, J. C.; Ganellin, C. R.; Roe, A. M.; Slater, R. A. (1976). "Potential histamine H2-receptor antagonists. ... ISBN 978-0-19-850346-0. "Tagamet®: Discovery of Histamine H2-receptor Antagonists". National Historic Chemical Landmarks. ... "Cyanoguanidine-thiourea equivalence in the development of the histamine H2-receptor antagonist, cimetidine". Journal of ...
*  Ranitidine
... is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid ... Ranitidine and other histamine H2 receptor antagonists may increase the risk of pneumonia in hospitalized patients. They may ... "Effect of histamine H2-receptor antagonists on vitamin B12 absorption." The Annals of Pharmacotherapy 26.10 (1992): 1283-1286. ... Its development was a response to the first in class histamine H2 receptor antagonist, cimetidine, developed by Sir James Black ...
*  National Historic Chemical Landmarks
"Tagamet: Discovery of Histamine H2-receptor Antagonists". National Historic Chemical Landmarks. American Chemical Society. ... California Discovery of histamine H2-receptor antagonists and the introduction of Tagamet by scientists at Smith Kline and ...
*  Burimamide
... is an antagonist at the H2 and H3 histamine receptors. It is largely inactive as an H2 antagonist at physiological ... ISBN 978-0-19-850346-0. "Tagamet®: Discovery of Histamine H2-receptor Antagonists". National Historic Chemical Landmarks. ... in their intent to develop a histamine antagonist for the treatment of peptic ulcers. The discovery of burimamide ultimately ...
*  Zolantidine
... is a brain-penetrating selective histamine H2 receptor (HRH2) antagonist developed by Smith, Kline & French, with ... is a Potent Selective Brain-penetrating Histamine H2-receptor Antagonist". British Journal of Pharmacology. 93 (1): 69-78. doi: ... It is a benzthiazole derivative with a 30-fold higher potency for H2 receptors than other peripheral and central receptors. ...
*  C19H28N2O4
... a histamine H2 receptor antagonist drug. ...
*  Iprindole
Tsai BS, Yellin TO (1984). "Differences in the interaction of histamine H2 receptor antagonists and tricyclic antidepressants ... Kanba S, Richelson E (1983). "Antidepressants are weak competitive antagonists of histamine H2 receptors in dissociated brain ... It is presumed to act as an inhibitor or antagonist/inverse agonist of all sites. Considering the range of its therapeutic ... Tran VT, Chang RS, Snyder SH (1978). "Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine". Proc ...
*  Nizatidine
... is a histamine H2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment ... Nizatidine proved to be the last new histamine H2 receptor antagonist introduced prior to the advent of proton pump inhibitors ... another popular H2 receptor antagonist "Nizatidine". Livertox.nih.gov. Retrieved 2015-10-11. [1] Archived May 26, 2008, at the ...
*  Tricyclic antidepressant
Tsai BS, Yellin TO (November 1984). "Differences in the interaction of histamine H2 receptor antagonists and tricyclic ... The TCAs also have varying but typically high affinity for antagonising the H1 and H2 histamine receptors, as well as the ... "Tricyclic antidepressant drugs block histamine H2 receptor in brain". Nature. 269 (5624): 163-5. Bibcode:1977Natur.269..163G. ... In addition to their reuptake inhibition, many TCAs also have high affinity as antagonists at the 5-HT2 (5-HT2A and 5-HT2C), 5- ...
*  Nonsteroidal antiandrogen
An over-the-counter histamine H2 receptor antagonist that also shows very weak activity as an AR antagonist. Also inhibits ... They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the ... Similar to enzalutamide and apalutamide, but with increased efficacy as an AR antagonist, little or no central nervous system ... Relative to enzalutamide and apalutamide, shows greater efficacy as an AR antagonist, improved activity against mutated AR ...
*  Zolmitriptan
... is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. ""2008 Top 200 generic drugs by ...
*  H2 antagonist
The H2 antagonists are competitive antagonists of histamine at the parietal cell's H2 receptor. They suppress the normal ... Like the H1 antagonists, some H2 antagonists function as inverse agonists rather than receptor antagonists, due to the ... H2 antagonists, sometimes referred to as H2RA and also called H2 blockers, are a class of medications that block the action of ... histamine at the histamine H2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid. H2 ...
*  Famotidine
... , sold under the trade name Pepcid among others, is a histamine H2 receptor antagonist that inhibits stomach acid ... long-acting histamine H2-receptor antagonist: comparison with cimetidine and ranitidine in the treatment of Zollinger-Ellison ... Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear ... Ranitidine, another popular H2 receptor antagonist Nizatidine Truven Health Analytics, Inc. DRUGDEX® System (Internet) [cited ...
*  Lafutidine
... (INN) is a second generation histamine H2 receptor antagonist having multimodal mechanism of action and used to ... Like other H2 receptor antagonists it prevents the secretion of gastric acid. It also activates calcitonin gene-related peptide ...
*  Zollinger-Ellison syndrome
Proton pump inhibitors (such as omeprazole and lansoprazole) and histamine H2-receptor antagonists (such as famotidine and ...
*  Zactane
... is the trade name of two different drugs: Famotidine, a histamine H2-receptor antagonist that inhibits stomach acid ...
*  Oxmetidine
... is an H2 histamine receptor receptor antagonist. Willson, R. A.; Hall, T; Hart, J. (24 October 1987). "Oxmetidine (H2 receptor ... antagonist) induced cytotoxicity in isolated rat hepatocytes". Journal of Applied Toxicology. 8 (3): 223-225. doi:10.1002/jat. ...
*  Niperotidine
... is a histamine antagonist selective for the H2 subtype. It was studied as a treatment for excessive gastric ... Palasciano, G; Maggi, V; Portincasa, P (1990). "The effect of the H2-antagonist niperotidine on intragastric acidity in healthy ...
*  Antihistamine
H2-antihistamines, like H1-antihistamines, occur as inverse agonists and neutral antagonists. They act on H2 histamine ... histamine acts on H2 to stimulate acid secretion; drugs that inhibit H2 signaling thus reduce the secretion of gastric acid. H2 ... H2-antihistamines bind to histamine H2 receptors in the upper gastrointestinal tract, primarily in the stomach. Histamine ... Research into these drugs led to the discovery that they were H1 antagonists and also to the development of H2 antagonists, ...
*  Roxatidine acetate
... is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, ...
*  Discovery and development of proton pump inhibitors
... and omeprazole was quickly shown to be clinically superior to the histamine H2 receptor antagonists, and was launched in 1988 ... sodium with other anti-secretory drugs showed that it was significantly more effective than H2-receptor antagonists and either ... Therefore, a new class of PPIs, potassium-competitive acid blockers (P-CABs) or acid pump antagonists (APAs), have been under ... of histamine, acetylcholine, or other yet to be discovered stimulants. Also, their mechanism of action involves covalent ...
*  Fine chemical
... when the overwhelming success of the histamine H2 receptor antagonists Tagamet (cimetidine) and Zantac (ranitidine ... the second H2 receptor antagonist, marketed as Zantac by Glaxo. Other pharmaceutical and agrochemical companies gradually ...
*  Histamine H3 receptor
... also weak H2 antagonist) Ciproxifan Clobenpropit (also H4 antagonist) Conessine Failproxifan (no tolerance formation, like with ... Histamine antagonist#H3-receptor antagonists GRCh38: Ensembl release 89: ENSG00000101180 - Ensembl, May 2017 GRCm38: Ensembl ... Esbenshade TA, Fox GB, Cowart MD (Apr 2006). "Histamine H3 receptor antagonists: preclinical promise for treating obesity and ... "Histamine and Histamine Receptors in Tourette Syndrome and Other Neuropsychiatric Conditions." Neuropharmacology 106 (July 2016 ...
*  C. Robin Ganellin
1, 2001, 13-vii-13-viii "Charon Robin Ganellin", EHRS Tagamet®: Discovery of Histamine H2-receptor Antagonists from American ... collaborating with Sir James Black researching histamine H2-receptor antagonists. This research eventually led to the discovery ... This discovery was crucial to their research, providing the impetus to search for a suitable H2-receptor antagonist to affect ... The end result of their trials was cimetidine, an H2-receptor antagonist superior to both burimamide and metiamide. The ...