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*  Mastocytoma
As they release histamine, they are associated with allergic reactions. Mast cells also respond to tissue trauma. Mast cell ... Release of a large amount of histamine at one time can result in ulceration of the stomach and duodenum (present in up to 25 ... Antihistamines, such as diphenhydramine, are given prior to surgery to protect against the effects of histamine released from ... H2 blockers, such as cimetidine, protect against stomach damage from histamine. Vinblastine and CCNU are common chemotherapy ...
*  Histamine H2 receptor
Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The histamine receptor H2 belongs to the rhodopsin- ... The drug betazole is an example of a histamine H2 receptor agonist. Histamine is a ubiquitous messenger molecule released from ... Classification of histamine receptors". Pharmacological Reviews. 49 (3): 253-78. PMID 9311023. "Entrez Gene: HRH2 histamine ... Wang LD, Wang M, Todisco A, Grand E, del Valle J (Jun 2000). "The human histamine H(2) receptor regulates c-jun and c-fos in a ...
*  Degranulation
The mast cell releases a mixture of compounds, including histamine, proteoglycans, serotonin, and serine proteases from its ...
*  Histamine H1 receptor
... s are activated by endogenous histamine, which is released by neurons that have their cell bodies in the ... While the best characterized function of the histamine system in the brain is regulation of sleep and arousal, histamine is ... Horváth BV, Szalai C, Mándi Y, László V, Radvány Z, Darvas Z, Falus A (Nov 1999). "Histamine and histamine-receptor antagonists ... Within the brain, histamine is synthesized exclusively by neurons with their cell bodies in the tuberomammillary nucleus (TMN) ...
*  Cimetidine
In the process, the SK&F scientists also proved the existence of histamine H2 receptors. The SK&F team used a rational drug- ... Tagamet®: Discovery of Histamine H2-receptor Antagonists from American Chemical Society National Historic Chemical Landmarks. ... Cimetidine's mechanism of action as an antacid is as a histamine H2 receptor antagonist. Cimetidine is a potent inhibitor of ... Sivelle PC, Underwood AH, Jelly JA (March 1982). "The effects of histamine H2 receptor antagonists on androgen action in vivo ...
*  Basophil activation
Allergic symptoms are caused by an initial systemic histamine release by activated basophiles and mast cells, that may lead to ...
*  Histamine
In aqueous solution, histamine exists in two tautomeric forms: Nπ-H-histamine and Nτ-H-histamine. The imidazole ring has two ... Thus, histamine is normally protonated to a singly charged cation. Histamine is a monoamine neurotransmitter. Histamine is ... Histamine intolerance Histamine receptor antagonist Red wine headache Scombroid food poisoning Histamine Material Safety Data ... Sake contains histamine in the 20-40 mg/L range; wines contain it in the 2-10 mg/L range. Most histamine in the body is ...
*  Histamine receptor
Holger Stark: Histamine Receptors, BIOTREND Reviews No. 01, November 2007 The Histamine Receptor Histamine Receptor at the US ... The histamine receptors are a class of G protein-coupled receptors which bind histamine as their primary endogenous ligand. ... Classification of histamine receptors". Pharmacol. Rev. 49 (3): 253-78. PMID 9311023. Hofstra CL, Desai PJ, Thurmond RL, Fung- ... "Histamine Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...
*  Histamine dihydrochloride
... (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of ... The combination of histamine dihydrochloride and interleukin-2 was approved for use in AML patients within the European Union ... Histamine dihydrochloride is administered in conjunction with low doses of the immune-activating cytokine interleukin-2 (IL-2) ... The drug is also available through a named patient program in several other countries (excluding the US). Histamine ...
*  Histamine intolerance
... , sometimes called histaminosis, is an over-accumulation of histamine in the human body. Histamine ... The imbalance in histamine intolerance is between the synthesis and selective release of histamine from certain granulocytes (i ... Mast cell Basophil Food intolerance Red wine headache Maintz, L.; Novak, N. (2007). "Histamine and histamine intolerance". ... Roughly 1% of the population suffers from histamine intolerance; of those, 80% are middle-aged. ...
*  Histamine agonist
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2 : ... Histamine antagonist Histamine agonist at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of ... H3 : Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). ... Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. ...
*  Histamine H4 receptor
Bioreagents.com: Histamine H4 Receptor Salem A, Rozov S, Al-Samadi A, et al. Histamine metabolism and transport are deranged in ... The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily ... "Molecular modeling and site-specific mutagenesis of the histamine-binding site of the histamine H4 receptor". Mol. Pharmacol. ... The Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cell chemotaxis. This ...
*  Histamine trifluoromethyl toluidide
... (HTFMT) is a mixed H1/H2 histamine agonist which is significantly more potent than ... Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of ... It also produces additional actions which appear to be independent of histamine receptors. Whyment AD, Blanks AM, Lee K, Renaud ... Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of ...
*  Histamine N-methyltransferase
... is encoded by a single gene which has been mapped to chromosome 2. In mammals, histamine is ... Histamine N-methyltransferase (HMT, HNMT) is an enzyme that in humans is encoded by the HNMT gene. Histamine N- ... Histamine N-methyltransferase catalyzes the methylation of histamine in the presence of S-adenosylmethionine (SAM) forming N- ... DAO Diamine oxidase Histamine Histamine intolerance GRCh38: Ensembl release 89: ENSG00000150540 - Ensembl, May 2017 GRCm38: ...
*  Histamine H3 receptor
"Histamine and Histamine Receptors in Tourette Syndrome and Other Neuropsychiatric Conditions." Neuropharmacology 106 (July 2016 ... Mouse-models and other research demonstrated that reducing histamine concentration in the H3R causes tics, but adding histamine ... and also control histamine turnover by feedback inhibition of histamine synthesis and release. The H3 receptor has also been ... Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where ...
*  Solar urticaria
Histamines are proteins associated with many allergic reactions. When the UV radiation or light comes in contact with a person ... "Histamine". Davidson College. 2000. Retrieved 2008-11-01. Taranova, NP (1975). "[Effect of whole-body x-irradiation on the ... When this occurs, the permeability of vessels near the area of histamine release is increased. This allows blood fluid to enter ... Antihistamines suppress the activity of the histamine. Diphenhydramine, a first-generation H1 receptor antagonist or medicine ...
*  H2 antagonist
... are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the ... Ranitidine was also the result of a rational drug design process utilising the by-then-fairly-refined model of the histamine H2 ... They designated the one acted upon by the traditional antihistamines as H1, and the one acted upon by histamine to stimulate ... They accomplish this by two mechanisms: Histamine released by ECL cells in the stomach is blocked from binding on parietal cell ...
*  List of psychoactive plants
Histamine alkaloids. Acacia sophorae, Tryptamine in leaves, bark Acacia macradenia, Tryptamine Acacia maidenii, 0.6% NMT and ...
*  Food intolerance
Maintz L, Novak N (2007). "Histamine and histamine intolerance". Am J Clin Nutr. 85 (5): 1185-96. PMID 17490952. Böttcher I, ... Food allergies are immune reactions, typically an IgE reaction caused by the release of histamine but also encompassing non-IgE ... Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N (May 2006). "Evidence for a reduced histamine degradation ... Götz M (1996). "[Pseudo-allergies are due to histamine intolerance]". Wien Med Wochenschr (in German). 146 (15): 426-30. PMID ...
*  Diphenhydramine
... acts primarily as an inverse agonist of the histamine H1 receptor. It is a member of the ethanolamine class of ... Histamine, Bradykinin, and Their Antagonists". In Brunton L. Goodman & Gilman's The Pharmacological Basis of Therapeutics (12e ... Krystal AD, Richelson E, Roth T (2013). "Review of the histamine system and the clinical effects of H1 antagonists: basis for a ... By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms. It also crosses the ...
*  Trevor M. Jones
... anti-histamine); Atovaquone (PCP/Malaria); Exosurf (infant respiratory distress); Mivacron and Nuromax (neuromuscular blockade ...
*  Pirzada Qasim
2 (1): 131-134 (1973). Histamine and its antagonists. I. Some stearic and pharmacodynamic consideration. J. Sci. 2(2): 249-258 ...
*  Methyltransferase
... and histamine N-methyltransferase (HNMT), which methylates histamine in the process of histamine metabolism. Catechol-O- ... "HNMT histamine N-methyltransferase". NCBI Genetic Testing Registry. Retrieved 18 February 2014. "COMT catechol-O- ...
*  Tourette syndrome
"Histamine and Histamine Receptors in Tourette Syndrome and Other Neuropsychiatric Conditions." Neuropharmacology 106 (July 2016 ... "Histamine Modulation of the Basal Ganglia Circuitry in the Development of Pathological Grooming." Proceedings of the National ... "The Magnificent Two: Histamine and the H3 Receptor as Key Modulators of Striatal Circuitry." Progress in Neuro- ... "Histamine and the Striatum." Neuropharmacology 106 (July 2016): 74-84 Sadek, Bassem, Ali Saad, Adel Sadeq, Fakhreya Jalal, and ...
*  Red wine headache
Maintz, Laura; Novak, N (May 2007). "Histamine and histamine intolerance". American Society for Clinical Nutrition. 85 (5): ... alcohol consumption may lead to elevated plasma histamine levels even in the absence of histamines in the beverage consumed. A ... Histamine is present in a variety of bacterially fermented products such as wine, aged cheeses, and sauerkraut. Red wine has 20 ... Dan L. Keiller, president of the Medical Wine Interest and Education Society, reports that histamine in wine may be a cause as ...